| Project/Area Number |
09041195
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Field Research |
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| Research Field |
Human genetics
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| Research Institution | Aichi Cancer Center |
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Principal Investigator |
TAJIMA Kazuo Aichi Cancer Center, Div.of Epidemiol・Cheif, 疫学部, 部長 (30150212)
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| Co-Investigator(Kenkyū-buntansha) |
NUNEZ Lautaro North Catholic Univ., Prof., 教授
CARTIER Luis Chile Univ., Prof., 医学部, 教授
HORAI Satoshi The Graduate Univ.for Advanced Studies, Prof., 先導科学研究科, 教授 (40126157)
WATANABE Hidenobu Niigata Univ., Sch.of Med., Prof., 医学部, 教授 (70037381)
SONODA Shunro Kagoshima Univ., Faculty of Med., Prof., 医学部, 教授 (40036463)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥8,900,000 (Direct Cost: ¥8,900,000)
Fiscal Year 1998: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 1997: ¥4,500,000 (Direct Cost: ¥4,500,000)
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| Keywords | Japanese / Andeans / Mummy / DNA / HTLV human / beta-globin / Mitochondrial DNA / Ethnoepidemiology / HLA |
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| Research Abstract |
To c1arify the paleoanthropological relationship between Japanese and Andeans, characteristics of provirus DNA of human T-cell leukemia virus (HTLV), mitochondrial DNA and nuclear DNA were compared among materials : 1) high and low landers in South America ; 2) Andean mummies ; and 3) southern Japanese. From DNA analysis of HTLV and human leukocyte antigens, it was clarified that high landers in the Andes area were closely related to southern Japanese, but people in other low lands were exclusively different from them. Specific gene human beta-globin was identified from two out of 104 mummies collected in Andes areas. Furthermore, one out two beta-globin positive Andean mummies about 1,500 years ago was positive for HTLV-I pX, too. Base analysis of D-loop regeon of mitochondrial DNA from 90 mummies in north Chile were completed and they showed four specific groups of mitochondrial DNA asshown in contemporary people in South America. These results porvides the first evidence that HTLV-I was carried by ancient Mongoloids to the Andes before the Colonial era. .
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