KAKEN — Research Projects | Researcher Number: 30360704

Search Results: 11 results / Researcher Number: 30360704

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1. 個別化医療に向けた機能的ｒＳＮＰの同定とデータベースの公開

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Applied biochemistry
Research Institution	Toho University
Principal Investigator	柳内和幸東邦大学, 理学部, 准教授
Project Period (FY)	2013-04-01 – 2015-03-31Discontinued
Keywords	転写因子 / 核内レセプター / 遺伝子多型 / ターゲット遺伝子
Outline of Annual Research Achievements	代表者が開発した改良型Y1H法（Methods in Molecular Biology Volume 977, 2013, pp 125-136）は、転写因子結合部位を系統的に同定するのにコストや効率面で非常に有用である。この手法を用いて、生理的に特に重要な３つの核内受容体（PGR、MR、CAR） ...

Research Products of this project	Journal Article (1 results, of which Peer Reviewed: 1 results, Open Access: 1 results, Acknowledgement Compliant: 1 results) Presentation (2 results) Book (1 results) Remarks (1 results)

2. Generation of rat iPS cells

Research Project

Research Category	Grant-in-Aid for Challenging Exploratory Research
Research Field	Applied animal science
Research Institution	Toho University
Principal Investigator	YANAI Kazuyuki 東邦大学, 理学部, 准教授
Project Period (FY)	2011 – 2012Completed
Keywords	発生工学 / iPS / モデル動物 / 再生医療 / iPS細胞 / ラット / 遺伝子導入ラット / 発現誘導
Research Abstract	We tried to generate iPS cells from our transgenic rat having drug-inducible reprogramming factors. However, there were some difficulties in mating. T ...

Research Products of this project	Presentation (7 results)

3. 再生医療モデルマウスの作成

Research Project

Research Category	Grant-in-Aid for Challenging Exploratory Research
Research Field	Applied biochemistry
Research Institution	Toho University
Principal Investigator	柳内和幸東邦大学, 理学部, 准教授
Project Period (FY)	2009 – 2010Completed
Keywords	再生医学 / 発現制御
Research Abstract	再生医療の研究は、「いかに多能性幹細胞を得るか」という点が主題であったが、京都大学の山中らが様々な細胞に4つの転写因子、すなわちOct3/4、 Sox2、 c-Myc、 Klf4を導入することにより、人工多能性幹細胞(induced pluripotent stem cell : iPS細胞)を樹立 ...

Research Products of this project	Journal Article (3 results, of which Peer Reviewed: 3 results) Presentation (6 results)

4. Development of new cross-linkers to detect DNA-protein interaction

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Chemistry related to living body
Research Institution	Toho University
Principal Investigator	WATANABE Soichiro 東邦大学, 理学部, 准教授
Project Period (FY)	2009 – 2011Completed
Keywords	生体機能関連化学 / 転写因子機能解析 / 転写因子 / DNA-タンパク質相互作用 / クロスリンカー / クロマチン免疫沈降法 / 光反応
Research Abstract	Design and synthesis of new cross-linkers having both DNA and protein binding moieties have been developed. Expression vectors for fusion protein with ...

Research Products of this project	Journal Article (8 results, of which Peer Reviewed: 8 results) Presentation (43 results)

5. Analysis of retinoid-responsive gene networks

Research Project

Research Category	Grant-in-Aid for Young Scientists (A)
Research Field	Applied genomics
Research Institution	Toho University
Principal Investigator	YANAI Kazuyuki Toho University
Project Period (FY)	2007 – 2009Completed
Keywords	機能ゲノミクス / 発生・分化 / ゲノム / 発現制御 / 遺伝子 / レチノイン酸受容体 / ヒトゲノム / 転写 / 核内受容体
Research Abstract	Retinoids play an important role in development, differentiation, and homeostasis. To identify RXR homodimer-binding sites in the human genome, we per ...

