KAKEN — Research Projects | Researcher Number: 30260483

1. 国際循環器デジタルオミックスコンソーシアムの創成

Research Project

Research Category	Fund for the Promotion of Joint International Research (International Leading Research )
Review Section	Biological Sciences
Research Institution	The University of Tokyo
Principal Investigator	小室一成東京大学, 医学部附属病院, 特任教授
Project Period (FY)	2024-11-15 – 2031-03-31Adopted

2. DNA damage and senescence in cardiomyocytes for the development of heart failure

Research Project

Research Category	Grant-in-Aid for Scientific Research (S)
Review Section	Broad Section I
Research Institution	The University of Tokyo
Principal Investigator	小室一成東京大学, 医学部附属病院, 特任教授
Project Period (FY)	2021-07-05 – 2026-03-31Granted
Keywords	心不全 / DNA損傷 / 老化 / シングルセル解析 / 臨床応用
Outline of Research at the Start	あらゆる心臓疾患の終末像である心不全は世界中で多くの患者の命を奪っている。高血圧・心筋梗塞・心筋症・弁膜症など様々な病態の心臓疾患は最終的に心不全を発症するが、これまで長らくその機序は明らかでなかった。我々は心臓シングルセル解析によって、心筋細胞におけるDNA損傷およびその後のp53シグナル活性化が ...
Outline of Annual Research Achievements	Step 1. 心筋細胞でDNA損傷が生じる機序の解明：心筋DNA損傷の分子機序を探索し、NOX4遺伝子を介したミトコンドリアROS（Ko, Komuro et al. Nat Commun. 2022）、VDR遺伝子を介したビタミンD受容体シグナル（Ito, Komuro et al. submi ...
Current Status of Research Progress	1: Research has progressed more than it was originally planned.
Interim Assessment Comments (Rating)	A+: In light of the aim of introducing the research area into the research categories, more progress has been made in research than expected.

Research Products of this project	Journal Article (18 results, of which Peer Reviewed: 18 results, Open Access: 17 results) Presentation (13 results, of which Int'l Joint Research: 2 results, Invited: 13 results) Book (1 results) Patent(Industrial Property Rights) (2 results, of which Overseas: 2 results)

3. 非分裂細胞である心筋細胞のDNA損傷と老化による心不全発症機序の解明

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Review Section	Medium-sized Section 53:Organ-based internal medicine and related fields
Research Institution	The University of Tokyo
Principal Investigator	小室一成東京大学, 医学部附属病院, 教授
Project Period (FY)	2021-04-05 – 2022-03-31Discontinued
Keywords	心不全 / DNA損傷 / 老化 / シングルセル解析
Outline of Research at the Start	循環器疾患の終末像である心不全は、患者数、死亡者数が世界的に急増しており、その病態解明が喫緊の課題となっています。我々は、DNA損傷およびp53シグナル活性化が心筋細胞の老化・不全化を招き、最終的には心不全を誘導すること、さらにDNA損傷の程度は心不全患者の重症度・治療応答性を規定していることを世界 ...
Outline of Annual Research Achievements	本研究では、心筋細胞でDNA損傷が生じる機序、DNA損傷・p53シグナルが心筋細胞機能を破綻させる機序、老化・不全化心筋が心不全を誘導する機序と心筋リプログラミングによる健常化の機序、について研究を行った。

Research Products of this project	Journal Article (8 results, of which Peer Reviewed: 8 results, Open Access: 8 results) Presentation (10 results, of which Invited: 10 results) Patent(Industrial Property Rights) (1 results, of which Overseas: 1 results)

4. Cardiomyocyte heterogeneity in heart failure

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Cardiovascular medicine
Research Institution	The University of Tokyo
Principal Investigator	Komuro Issei 東京大学, 医学部附属病院, 教授
Project Period (FY)	2017-04-01 – 2020-03-31Completed
Keywords	心不全 / シングルセル解析 / 不均一性 / シングルセル生物学 / 心筋細胞不均一性 / シングルセルRNA-seq解析 / 時空間的遺伝子発現 / シングルセルRNA-seq / イメージング / バイオインフォマティクス / 精密医療 / 心筋細胞 / 遺伝子発現 / イメージング解析 / 分子心臓病学 / 循環器内科学
Outline of Final Research Achievements	Heart failure is caused by dysregulation of mechanical stress response, but the molecular mechanisms underlying cardiomyocyte heterogeneity remain elu ...

