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Functional anatomy of motor control system of the cortico-basal ganglial-thalamo loop without passing through the cerebral cortex

Research Project

Project/Area Number 15500247
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionTokyo Women's Medical University

Principal Investigator

SATO Fumi  Tokyo Women's Medical University, Department of Anatomy, Associate professor, 医学部, 助教授 (60205961)

Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2004: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2003: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywordssuperior colliculus / basal ganglia / thalamus / axonal trajectory / single axon / motor control / BDA / cerebral cortex / 軸索分枝
Research Abstract

The main purpose of the present study was to determine the characteristics of ascending projection pattern of neurons in the deep layers of the SC constituting the tecto-reticulospinal tract. We studied ascending axonal trajectories of single neurons in the deep layers of the cat superior colliculus(SC) by labeling a small pool of neurons with biotinylated dextran amine(BDA). All of the SC axons forming the predorsal bundle emitted 1-3 ascending branches before decussation. Ipsilateral ascending branches ran rostrally and gave rise to several collaterals to the central gray and mesencephalic reticular formation before entering the thalamus. At the meso-diencephalic junction, these branches began to run dorsally and/or ventrally towards the thalamus. Based on the distribution of axon collaterals and terminals in the thalamus, 28 SC neurons reconstructed on serial sections were classified into 3 types : 1) neurons projecting to the ventral thalamus (the fields of Forel and zona incerta)(n=10), 2)neurons projecting to the dorsal thalamus (mainly to the intralaminar nuclei) (n=4), and 3)neurons projecting to both the ventral and dorsal thalamus (n=14). Our data indicate that SC neurons convey the same information to the spinal cord, brainstem, and the thalamus. These results suggest that single SC neurons simultaneously control eyes, head and body movements, and also send their information to the cerebral cortex and the basal ganglia via the thalamus as a collorary discharge. Anatomical studies have indicated that predorsal bundle neurons could be influenced by extensive nigrotectal projections. The present study has revealed that predorsal bundle cells projected to the CM-pf complex, which is known as a major source of thalamostriatal projection. Therefore, outputs of the basal ganglia from the substantia nigra could be transmitted by way of the nigrotectal-tectothalamic-thalamostriatal projection back to the striatum.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (6 results)

All 2004 2003 Other

All Journal Article (4 results) Publications (2 results)

  • [Journal Article] Projections of the deep layers of the superioro colliculus to the thalamus in the rat.2004

    • Author(s)
      H.Ikeda, F.Sato, H.H.Hijikata, H.Sasaki
    • Journal Title

      Anatomical Science international 79 Suppl.

      Pages: 376-376

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Morphological differences of the perivascular glial limiting membrane between capillaries and large vessels.2004

    • Author(s)
      K.Watanabe, H.Sasaki, F.Sato, Y.Honda
    • Journal Title

      Anatomical Science International 79 Suppl.

      Pages: 332-332

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Bilateral aberrant biceps brachii muscles with special reference to their common nerve trunks.2003

    • Author(s)
      T.Kawashima, S.Yoshitomi, M.Ito, Y.Hoshino, E.Oh-Ichi, E.Ikeda, M.Igarashi, Y.Yoshimura, F.Sato, H.Sasaki
    • Journal Title

      Okajimas Folia Anatomica Japonica 80

      Pages: 77-84

    • NAID

      130004773548

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] An Anatomical study of the human cardiac veins with special reference to the drainage of the great cardiac vein.2003

    • Author(s)
      T.Kawashima, K.Sato, F.Sato, H.Sasaki
    • Journal Title

      Annals of Anatomy 185

      Pages: 535-542

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] T.Kawashima, S.Yoshitomi, M.Ito, Y.Hoshino, E.Oh-Ichi, E.Ikeda, M.Igarashi, Y.Yoshimura, F.Sato, H.Sasaki: "Bilateral aberrant biceps brachii muscles with special reference to their common nerve trunks."Okajimas Folia Anatomica Japonica. 80. 77-84 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Kawashima, K.Sato, F.Sato, H.Sasaki: "An Anatomical study of the human cardiac veins with special reference to the drainage of the great cardiac vein."Annals of Anatomy. 185. 535-542 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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