KAKEN — Research Projects | Researcher Number: 00080622

Search Results: 14 results / Researcher Number: 00080622

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1. 慢性砒素中毒によるNO産生に係る因子の変動とそれに起因する血管調節系の撹乱

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	環境影響評価(含放射線生物学)
Research Institution	University of Tsukuba
Principal Investigator	下條信弘 (下条信弘) University of Tsukuba
Project Period (FY)	2001 – 2002Completed
Keywords	慢性砒素中毒 / 一酸化窒素 / 機能障害 / 循環器疾患 / 砒素 / NO / 血管調節
Research Abstract	【目的】我々は中国内モンゴル自治区の慢性砒素汚染地域においてフィールド調査を行い、砒素暴露群の血清中一酸化窒素(NO)代謝物濃度は、対照群のそれの約半分まで低下していたことを明らかにした。一方、血管内皮型NO合成酵素(eNOS)はアルギニンからNOを産生し、血管調節に重要な役割を担っている。本研究で ...

Research Products of this project	Journal Article (2 results) Publications (2 results)

2. 中国の慢性砒素汚染地域での介入研究:生体内NO産生変動と中毒症状軽減との関係

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Environmental pharmacy
Research Institution	University of Tsukuba
Principal Investigator	熊谷嘉人 University of Tsukuba
Project Period (FY)	2001 – 2002Completed
Keywords	慢性砒素中毒 / 井戸水中砒素 / 一酸化窒素 / 介入研究 / 井地水中砒素 / ヒ素 / サイクリックGMP / 慢性中毒
Research Abstract	【方法】アジア諸国のうち,中国やバングラディシュ等では高濃度の砒素を含む地下水汚染が頻発しており,国際的な自然災害汚染問題のひとつとなっている。一酸化窒素(NO)は神経伝達,血管調節,免疫応答等に重要な働きを担うガス状シグナル分子である。我々は中国内モンゴル自治区の飲水型慢性砒素汚染地域において,砒 ...

Research Products of this project	Journal Article (3 results) Publications (3 results)

3. 内モンゴルの慢性砒素汚染地域での介入研究

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	環境影響評価(含放射線生物学)
Research Institution	University of Tsukuba
Principal Investigator	下條信弘 (下条信弘) University of Tsukuba
Project Period (FY)	2001 – 2002Completed
Keywords	砒素の地下水汚染 / 角化症 / 色素沈着・脱失 / 慢性中毒 / 砒素 / 介入研究
Research Abstract	【目的】砒素は自然界に存在し、地下水等への浸入に由来する生体影響が懸念されている。特にアジア諸国のうち、中国やバングラディシュ等では高濃度の砒素を含む地下水汚染が頻発している。砒素を高濃度含んだ井戸水の慢性飲水により手足の角化症や皮膚の色素沈着、脱失等の砒素中毒症状を呈する。そこで我々は、中国内モン ...

Research Products of this project	Journal Article (2 results) Publications (2 results)

4. 環境物質であるキノン系化合物の曝露による生体内NOの産生低下と循環器疾患の誘発

Research Project

Research Category	Grant-in-Aid for Exploratory Research
Research Field	Environmental pharmacy
Research Institution	University of Tsukuba
Principal Investigator	熊谷嘉人筑波大学, 社会医学系, 助教授
Project Period (FY)	1999 – 2000Completed
Keywords	ディーゼル排出微粒子 / 循環器疾患 / キノン系化合物 / 一酸化窒素 / 環境化学物質 / 血管調節
Research Abstract	血管内皮細胞において、一酸化窒素(NO)は血管弛緩や血管内皮細胞の保護に働くガス状物質であり、内皮型NO合成酵素(eNOS)により産生される。一方、ディーゼル排出微粒子曝露と循環器疾患との関連性が示唆されているが、その実態は明らかにされていない。本研究では、ディーゼル排出微粒子に含まれているキノン系 ...

Research Products of this project	Publications (2 results)

5. Role of nitric oxide synthase in mercury toxicity

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Hygiene
Research Institution	University of Tsukuba
Principal Investigator	KUMAGAI Yoshito Univ.of Tsukuba Inst.of Community Med.Associate Professor
Project Period (FY)	1996 – 1998Completed
Keywords	mercury / nitric oxide synthase / toxicity / alteration in gene expression
Research Abstract	Alterations in mRNA levels, protein content and enzyme activity for nitric oxide synthase (NOS) in the cerebrum and cerebellum during a continuous exp ...

Research Products of this project	Publications (22 results)

6. A study of the distribution of trace elements on the urogenital cancerous lesion or its periphery and tumor progression

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	Urology
Research Institution	University of Tsukuba
Principal Investigator	UCHIDA Katsunori Univ.of Tsukuba, Inst.of Clin.Med.Assistant Professor
Project Period (FY)	1994 – 1995Completed
Keywords	BPH / prostate cancer / trace elements / renal tumor / bladder tumor / synchrotron radiation X-ray fluorescence imaging (SR-XRF)
Research Abstract	Zink and copper are elements with biologic functions as catalysts in various enzymatic reactions. The accumulation and secretion of Zn are known tobe ...