Research Products of this project	Journal Article (38 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 38 results, Open Access: 23 results) Presentation (19 results, of which Int'l Joint Research: 6 results, Invited: 18 results) Book (4 results) Patent(Industrial Property Rights) (3 results, of which Overseas: 2 results)

5. アジア諸国における歯周病と生活習慣病の関連を解明する調査研究

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Epidemiology and preventive medicine
Research Institution	The University of Tokyo
Principal Investigator	鈴木淳一東京大学, 医学部附属病院, 特任准教授
Project Period (FY)	2016-04-01 – 2019-03-31Declined
Keywords	歯周病 / 生活習慣病 / 細菌感染 / 疫学調査 / アジア / 循環器疾患
Outline of Annual Research Achievements	歯周病が生活習慣病の発症リスクとなることが報告されているが、日本及びアジア諸国間で比較検討した報告はない。生活習慣病において歯周病がどのように関与しているかを、日本およびアジア諸国の患者において明らかにすることが本臨床試験全体の目的である。

Research Products of this project	Int'l Joint Research (5 results) Journal Article (10 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 10 results, Open Access: 5 results, Acknowledgement Compliant: 3 results) Presentation (1 results) Book (2 results) Remarks (1 results)

6. Identification and mechanical analysis of the functional lncRNA in pro-inflammatory macrophages

Research Project

Research Category	Grant-in-Aid for Young Scientists (B)
Research Field	Cardiovascular medicine
Research Institution	The University of Tokyo
Principal Investigator	Nakayama Yukiteru 東京大学, 医学部附属病院, 助教
Project Period (FY)	2014-04-01 – 2016-03-31Completed
Keywords	マクロファージ / ノンコーディングRNA / 慢性炎症
Outline of Final Research Achievements	Macrophages play pivotal roles in metabolic syndrome and atherosclerosis, fluctuating the function dynamically. The molecular mechanism of the regulat ...

Research Products of this project	Presentation (8 results)

7. Elucidation of functional role of gut microbiota in heart failure

Research Project

Research Category	Grant-in-Aid for Challenging Exploratory Research
Research Field	Cardiovascular medicine
Research Institution	The University of Tokyo
Principal Investigator	Akazawa Hiroshi 東京大学, 医学部附属病院, 講師
Project Period (FY)	2014-04-01 – 2016-03-31Completed
Keywords	心不全 / 腸内細菌叢 / 循環器・高血圧 / 細菌
Outline of Final Research Achievements	To investigate whether gut microbiota in patients with heart failure (HF) is altered, we compared the gut microbiota of HF patients with that of healt ...

Research Products of this project	Journal Article (29 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 29 results, Acknowledgement Compliant: 5 results, Open Access: 9 results) Presentation (23 results, of which Int'l Joint Research: 1 results, Invited: 12 results) Book (3 results)

8. Nationwide database platform of cardiovascular diseases to measure quality indicator and develop predicting model

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Medical and hospital managemen
Research Institution	National Cardiovascular Center Research Institute
Principal Investigator	Yasuda Satoshi 国立研究開発法人国立循環器病研究センター, その他部局等, その他
Project Period (FY)	2014-04-01 – 2017-03-31Completed
Keywords	医療の質評価 / 臨床心臓病学 / 社会医学 / 循環器・高血圧 / 内科
Outline of Final Research Achievements	First,we developed a nationwide database using the administrative case-mix Diagnostic Procedure Combination(DPC)system(ie, the Japanese Registry Of Al ...

