Proteomic amalysis in Angiotensin signaling

• Project/Area Number: 17390068
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Osaka City University
• Principal Investigator: IWAO Hiroshi Osaka City University, Graduate school of medicine, Professor (00137192)
• Co-Investigator(Kenkyū-buntansha): IZUMI Yasukatsu Osaka city university, Graduate school of medicine, Lecturer (10347495) ; NAKAO Takafumi Osaka city university, Graduate school of medicine, Lecturer (50326261) ; SHIOTA Masayuki Osaka city university, Graduate school of medicine, Assistant Professor (30381990)
• Project Period (FY): 2005 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥15,770,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥1,170,000); Fiscal Year 2007: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2006: ¥3,900,000 (Direct Cost: ¥3,900,000); Fiscal Year 2005: ¥6,800,000 (Direct Cost: ¥6,800,000)
• Keywords: Angiotensin / network analysis / proteome / Akt / シグナル伝達 / 循環器・高血圧 / アンジオテンシンII / 薬理学 / シグナル / 血管 / プロテオーム解析 / TAPタグ

Research Abstract

Intracellular signaling constitutes a complicated network, which are regulated by specific protein-protein interactions. Therefore identification of protein complexes is the key to understanding cellular functions. The crosstalk of Angiotensin signaling is mediated, in part, through the activation of Akt. The Akt-driven signaling network is capable of regulating cellular processes by modulating transcription and translation, and by modifying proteins at the posttranslational level. To elucidate the crosstalk of Angiotensin signaling, we searched for the binding molecule of Akt1. Here, we made attempts to perform affinity purification and proteomic analysis to elucidate the role of Akt in AngiotensinII signaling.
We explored the use of strep-tag method for the isolation of Akt1 complexes from rAECs. The strep-Akt1 introduced into the rAECs by adenoviral vectors, and the cells were stimulated by AnguitensinII, Angiotensin receptor blocker, and ACE inhibitor for 10-30 min. Lysates expressing the strep-tagged Akt1 were then passed through a strep-Tactin column and bound proteins were specifically eluted using a desthiobiotin. The purified protein assemblies were separated by denaturing gel electrophoresis, and individual bands were digested by trypsin, analyzed by matrix-assisted laser desorption/vionization-time-of-flight mass spectrometry (MALDI-TOF MS) and identified by database search algorithms. As a result, at least 50 kinds of interaction partners were systematically purified and identified. Some of these proteins were changed the expresion level depend on stimulation. These included enzymes, protein kinases, translational regulators, cytoskeletal proteins, and hypothetical proteins. These results suggest that Angiotensin signaling has effects on the many biomolecular response and physiological consequence of vascular endothelium functions. This methodology would provide a new tool for chemical proteomics in medicinal science.

Research Products

• [Journal Article] PI3K/Akt/FOXO3a pathway contributes to thrombopoietin-induced proliferation of primary megakaryocytes in vitro and in vivo via modulation of p27(Kip1) (2008)
  • Author(s): Nakao, T., Geddis, A.E., Fox, N.E., Kaushansky, K.
  • Journal Title: Cell Cycle 7 Pages: 257-266
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cobalt Protoporphyrin Attenuates Rat Obstructive Nephropathy:Role of Cellular Infiltration (2008)
  • Author(s): Iwai, T., Kitamoto, K., Teramoto, K., Machida, Y., Tamada, S., YukimuraT., Iwao, H., Nakatani, T., Miura, K.
  • Journal Title: Urology (In press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Microarray analysis of glomerular gene expression in murine lupus nephritis (2008)
  • Author(s): Teramoto, K., Negoro, N., Kitamoto, K., Iwai, T., Iwao, H., Okamura, M., Miura, K.
  • Journal Title: J Pharmacol Sci 106 Pages: 56-67
  • NAID: 10024317476
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Interleukin-10 gene transfer to peritonealmesothelial cells suppresses peritoneal dissemination of gastri ccancer cells due to a persistently high concentration in the peritoneal cavity (2008)
  • Author(s): Tanaka, F., Tominaga, K., Shiota, M.Ochi, M., Kuwamura, H., Tanigawa, T., Watanabe, T., Fujiwara, Y., Oshitani, N., Higuchi, K., Iwao, H., Arakawa, T.
  • Journal Title: Cancer Gene Ther 15 Pages: 51-59
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation (2008)
  • Author(s): Toyo-oka, K., Mori, D., Yano, Y., Shiota, M., Iwao, H., Goto, H., Inagaki, M., Hiraiwa, N., Muramatsu, M., Wynshaw-Boris, A., Yoshiki, A., Hirotsune, S.
  • Journal Title: J Cell Biol 180 Pages: 1133-1147
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Pharmacogenomics of cardiovascular pharmacology:molecular network analysis in pleiotropic effects of statin-an experimental elucidation of the pharmacologic action from protein-protein interaction analysis (2008)
  • Author(s): Shiota, M., Kusakabe, H., Hikita, Y., Nakao, T., IzumiY., Iwao, H.
  • Journal Title: J Pharmacol Sci 107 Pages: 15-19
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Microarray analysis of glomerular gene expression in murine lupus (2008)
  • Author(s): Teramoto, K., Negoro, N., Kitamoto, K., Iwai, T., Iwao, H., Okamura, M., Miura, K
  • Journal Title: J Pharmacol Sci 106 Pages: 56-67
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Interleukin-10 gene transfer to peritoneal mesothelial cells suppresses peritoneal dissemination of gastric cancer cells due to a persistently high concentration in the peritoneal cavity (2008)
  • Author(s): Tanaka, F., Tominaga, K., Shiota, M., Ochi, M., Kuwamura, H., Tanigawa, T., Watanabe, T., Fujiwara, Y., Oshitani, N., Higuchi, K., Iwao, H., Arakawa, T
  • Journal Title: Cancer Gene Ther 15 Pages: 51-59
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation (2008)
  • Author(s): Toyo-oka, K., Mori, D., Yano, Y., Shiota, M., Iwao, H., Goto, H., Inagaki, M., Hiraiwa, N., Muramatsu, M., Wynshaw-Boris, A., Yoshiki, A., Hirotsune, S
  • Journal Title: J Cell Biol 180 Pages: 1133-1147
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pharmacogenomics of cardiovascular pharmacology: molecular network analysis in pleiotropic effects of statin-an experimental elucidation of the pharmacologic action from protein-protein interaction analysis (2008)
  • Author(s): Shiota, M., Kusakabe, H., Hikita, Y., Nakao, T., Izumi, Y., Iwao, H
  • Journal Title: J Pharmacol Sci 107 Pages: 15-19
  • NAID: 10024320291
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] PI3K/Akt/FOXO3a pathway contributes to thrombopoietin-induced proliferation of primary megakaryocytes in vitro and in vivo via modulation of p27(Kip1). (2008)
  • Author(s): Nakao, T., Geddis, A.E., Fox, N.E., and Kaushansky, K.
