KAKEN — Research Projects | Researcher Number: 00230160

1. 癌微小環境からみたトリプルネガティブ乳癌の発癌メカニズムに関する病理学的解析

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Review Section	Basic Section 49020:Human pathology-related
Research Institution	Kawasaki Medical School
Principal Investigator	森谷卓也川崎医科大学, 医学部, 教授
Project Period (FY)	2021-04-01 – 2024-03-31Granted
Keywords	乳癌 / 病理 / 免疫組織化学 / 非浸潤癌 / コラーゲン / 低酸素 / 非浸潤性乳管癌 / 癌微小環境 / 病理組織 / トリプルネガティブ / P4HA / HIF / 早期癌
Outline of Research at the Start	エストロゲンとプロゲステロンのホルモンに対する感受性と、HER2（ハーツー）タンパクを持たない乳がんをトリプルネガティブ乳がんと呼ぶ。ホルモン感受性の乳がんなどと比べても、治療に難渋し、予後不良の一群と目されている。この型のがんを取り巻いている乳腺組織が、がんに対してどのように作用しているのかを明ら ...
Outline of Annual Research Achievements	細胞外マトリックス内にコラーゲンが異常沈着することにより、癌細胞の浸潤・転移が促される可能性が示唆される。コラーゲン代謝の翻訳後修飾を担うprolyl-4-hydroxase(P4H)は、浸潤性乳管癌の悪性度や予後に関連する因子であることが知られているが、早期乳癌における発現については不明な点が多い ...
Current Status of Research Progress	2: Research has progressed on the whole more than it was originally planned.

Research Products of this project	Journal Article (1 results, of which Peer Reviewed: 1 results) Presentation (4 results) Remarks (2 results)

2. Molecular mechanisms responsible for the development of acquired resistance to endocrine therapy in breast cancer

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	General surgery
Research Institution	Kawasaki Medical School
Principal Investigator	Junichi Kurebayashi 川崎医科大学, 医学部, 教授
Project Period (FY)	2017-04-01 – 2020-03-31Completed
Keywords	乳癌 / 内分泌療法 / 耐性 / マイクロアレイ / エストロゲン / HER4 / CXCR4 / 癌幹細胞 / 細胞株 / エストロゲン枯渇 / 抗エストロゲン薬 / 低酸素 / 抵抗性 / エストロゲン受容体 / ヘッジホッグシグナル / 内分泌療法耐性 / 低酸素微小環境 / ヘッジホッグシグナル伝達経路
Outline of Final Research Achievements	We have developed endocrine-resistant breast cancer models using estrogen-sensitive MCF-7 cells. They were cultivated under an estrogen-deprived condi ...

Research Products of this project	Journal Article (13 results, of which Peer Reviewed: 13 results, Open Access: 4 results) Presentation (15 results, of which Int'l Joint Research: 3 results, Invited: 4 results) Book (1 results) Remarks (2 results)

3. Histopathological analysis for the heterogeneity of pathogenesis in breast carcinomas

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Human pathology
Research Institution	Kawasaki Medical School
Principal Investigator	Moriya Takuya 川崎医科大学, 医学部, 教授
Project Period (FY)	2016-04-01 – 2019-03-31Completed
Keywords	乳癌 / 病理 / 前癌病変 / 早期癌 / 非浸潤癌 / 免疫組織化学 / 初期浸潤癌 / 人体病理学 / 悪性度 / 上皮内癌 / 異型乳管過形成 / 発癌 / 乳腺
Outline of Final Research Achievements	Breast carcinomas are pathologically heterogeneous diseases, according to the hormone receptor status and HER2 status. If the pathogenesis of tumor de ...

