| Project/Area Number |
13460058
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
食品科学・栄養科学
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
KAWADA Teruo KAWADA,Teruo, 農学研究科, 助教授 (10177701)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TSUZUKI Satoshi KYOTO UNIVERSITY, GRADUATE SCHOOL OF AGRICULTURE, ASITANT APROFESSIR, 農学研究科, 助手 (50283651)
INOUE Kazuo KYOTO UNIVERSITY, GRADUATE SCHOOL OF AGRICULTURE, ASITANT APROFESSIR, 農学研究科, 助手 (80213148)
FUSHIKI Tohru KYOTO UNIVERSITY, GRADUATE SCHOOL OF AGRICULTURE, APROFESSIR, 農学研究科, 教授 (20135544)
|
|---|
| Project Period (FY) |
2001 – 2003
|
| Project Status |
Completed (Fiscal Year 2003)
|
| Budget Amount *help |
¥15,100,000 (Direct Cost: ¥15,100,000)
Fiscal Year 2003: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥4,900,000 (Direct Cost: ¥4,900,000)
Fiscal Year 2001: ¥6,700,000 (Direct Cost: ¥6,700,000)
|
|---|
| Keywords | OBESITY / LIPID METABOLISM / ENERGY METABOLISM / FAT / NUCREAR RECEPTOR / PPAR / AGONIST / ANTAGONIST |
|---|
| Research Abstract |
Obesity became the basis, namely principal factor of many generally known life, habit illness emergences, being related with sick condition emergence deeply was ascertained. As for this research, foundation of that kind of obesity formation it is not we pay attention to lipid metabolism and the energy exchangemechanism. The mechanism decisively carry out important role in hyperplasia of adipose tissue, relation between the control of revelation of knitting machine structure and differentiation formation of white and the brown fat cell was analyzed. As for the execution. people, so far, the long-chain fatty acid became the ligand in hyperplasia of obesity namely white adipose tissue and PPAR controlled gene revelation at transcriptional level as a master regulator, beginning discovered the fact that the function receives decoration furthermore with the various nutrients promptly in the world.
At the time of this researching PPAR as a fatty acid sensor, lipid metabolism and energy metabol
… More
ism relating gene revelation are controlled with some kind of signal transduction mechanism whether the above-mentioned signal transduction mechanism, it receives the decoration with meal factor whether the lipid metabolism which decreases as for functional playback of energy exchange system possibility research. We analyzed clear 3 points as study purposes.
As a result, PPAR controlling transcription of the.,lipid' metabolism and the energy exchange type gene having a meal the fatty acid of origin a ligand, furthermore in signal transduction system inside 'this cell coactivator factor of nuclear transcriptional factor, the especially CREB connection protein (CBP) with the PPAR ligand over saturation under condition, the revelation quantity Of the metabolism details electron being stipulated by the revelation quantity of CBP became clearr in vivo such as thing and the high fat food intake where that homolog p300 has participated deeply. In addition, it existed in brown adipose tissue and the deviation from coactivator protein which relates to body thermal production deeply (UCP) as for revelation the lipid metabolism which decreases from thefact that. it is controlled by PPAR, with PPAR ligand such as highly' unsaturated fatty acid and plant origin isoprenoid, possibility of functional playback of energy exchange system was suggested. Less
|