Research Products of this project	Journal Article (7 results, of which Peer Reviewed: 7 results) Presentation (10 results) Remarks (2 results)

6. 脳卒中の遺伝素因解明に向けた網羅的アプローチ

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Review Section	Biological Sciences
Research Institution	Research Institute, International Medical Center of Japan
Principal Investigator	加藤規弘 Research Institute, International Medical Center of Japan
Project Period (FY)	2006 – 2007Completed
Keywords	遺伝子 / 脳卒中 / 疾患感受性 / SNP / 関連研究 / 高血圧 / 環境因子 / 多因子疾患
Research Abstract	研究計画として,脳卒中という成因的に"ヘテロ"な疾病カテゴリーを対象として感受性遺伝子を探索するために,(1)臨床病型間比較に基づく関連解析と,(2)既知の生理的機序等に基づく候補遺伝子アプローチ,さらに(3)モデル動物を用いた疾患感受性遺伝子の探索を進める。本年度の研究実績の概要は,以下の通りであ ...

Research Products of this project	Journal Article (6 results, of which Peer Reviewed: 3 results) Presentation (1 results) Book (1 results)

7. エストロゲン受容体ゲノムネットワークの解析

Research Project

Research Category	Grant-in-Aid for Young Scientists (B)
Research Field	Applied genomics
Research Institution	Research Institute, International Medical Center of Japan
Principal Investigator	柳内和幸国立国際医療センター(研究所), 遺伝子診断治療開発研究部, 室長
Project Period (FY)	2005 – 2006Completed
Keywords	エストロゲン / 機能ゲノム学 / ターゲット遺伝子 / 転写因子
Research Abstract	ヒトのような複雑な制御機構を持つ生物における転写調節領域のゲノム規模での解析は、有効な手法が模索されている現状であり、転写因子ネットワークの解明が機能ゲノム学の重要課題となっている。近年、我々は、ヒトゲノムからの転写因子結合配列の網羅的かつ効率的な同定を可能とする改良型酵母one-hybridシステ ...

Research Products of this project	Journal Article (1 results)

8. 脳卒中の遺伝素因解明に向けた網羅的アプローチ

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Review Section	Biological Sciences
Research Institution	Research Institute, International Medical Center of Japan
Principal Investigator	加藤規弘国立国際医療センター(研究所), 遺伝子診断治療開発研究部, 部長
Project Period (FY)	2005 – 2006Completed
Keywords	遺伝子 / 脳卒中 / 疾患感受性 / SNP / 関連研究 / 高血圧 / 環境因子 / 多因子疾患
Research Abstract	研究計画として、脳卒中という成因的に"ヘテロ"な疾病カテゴリーを対象として感受性遺伝子を探索するために、(1)臨床病型間比較に基づく関連解析と、(2)多角的かつゲノムワイドな標的遺伝子の選出とを進める。本年度当初計画の概要は、以下の通りである。

Research Products of this project	Journal Article (3 results)

9. Development of animal models to investigate the pathogenesis and genome-network in lifestyle related diseases

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Circulatory organs internal medicine
Research Institution	Research Institute, International Medical Center of Japan
Principal Investigator	KATO Norihiro Research Institute, International Medical Center of Japan, Dept.of Gene Diagnostics and Therapeutics, Research Institute, Director
Project Period (FY)	2004 – 2006Completed
Keywords	hypertension / genome / gene expression / model organism / network / lifestyle related disease / environmental factor / multifactorial disease
Research Abstract	Atherosclerotic diseases, which are also know as lifestyle related diseases, are a major cause of death worldwide and draw substantial attention in th ...

Research Products of this project	Journal Article (19 results)

10. Studies on the ethnic specificity and genetic susceptibility for salt sensitivity

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Review Section	Biological Sciences
Research Institution	International Medical Center of Japan (Research Institute)
Principal Investigator	KATO Norihiro International Medical Center of Japan (Research Institute), Dept. of Gene Diagnostics and Therapeutics, Director
Project Period (FY)	2000 – 2004Completed
Keywords	Salt sensitivity / Hypertension / Genetic analysis / Ethnic specificity / Water-electrolyte homeostasis / Natriuretic peptide
Research Abstract	In the present study, we have focused on salt sensitivity as a target 'intermediate' phenotype to investigate genetic susceptibility for hypertension. ...

Research Products of this project	Journal Article (25 results) Publications (13 results)

11. レニン遺伝子欠損マウスの作製と新規なアンギオテンシノーゲン転写調節因子の解析

Research Project

Research Category	Grant-in-Aid for JSPS Fellows
Research Field	Structural biochemistry
Research Institution	University of Tsukuba
Principal Investigator	柳内和幸
Project Period (FY)	1998 – 1999Completed