Research Products of this project	Journal Article (7 results, of which Peer Reviewed: 2 results, Open Access: 1 results) Presentation (9 results, of which Invited: 1 results) Book (1 results) Remarks (4 results)

4. Action mechanisms responsible for the development of resistance to endocrine therapy in breast cancer and overcoming the resistance: focusing on a role of breast cancer stem cells

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	General surgery
Research Institution	Kawasaki Medical School
Principal Investigator	Junichi Kurebayashi 川崎医科大学, 医学部, 教授
Project Period (FY)	2014-04-01 – 2017-03-31Completed
Keywords	乳癌 / 癌幹細胞 / エストロゲン / ヘッジホッグシグナル / 内分泌療法抵抗性 / GANT61 / 抗エストロゲン薬 / 細胞増殖抑制 / GLI / Hedgehogシグナル / Gli1
Outline of Final Research Achievements	Most breast cancers are estrogen-dependent and sensitive to endocrine therapy. However, resistance to endocrine therapy occurs and makes endocrine the ...

Research Products of this project	Journal Article (7 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 7 results, Acknowledgement Compliant: 5 results, Open Access: 2 results) Presentation (12 results, of which Int'l Joint Research: 3 results, Invited: 3 results) Book (2 results) Remarks (1 results)

5. Histopathological approach for early invasive breast carcinoma

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Human pathology
Research Institution	Kawasaki Medical School
Principal Investigator	Moriya Takuya 川崎医科大学, 医学部, 教授
Project Period (FY)	2013-04-01 – 2016-03-31Completed
Keywords	病理 / 乳癌 / 浸潤 / 間質 / 早期癌 / 初期浸潤 / 免疫組織化学 / 病理診断学 / 乳腺 / 非浸潤癌 / 浸潤癌 / 病理学 / 人体病理学 / 免疫組織染色 / 診断病理学 / 筋上皮細胞 / 基質
Outline of Final Research Achievements	Clinicopathological analysis of early invasive carcinomas of the breast had been performed. The criteria of invasion may not be consistent among exper ...

Research Products of this project	Journal Article (10 results, of which Peer Reviewed: 5 results, Open Access: 4 results) Presentation (17 results, of which Invited: 4 results) Book (1 results) Remarks (5 results)

6. Investigation of the peculiar invasion/metastasis mechanism of breast invasive micropapillary carcinoma.

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Human pathology
Research Institution	Kawasaki Medical School
Principal Investigator	Kanomata Naoki 川崎医科大学, 医学部, 准教授
Project Period (FY)	2013-04-01 – 2016-03-31Completed
Keywords	浸潤性微小乳頭癌 / リンパ節転移 / 免疫染色 / 乳癌 / マイクロアレイ / 予後 / BC-1514 / CD1D / 病理組織 / 極性逆転
Outline of Final Research Achievements	Invasive micropapillary carcinoma has the peculiar pseudopapillary and/or micropapillary structures. Invasive micropapillary carcinoma has been known ...

Research Products of this project	Journal Article (28 results, of which Peer Reviewed: 18 results, Open Access: 2 results) Presentation (20 results) Book (2 results) Remarks (3 results)

7. Experimental research on the development of new treatment strategies for triple negative breast cancer

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	General surgery
Research Institution	Kawasaki Medical School
Principal Investigator	KUREBAYASHI Junichi 川崎医科大学, 医学部, 准教授
Project Period (FY)	2011 – 2013Completed
Keywords	乳癌 / トリプルネガティブ・サブタイプ / PARP阻害薬 / mTOR阻害薬 / 癌幹細胞 / トリプルネガティブ乳癌 / 抗エストロゲン薬 / マイクロアレイ / 乳癌幹細胞 / 内分泌療法抵抗性 / トリプルネガティブ / SN38
Research Abstract	We conducted experimental studies to investigate anti-tumor activity of a poly-ADP-ribose polymerase (PARP) 1 inhibitor olaparib and a mTOR inhibitor ...

Research Products of this project	Journal Article (23 results, of which Peer Reviewed: 15 results) Presentation (20 results, of which Invited: 6 results) Book (7 results)

8. Precancerous lesion of the breast: Establishment of disease entity and verification of clinic-pathological significance

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Human pathology
Research Institution	Kawasaki Medical School
Principal Investigator	MORIYA Takuya 川崎医科大学, 医学部, 教授
Project Period (FY)	2010 – 2012Completed
Keywords	乳腺 / 乳癌 / 前癌病変 / 非浸潤癌 / 上皮内癌 / 異型過形成 / 診断病理学 / 免疫組 / 織化学 / 病理 / 免疫組織科学 / 非浸潤性乳管癌 / トリプルネガチブ乳癌 / 免疫組織化学
Research Abstract	Most of breast cancers occur within the mammary duct, as ductal carcinoma in situ, and many cases will extend into invasive carcinoma in the future. H ...