Research Products of this project	Journal Article (1 results, of which Peer Reviewed: 1 results, Open Access: 1 results) Presentation (3 results) Book (2 results)

9. Epigenome analysis in cardiomyocyte differentiation and failure

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Cardiovascular medicine
Research Institution	The University of Tokyo
Principal Investigator	Komuro Issei 東京大学, 医学部附属病院, 教授
Project Period (FY)	2014-04-01 – 2017-03-31Completed
Keywords	分子心臓学 / エピゲノム / 遺伝子制御 / 分子心臓病学 / 転写制御 / 循環器 / ゲノム / 心不全 / 心筋細胞分化
Outline of Final Research Achievements	We analyzed epigenomic regulation of cardiomyocyte differentiation and heart failure. Genome-wide enhancer analysis revealed that β-catenin, which is ...

Research Products of this project	Journal Article (22 results, of which Peer Reviewed: 18 results, Open Access: 11 results) Presentation (21 results, of which Int'l Joint Research: 1 results, Invited: 18 results)

10. The novel therapeutic strategy for pulmonary hypertension targeting inflammation amplification loop mediated by IL-6

Research Project

Research Category	Grant-in-Aid for Challenging Exploratory Research
Research Field	Cardiovascular medicine
Research Institution	Osaka University
Principal Investigator	NAKAOKA YOSHIKAZU 大阪大学, 医学(系)研究科(研究院), 助教
Project Period (FY)	2013-04-01 – 2015-03-31Completed
Keywords	肺高血圧症 / 炎症 / interleukin-6 / Th17細胞 / interleukin-21 / M2マクロファージ / サイトカイン / interleukin-6受容体抗体 / インターロイキン６ / インターロイキン６受容体抗体
Outline of Final Research Achievements	The molecular mechanisms of interleukin-6(IL-6)-mediated pathogenesis of PAH have been elusive. Here, we identified IL-21 as a novel downstream target ...

Research Products of this project	Journal Article (13 results, of which Peer Reviewed: 7 results, Acknowledgement Compliant: 4 results, Open Access: 3 results) Presentation (17 results, of which Invited: 5 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

11. Angiopoietin-1-mediated vascular development and maturation in the developing heart

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Cardiovascular medicine
Research Institution	National Cardiovascular Center Research Institute (2015) Osaka University
Principal Investigator	NAKAOKA YOSHIKAZU 国立研究開発法人国立循環器病研究センター, 研究所, 部長
Project Period (FY)	2013-04-01 – 2016-03-31Completed
Keywords	angiopoietin-1 / 冠静脈 / 静脈洞 / 内皮細胞 / 血管形成 / 静脈分化 / アンジオポイエチン１ / 冠動脈 / 血管新生 / 心筋梗塞 / COUP-TFII / APJ / 静脈 / 冠血管 / 動脈 / 血管成熟化
Outline of Final Research Achievements	The origin and developmental mechanisms underlying coronary vessels are not fully elucidated. Here we examined the role of myocardium-derived angiopoi ...

Research Products of this project	Int'l Joint Research (2 results) Journal Article (21 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 11 results, Acknowledgement Compliant: 8 results, Open Access: 5 results) Presentation (26 results, of which Invited: 7 results) Book (1 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

12. Analysis of the origin of newly formed cardiomyocytes and their growth and mitotic factor by cardiac progenitor cell scaffold transplantation model.

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Cardiovascular medicine
Research Institution	Chiba University
Principal Investigator	Nagai Toshio 千葉大学, 医学(系)研究科(研究院), 准教授
Project Period (FY)	2013-04-01 – 2017-03-31Completed
Keywords	心筋前駆細胞 / DNA傷害 / 細胞移植床 / 心筋再生 / パラクライン効果 / side population細胞 / 細胞移植
Outline of Final Research Achievements	Activation and subsequent induction into cardiomyocytes differentiation of endogenous cardiac stem or progenitor cells is a new strategy for cardiac r ...

Research Products of this project	Journal Article (7 results, of which Peer Reviewed: 6 results, Open Access: 3 results, Acknowledgement Compliant: 4 results) Presentation (5 results, of which Int'l Joint Research: 2 results, Invited: 2 results)

13. The role of sarcomere-specific isoform of docking protein Gab1in heart failure

Research Project

Research Category	Grant-in-Aid for Challenging Exploratory Research
Research Field	Circulatory organs internal medicine
Research Institution	Osaka University
Principal Investigator	NAKAOKA Yoshikazu 大阪大学, 医学系研究科, 助教
Project Period (FY)	2012Completed
Keywords	Gab1 / ドッキングタンパク質 / neuregulin-1 / サルコメア / アイソフォーム
Research Abstract	We are focusing on the role of Gab docking proteins in the cardiovascular field. In the present study, we identified a novel isoformof Gab1 (120 kDa) ...