  • Journal Title: Cell Cycle 7 Pages: 257-266
  • Peer Reviewed
• [Journal Article] Cobalt Protoporphyrin Attenuates Rat Obstructive Nephropathy:Role of Cellular Infiltration. (2008)
  • Author(s): Iwai, T., Kitamoto, K., Teramoto, K., Machida, Y., Tamada, S., Yukimura, T., Iwao, H., Nakatani, T., and Miura, K.
  • Journal Title: Urology. (in press)
  • Peer Reviewed
• [Journal Article] Microarray analysis of glomerular gene expression in murinelupus nephritis. (2008)
  • Author(s): Teramoto, K., Negoro, N., Kitamoto, K., Iwai, T., Iwao, H., Okamura, M., and Miura, K.
  • Journal Title: J Pharmaeol Sci 106 Pages: 56-67
  • Peer Reviewed
• [Journal Article] Interleukin-10 gene transfer to peritoneal mesothelial cells suppresses peritoneal dissemination of gastric cancer cells due to a persistently high concentration in the peritoneal cavity. (2008)
  • Author(s): Tanaka, F., Tominaga, K., Shiota, M., Ochi, M., Kuwamura, H., Tanigawa, T., Watanabe, T., Fujiwara, Y., Oshitani, N., Higuchi, K., Iwao, H., and Arakawa, T.
  • Journal Title: Cancer Gene Ther 15 Pages: 51-59
  • Peer Reviewed
• [Journal Article] Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation. (2008)
  • Author(s): Toyo-oka, K., Mori, D., Yano, Y., Shiota, M., Iwao, H., Goto, H., Inagaki, M., Hiraiwa, N., Muramatsu, M., Wynshaw-Boris, A., Yoshiki, A., and Hirotsune, S.
  • Journal Title: J Cell Biol 180 Pages: 1133-1147
  • Peer Reviewed
• [Journal Article] Left ventricular volume and function in cynomolgus monkeys using real-time three-dimensional echocardiography (2007)
  • Author(s): Tsusaki, H., Yonamine, H., Tamai, A., Shimomoto, M., Kuwano, K., Iwao, H., Nagata, R., Kito, G
  • Journal Title: J Med Primatol 36 Pages: 39-46
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Pravastatin induces rat aortic endothelial cell proliferation anmigration via activation of PI3K/Akt/mTOR/p70 S6 kinase signaling (2007)
  • Author(s): Nakao, T., Shiota, M., Tatemoto, Y, Izumi, Y., Iwao, H.
  • Journal Title: J Pharmacol Sci 105 Pages: 334-341
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Growth inhibition of colon cancer cells by transfection of dominant-negative apopoptosis signal-regulating kinase-1 (2007)
  • Author(s): Kuwamura, H., Tominaga, K., Shiota, M., Ashida, R., Nakao, T., Sasaki, E., Watanabe, T., Fujiwara, Y., Oshitani, N., Higuchi, K., Ichijo, H., Arakawa, T., lwao, H.
  • Journal Title: Oncol Rep 17 Pages: 781-786
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Menage-a-trois lis critical for the transcriptional function of PPARgamma coactivator 1 (2007)
  • Author(s): Sano, M., Izumi, Y., Helenius, K., Asakura, M., Rossi, D.J., Xie, M., Taffet, G., Hu, L., Pautler, R.G., Wilson, C.R., Boudina, S., Abel, E.D., Taegtmeyer, H., Scaglia, F., Graham, B.H., Kralli, A., Shimizu, N., Tanaka, H., Makela, T.P., Schneider, M.D.
  • Journal Title: Cell Metab 5 Pages: 129-142
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The long-acting Ca^<2+>-channel blocker azelnidipine prevents left ventricular remodeling after myocardial infarction (2007)
  • Author(s): Nishiya, D., Enomoto, S., Omura, T., Matsumoto, R., Kusuyama, T., Izumi, Y., Iwao, H., Takeuchi, K., Yoshiyama, M.
  • Journal Title: J Pharmacol Sci 103 Pages: 391-397
  • NAID: 10024313539
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Left ventricular volume and function in cynomolgus monkeys using real-time three- dimensional echocardiography (2007)
  • Author(s): Tsusaki, H., Yonamine, H., Tamai, A., Shimomoto, M., Kuwano, K., Iwao, H., Nagata, R., Kito, G
  • Journal Title: J Med Primatol 36 Pages: 39-46
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pravastatin induces rat aortic endothelial cell proliferation and migration via activation of PI3K/Akt/mTOR/p70 S6 kinase signaling (2007)
  • Author(s): Nakao, T., Shiota, M., Tatemoto, Y., Izumi, Y., Iwao, H
  • Journal Title: J Pharmacol Sci 105 Pages: 334-341
  • NAID: 10024317024
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Growth inhibition of colon cancer cells by transfection of dominant -negative apoptosis signal-regulating kinase-1 (2007)
  • Author(s): Kuwamura, H., Tominaga, K., Shiota, M., Ashida, R., Nakao, T., Sasaki, E., Watanabe, T., Fujiwara, Y., Oshitani, N., Higuchi, K., Ichijo, H., Arakawa, T., Iwao, H
  • Journal Title: Oncol Rep 17 Pages: 781-786
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Menage-a-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1 (2007)
  • Author(s): Sano, M., Izumi, Y., Helenius, K., Asakura, M., Rossi, D.J., Xie, M., Taffet, G., Hu, L., Pautler, R.G., Wilson, C.R., Boudina, S., Abel, E.D., Taegtmeyer, H., Scaglia, F., Graham, B.H., Kralli, A. Shimizu, N., Tanaka, H., Makela, T. P., Schneider, M.D
  • Journal Title: Cell Metab 5 Pages: 129-142
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The long-acting Ca2+-channel blocker azelnidipine prevents left ventricular remodeling after myocardial infarction (2007)
  • Author(s): Nishiya, D., Enomoto, S., Omura, T., Matsumoto, R., Kusuyama, T., Izumi, Y., Iwao, H., Takeuchi, K., Yoshiyama, M
  • Journal Title: J Pharmacol Sci 103 Pages: 391-397
  • NAID: 10024313539
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] PI3K/Akt/FOXO3a pathway contributes to thrombopoietin-induced proliferation of primary megakaryocytes in vitro and in vivo via modulation of p27(Kip1) (2007)
  • Author(s): Nakao, T., Geddis, A E., Fox, N E., Kaushansky, K
  • Journal Title: Cell Cycle 7 Pages: 257-266
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Left ventricular volume and function in cynomolgus monkeys using real-time three-dimensional echocardiography. (2007)
  • Author(s): Tsusaki, H., Yonamine, H., Tamai, A., Shimomoto, M., Kuwano, K., Iwao, H., Nagata, R., and Kito, G.
