| Project/Area Number |
24245037
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional materials/Devices
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| Research Institution | Kanagawa University |
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Principal Investigator |
Ono Akira 神奈川大学, 工学部, 教授 (10183253)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Jiro 上智大学, 理工学部, 准教授 (10546576)
SANEYOSHI Hisao 神奈川大学, 工学部, 助教 (10564784)
TANAKA Yoshiyuki 徳島文理大学, 薬学部, 教授 (70333797)
URATA Hidehito 大阪薬科大学, 薬学部, 教授 (80211085)
TORIGOE Hidetake 東京理科大学, 理学部, 教授 (80227678)
MINAKAWA Noriaki 徳島大学, 理学部, 教授 (40209820)
岡本 到 神奈川大学, 工学部, 助教 (40460133)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥46,670,000 (Direct Cost: ¥35,900,000、Indirect Cost: ¥10,770,000)
Fiscal Year 2015: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2012: ¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000)
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| Keywords | 環境浄化 / 水銀イオンの除去 / 水銀イオンの検出 / 結晶構造解析 / 多次元多核種NMR法 / ナノワイヤー / 水銀イオン検出 / 水銀イオン / 金属含有DNA / 機能性核酸 / NMR / 結晶解析 / 等温滴定型カロリメトリー / DNA合成酵素 / 検出 / 除去 / ポリメラーゼ |
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| Outline of Final Research Achievements |
The applicants have found that heavy metal ions and pyrimidine-pyrimidine base pairs in duplexes form metal ion mediated base pairs such as thymine-Hg(II)-thymine and cytosine-Ag(I)-cytosine. In the project, for developing DNA based heavy metal ions removing membranes and nanowires in future, we have studied structures and properties of the metal ion mediated base pairs. Crystal structures of duplexes having the metal ion mediated base pairs have been solved, and electron density distributions were calculated. As application study, we developed a mercury ion removing material consisting of polystyrene and thymine residues.
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