Research Products of this project	Journal Article (12 results, of which Peer Reviewed: 6 results) Presentation (18 results) Book (2 results) Remarks (2 results)

14. Elucidation of molecular bases for phenotypical modification of dilated cardiomyopathy by environmental factors

Research Project

Research Category	Grant-in-Aid for Challenging Exploratory Research
Research Field	Circulatory organs internal medicine
Research Institution	The University of Tokyo (2013) Osaka University (2012)
Principal Investigator	AKAZAWA Hiroshi 東京大学, 医学部附属病院, 講師
Project Period (FY)	2012-04-01 – 2014-03-31Completed
Keywords	分子心臓病態学 / モデルマウス / 心不全 / 不整脈 / 循環器・高血圧 / 遺伝子
Research Abstract	As animal models for dilated cardiomyopathy (DCM), we analyzed the knock-in mice in which a deletion of 3 base pairs coding for K210 in cardiac tropon ...

Research Products of this project	Journal Article (14 results, of which Peer Reviewed: 14 results) Presentation (59 results, of which Invited: 11 results) Book (10 results) Remarks (2 results)

15. ブタ心筋梗塞、心不全モデルでの腎動脈周囲高周波焼灼術による心機能改善効果の検討

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	General physiology
Research Institution	Osaka University
Principal Investigator	中谷大作大阪大学, 医学(系)研究科(研究院), 招へい教員
Project Period (FY)	2012-04-01 – 2014-03-31Discontinued
Keywords	交感神経 / 腎動脈 / 焼灼術 / 高血圧 / 腎動脈焼灼術
Research Abstract	平成25年度の研究実施計画は、ブタ左右腎動脈内に焼灼を実施し、6か月後の腎動脈および腎動脈周囲の傷害の程度を腎動脈造影および病理学的に評価を行うことである。また、腎動脈周囲の交感神経の傷害の程度を生理的に評価するために昇圧反応の有無からアデノシン（一般名：アデノシン三リン酸二ナトリウム）の至適投与量 ...

16. Elucidation of inflammatory network underlying the pathogenesis of atrial fibrillation

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Circulatory organs internal medicine
Research Institution	The University of Tokyo (2013) Osaka University (2011-2012)
Principal Investigator	AKAZAWA Hiroshi 東京大学, 医学部附属病院, 講師
Project Period (FY)	2011-04-01 – 2014-03-31Completed
Keywords	分子心臓病態学 / 肥満細胞 / リモデリング / スタチン / 細胞・組織 / 循環器・高血圧 / ストレス / 生体分子
Research Abstract	Endothelin-1 (ET-1) is profoundly involved in the activation of mast cells in hemodyamically stressed atria. ET-1-induced secretion of monocyte chemo ...

Research Products of this project	Journal Article (22 results, of which Peer Reviewed: 22 results) Presentation (69 results, of which Invited: 11 results) Book (10 results) Remarks (2 results)

17. Elucidation of the mechanism of cardiac regeneration after transplantation of a complex of cardiac progenitor cells and nanofiber

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Circulatory organs internal medicine
Research Institution	Chiba University
Principal Investigator	NAGAI TOSHIO 千葉大学, 医学(系)研究科(研究院), 准教授
Project Period (FY)	2010-04-01 – 2013-03-31Completed
Keywords	分子心臓学 / 心臓前駆細胞 / 内在性心筋幹細胞 / 細胞移植 / パラクライン因子 / 心筋前駆細胞 / side population細胞 / DNA傷害 / 内在性心臓幹細胞 / 心臓side population細胞 / leukemia inhibitory factor / JAM-A
Research Abstract	Cardiac cell therapy has been proposed as one of the new strategies against heart failure; however, the mechanisms of the beneficial effects are large ...