  • Journal Title: J Med Primatol 36 Pages: 39-46
  • Peer Reviewed
• [Journal Article] Pravastatin induces rat aortic endothelial cell proliferation and migration via activation of PI3K/Akt/mTOR/p70 S6 kinase signaling. (2007)
  • Author(s): Nakao, T, Shiota, M., Tatemoto, Y., Izumi, Y., and Iwao, H.
  • Journal Title: J Pharmaeol Sci 105 Pages: 334-341
  • NAID: 10024317024
  • Peer Reviewed
• [Journal Article] Growth inhibition of colon cancer cells by transfection of dominant-negative apoptosis signal-regulating kinase-1. (2007)
  • Author(s): Kuwamura, H., Tominaga, K., Shiota, M., Ashida, R., Nakao, T., Sasaki, E., Watanabe, T., Fujiwara, Y., Oshitani, N., Higuchi, K., Ichijo, H., Arakawa, T., and Iwao, H.
  • Journal Title: Oncol Rep 17 Pages: 781-786
  • Peer Reviewed
• [Journal Article] Menage-a-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1. (2007)
  • Author(s): Sano, M., Izumi, Y., Helenius, K., Asakura, M., Rossi, D.J., Xie, M., Taffet, G., Hu, L., Pautler, R.G., Wilson, C, R., Boudina, S., Abel, E.D., Taegtmeyer, H., Scaglia, F., Graham, B.H., Kralli, A., Shimizu, N., Tanaka, H., Makela, T.P., and Schneider, M.D.
  • Journal Title: Cell Metab 5 Pages: 129-142
  • Peer Reviewed
• [Journal Article] The long-acting Ca2+-channel blocker azelnidipine prevents left ventricular remodeling after myocardial infarction. (2007)
  • Author(s): Nishiya, D., Enomoto, S., Omura, T., Matsumoto, R., Kusuyama, T., Izumi, Y., Iwao, H., Takeuchi, K., and Yoshiyama, M.
  • Journal Title: J Pharmacol Sci 103 Pages: 391-397
  • NAID: 10024313539
  • Peer Reviewed
• [Journal Article] The Long-Acting Ca(2+)-Channel Blocker Azelnidipine Prevents Left Ventricular Remodeling After Myocardial Infarction (2007)
  • Author(s): Nishiya D, Enomoto S, Omura T, Matsumoto R, Kusuyama T, Izumi Y, Iwao H, Takeuchi K, Yoshiyama M.
  • Journal Title: Journal of Pharmacological Sciences 103・4 Pages: 391-397
  • NAID: 10024313539
• [Journal Article] Microbubble destruction with ultrasound augments neovascularisation by bone marrow cell transplantation in rat hind limb ischaemia (2006)
  • Author(s): Enomoto, S., Yoshiyama, M., Omura, T., Matsumoto, R., Kusuyama, T., Nishiya, D., Izumi, Y., Akioka, K., Iwao, H., Takeuchi, K., Yoshikawa, J.
  • Journal Title: Heart 92 Pages: 515-20
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Dominant-negative c-Jun inhibits rat cardiac hypertrophy induced by angiotensin II and hypertension (2006)
  • Author(s): Kim-Mitsuyama, S., Izumi, Y., Izumiya, Y., Namba, M., Yoshida, K., Wake, R., Yoshiyama, M., Iwao, H.
  • Journal Title: Gene Ther 13 Pages: 348-355
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Coronary flow velocity reserve measurement in three major coronary arteries using transthoracic Doppler echocardiography (2006)
  • Author(s): Murata, E., Hozumi, T., Matsumura, Y., Fujimoto, K., Sugioka, K., Takemoto, Y., Watanabe, H., Yamagishi, H., Yoshiyama, M., Iwao, H., Yoshikawa, J
  • Journal Title: Echocardiography 23 Pages: 279-286
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Smoking history and prior surgical resection predict sensitivity to gefitinib in advanced non-small-cell lung cancer (2006)
  • Author(s): Matsuura, K., Kudoh, S., Yoshimura, N., Kimura, T., Mitsuoka, S., Hirata, K., Yoshikawa, J., Iwao, H
  • Journal Title: Osaka City Med J 52 Pages: 1-8
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Effects of erythropoietin on cardiac remodeling after myocardial infarction (2006)
  • Author(s): Nishiya, D., Omura, T., Shimada, K.Matsumoto, R., Kusuyama, T., Enomoto, S., Iwao, H., Takeuchi, K., Yoshikawa, J., Yoshiyama, M.
