The analysis of molecular mechanisms of the inflammatory macrophage migration by using a small molecule inhibitor to plasminogen activator inhibitor 1.

• Project/Area Number: 23890019
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Endocrinology
• Research Institution: Tohoku University
• Principal Investigator: ICHIMURA Atsuhiko 東北大学, 大学院・医学系研究科, 助教 (10609209)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 薬理学 / 免疫学 / 炎症 / マクロファージ / PAI-1 / 免疫細胞遊走 / 抗炎症 / 線溶系

Research Abstract

Our findings demonstrated that a small molecule PAI-1 inhibitor represents a novel class of anti-inflammatory agents targeting MФ migration by the inhibition of the interaction of PAI-1 with low-density lipoprotein receptor-related protein.

Research Products

• [Journal Article] A smoll molecule inhibitor to plasminogen activator inhibitor 1 inhibits macrophage migration. (2013)
  • Author(s): Ichimura A, Matsumoto S, Suzuki S, Dan T, Yamaki S, Sato Y, Kiyomoto H, Ishii N, Okada K, Matsuo O, Hou FF, Vaughan DE, van Ypersele de Strihou S, Miyata T.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 33 Issue: 5 Pages: 935-942
  • DOI: 10.1161/atvbaha.113.301224
  • Peer Reviewed
• [Journal Article] A Small Molecule Inhibitor to Plasminogen Activator Inhibitor 1 Inhibits Macrophage Migration. (2013)
  • Author(s): Ichimura Atsuhiko
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 掲載確定
  • Peer Reviewed
• [Journal Article] Physiological functions of fatty acid receptors andtheir therapeutic potential (2012)
  • Author(s): Hara T, Hirasawa A, Ichimura A, Kimura I, Tsujimoto G.
  • Journal Title: Nihon Yakurigaku Zasshi Volume: 140 Pages: 275-279
  • Peer Reviewed
• [Journal Article] Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human (2012)
  • Author(s): Ichimura A
  • Journal Title: Nature Volume: 483 Issue: 7389 Pages: 350-354
  • DOI: 10.1038/nature10798
  • Peer Reviewed
• [Journal Article] Early Treatment With Olmesartan Prevents Juxtamedullary Glomerular Podocyte Injury and the Onset of Microalbuminuria in Type 2 Diabetic Rats (2012)
  • Author(s): Sofue T, 他
  • Journal Title: Am J Hypertens Volume: 34(3)(In Press) Issue: 5 Pages: 604-11
  • DOI: 10.1038/ajh.2012.1
  • Peer Reviewed
• [Journal Article] miRNAs and regulation of cell signaling (2011)
  • Author(s): Ichimura A, Ruike Y, Terasawa K, Tsujimoto G
  • Journal Title: FEBS Journal Volume: 278 Pages: 1610-1618
  • Peer Reviewed
• [Journal Article] Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41) (2011)
  • Author(s): Kimura I, Inoue D, Maeda T, Hara T, Ichimura A, Miyauchi S, Kobayashi M, Hirasawa A, Tsujimoto G
  • Journal Title: Proc Natl Acad Sci U S A Volume: 108 Pages: 8030-8035
  • Peer Reviewed
• [Journal Article] Free fatty acid receptors FFAR1 and GPR120 as novel therapeutic targets for metabolic disorders (2011)
  • Author(s): Hara T, Hirasawa A, et al
  • Journal Title: J Pharm Sci Volume: 100(9) Issue: 9 Pages: 3594-3601
  • DOI: 10.1002/jps.22639
  • Peer Reviewed
• [Journal Article] Free fatty acid receptors and their physiological role in metabolic regulation (2011)
  • Author(s): Hirasawa A, Hara T, Ichimura A, Tsujimoto G
  • Journal Title: Yakugaku Zasshi Volume: 131 Pages: 1683-1689
  • NAID: 130001871764
  • Peer Reviewed
• [Journal Article] 創薬標的としての遊離脂肪酸受容体:循環器疾患とメタボリックシンドローム (2011)
  • Author(s): 市村敦彦, 原貴史, 木村郁夫, 平津明, 辻本豪三
  • Journal Title: 血管 Volume: 34 Pages: 145-152
  • NAID: 10030334780
• [Presentation] International Symposium on the Maillard Reaction (2012)
  • Author(s): Atsuhiko Ichimura, Takashi Dan, Tadayuki Tsujita, Miyata Toshio
  • Organizer: Generation of Glyoxalase 1-deficient mice 11^<th>
  • Place of Presentation: Nacy France
  • Year and Date: 2012-09-18
• [Presentation] Generation of Glyoxalase 1-deficient mouse (2012)
  • Author(s): Atsuhiko Ichimura
  • Organizer: 11th International Symposium on the Maillard Reaction
  • Place of Presentation: Nancy, France
• [Presentation] グリオキサラーゼ1欠損マウスの創出 (2011)
  • Author(s): 市村敦彦、段孝、宮田敏男
  • Organizer: 第21回日本メイラード学会
  • Place of Presentation: 東京ステーションコンファレンス602,東京
  • Year and Date: 2011-10-28
• [Remarks]
  • URL: http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2011/120220_1.htm
• [Remarks]
  • URL: http://first.lifesciencedb.jp/archives/4509#more-4509