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Basic Research on the Treatment of Cardiovasular Disease by Regulating Aging Signals

Research Project

Project/Area Number 21390237
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionChiba University

Principal Investigator

MINAMINO Tohru  千葉大学, 大学院・医学研究院, 講師 (90328063)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2009: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Keywords分子心臓病態学 / 老化 / 心不全 / p53 / 炎症 / インスリン抵抗性 / 脂肪組織 / インスリン / 血管新生
Research Abstract

he incidence and the prevalence of diabetes, heart failure, coronary heart disease and hypertension increase with advancing age. However, the molecular mechanisms underlying the increased risk of such diseases that is conferred by aging remain unclear. In the present study, we demonstrated that cellular aging signals contribute to the pathogenesis of cardiovascular disease.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (42 results)

All 2012 2011 2010 2009 Other

All Journal Article (29 results) (of which Peer Reviewed: 23 results) Presentation (7 results) Book (4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice2012

    • Author(s)
      Yasuda N, Akazawa H, Ito K, Shimizu I, Kudo-Sakamoto Y, Yabumoto C, Yano M, Yamamoto R, Ozasa Y, Minamino T, Naito AT, Oka T, Shiojima I, Tamura K, Umemura S, Nemer M, Komuro I
    • Journal Title

      Hypertension

      Volume: 59 Issue: 3 Pages: 627-633

    • DOI

      10.1161/hypertensionaha.111.175208

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure2012

    • Author(s)
      Shimizu I, Yoshida Y, Katsuno T, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A, Ito T, Zechner R, Komuro I, Kobayashi Y, Minamino T
    • Journal Title

      Cell Metab

      Volume: 15 Issue: 1 Pages: 51-64

    • DOI

      10.1016/j.cmet.2011.12.006

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aldosterone Does Not Contribute to Renal p21 Expression During the Development of Angiotensin II-Induced Hypertension in Mice2012

    • Author(s)
      Nakano D, Minamino T, et al
    • Journal Title

      Am J Hypertens

      Volume: 25 Issue: 3 Pages: 354-358

    • DOI

      10.1038/ajh.2011.224

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of JAGGED1 in arterial lesions after vascular injury2011

    • Author(s)
      Wu X, Zou Y, Zhou Q, Huang L, Gong H, Sun A, Tateno K, Katsube K, Radtke F, Ge J, Minamino T, Komuro I
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 31 Pages: 2000-2006

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 心不全と炎症2011

    • Author(s)
      南野徹
    • Journal Title

      日本薬理学会雑誌

      Volume: 138 Issue: 6 Pages: 187-191

    • DOI

      10.1161/atvbaha.109.185694

    • Related Report
      2011 Final Research Report
  • [Journal Article] 脂肪老化とインスリン抵抗性2011

    • Author(s)
      南野徹
    • Journal Title

      日本老年医学会雑誌

      Volume: 48 Pages: 123-126

    • NAID

      10030469312

    • Related Report
      2011 Final Research Report
  • [Journal Article] In vivo tracking of transplanted mononuclear cells using manganese-enhanced magnetic resonance imaging2011

    • Author(s)
      Odaka K, Minamino T, et al
    • Journal Title

      PLos One

      Volume: 6 Issue: 10 Pages: e25487-e25487

    • DOI

      10.1371/journal.pone.0025487

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ca2+/calmodulin-dependent kinase IIdelta causes heart failure by accumulation of p53 in dilated cardiomyopathy2010

    • Author(s)
      Toko H, Takahashi H, Kayama Y, Oka T, Minamino T, Okada S, Morimoto S, Zhan DY, Terasaki F, Anderson ME, Inoue M, Yao A, Nagai R, Kitaura Y, Sasaguri T, Komuro I
    • Journal Title

      Circulation

      Volume: 122 Pages: 891-899

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ATF6 is important under both pathological and physiological states in the heart2010

    • Author(s)
      Toko H, Takahashi H, Kayama Y, Okada S, Minamino T, Terasaki F, Kitaura Y, Komuro I
    • Journal Title

      J. Mol. Cell Cardiol

      Volume: 49 Issue: 9 Pages: 113-20

    • DOI

      10.1161/circulationaha.109.935296

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury2010

    • Author(s)
      Naito AT, Okada S, Minamino T, Iwanaga K, Liu M, Sumida T, Nomura S, Sahara N, Mizoroki T, Takashima A, Akazawa H, Nagai T, Shiojima I, Komuro I
    • Journal Title

