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Multiple testing theory for systematic analysis of meta genes and its applications

Research Project

Project/Area Number 21700313
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Statistical science
Research InstitutionThe Institute of Statistical Mathematics

Principal Investigator

YOSHIDA Ryo  The Institute of Statistical Mathematics, モデリング研究系, 助教 (70401263)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsバイオインフォマティクス / 多重検定 / メタ遺伝子 / トランスクリプトーム / バイオマーカー探索 / メタアナリシス / ソフトウェア / 遺伝子発現 / ソフトウエア
Research Abstract

This research project aims to develop statistical testing theory and integrated analytic tools for analyzing massively-collected information on cellular regulatory programs, called 'omics data', involving genomics, transcriptomics, proteomics, and metabolomics. Specifically, the newly-derived methods enable us to identify key regulatory units of genes characterizing molecular basis of different cellular phenotypes, such as tumor cells demonstrating sensitivity or resistance to anticancer drugs.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (22 results)

All 2011 2010 2009 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (14 results) Remarks (2 results)

  • [Journal Article] SiGN-SSM : open source parallel software for estimating gene networks with state space models2011

    • Author(s)
      Y.Tamada, R.Yamaguchi, S.Imoto, O.Hirose, R.Yoshida, M.Nagasaki, S.Miyano
    • Journal Title

      Bioinformatics 15l;27(8)

      Pages: 1172-1173

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bayesian experts in exploring reaction kinetics of transcription circuits2010

    • Author(s)
      R.Yoshida, M.Saito, H.Nagao, T.Higuchi
    • Journal Title

      Bioinformatics 26(18)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bayesian learning in sparse graphical factor models via variational mean-field annealing2010

    • Author(s)
      R.Yoshida, M.West
    • Journal Title

      Journal of Machine Learning Research 11

      Pages: 1771-1798

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bayesian experts in exploring reaction kinetics of transcription circuits2010

    • Author(s)
      Yoshida, et al.
    • Journal Title

      Bioinformatics

      Volume: 26

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bayesian learning in sparse graphical factor models via variational mean-field annealing2010

    • Author(s)
      R.Yoshida, M.West
    • Journal Title

      Journal of Machine Learning Research

      Volume: 11 Pages: 1771-1798

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 細胞内生化学反応経路のグラフィカルモデリングと統計的推測手法の新展開2009

    • Author(s)
      吉田亮, 樋口知之
    • Journal Title

      日本統計学会誌 38

      Pages: 213-236

    • NAID

      110007226104

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Bayesian experts in exploring reaction kinetics of transcription circuits2010

    • Author(s)
      R.Yoshida, M.Saito, H.Nagao, T.Higuchi
    • Organizer
      9th European Conference on Computational Biology (ECCB2010)
    • Place of Presentation
      Belgium
    • Year and Date
      2010-09-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Bayesian experts in exploring reaction kinetics of transcription circuits2010

    • Author(s)
      Yoshida
    • Organizer
      9th European Conference on Computational Biology (ECCB2010)
    • Place of Presentation
      Ghent, Belgium
    • Year and Date
      2010-09-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 癌細胞シミュレーションと生化学反応系の統計モデリング2010

    • Author(s)
      吉田亮, 長尾大道, 斎藤正也, 長崎正朗, 長崎正朗, 井元清哉, 山口類, 山内麻衣, 後藤典子, 宮野悟, 樋口知之
    • Organizer
      2010年度統計関連学会連合大会
    • Place of Presentation
      東京(早稲田大学)
    • Year and Date
      2010-09-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 遺伝子発現時系列データおよびバイオデータベース情報を基にした活性/抑制型転写因子の同定2010

    • Author(s)
      長尾大道, 吉田亮, 斎藤正也, 樋口知之, 長崎正朗, 井元清哉, 山口類, 宮野悟, 山内麻衣, 後藤典子
    • Organizer
      2010年度統計関連学会連合大会
    • Place of Presentation
      東京(早稲田大学)
    • Year and Date
      2010-09-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 状態空間モデリングによる遺伝子発現制御に関わる動的薬剤効果の推定2010

    • Author(s)
      山口類, 井元清哉, 山内麻衣, 島村徹平, 長崎正朗, 吉田亮, 樋口知之, 後藤典子, 宮野悟
    • Place of Presentation
      東京(早稲田大学)
    • Year and Date
      2010-09-06
    • Related Report
      2010 Final Research Report
  • [Presentation] LiSDAS : Life Science DataAssimilation Systems2010

    • Author(s)
      吉田亮
    • Organizer
      生命体統合シミュレーションサマースクール2010
    • Place of Presentation
      湘南国際村
    • Year and Date
      2010-07-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Life Science Data Assimilation Systems : 生化学反応系の複雑性とその克服へ向けて2010

    • Author(s)
      吉田亮
    • Organizer
      第1回「バイオモデリングと統計科学」研究会
    • Place of Presentation
      東京(統計数理研究所)
    • Year and Date
      2010-06-30
    • Related Report
      2010 Final Research Report
  • [Presentation] LiSDAS : Life Science Data Assimilation Systems2010

    • Author(s)
      吉田亮
    • Organizer
      第59回理論応用力学講演会
    • Place of Presentation
      東京(日本学術会議)
    • Year and Date
      2010-06-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Life Science Data Assimilation Systems : 生化学反応系の複雑性とその克服へ向けて2010

    • Author(s)
      吉田亮
    • Organizer
      グローバルCOE特別セミナー
    • Place of Presentation
      東京大学(本郷)
    • Year and Date
      2010-05-14
    • Related Report
      2010 Final Research Report
  • [Presentation] グラフィカルファクターモデルと事後エントロピーにもとづく決定論的アニーリング:システムズバイオロジーへの応用2010

    • Author(s)
      吉田亮
    • Organizer
      御殿場基礎科学研究会「最適化を基軸とする数理的展開」
    • Place of Presentation
      静岡(御殿場)
    • Year and Date
      2010-01-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 状態空間モデルからの動的予測に基づく遺伝子発現制御関係の差異の探索2009

    • Author(s)
      山口類, 井元清哉, 島村徹平, 山内麻衣, 長崎正朗, 吉田亮, 樋口知之, 後藤典子, 宮野悟
    • Organizer
      2009年度統計関連学会連合大会
    • Place of Presentation
      京都(同志社大学)
    • Year and Date
      2009-09-08
    • Related Report
      2010 Final Research Report
  • [Presentation] 事後エントロピーを利用した焼きなまし法と遺伝子発現データのスパース学習2009

    • Author(s)
      吉田亮, Mike West
    • Organizer
      2009年度統計関連学会連合大会
    • Place of Presentation
      同志社大学(京都)
    • Year and Date
      2009-09-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mike West,事後エントロピーを利用した焼きなまし法と遺伝子発現データのスパース学習2009

    • Author(s)
      吉田亮
    • Organizer
      2009年度統計関連学会連合大会
    • Place of Presentation
      京都(同志社大学)
    • Year and Date
      2009-09-07
    • Related Report
      2010 Final Research Report
  • [Presentation] 超多数粒子フィルタによる遺伝子ネットワークデータ同化2009

    • Author(s)
      中村和幸, 吉田亮, 長崎正朗, 宮野悟, 樋口知之
    • Organizer
      2009年度統計関連学会連合大会
    • Place of Presentation
      京都(同志社大学)
    • Year and Date
      2009-09-07
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://metagp.ism.ac.jp/

    • Related Report
      2010 Final Research Report
  • [Remarks] ソフトウェア公開ページ

    • URL

      http://metagp.ism.ac.jp

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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