  • Journal Title: J Pharmacol Sci 101 Pages: 31-39
  • NAID: 10018237269
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] パスウェイ解析からネットワーク解析へ (2006)
  • Author(s): 田中 利男、岡岳 彦、岩尾 洋
  • Journal Title: 日薬理誌 128 Pages: 130-132
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] スタチンのpleiotropic effectsとその分子機序 (2006)
  • Author(s): 塩田 正之、泉 康雄、中尾 隆文、岩尾 洋
  • Journal Title: 日薬理誌 128 Pages: 161-166
  • NAID: 10018399894
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Microbubble destruction with ultrasound augments neovascularisation by bone marrow cell transplantation in rat hind limb ischaemia (2006)
  • Author(s): Enomoto, S., Yoshiyama, M., Omura, T., Matsumoto, R., Kusuyama,T., Nishiya, D., Izumi, Y., Akioka, K., Iwao, H., Takeuchi, K., Yoshikawa, J
  • Journal Title: Heart 92 Pages: 515-520
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Dominant-negative c-Jun inhibits rat cardiac hypertrophy induced by angiotensin II and hypertension (2006)
  • Author(s): Kim-Mitsuyama, S., Izumi, Y., Izumiya, Y., Namba, M., Yoshida, K., Wake, R., Yoshiyama, M., Iwao, H
  • Journal Title: gene Ther 13 Pages: 348-355
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Smoking history and prior surgical resection predict sensitivity to gefitinib in advanced non- small-cell lung cancer (2006)
  • Author(s): Matsuura, K., Kudoh, S., Yoshimura, N., Kimura, T., Mitsuoka, S., Hirata, K., Yoshikawa, J., Iwao, H
  • Journal Title: Osaka City Med J 52 Pages: 1-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of erythropoietin on cardiac remodeling after myocardial infarction (2006)
  • Author(s): Nishiya, D., Omura, T., Shimada, K., Matsumoto, R., Kusuyama, T., Enomoto, S., Iwao, H., Takeuchi, K., Yoshikawa, J., Yoshiyama, M
  • Journal Title: J Pharmacol Sci 101 Pages: 31-39
  • NAID: 10018237269
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pharmacogenomics of caediovascular pharmacology (2006)
  • Author(s): Tanaka, T., Oka, Y, Iwao, H
  • Journal Title: Nitiyakurishi 128 Pages: 130-132
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pleiotropic effects of statins on endothelium and signaling mechanisms (2006)
  • Author(s): Shiota, M., Izumi, Y., Nakao, T., Iwao, H
  • Journal Title: Nitiyakurishi 128 Pages: 161-166
  • NAID: 10018399894
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] スタチンのpleiotropic effectsとその分子機序 (2006)
  • Author(s): 塩田正之, 泉康雄, 中尾隆文, 岩尾洋
  • Journal Title: 日本薬理学雑誌 128・3 Pages: 161-166
  • NAID: 10018399894
• [Journal Article] Dominant-negative c-Jun inhibits rat cardiac hypertrophy induced by angiotensin II and hypertension (2006)
  • Author(s): Kim-Mitsuyama S, Izumi Y, Izumiya Y, Namba M, Yoshida K, Wake R, Yoshiyama M, Iwao H.
  • Journal Title: Gene Therapy 13・4
• [Journal Article] AP-1 and colorectal cancer (2005)
  • Author(s): Ashida, R., Tominaga, K., Sasaki, E., Watanabe, T., Fujiwara, Y., Oshitani, N., Higuchi, K., Mitsuyama, S., Iwao, H., Arakawa, T.
  • Journal Title: Inflammpharmacology 13 Pages: 113-125
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Effects of eplerenone on transcriptional factors and mRNA expression related to cardiac remodelling after myocardial infarction (2005)
  • Author(s): Enomoto, S., Yoshiyama, M., Omura, T., Matsumoto, R., Kusuyama, T., Kim, S., Izumi, Y., Akioka, K., Iwao, H., Takeuchi, K., Yoshikawa, J.
  • Journal Title: Heart 91 Pages: 1595-1600
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Important role of apoptosis signal-regulating kinase 1 in ischemia-induced angiogenesis (2005)
  • Author(s): Izumi, Y., Kim-Mitsuyama, S., Yoshiyama, M., Omura, T., Shiota, M., Matsuzawa, A., Yukimura, T., Murohara, T., Takeya, M., Ichijo, H., Yoshikawa, J., Iwao, H.
  • Journal Title: Arterioscler Thromb Vasc Biol 25 Pages: 1877-1883
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Critical role of angiotensin II in excesssalt-induced brain oxidative stress of stroke-prone spontaneously hypertensive rats (2005)
  • Author(s): Kim-Mitsuyama, S., Yamamoto, E., Tanaka, T., Zhan, Y., Izumi, Y., Izumiya, Y., Ioroi, T., Wanibuchi, H., I wao, H.
  • Journal Title: Stroke 36 Pages: 1083-1088
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Angiotensin blockade inhibits osteoponin expression in noninfarcted myocardium after myocardial infarction (2005)
  • Author(s): Kusuyama, T., Yoshiyama, M., Omura, T., Nishiya, D., Enomoto, S., Matsumoto, R., Izumi, Y., Akioka, K., Takeuchi, K., Iwao, H., Yoshikawa, J.
  • Journal Title: J Pharmacol Sci 98 Pages: 283-289
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Relationship between vascular endothelial growth factor and angiopoietin-2 in asthmatics before and after inhaled beclomethasone therapy (2005)
  • Author(s): Nomura, S., Kanazawa, H., Hirata, K., Iwao, H., Yoshikawa, J.
  • Journal Title: J Asthma 42 Pages: 141-146
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] angiotensin II type 1 receptor knockout mice (2005)
  • Author(s): S., Takeuchi, K., Kim, S., Iwao, H.Yoshikawa, J.
  • Journal Title: Heart 91 Pages: 1080-1085
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Evaluation of cardiac function in primates using real-time three-dimensional echocardiography as applications to safety assessment (2005)
  • Author(s): Tsusaki, H., Yonamine, H., Tamai, A., Shimomoto, M., Iwao, H., Nagata, R., Kito, G
  • Journal Title: J Pharmacol 52 Pages: 182-187
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] アンジオテンシノーゲンの遺伝子、生合成、機能 (2005)
  • Author(s): 塩田 正之、泉 康雄、雪村 時人、岩尾 洋
  • Journal Title: 日本臨床 63-3 Pages: 17-21
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] アルドステロンの心臓傷害における酸化ストレスの役割 (2005)
  • Author(s): 吉田 華央留、光山 勝慶、泉 康雄、岩尾 洋
  • Journal Title: 血圧 12-13 Pages: 31-26
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] レニン・アンジオテンシン系活性化による血管リモデリングとその細胞内分子機構について (2005)
  • Author(s): 泉 康雄、岩尾 洋
  • Journal Title: 血管 28-3 Pages: 94-99
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] inhibitor-1 expression (2005)
  • Author(s): Nishiya, D., Izumi, Y., Kim, S., Ichijo, H., Motojima, M., Akioka, K., Iwao, H., Takeuchi, K., Yoshikawa, J.