Research Products of this project	Journal Article (11 results, of which Peer Reviewed: 11 results) Presentation (18 results)

18. Wntシグナルによる心筋分化ならびに心臓疾患発症機序の解明

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Circulatory organs internal medicine
Research Institution	Chiba University
Principal Investigator	小室一成千葉大, 医学(系)研究科(研究院), 教授
Project Period (FY)	2009Completed

19. Role of Wnt signaling in cardiomyocyte differentiation and its implication for the treatment of heart diseases

Research Project

Research Category	Grant-in-Aid for Scientific Research (S)
Research Field	Circulatory organs internal medicine
Research Institution	The University of Tokyo (2013) Osaka University (2010-2012) Chiba University (2009)
Principal Investigator	KOMURO Issei 東京大学, 医学部附属病院, 教授
Project Period (FY)	2009-05-11 – 2014-03-31Completed
Keywords	循環器・高血圧 / 発生・分化 / Wntシグナル / iPS細胞 / 間葉系幹細胞 / 心不全 / 心筋細胞 / 多能性幹細胞 / 心筋細胞分化 / Wnt / C1q / ES細胞 / IGFBP-4
Research Abstract	Patients with heart diseases are increasing in number, and elucidation of the pathophysiology and development of novel therapeutic strategies for hear ...
Verification Result (Rating)	A-

Research Products of this project	Journal Article (22 results, of which Peer Reviewed: 13 results) Presentation (18 results, of which Invited: 8 results) Book (3 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results, of which Overseas: 1 results)

20. Analysis of rennin/histamine secreted from cardiac mast cells during heart failure

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Circulatory organs internal medicine
Research Institution	Chiba University
Principal Investigator	OKA Toru Chiba University
Project Period (FY)	2008 – 2010Completed
Keywords	循環器・高血圧 / 心不全 / 肥満細胞 / 心房細動
Research Abstract	To explore role of cardiac mast cell, which is thought to be a source of cytokines such as rennin and histamine, we have investigated pressure-overloa ...

Research Products of this project	Journal Article (7 results, of which Peer Reviewed: 4 results) Presentation (3 results)

Project Period (Start Year [FY])

1. 国際循環器デジタルオミックスコンソーシアムの創成 Research Project

小室 一成 東京大学, 医学部附属病院, 特任教授

2. DNA damage and senescence in cardiomyocytes for the development of heart failure Research Project

小室 一成 東京大学, 医学部附属病院, 特任教授

3. 非分裂細胞である心筋細胞のDNA損傷と老化による心不全発症機序の解明 Research Project

小室 一成 東京大学, 医学部附属病院, 教授

4. Cardiomyocyte heterogeneity in heart failure Research Project

Komuro Issei 東京大学, 医学部附属病院, 教授

5. アジア諸国における歯周病と生活習慣病の関連を解明する調査研究 Research Project

鈴木 淳一 東京大学, 医学部附属病院, 特任准教授

6. Identification and mechanical analysis of the functional lncRNA in pro-inflammatory macrophages Research Project

Nakayama Yukiteru 東京大学, 医学部附属病院, 助教

7. Elucidation of functional role of gut microbiota in heart failure Research Project

Akazawa Hiroshi 東京大学, 医学部附属病院, 講師

8. Nationwide database platform of cardiovascular diseases to measure quality indicator and develop predicting model Research Project

Yasuda Satoshi 国立研究開発法人国立循環器病研究センター, その他部局等, その他

9. Epigenome analysis in cardiomyocyte differentiation and failure Research Project

Komuro Issei 東京大学, 医学部附属病院, 教授

10. The novel therapeutic strategy for pulmonary hypertension targeting inflammation amplification loop mediated by IL-6 Research Project

NAKAOKA YOSHIKAZU 大阪大学, 医学(系)研究科(研究院), 助教

11. Angiopoietin-1-mediated vascular development and maturation in the developing heart Research Project

NAKAOKA YOSHIKAZU 国立研究開発法人国立循環器病研究センター, 研究所, 部長

12. Analysis of the origin of newly formed cardiomyocytes and their growth and mitotic factor by cardiac progenitor cell scaffold transplantation model. Research Project