Research Products of this project	Journal Article (18 results, of which Peer Reviewed: 16 results) Presentation (32 results, of which Invited: 1 results) Book (9 results) Remarks (5 results) Patent(Industrial Property Rights) (2 results)

9. Clinical trials for the establishment of standard radiation therapy methods and the selection of radiosensitive tumors in early cancer patients

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Radiation science
Research Institution	Tohoku University
Principal Investigator	YAMADA Shogo 東北大学, 医学系研究科, 名誉教授
Project Period (FY)	2009 – 2012Completed
Keywords	放射線治療学 / 早期の癌 / 標準的放射線治療 / 各種臓器がん / 臨床試験 / 定位放射線治療 / 強度変調放射線治療(IMRT) / 小線源治療 / 放射線治療 / 放射線適応 / 放射線感受性 / QOL / PET / 放射線治療適応 / 低酸素細胞
Research Abstract	The progress of diagnostic imaging enables early detection of cancers. The importance of radiation therapy for early cancers is increasing for the bet ...

Research Products of this project	Journal Article (161 results, of which Peer Reviewed: 143 results) Presentation (104 results, of which Invited: 17 results) Book (15 results) Patent(Industrial Property Rights) (5 results, of which Overseas: 1 results)

10. Fundamental research on the development of treatment for triple negative breast cancer

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	General surgery
Research Institution	Kawasaki Medical School
Principal Investigator	KUREBAYASHI Junichi Kawasaki Medical School
Project Period (FY)	2008 – 2010Completed
Keywords	乳癌 / トリプルネガティブサブタイプ / Src / エトポシド / 癌幹細胞 / トリプルネガティブ / ダサチニブ / BRCA1
Research Abstract	Expression levels of estrogen receptor, progesterone receptor and HER2 in breast cancer tissues have been routinely measured in clinics to predict res ...

Research Products of this project	Journal Article (35 results, of which Peer Reviewed: 26 results) Presentation (14 results) Book (6 results)

11. The evaluation of the response to neoadjuvant chemotherapy and lesion extension of the local advanced breast cancer using MRI

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Radiation science
Research Institution	Tohoku University
Principal Investigator	YAMADA Takayuki Tohoku University
Project Period (FY)	2007 – 2008Completed
Keywords	乳癌 / 術前化学療法 / MRI / 放射線 / 病理学 / 癌 / 臨床 / 外科
Research Abstract	3T-MRI装置におけるMRSの意義としてMRSのコリンピークの検出率は、まだ向上させる必要のある段階で、病変のサイズ・位置がピークの検出に有意に影響を与える。さらに、MRSは腫瘍の治療効果を反映するが、腫瘍残存の有無の判断すなわち病変進展範囲の評価に使用するのは困難であり、現時点では、ダイナミック ...

Research Products of this project	Journal Article (2 results, of which Peer Reviewed: 2 results) Presentation (2 results)

12. Pathological Diagnosis of Cancer by Immediate Biophoton Imaging

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Biomedical engineering/Biological material science
Research Institution	Tohoku University
Principal Investigator	TAKEDA Motohiro Tohoku University
Project Period (FY)	2006 – 2008Completed
Keywords	生物フォトン / がん / 外科学 / 病理学 / 生物物理
Research Abstract	がん手術において迅速病理診断は病変の悪性診断のみならず、切除断端における腫瘍の遺残の判定により正確な切除範囲を決定する上で欠かせない病理検査であり、個々の患者の病期に合わせた、いわば外科手術の個別化を実現する基本的検査法と言うことができる。しかしすべての病院に病理医がいるわけではないため、迅速病理診 ...