  • Journal Title: J Mol Cell Cardiol 38 Pages: 583-592
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Involvement of c-Jun NH2 terminal kinase and p38MAPK in rapamycin-mediated inhibition of neointimal formation in rat carotid arteries (2005)
  • Author(s): Omura, T., Yoshiyama, M., Izumi, Y.Kim, S., Matsumoto, R., Enomoto, S., Kusuyama, T., Nishiya, D., Nakamura, Y., Akioka, K., Iwao, H., Takeuchi, K., Yoshikawa, J
  • Journal Title: J Cardiovasc Pharmacol 46 Pages: 519-525
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Core protein of hepatitis C virus induces cardiomyopathy (2005)
  • Author(s): Omura, T., Yoshiyama, M., Hayashi, T., Nishiguchi, S., Kaito, M., Horiike, S., Fukuda, K., Inamoto, S., Kitaura, Y., Nakamura, Y., Teragaki, M., Tokuhisa, T., Iwao, H., Takeuchi, K., Yoshikawa, J.
  • Journal Title: Circ Res 96 Pages: 148-150
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Granulocyte-colony stimulating factor augments neovascularization induced by bone marrow transplantation in rat hindlimb ischemia (2005)
  • Author(s): Takagi, Y., Omura, T., Yoshiyama, M., Matsumoto, R., Enomoto, S., Kusuyama, T., Nishiya, D., Akioka, K., Iwao, H., Takeuchi, K., Yoshikawa, J.
  • Journal Title: J Pharmacol Sci 99 Pages: 45-51
  • NAID: 10025730305
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Excess aldosterone under normal salt diet induces cardiachypertrophy and infiltration via oxidative stress (2005)
  • Author(s): Yoshida, K., Kim-Mitsuyama, S., Wake, R., Izumiya, Y., Izumi, Y., Yukimura, T., Ueda, M., Yoshiyama, M., Iwao, H.
  • Journal Title: Hypertens Res 28 Pages: 447-455
  • NAID: 10016625254
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Beneficial effect of candesartan on rat diastolic heart failure. (2005)
  • Author(s): Wake, R., Kim-Mitsuyama, S., zumiY., Yoshida, K., Izumiya, Y., Yukimura, T., Shiota, M., Yoshiyama, M., Yoshikawa, J., Iwao, H.
  • Journal Title: J Pharmacol Sci 98 Pages: 372-379
  • NAID: 10025729489
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] AP-1 and colorectal cancer assessment (2005)
  • Author(s): Ashida, R. Tominaga, K., Sasaki, E., Watanabe, T., Fujiwara, Y., Oshitani, N., Higuchi, K., Mitsuyama, S., Iwao, H., Arakawa, T
  • Journal Title: Inflammopharmacology 13 Pages: 113-125
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of eplerenone on transcriptional factors and mRNA expression related to cardiac remodelling after myocardial infarction. (2005)
  • Author(s): Enomoto, S., Yoshiyama, M., Omura, T., Matsumoto, R., Kusuyama, T., Kim, S., Izumi, Y., Akioka, K., Iwao, H., Takeuchi, K., Yoshikawa, J
  • Journal Title: Heart 91 Pages: 1595-1600
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Important role of apoptosis signal-regulating kinase 1 in ischemia -induced angiogenesis (2005)
  • Author(s): Izumi, Y., Kim-Mitsuyama, S., Yoshiyama, M., Omura, T., Shiota, M.,Matsuzawa, A., Yukimura, T., Murohara, T., Takeya, M., Ichijo, H., Yoshikawa, J., Iwao, H
  • Journal Title: Arterioscler Thromb Vasc Biol 25 Pages: 1877-1883
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Critical role of angiotensin II in excess salt-induced brain oxidative stress of stroke-prone spontaneously hypertensive rats (2005)
  • Author(s): Kim-Mitsuyama, S., Yamamoto, E., Tanaka, T., Zhan, Y., Izumi, Y., Izumiya, Y., Ioroi, T., Wanibuchi, H., Iwao, H
  • Journal Title: Stroke 36 Pages: 1083-1088
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Angiotensin blockade inhibits osteopontin expression in non-infarcted myocardium after myocardial infarction (2005)
  • Author(s): Kusuyama, T., Yoshiyama, M., Omura, T., Nishiya, D., Enomoto, S., Matsumoto, R., Izumi, Y., Akioka, K., Takeuchi, K., Iwao, H., Yoshikawa, J
  • Journal Title: J Pharmacol Sci 98 Pages: 283-289
  • NAID: 10025729037
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Relationship between vascular endothelial growth factor and angiopoietin-2 in asthmatics before and after inhaled beclomethasone therapy (2005)
  • Author(s): Nomura, S., Kanazawa, H., Hirata, K., Iwao, H., Yoshikawa, J
  • Journal Title: J Asthma 42 Pages: 141-146
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of c-Jun NH2-terminal kinase in G-protein- coupled receptor agonist-induced cardiac plasminogen activator inhibitor-1 expression (2005)
  • Author(s): Omura, T., Yoshiyama, M., Matsumoto, R., Kusuyama, T., Enomoto,S.,Nishiya, D., Izumi, Y., Kim, S., Ichijo, H., Motojima, M., Akioka, K.,Iwao, H., Takeuchi, K., Yoshikawa, J
  • Journal Title: J Mol Cell Cardiol 38 Pages: 583-592
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Involvement of c-Jun NH2 terminal kinase and p38MAPK in rapamycin -mediated inhibition of neointimal forma rat tion in carotid arteries (2005)
  • Author(s): Omura, T., Yoshiyama, M., Izumi, Y., Kim, S., Matsumoto, R., Enomoto,S., Kusuyama, T., Nishiya, D., Nakamura, Y., Akioka, K., Iwao, H., Takeuchi, K., Yoshikawa, J
  • Journal Title: J Cardiovasc Pharmacol 46 Pages: 519-525
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Core protein of hepatitis C virus induces cardiomyopathy (2005)
  • Author(s): Omura, T., Yoshiyama, M., Hayashi, T., Nishiguchi, S., Kaito, M., Horiike, S., Fukuda, K., Inamoto, S., Kitaura, Y., Nakamura, Y., Teragaki, M., Tokuhisa, T., Iwao, H., Takeuchi, K., Yoshikawa, J
