| Project/Area Number |
17015006
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | University of Tsukuba |
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Principal Investigator |
AKAZA Hideyuki University of Tsukuba, 大学院・人間総合科学研究科, 教授 (70010486)
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| Co-Investigator(Kenkyū-buntansha) |
TSUKAMOTO Taiji 札幌医科大学, 医学部, 教授 (50112454)
NAITO Seiji 九州大学, 大学院・医学研究院, 教授 (40164107)
NAMIKI Mikio 金沢大学, 大学院・医学系研究科, 教授 (70155985)
HIRAO Yoshihiko 奈良県立医科大学, 医学部, 教授 (00133207)
FUJIOKA Tomoaki 岩手医科大学, 医学部, 教授 (80173409)
MORI Misturu 札幌医科大学, 医学部, 教授 (50175634)
TAKAHASHI Satoru 日本大学, 医学部, 教授 (50197141)
HORIE Shigeo 帝京大学, 医学部, 教授 (40190243)
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| Project Period (FY) |
2005 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥80,700,000 (Direct Cost: ¥80,700,000)
Fiscal Year 2009: ¥16,100,000 (Direct Cost: ¥16,100,000)
Fiscal Year 2008: ¥16,200,000 (Direct Cost: ¥16,200,000)
Fiscal Year 2007: ¥16,200,000 (Direct Cost: ¥16,200,000)
Fiscal Year 2006: ¥16,200,000 (Direct Cost: ¥16,200,000)
Fiscal Year 2005: ¥16,000,000 (Direct Cost: ¥16,000,000)
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| Keywords | がん / ゲノム / 食品 / 大豆イソフラボン / 細菌 / 癌 |
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| Research Abstract |
The patients with prostate cancer were proved to have low equol-producing ability to metabolize daidzein to equol. For the first time, by the stool culture of the equol-producing volunteers persons, we isolated gram-positive bacilli "NATTS strain" which was a non-spore-forming rod bacterium with high ability to convert daidzein to equol. By the double-blind study of the high risk persons for prostate cancer, the prostate cancer incidence of the isoflavone group was lower than the placebo group. Based on this study, we will make a prostate cancer chemoprevention strategy in the future.
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