      Circ Res

      Volume: 106 Issue: 1 Pages: 1692-1702

    • DOI

      10.1016/j.yjmcc.2010.03.020

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury2010

    • Author(s)
      Naito AT, Okada S, Minamino T, Iwanaga K, Liu ML, Sumida T, Nomura S, Sahara N, Mizoroki T, Takashima A, Akazawa H, Nagai T, Shiojima I, Komuro I
    • Journal Title

      Circ Res

      Volume: 106 Issue: 11 Pages: 1692-1702

    • DOI

      10.1161/circresaha.109.214346

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of semaphorin as a novel strategy for therapeutic angiogenesis2010

    • Author(s)
      Moriya J, Minamino T, Tateno K, Okada S, Uemura A, Shimizu I, Yokoyama M, Nojima A, Okada M, Koga H, Komuro I
    • Journal Title

      Circ. Res

      Volume: 106 Issue: 5 Pages: 391-398

    • DOI

      10.1172/jci40096

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 老化と酸化ストレス2010

    • Author(s)
      小笠原陽子, 南野徹
    • Journal Title

      Heart View

      Volume: 14 Pages: 74-78

    • Related Report
      2011 Final Research Report
  • [Journal Article] 心血管老化のメカニズム2010

    • Author(s)
      南野徹
    • Journal Title

      循環器専門医

      Volume: 18 Pages: 11-17

    • Related Report
      2011 Final Research Report
  • [Journal Article] 老化分子としてのp53と生活習慣病2010

    • Author(s)
      南野徹
    • Journal Title

      実験医学

      Volume: 28 Pages: 383-389

    • Related Report
      2011 Final Research Report
  • [Journal Article] Ca2+/calmodulin-dependent kinase IIdelta causes heart failure by accum ulation of p53 in dilated cardiomyopathy2010

    • Author(s)
      Toko H, Minamino T, et al
    • Journal Title

      Circulation

      Volume: 122 Pages: 891-899

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ATF6 is important under both pathological and physiological states in the heart2010

    • Author(s)
      Toko H, Minamino T, et al
    • Journal Title

      J Mol Cell Cardiol

      Volume: 49 Pages: 113-120

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of cellular senescence in lifestyle-related disease2010

    • Author(s)
      Minamino T
    • Journal Title

      Circ J

      Volume: 74 Pages: 2527-2533

    • NAID

      10027423858

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of semaphorin as a novel strategy for therapeutic angiogenesis2010

    • Author(s)
      Moriya J, Minamino T, et al
    • Journal Title

      Circ Res 106

      Pages: 391-398

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A crucial role for adipose tissue p53 in the regulation of insulin resistance2009

    • Author(s)
      Minamino T, Orimo M, Shimizu I, Kunieda T, Yokoyama M, Ito T, Nojima A, Nabetani A, Oike Y, Matsubara H, Ishikawa F, Komuro I
    • Journal Title

      Nat. Med

      Volume: 15 Issue: 2 Pages: 1082-1087

    • DOI

      10.1161/circresaha.109.210815

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cardiac 12/15-lipoxygenase-induced inflammation is involved in heart failure2009

    • Author(s)
      Kayama Y, Minamino T, Toko H, Sakamoto M, Shimizu I, Takahashi H, Okada S, Tateno K, Moriya J, Yokoyama M, Nojima A, Yoshimura M, Egashira K, Aburatani H Komuro I
    • Journal Title

      J. Exp. Med

      Volume: 206 Issue: 9 Pages: 1565-1574

    • DOI

      10.1038/nm.2014

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term outcome of therapeutic neovascularization using peripheral blood mononuclear cells for limb ischemia2009

    • Author(s)
      Moriya J, Minamino T, Tateno K, Shimizu N, Kuwabara Y, Sato Y, Saito Y Komuro I
    • Journal Title

      Circ Cardiovasc Interven

      Volume: 2 Issue: 7 Pages: 245-254

    • DOI

      10.1084/jem.20082596

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protective role of SIRT1 in diabetic vascular dysfunction2009

    • Author(s)
      Orimo M, Minamino T, Miyauchi H, Tateno K, Okada S, Moriya J, Komuro I
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 29 Issue: 3 Pages: 889-894