Research Products of this project	Journal Article (18 results, of which Peer Reviewed: 9 results) Presentation (7 results) Book (4 results)

13. Clinical trials for the establishment of standard radiation therapy methods for early cancers

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Radiation science
Research Institution	Tohoku University
Principal Investigator	YAMADA Shogo Tohoku University
Project Period (FY)	2006 – 2008Completed
Keywords	放射線治療 / 早期の癌 / 標準的放射線治療 / 臨床試験 / 定位放射線治療 / 強度変調放射線治療(IMRT) / 粒子線治療 / 化学放射線療法 / 各種臓器がん / 小線源治療 / 各種臓器癌 / 粒子線治 / 標準的治療法 / 頭頚部癌 / 肺癌 / 食道癌 / 子宮頸癌 / 前立腺癌
Research Abstract	画像診断の進歩により早期の癌が高率に発見されるようになり、またQOL重視の風潮の中で早期のがんに対する放射線治療の役割が急増している。しかし、治癒の可能性の高いこれらの癌に対する標準的放射線治療方法はいまだ確立していない。私どもは種々の早期のがんに対して全国集計を行い、結果を解析し、標準的と考えられ ...

Research Products of this project	Journal Article (152 results, of which Peer Reviewed: 91 results) Presentation (32 results) Book (34 results) Remarks (1 results)

14. Establishment of breast cancer diagnosis system using alternative splicing detecting DNA microarray

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	General surgery
Research Institution	Tohoku University
Principal Investigator	SUZUKI Akiko Tohoku University, Graduate School of Medicine, Research Associate
Project Period (FY)	2005 – 2006Completed
Keywords	alternative splicing / splice valiant / DNA microarray / breast cancer
Research Abstract	A gene arranged on genome creates a functional different gene by alternative splicing. That the ratio of splice valiant changes in estrogen-receptor i ...

15. Development of novel mass-screening methods by three-dimension microarray for endometrial cancer

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Obstetrics and gynecology
Research Institution	Tohoku University
Principal Investigator	YAEGASHI Nobuo Tohoku University, Tohoku University, Graduate school of medicine, professor
Project Period (FY)	2005 – 2007Completed
Keywords	Endometrial cancer / Three-dimension Microarray / Cancer screening
Research Abstract	In this study, our final goal is application of three-dimensional Microarray system which is new microarray technology to endometrial cancer (EC) scre ...

Research Products of this project	Journal Article (76 results, of which Peer Reviewed: 28 results) Presentation (56 results) Book (1 results) Remarks (1 results)

16. EARLY INVASIVE BREAST CANCER. ANALYSIS OF CLINICOPATHOLOGICAL PARAMETERS CORRELATED WITH EARLY METASTASIS

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Human pathology
Research Institution	TOHOKU UNIVERSITY
Principal Investigator	MORIYA Takuya TOHOKU UNIVERSITY, HOSPITAL, ASSOCIATE PROFESSOR
Project Period (FY)	2004 – 2005Completed
Keywords	PATHOLOGY / BREAST CANCER / HUMAN PATHOLOGY / CANCER / EARLY INVASIVE CARCINOMA / IMMUNOHISTOCHEMISTRY / MICROINVASIVE CARCINOMA / NONINVASIVE CARCINOMA
Research Abstract	1)We have retrospectively re-evaluated 45 cases of non-invasive ductal carcinomas, which had been diagnosed on core needle biopsy (CNB) specimen (16 g ...

Research Products of this project	Journal Article (21 results)

17. 原子間力顕微鏡によるヒト胃癌培養細胞における癌進行度評価の試み

Research Project

Research Category	Grant-in-Aid for Exploratory Research
Research Field	Gastroenterology
Research Institution	Tohoku University
Principal Investigator	和田仁東北大学, 大学院・工学研究科, 教授
Project Period (FY)	2003 – 2004Completed
Keywords	原子間力顕微鏡 / 腫瘍細胞 / ヤング率
Research Abstract	現在,細胞診は臨床において経験により培われた主観的な判断により行われている.そのため,細胞診は再現性などの重要な問題点があると考えられており,形態学的な診断はその大部分において細胞診は敬遠され,組織病理診が中心となって行なわれているのが現状である.しかしながら,穿刺吸引細胞診による乳腺,甲状腺及び前 ...