  • Journal Title: Circ Res 96 Pages: 148-150
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Granulocyte-colony stimulating factor augments neovascularization induced by bone marrow transplantation in rat hindlimb ischemia (2005)
  • Author(s): Takagi, Y., Omura, T., Yoshiyama, M., Matsumoto, R., Enomoto, S., Kusuyama, T., Nishiya, D., Akioka, K., Iwao, H., Takeuchi, K., Yoshikawa, J
  • Journal Title: J Pharmacol Sci 99 Pages: 45-51
  • NAID: 10025730305
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Excess aldosterone under normal salt diet induces cardiac hypertrophy and infiltration via oxidative stress (2005)
  • Author(s): Yoshida, K., Kim-Mitsuyama, S., Wake, R., Izumiya, Y., Izumi, Y., Yukimura, T., Ueda, M., Yoshiyama, M., Iwao, H
  • Journal Title: Hypertens Res 28 Pages: 447-455
  • NAID: 10016625254
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Beneficial effect of candesartan on rat diastolic heart failure (2005)
  • Author(s): Wake, R., Kim-Mitsuyama, S., Izumi, Y., Yoshida, K., Izumiya, Y., Yukimura, T., Shiota, M., Yoshiyama, M., Yoshikawa, J., Iwao, H
  • Journal Title: J Pharmacol Sci 98 Pages: 372-379
  • NAID: 10025729489
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Angiotensin converting enzyme inhibitor prevents left ventricular remodelling after myocardial infarction in angiotensin II type 1 receptor knockout mice (2005)
  • Author(s): Yoshiyama, M., Nakamura, Y., Omura, T., Izumi, Y., Matsumoto, R., Oda, S., Takeuchi, K., Kim, S., Iwao, H., Yoshikawa, J
  • Journal Title: Heart 91 Pages: 1080-1085
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Evaluation of cardiac function in primates using real-time three-dimensional echocardiography as applications to safety (2005)
  • Author(s): Tsusaki, H., Yonamine, H., Tamai, A., Shimomoto, M., Iwao, H., Nagata, R., Kito, G
  • Journal Title: J Pharmacol Toxicol Methods 52 Pages: 182-187
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Gene, biosynthesis, and function of angiotensinogen (2005)
  • Author(s): Shiota, M., Izumi, Y., Yukimura, T., Iwao, H
  • Journal Title: Nipponrinsyo 63-3 Pages: 17-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Excess aldosterone under normal salt diet induces cardiac hypertrophy and infiltration via oxidative stress (2005)
  • Author(s): Yoshida, K., Kim, S., Izumi, Y., Iwao, H
  • Journal Title: Ketsuatu 12-13
  • NAID: 10016625254
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Vascular remodeling by acivation of renin-angiotensin system and its molecular mechanism (2005)
  • Author(s): Izumi, Y., Iwao, H
  • Journal Title: Kekkan 28-3 Pages: 94-99
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Excess Aldosterone under Normal Salt Diet Induces Cardiac Hypertrophy and Infiktration via Oxidative Stress (2005)
  • Author(s): Kaoru Yoshida, Shokei Kim, Ryotaro Wake, Yasuhiro Izumiya, Yasukatsu Izumi, Tokihito Yukimura, Makiko Ueda, Minoru Yoshiyama, Hiroshi Iwao
  • Journal Title: Hypertens Res 28-5 Pages: 447-455
• [Journal Article] Beneficial Effect of Candesartan on Rat Diastolic Heart Failure (2005)
  • Author(s): Ryotaro Wake, Shokei Kim, Yasukatu Izumi, Kaoru Yoshida, Yasuhiro Izumiya, Tokihito Yukimura, Masayuki Shiota, Minoru Yoshikama, Junichi Yoshikawa, Hiroshi Iwao
  • Journal Title: Journal of Pharmacological Sciences 98 Pages: 372-379
  • NAID: 10025729489
• [Journal Article] レニン・アンジオテンシン系活性化による血管リモデリングとその細胞内分子機構について (2005)
  • Author(s): 泉 康雄, 岩尾 洋
  • Journal Title: 血管 28-3 Pages: 95-99
• [Journal Article] Cobalt Protoporphyrin Attenuates Rat Obstructive Nephropathy: Role of Cellular Infiltration
  • Author(s): Iwai, T., Kitamoto, K., Teramoto, K., Machida, Y., Tamada, S., Yukimura, T., Iwao, H., Nakatani, T., Miura, K
  • Journal Title: Urology (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Hsp70はAktの活性を制御し、血管新生に関与する (2008)
  • Author(s): 日下部 裕美、塩田 正之、疋田 優子、泉 康雄、中尾 隆文、三浦 克之、岩尾 洋
  • Organizer: 第81回薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-19
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Hsp70 is critical in angiogenesis (2008)
  • Author(s): Kusakabe, H., Shiota, M., Hikita, Y., Izumi, Y., Nakao, T., Miura, K., Iwao, H
  • Organizer: The 81th Annual Meeting of The Japanese Pharmacological Society
  • Place of Presentation: Yokohama
  • Year and Date: 2008-03-19
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] FGF2 is concerned in pravastatin-induced angiogenesis (2008)
  • Author(s): Hikita, Y., Shiota, M., Kusakabe, H., Izumi, Y., Nakao, T., Miura, K., Iwao, H
  • Organizer: The 81th Annual Meeting of The Japanese Pharmacological Society
  • Place of Presentation: Yokohama
  • Year and Date: 2008-03-19
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] FGF-2はプラバスタチンが誘導する血管新生に関与する (2008)
  • Author(s): 疋田 優子、塩田 正之、日下部 裕美、泉康 雄、中尾 隆文、三浦 克之、岩尾 洋
  • Organizer: 第81回薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-19
• [Presentation] Menage-a-trois1は心筋代謝機能の維持に重要である (2008)
  • Author(s): 泉 康雄、佐野 元明、塩田 正之、中尾 隆文、岩尾 洋
  • Organizer: 第37回心脈管作動物質学会
  • Place of Presentation: 仙台
  • Year and Date: 2008-02-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Menage-a-trois 1 is critical for the metabolic function in myocardium (2008)
  • Author(s): Izumi, Y, Sano, M., Shiota, M., Nakao, T., Iwao, H