Research Products of this project	Publications (8 results)

7. Animal Experiments to Assess Toxicity Following Subcutaneous Administration of N-Isopropylacrylamide Gels Having Biochemo-Mechanical Function

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	Biomedical engineering/Biological material science
Research Institution	University of Tsukuba
Principal Investigator	KOKUFUTA Etsuo University of Tsukuba, Institute of Applied Biochemistry, Professor
Project Period (FY)	1994 – 1995Completed
Keywords	N-Isopropylacrylamide / biomaterials / neurotoxicity / animal experiments
Research Abstract	Hydrogels consisting of N-Isopropylacrylamide (NIPAAm) undergo a thermosensitive and discontinuous volume-phase transition (I.e., volume collapse) at ...

8. A novel hair analysis for trace elements on hair cross section by synchrotron radiation X-ray fluorescence imaging with X-ray microprobe.

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Hygiene
Research Institution	The University of Tsukuba
Principal Investigator	SHIMOJO Nobuhiro Institute of Community Medicine, The University of Tsukuba proffesor
Project Period (FY)	1994 – 1996Completed
Keywords	SR-XRF / smelter / hair / heavy metals / biological monitoring / time lag / SOD / methylmercury
Research Abstract	The result of the studies carried out for three years, 1994 to 1996, can be summarized as follows. ...

Research Products of this project	Publications (32 results)

9. Epidemiological and molecular genetic study for environmental and occupational cancers.

Research Project

Research Category	Grant-in-Aid for General Scientific Research (B)
Research Field	Public health/Health science
Research Institution	University of Tsukuba
Principal Investigator	HARADA Shoji Institute of Community Medicine, University of Tsukuba Associate Professor
Project Period (FY)	1994 – 1995Completed
Keywords	GSTM1 gene deletion / CYP1A1 / polymorphism / lung cancer / genetic association / case control study / genetic risk factor / Xenobiotics
Research Abstract	Individual susceptibility to lung cancer due to occupational and environmental exposures to carcinogenetic agents has been shown to be modulated by ho ...

Research Products of this project	Publications (27 results)

10. NEW METHODOLOGY FOR EVALUATION OF RENAL DAMAGE CAUSED BY HEAVY METALS ON THE TUBULAR LEVEL

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	環境影響評価(含放射線生物学)
Research Institution	NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES
Principal Investigator	TOHYAMA Chiharu NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES,ENVIRONMENTAL HEALTH SCIENCES DIVISION,DIRECTOR
Project Period (FY)	1993 – 1994Completed
Keywords	X-RAY FLUORESCENCE MICROANALYSIS / RENAL DAMAGE / HEAVY METALS / CADMIUM / MERCURY / METALLOTHIONEIN / IN SITU HYBRIDIZATION
Research Abstract	Renal damage that is caused by heavy metals like cadmium and mercury has been characterized by proximal tubular dysfunction. However, we have found th ...

Research Products of this project	Publications (6 results)

11. Development of Instruments for Medical Diagnosis Applying Synchrotron Radiation X-ray

Research Project

Research Category	Grant-in-Aid for Co-operative Research (A)
Research Field	Biomedical engineering/Biological material science
Research Institution	NATIONAL CARDIOVASCULAR CENTER RESEARCH INSTITUTE
Principal Investigator	UYAMA Chikao National Cardiovascular Center Research Institute, Dept. of Investigative Radiology, Director
Project Period (FY)	1993 – 1994Completed
Keywords	Synchrotron radiation / K-edge energy subtraction coronary angiography / Monochromatic X-ray computed tomography / Microdetection of metals in human tissue / Fluorescent X-ray / X-ray microscopy / Beam line for medical use / X-ray exposure dose
Research Abstract	The most atractive characteristics of synchrotron rediation X-ray for applying to medical use is, first of all, a extraordinary lot of photon number. ...

Research Products of this project	Publications (10 results)

12. Nondestructive chemical imaging of trace elements in biochemical tissues by synchrotron radiation induced x-ray fluorescence analysis.

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	Hygiene
Research Institution	The University of Tsukuba
Principal Investigator	SHIMOJO Nobuhiro Univ.of Tsukuba, Inst.Community Med.Sci., Prof.
Project Period (FY)	1991 – 1993Completed
Keywords	SR-XRF / distribution / Zn / Cu / Se / Hg / BPH / cancerous-tissue
Research Abstract	The results of the studies carried out for three years, 1991 to 1993, can be summarized as follows.

Research Products of this project	Publications (38 results)

13. Genetic and Epidemiological study on alcohol withdrawal

Research Project

Research Category	Grant-in-Aid for General Scientific Research (B)
Research Field	公衆衛生学
Research Institution	University of Tsukuba
Principal Investigator	HARADA Shoji University of Tsukuba Institute of Community Medicine Associate Professor
Project Period (FY)	1991 – 1993Completed
Keywords	GABA / GABA autoreceptor / GABA-Transaminase / ALA / ALA-Dehydratase / Gs protein / Alcoholism / genetic polymorphism
Research Abstract	This study aimed investigation of genetic backgrounds for the symptoms such as siezurs and hallucination in relating with alcoholism. There has been s ...

Research Products of this project	Publications (28 results)

14. Experimental Studies of Mercury Compounds on the Permeability at the Blood Brain Barrier in Rats

Research Project

Research Category	Grant-in-Aid for General Scientific Research (A)
Research Field	公衆衛生学
Research Institution	The University of Tsukuba
Principal Investigator	YAMAGUCHI Seiya Institute of Community Medicine, Professor
Project Period (FY)	1985 – 1988Completed
Keywords	Organic mercury / Modified factor / Changes of Locomoter activity / Rhythm element / Catecholamine / Cadmium
Research Abstract	The results of the studies carried out for four years, 1985 to 1988, can be summarized as follows.

Research Products of this project	Publications (96 results)