18. Comparative analysis of intraductal spread of breast cancer between helical computed tomography and magnetic resonance imaging.

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	General surgery
Research Institution	TOHOKU University
Principal Investigator	ISHIDA Takanori Tohoku Univ, Hospital, Research Associate
Project Period (FY)	2001 – 2002Completed
Keywords	Breast Cancer / Breast Conserving Surgery / 3-D Helical CT / helical CT / MRI / Intraductal Spread of Carcinoma / Multicentricity
Research Abstract	BACKGROUND. Surgical clearance of all the cells is important to avoid local failure in breast conserving surgery. Various imaging modalities have been ...

Research Products of this project	Publications (10 results)

19. Early invasive cancer of the breast. Clinico-pathological analysis for establishment a new disease entity

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Human pathology
Research Institution	Tohoku University
Principal Investigator	MORIYA Takuya Tohoku University Hospital, Associate Professor
Project Period (FY)	2000 – 2001Completed
Keywords	Breast / Breast Cancer / Noninvasive carcinoma / Invasion / Microinvasive carcinoma / Ductal carcinoma / Pathology / Cytology
Research Abstract	Most of the cases of invasive ductal carcinoma (IDC) of the breast may be developed through the stage of in situ carcinoma (DCIS). Thus we have analyz ...

Research Products of this project	Publications (52 results)

20. The analysis of intratumoral estrogen metabolism and production in human breast and endometrial carcinoma

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Human pathology
Research Institution	Tohoku University
Principal Investigator	SASANO Hironobu Department of Pathology, Tohoku University School of Medicine, Professor
Project Period (FY)	1999 – 2001Completed
Keywords	breast cancer / endometrial cancer / estrogen / androgen / progesterone / steroid metabolism / retinoid / receptor
Research Abstract	We have studied intratumoral metabolism and production of estrogens and its biological significance in estrogen dependent neoplasms including human en ...

Research Products of this project	Publications (163 results)

Project Period (Start Year [FY])

1. 癌微小環境からみたトリプルネガティブ乳癌の発癌メカニズムに関する病理学的解析 Research Project

森谷 卓也 川崎医科大学, 医学部, 教授

2. Molecular mechanisms responsible for the development of acquired resistance to endocrine therapy in breast cancer Research Project

Junichi Kurebayashi 川崎医科大学, 医学部, 教授

3. Histopathological analysis for the heterogeneity of pathogenesis in breast carcinomas Research Project

Moriya Takuya 川崎医科大学, 医学部, 教授

4. Action mechanisms responsible for the development of resistance to endocrine therapy in breast cancer and overcoming the resistance: focusing on a role of breast cancer stem cells Research Project

Junichi Kurebayashi 川崎医科大学, 医学部, 教授

5. Histopathological approach for early invasive breast carcinoma Research Project

Moriya Takuya 川崎医科大学, 医学部, 教授

6. Investigation of the peculiar invasion/metastasis mechanism of breast invasive micropapillary carcinoma. Research Project

Kanomata Naoki 川崎医科大学, 医学部, 准教授

7. Experimental research on the development of new treatment strategies for triple negative breast cancer Research Project

KUREBAYASHI Junichi 川崎医科大学, 医学部, 准教授

8. Precancerous lesion of the breast: Establishment of disease entity and verification of clinic-pathological significance Research Project

MORIYA Takuya 川崎医科大学, 医学部, 教授

9. Clinical trials for the establishment of standard radiation therapy methods and the selection of radiosensitive tumors in early cancer patients Research Project

YAMADA Shogo 東北大学, 医学系研究科, 名誉教授

10. Fundamental research on the development of treatment for triple negative breast cancer Research Project

KUREBAYASHI Junichi Kawasaki Medical School

11. The evaluation of the response to neoadjuvant chemotherapy and lesion extension of the local advanced breast cancer using MRI Research Project