  • Organizer: The 37th Annual Meeting of Japanese Society for Circulation Research
  • Place of Presentation: Sendai
  • Year and Date: 2008-02-02
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Menage-a-trois1は心筋の代謝機能保持に不可欠である (2007)
  • Author(s): 泉 康雄、塩田 正之、中尾 隆文、岩尾 洋
  • Organizer: 第17回循環薬理学会
  • Place of Presentation: 大阪
  • Year and Date: 2007-11-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Menage-a-trois 1 is critical for the metabolic function in myocardium (2007)
  • Author(s): Izumi, Y., Shiota, M., Nakao, T., Iwao, H
  • Organizer: The 17th Annual Meeting of Japanese Association of cardiovascular pharmacology
  • Place of Presentation: Osaka
  • Year and Date: 2007-11-30
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] スタチンの多面的作用発現の分子機序の解析 (2007)
  • Author(s): 塩田 正之、日下部 裕美、疋田 優子、中尾 隆文、泉 康雄、岩尾 洋
  • Organizer: 第112回薬理学会近畿部会
  • Place of Presentation: 大阪
  • Year and Date: 2007-11-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Menage-a-trois1は心筋のミトコンドリア機能に不可欠である (2007)
  • Author(s): 泉 康雄、岩尾 洋
  • Organizer: 第11回心血管内分泌代謝学会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Molecular mechanism in pleiotropic effects of statins (2007)
  • Author(s): Shiota, M., Kusakabe, H., Hikita, Y., Nakao, T., Izumi, Y., Iwao, H
  • Organizer: The 112^h Kinki Branch Meeting of The Japanese Pharmacological Society
  • Place of Presentation: Osaka
  • Year and Date: 2007-11-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Menage-a-trois 1 is critical for the mitochondrial function (2007)
  • Author(s): Izumi, Y., Iwao, H
  • Organizer: The 11th Annual Meeting of The society of cardiovascular Endocrinology and Metabolism
  • Place of Presentation: Tokyo
  • Year and Date: 2007-11-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 心臓特異的なMAT1遺伝子欠失マウスは劇的な心不全を引き起こす (2007)
  • Author(s): 泉 康雄、塩田 正之、三浦 克之、岩尾 洋
  • Organizer: 第30回日本高血圧学会
  • Place of Presentation: 沖縄
  • Year and Date: 2007-10-25
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] HSP70はスタチンによるAk七の活性化を制御し、血管内皮細胞遊走および脈管形成に関与する (2007)
  • Author(s): 日下部 裕美、塩田 正之、疋田 優子、泉 康雄、岩尾 洋
  • Organizer: 第30回日本高血圧学会
  • Place of Presentation: 沖縄
  • Year and Date: 2007-10-25
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] プラバスタチン依存的FGF-2発現は血管新生に関与する (2007)
  • Author(s): 疋田 優子、塩田 正之、日下部 裕美、泉 康雄、岩尾 洋
  • Organizer: 第30回日本高血圧学会
  • Place of Presentation: 沖縄
  • Year and Date: 2007-10-25
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Menage-a-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1 (2007)
  • Author(s): Izumi, Y., Shiota, M., Miura, K., Iwao, H
  • Organizer: The 30th Annual Meeting of The Japanese Society of Hypertension
  • Place of Presentation: Okinawa
  • Year and Date: 2007-10-25
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Statins-induced angiogenesis is regulated by Hsp70 (2007)
  • Author(s): Kusakabe, H., Shiota, M., Hikita, Y., Izumi, Y., Iwao, H
  • Organizer: The 30th Annual Meeting of The Japanese Society of Hypertension
  • Place of Presentation: Okinawa
  • Year and Date: 2007-10-25
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Pravastatin-induced FGF2 production is concerned in angiogenesis (2007)
  • Author(s): Hikita, Y., Shiota, M., Kusakabe, H., Izumi, Y., Iwao, H
  • Organizer: The 30th Annual Meeting of The Japanese Society of Hypertension
  • Place of Presentation: Okinawa
  • Year and Date: 2007-10-25
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] HSP70はスタチンによるAktの活性化を制御し、血管内皮細胞遊走および脈管形成に関与する (2007)
  • Author(s): 日下部 裕美、塩田 正之、疋田 優子、泉 康雄、岩尾 洋
  • Organizer: 第30回日本高血圧学会
  • Place of Presentation: 沖縄
  • Year and Date: 2007-10-25
• [Presentation] プラバスタチンはラット大動脈血管内皮細胞において:FGF-2の産生を増加させる (2007)
  • Author(s): 疋田 優子、塩田 正之、日下部 裕美、泉 康雄、中尾 隆文、岩尾 洋
  • Organizer: 第111回薬理学会近畿部会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-06-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Pravastatin induces FGF2 production in endothelial cells (2007)
  • Author(s): Hikita, Y., Shiota, M., Kusakabe, H., Izumi, Y., Nakao, T., Iwao, H
  • Organizer: The 111^h Kinki Branch Meeting of The Japanese Pharmacological Society
  • Place of Presentation: Nagoya
  • Year and Date: 2007-06-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] プラバスタチンはラット大動脈血管内皮細胞においてFGF-2の産生を増加させる (2007)
  • Author(s): 疋田 優子、塩田 正之、日下部 裕美、泉康 雄、中尾 隆文、岩尾 洋
  • Organizer: 第111回薬理学会近畿部会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-06-15
• [Presentation] FGF-2はプラバスタチンが誘導する血管新生に関与する (2007)
  • Author(s): 疋田 優子、塩田 正之、日下部 裕美、泉 康雄、中尾 隆文、三浦 克之、岩尾 洋
  • Organizer: 第81回薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2007-03-19
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] スタチンによる血管保護作用の分子ネットワーク解析 (2007)
  • Author(s): 塩田 正之、日下部 裕美、疋田 優子、中尾 隆文、泉 康雄、岩尾 洋
  • Organizer: 第80回薬理学会年会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-03-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The molecular network analysis in pleiotropic effects of statin (2007)
  • Author(s): Shiota, M., Kusakabe, H., Hikita, Y., Nakao, T., Izumi, Y., Iwao, H
  • Organizer: The 80th Annual Meeting of The Japanese Pharmacological Society
  • Place of Presentation: Nagoya
  • Year and Date: 2007-03-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] プラバスタチンの血管内皮細胞増殖作用におけるmTOR/p70S6 kinase経路の役割 (2007)
  • Author(s): 中尾 隆文、塩田 正之、泉 康雄、岩尾 洋
  • Organizer: 第36回心脈管作動物質学会