Nagai Toshio 千葉大学, 医学(系)研究科(研究院), 准教授

13. The role of sarcomere-specific isoform of docking protein Gab1in heart failure Research Project

NAKAOKA Yoshikazu 大阪大学, 医学系研究科, 助教

14. Elucidation of molecular bases for phenotypical modification of dilated cardiomyopathy by environmental factors Research Project

AKAZAWA Hiroshi 東京大学, 医学部附属病院, 講師

15. ブタ心筋梗塞、心不全モデルでの腎動脈周囲高周波焼灼術による心機能改善効果の検討 Research Project

中谷 大作 大阪大学, 医学(系)研究科(研究院), 招へい教員

16. Elucidation of inflammatory network underlying the pathogenesis of atrial fibrillation Research Project

AKAZAWA Hiroshi 東京大学, 医学部附属病院, 講師

17. Elucidation of the mechanism of cardiac regeneration after transplantation of a complex of cardiac progenitor cells and nanofiber Research Project

NAGAI TOSHIO 千葉大学, 医学(系)研究科(研究院), 准教授

18. Wntシグナルによる心筋分化ならびに心臓疾患発症機序の解明 Research Project

小室 一成 千葉大, 医学(系)研究科(研究院), 教授

19. Role of Wnt signaling in cardiomyocyte differentiation and its implication for the treatment of heart diseases Research Project

KOMURO Issei 東京大学, 医学部附属病院, 教授

20. Analysis of rennin/histamine secreted from cardiac mast cells during heart failure Research Project

OKA Toru Chiba University

1. 国際循環器デジタルオミックスコンソーシアムの創成

Research Project

小室一成東京大学, 医学部附属病院, 特任教授

2. DNA damage and senescence in cardiomyocytes for the development of heart failure

Research Project

小室一成東京大学, 医学部附属病院, 特任教授

3. 非分裂細胞である心筋細胞のDNA損傷と老化による心不全発症機序の解明

Research Project

小室一成東京大学, 医学部附属病院, 教授

4. Cardiomyocyte heterogeneity in heart failure

Research Project

5. アジア諸国における歯周病と生活習慣病の関連を解明する調査研究

Research Project

鈴木淳一東京大学, 医学部附属病院, 特任准教授

6. Identification and mechanical analysis of the functional lncRNA in pro-inflammatory macrophages

Research Project

7. Elucidation of functional role of gut microbiota in heart failure

Research Project

8. Nationwide database platform of cardiovascular diseases to measure quality indicator and develop predicting model

Research Project

9. Epigenome analysis in cardiomyocyte differentiation and failure

Research Project

10. The novel therapeutic strategy for pulmonary hypertension targeting inflammation amplification loop mediated by IL-6

Research Project

11. Angiopoietin-1-mediated vascular development and maturation in the developing heart

Research Project

12. Analysis of the origin of newly formed cardiomyocytes and their growth and mitotic factor by cardiac progenitor cell scaffold transplantation model.

Research Project

13. The role of sarcomere-specific isoform of docking protein Gab1in heart failure

Research Project

14. Elucidation of molecular bases for phenotypical modification of dilated cardiomyopathy by environmental factors

Research Project

15. ブタ心筋梗塞、心不全モデルでの腎動脈周囲高周波焼灼術による心機能改善効果の検討

Research Project

中谷大作大阪大学, 医学(系)研究科(研究院), 招へい教員

16. Elucidation of inflammatory network underlying the pathogenesis of atrial fibrillation

Research Project

17. Elucidation of the mechanism of cardiac regeneration after transplantation of a complex of cardiac progenitor cells and nanofiber

Research Project

18. Wntシグナルによる心筋分化ならびに心臓疾患発症機序の解明

Research Project

小室一成千葉大, 医学(系)研究科(研究院), 教授

19. Role of Wnt signaling in cardiomyocyte differentiation and its implication for the treatment of heart diseases

Research Project

20. Analysis of rennin/histamine secreted from cardiac mast cells during heart failure

Research Project