    • DOI

      10.1161/circinterventions.108.799361

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] アンジオテンシンII.高血圧(上)第4版日本における最新の研究動向2009

    • Author(s)
      南野徹
    • Journal Title

      日本臨床

      Volume: 67 Pages: 179-183

    • Related Report
      2011 Final Research Report
  • [Journal Article] A crucial role for adipose tissue p53 in the regulation of insulin resistance2009

    • Author(s)
      Minamino T, et al
    • Journal Title

      Nat Med 15

      Pages: 1082-1087

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardiac 12/15-lipoxygenase-induced inflammation is involved in heart failure2009

    • Author(s)
      Kayama Y, Minamino T, et al
    • Journal Title

      J Exp Med 206

      Pages: 1565-1574

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term outcome of therapeutic neovascularization using peripheral blood mononuclear cells for limb ischemia2009

    • Author(s)
      Moriya J, Minamino T, et al
    • Journal Title

      Circ Cardiovasc Intervent 2

      Pages: 245-254

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective role of SIRT1 in diabetic vascular dysfunction2009

    • Author(s)
      Orimo M, Minamino T, et al
    • Journal Title

      Arterioscler Thromb Vasc Biol 29

      Pages: 889-894

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gap junctions mediate the spread of ischemia-reperfusion injury2009

    • Author(s)
      Minamino T
    • Journal Title

      Circ J 73

      Pages: 1591-1592

    • NAID

      10025934585

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Lifespan regulatory system and cardiovascular disease2012

    • Author(s)
      Minamino T
    • Organizer
      第76回日本循環器学会・学術集会
    • Place of Presentation
      Topics福岡
    • Related Report
      2011 Final Research Report
  • [Presentation] Lifestyle-related disease and cellular aging signal network2011

    • Author(s)
      南野徹
    • Organizer
      日本血管生物医学会
    • Place of Presentation
      京都
    • Year and Date
      2011-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 細胞老化シグナルによる寿命制御と加齢関連疾患2011

    • Author(s)
      南野徹
    • Organizer
      第84回日本内分泌学会 教育講演
    • Place of Presentation
      神戸(招待講演)
    • Year and Date
      2011-04-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Molecular mechanism of cardiovascular aging and regeneration2010

    • Author(s)
      Minamino T
    • Organizer
      日本循環器学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cellular aging and lifestyle-related disease2010

    • Author(s)
      Minamino T
    • Organizer
      7th Japanese-German Frontiers of Science Symposium Potsdam
    • Place of Presentation
      Germany
    • Related Report
      2011 Final Research Report
  • [Presentation] Aging signals involved in glucose homeostasis JST Danish-Japanese Workshop "Molecular Diabetology" Copenhagen2010

    • Author(s)
      Minamino T
    • Place of Presentation
      Denmark
    • Related Report
      2011 Final Research Report
  • [Presentation] Vascular aging and vascular injury : synonymous or analogous?2010

    • Author(s)
      Minamino T
    • Organizer
      20th World Congress of the International Society of Heart Research
    • Related Report
      2011 Final Research Report
  • [Book] Annual Review糖尿病・代謝・内分泌20112011

    • Author(s)
      横山真隆, 南野徹
    • Publisher
      中外医学社
    • Related Report
      2011 Annual Research Report
  • [Book] Annual Review循環器20112011

    • Author(s)
      森谷純治, 南野徹
    • Publisher
      中外医学社
    • Related Report
      2010 Annual Research Report
  • [Book] 老年医学Update 2010-20112010

    • Author(s)
      南野徹
    • Publisher
      メジカルビュー社(印刷中)
    • Related Report
      2009 Annual Research Report
  • [Book] II.疾患の病因と病態,1.p53と生活習慣病,Annual Review循環器2011,山口徹編

    • Author(s)
      森谷純治, 南野徹
    • Publisher
      中外医学社
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 抗ノッチ1アゴニスト抗体を含む組織再生治療剤及び該抗体を使用する組織再生治療方法2012

    • Inventor(s)
      南野徹, 舘野馨, 八木田秀雄
    • Industrial Property Rights Holder
      千葉大学
    • Patent Publication Number
      2012-056934
    • Acquisition Date
      2012-03-22
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 糖尿病の治療剤2010

    • Inventor(s)
      南野徹, 森谷純治
    • Industrial Property Rights Holder
      千葉大学
    • Industrial Property Number
      2010-232400
    • Filing Date
      2010-10-15
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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