YAMADA Takayuki Tohoku University

12. Pathological Diagnosis of Cancer by Immediate Biophoton Imaging Research Project

TAKEDA Motohiro Tohoku University

13. Clinical trials for the establishment of standard radiation therapy methods for early cancers Research Project

YAMADA Shogo Tohoku University

14. Establishment of breast cancer diagnosis system using alternative splicing detecting DNA microarray Research Project

SUZUKI Akiko Tohoku University, Graduate School of Medicine, Research Associate

15. Development of novel mass-screening methods by three-dimension microarray for endometrial cancer Research Project

YAEGASHI Nobuo Tohoku University, Tohoku University, Graduate school of medicine, professor

16. EARLY INVASIVE BREAST CANCER. ANALYSIS OF CLINICOPATHOLOGICAL PARAMETERS CORRELATED WITH EARLY METASTASIS Research Project

MORIYA Takuya TOHOKU UNIVERSITY, HOSPITAL, ASSOCIATE PROFESSOR

17. 原子間力顕微鏡によるヒト胃癌培養細胞における癌進行度評価の試み Research Project

和田 仁 東北大学, 大学院・工学研究科, 教授

18. Comparative analysis of intraductal spread of breast cancer between helical computed tomography and magnetic resonance imaging. Research Project

ISHIDA Takanori Tohoku Univ, Hospital, Research Associate

19. Early invasive cancer of the breast. Clinico-pathological analysis for establishment a new disease entity Research Project

MORIYA Takuya Tohoku University Hospital, Associate Professor

20. The analysis of intratumoral estrogen metabolism and production in human breast and endometrial carcinoma Research Project

SASANO Hironobu Department of Pathology, Tohoku University School of Medicine, Professor

1. 癌微小環境からみたトリプルネガティブ乳癌の発癌メカニズムに関する病理学的解析

Research Project

森谷卓也川崎医科大学, 医学部, 教授

2. Molecular mechanisms responsible for the development of acquired resistance to endocrine therapy in breast cancer

Research Project

3. Histopathological analysis for the heterogeneity of pathogenesis in breast carcinomas

Research Project

4. Action mechanisms responsible for the development of resistance to endocrine therapy in breast cancer and overcoming the resistance: focusing on a role of breast cancer stem cells

Research Project

5. Histopathological approach for early invasive breast carcinoma

Research Project

6. Investigation of the peculiar invasion/metastasis mechanism of breast invasive micropapillary carcinoma.

Research Project

7. Experimental research on the development of new treatment strategies for triple negative breast cancer

Research Project

8. Precancerous lesion of the breast: Establishment of disease entity and verification of clinic-pathological significance

Research Project

9. Clinical trials for the establishment of standard radiation therapy methods and the selection of radiosensitive tumors in early cancer patients

Research Project

10. Fundamental research on the development of treatment for triple negative breast cancer

Research Project

11. The evaluation of the response to neoadjuvant chemotherapy and lesion extension of the local advanced breast cancer using MRI

Research Project

12. Pathological Diagnosis of Cancer by Immediate Biophoton Imaging

Research Project

13. Clinical trials for the establishment of standard radiation therapy methods for early cancers

Research Project

14. Establishment of breast cancer diagnosis system using alternative splicing detecting DNA microarray

Research Project

15. Development of novel mass-screening methods by three-dimension microarray for endometrial cancer

Research Project

16. EARLY INVASIVE BREAST CANCER. ANALYSIS OF CLINICOPATHOLOGICAL PARAMETERS CORRELATED WITH EARLY METASTASIS

Research Project

17. 原子間力顕微鏡によるヒト胃癌培養細胞における癌進行度評価の試み

Research Project

和田仁東北大学, 大学院・工学研究科, 教授

18. Comparative analysis of intraductal spread of breast cancer between helical computed tomography and magnetic resonance imaging.

Research Project

19. Early invasive cancer of the breast. Clinico-pathological analysis for establishment a new disease entity

Research Project

20. The analysis of intratumoral estrogen metabolism and production in human breast and endometrial carcinoma

Research Project