Involvement of fatty acids and Kupffer cells for development of liver disease
Project/Area Number |
20590755
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
|
Research Institution | Tohoku University |
Principal Investigator |
FUKUSHIMA Koji Tohoku University, 病院, 助教 (20400476)
|
Co-Investigator(Kenkyū-buntansha) |
上野 義之 東北大学, 病院, 准教授 (70282126)
|
Research Collaborator |
NORIYUKI Obara 東北大学, 大学院・医学系研究科, 大学院生
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 肝臓学 / 非アルコール性脂肪性肝炎 / トランス脂肪酸 / クッパー細胞 / TNFα / 脂肪合成 / 脂肪性肝疾患 / NAFLD / NASH / 脂肪酸 / TNF / 炎症 / 肝臓 / インスリン抵抗性 / Kupffer細胞 / autophagy |
Research Abstract |
We clarified the pathogenic mechanism of trans-fatty acid to the mouse liver summarized as caused by the upregulation of lipogenesis in the liver and elevated level of free fatty acids accompanied by the secretion of TNF-a by Kupffer cells.
|
Report
(4 results)
Research Products
(18 results)