  • Place of Presentation: 徳島
  • Year and Date: 2007-02-09
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Pravastatin induces rat aortic endothelial cell proliferation via activation of PI3K/Akt/mTOR/p70 S6 kinase signaling (2007)
  • Author(s): Nakao, T., Shiota, M., Izumi, Y., Iwao, H
  • Organizer: The 36th Annual Meeting of Japanese Society for Circulation Research
  • Place of Presentation: Tokushima
  • Year and Date: 2007-02-09
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] スタチンの多面的作用発現におけるPI3KZAkt経路の関与 (2006)
  • Author(s): 塩田 正之、日下部 裕美、疋田 優子、中尾 隆文、泉 康雄、岩尾 洋
  • Organizer: 第16回日本循環薬理学会
  • Place of Presentation: 京都
  • Year and Date: 2006-12-01
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Pleiotropic effects of statins via Akt pathway (2006)
  • Author(s): Shiota, M., Kusakabe, H., Hikita, Y., Nakao, T., Izumi, Y., Iwao, H
  • Organizer: The 16th Annual Meeting of Japanese Association of cardiovascular pharmacology
  • Place of Presentation: Tokyo
  • Year and Date: 2006-12-01
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] プラバスタチンはPI3K∠Akt/mTOR/p70S6 kinase経路を介して血管内皮細胞の増殖を促進する (2006)
  • Author(s): 中尾 隆文、塩田 正之、泉 康雄、岩尾 洋
  • Organizer: 第110回日本薬理学会近畿部会
  • Place of Presentation: 京都
  • Year and Date: 2006-11-10
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Pravastatin induces rat aortic endothelial cell proliferation and migration via activation of PI3K/Akt/mTOR/p70 S6 kinase signaling (2006)
  • Author(s): Nakao, T., Shiota, M., Izumi, Y., Iwao, H
  • Organizer: The 110^h Kinki Branch Meeting of The Japanese Pharmacological Society
  • Place of Presentation: Kyoto
  • Year and Date: 2006-11-10
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Effects of statinson activation of Akt in vascular endothelial cells (2006)
  • Author(s): Shiota, M.Izumi, Y., Nakao, T., Iwao, H.
  • Organizer: The 21St Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: 福岡
  • Year and Date: 2006-10-17
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Effects of statins on activation of Akt in vascular endothelial cells (2006)
  • Author(s): Shiota, M., Izumi, Y., Nakao, T., Iwao, H
  • Organizer: The 21st Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: Fukuoka
  • Year and Date: 2006-10-17
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 血管内皮細胞におけるスタチンのAkt機能へ与える影響 (2006)
  • Author(s): 塩田 正之、泉 康雄、中尾 隆文、岩尾 洋
  • Organizer: 第109回日本薬理学会近畿部会
  • Place of Presentation: 岡山
  • Year and Date: 2006-06-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Pleiotropic effects of statins on Akt in endothelial cells (2006)
  • Author(s): Shiota, M., Izumi, Y., Nakao, T., Iwao, H
  • Organizer: The 109th Kinki Branch Meeting of The Japanese Pharmacological Society
  • Place of Presentation: Okayama
  • Year and Date: 2006-06-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] トロンボポエチンは転写因子をFOXO3aを不活性化することにより巨核球造血を促進する (2006)
  • Author(s): 中尾 隆文、三浦 克之、岩尾 洋、Kenneth Kaushansky
  • Organizer: 第79回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2006-03-10
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] PI3K/Akt/FOXO3a pathway contributes to thrombopoietin-induced proliferation of primary megakaryocytes (2006)
  • Author(s): Nakao, T., Miura, K., Iwao, H., Kaushansky, K
  • Organizer: The 79th Annual Meeting of The Japanese Pharmacological Society
  • Place of Presentation: Yokohama
  • Year and Date: 2006-03-10
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Ginsenoside Rb1の脳梗塞治療への応用 (2005)
  • Author(s): 秋吉 祐樹、吉川 哲也、進照 夫、寒川 慶一、福崎 好一郎、永田 良一、岩尾 洋、鬼頭 剛
  • Organizer: 第26回日本臨床薬理学会
  • Place of Presentation: 別府
  • Year and Date: 2005-12-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Application to the cerebral infarction therapy of Ginsenoside Rb1 (2005)
  • Author(s): Akiyoshi, Y., Yoshikawa, T., Susumu, T., Samukawa, K., Fukuzaki, K., Nagata, R., Iwao, H., Kitoh, G
  • Organizer: The 26th Annual Meeting of The Japanese Society of Clinical Pharmacology and Therapeutics
  • Place of Presentation: Beppu
  • Year and Date: 2005-12-03
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 巨核球前駆細胞の分化・増殖における転写因子FOXO3aの役割 (2005)
  • Author(s): 中尾 隆文、岩尾 洋、Kenneth Kaushansky
  • Organizer: 第15回日本循環薬理学会
  • Place of Presentation: 徳島
  • Year and Date: 2005-11-25
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] PI3K/Akt/FOXO3a pathway contributes to thrombopoietin-induced proliferation of primary megakaryocytes in vitro and in vivo via modulation of p27(Kip1) (2005)
  • Author(s): Nakao, T., Iwao, H., Kaushansky, K
  • Organizer: The 15th Annual Meeting of Japanese Association of cardiovascular pharmacology, 25
  • Place of Presentation: Tokushima
  • Year and Date: 2005-11-25
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 心臓の左室拡張不全期からでもアンジオテンシン受容体阻害薬は有効である (2005)
  • Author(s): 和気 亮太郎、光山 勝慶、泉 康雄、桑村 光、塩田 正之、岩尾 洋
  • Organizer: 第28回日本高血圧学会
  • Place of Presentation: 北海道
  • Year and Date: 2005-09-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Beneficial effect of candesartan on rat diastolic heart failure (2005)
  • Author(s): Wake, R., Kim, S., Izumi, Y., Kuwamura, H., Shiota, M., Iwao, H
  • Organizer: The 28th Annual Meeting of The Japanese Society of Hypertension
  • Place of Presentation: Hokkaido
  • Year and Date: 2005-09-15
  • Description: 「研究成果報告書概要(欧文)」より