KAKEN — Research Projects | Researcher Number: 40244933

Search Results: 23 results / Researcher Number: 40244933

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1. 拡散MRI法を用いた妊娠第1三半期胎児の脳神経ネットワーク形成過程の解析

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Review Section	Basic Section 52050:Embryonic medicine and pediatrics-related
Research Institution	Kyoto University
Principal Investigator	高桑徹也京都大学, 医学研究科, 教授
Project Period (FY)	2021-04-01 – 2025-03-31Granted
Keywords	脳神経ネットワーク / MRI / 拡散強調画像 / ヒト胎児 / 胎児脳 / 拡散MRI
Outline of Research at the Start	ヒトの脳神経ネットワーク形成過程を知るために、島根大学が保存している妊娠第1三半期胎児標本(CRL33.5-93.7 mm)を対象として、高解像 MRI(T1, DTI)を取得し、経時的な脳の形態形成をT1強調画像で解剖学的に観察するとともに脳神経ネットワークの形成過程をDT-MRIを用い可視化し ...
Outline of Annual Research Achievements	脳の機能と病態を理解するために、ヒトの脳では、様々なタスクに伴う脳の活動領域を観察する脳の機能的なマッピングや、脳全体を視野にいれた巨視的なコネクトームか関心を持たれている。機能的解析にはfMRI, PET, 脳波等が用いられるのに対して、形態学的な解析は拡散強調MRI画像(DT-MRI)か中心的な ...
Current Status of Research Progress	3: Progress in research has been slightly delayed.

Research Products of this project	Journal Article (22 results, of which Int'l Joint Research: 7 results, Peer Reviewed: 22 results, Open Access: 5 results) Presentation (40 results, of which Int'l Joint Research: 2 results, Invited: 13 results) Book (4 results) Remarks (2 results)

2. hierarchical database for better understanding of human fetal morphogenesis

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Review Section	Basic Section 52050:Embryonic medicine and pediatrics-related
Research Institution	Kyoto University
Principal Investigator	Takakuwa Tetsuya 京都大学, 医学研究科, 教授
Project Period (FY)	2018-04-01 – 2021-03-31Completed
Keywords	ヒト胎児 / 画像データベース / MRI / 位相CT / 立体解剖データベース / 形態形成 / 胎児診断
Outline of Final Research Achievements	Morphogenesis during human embryonic and early-fetal period was analysed three-dimensionally using digitized datasets include high-resolution MRI and ...

Research Products of this project	Journal Article (37 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 32 results, Open Access: 4 results) Presentation (27 results, of which Int'l Joint Research: 4 results, Invited: 2 results) Book (4 results) Remarks (2 results)

3. ヒト胎児脳神経系、骨格器系の多元計算解剖学的解析

Publicly Offered Research

Research Category	Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Review Section	Science and Engineering
Research Institution	Kyoto University
Principal Investigator	高桑徹也京都大学, 医学研究科, 教授
Project Period (FY)	2017-04-01 – 2019-03-31Completed
Keywords	ヒト胎児 / MRI / 位相CT / 統計モデル / ヒト胚子 / 主成分分析 / 胸郭形成 / ヒト発生 / 胚子期 / 立体情報
Outline of Annual Research Achievements	脳神経・感覚器系、四肢・骨格器系等の形成が行われる発生時期で、高解像度の立体情報を撮像しうる受精後12週まで(CRL<100mm)のヒト胎児を対象に、研究期間以前のものを含めMRI約100例,位相CT約100例の画像取得が終了し、定量的、統計学的な解析が十分可能な例数を確保した。標本ごとにMRI等の ...
Project Area	Multidisciplinary computational anatomy and its application to highly intelligent diagnosis and therapy

Research Products of this project	Journal Article (20 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 18 results, Open Access: 2 results) Presentation (26 results, of which Int'l Joint Research: 3 results) Book (1 results) Remarks (1 results)

4. Myocardial fiber formation in the human fetus detected by diffusion tensor imaging

Research Project

Research Category	Grant-in-Aid for Challenging Exploratory Research
Research Field	Embryonic/Neonatal medicine
Research Institution	Kyoto University
Principal Investigator	Takakuwa Tetsuya 京都大学, 医学研究科, 教授
Project Period (FY)	2016-04-01 – 2018-03-31Completed
Keywords	ヒト胎児 / 心臓 / 心筋走行 / MRI / DTI / 心筋発生 / 心筋 / ヒト心臓発生
Outline of Final Research Achievements	Histologic examination shows that myocardial fibers gradually change direction from endocardium to epicardium in adults. Little is known about the dev ...

Research Products of this project	Journal Article (24 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 24 results, Open Access: 16 results, Acknowledgement Compliant: 14 results) Presentation (15 results) Remarks (2 results)

5. Three-dimensional analyses of human embryos using phase-contrast X-ray computed tomography

Research Project

Research Category	Grant-in-Aid for Challenging Exploratory Research
Research Field	General anatomy (including histology/embryology)
Research Institution	Kyoto University
Principal Investigator	Zhao Langying 京都大学, 医学研究科, 研究員
Project Period (FY)	2015-04-01 – 2017-03-31Completed
Keywords	発生学 / 画像解剖学 / 位相Ｘ線ＣＴ / ヒト胚子 / イメージング / 放射光 / 仮入力
Outline of Final Research Achievements	Using the new imaging method called phase-contrast X-ray computed tomography, the human embryo specimens called Kyoto Collection were imaged and analy ...

Research Products of this project	Journal Article (35 results, of which Int'l Joint Research: 2 results, Peer Reviewed: 31 results, Open Access: 15 results, Acknowledgement Compliant: 8 results) Presentation (57 results, of which Int'l Joint Research: 7 results, Invited: 6 results) Book (2 results)

6. Digitization, Histological Analyses and Making Web Atlas of Blechschmidt Collection

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	General anatomy (including histology/embryology)
Research Institution	Kyoto University
Principal Investigator	YAMADA SHIGEHITO 京都大学, 医学研究科, 教授
Project Period (FY)	2015-04-01 – 2018-03-31Completed
Keywords	Human Embryo / Blechschmidt Collection / digitization / flatbed scanner / digitize / 3D reconstrcution / sliced specimen / 解剖学 / 発生学
Outline of Final Research Achievements	Regenerative medicine is now developing, and it is important to understand the mechanism of human development. Sets of serial sections of embryos and ...

Research Products of this project	Int'l Joint Research (3 results) Journal Article (36 results, of which Int'l Joint Research: 3 results, Peer Reviewed: 32 results, Open Access: 6 results, Acknowledgement Compliant: 14 results) Presentation (69 results, of which Int'l Joint Research: 13 results, Invited: 5 results) Book (2 results) Remarks (1 results)

7. ヒト器官形成期において分岐構造を有する器官の３次元分枝パターンを解析する

Publicly Offered Research

Research Category	Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Review Section	Science and Engineering
Research Institution	Kyoto University
Principal Investigator	高桑徹也京都大学, 医学研究科, 教授
Project Period (FY)	2015-04-01 – 2017-03-31Completed
Keywords	器官形成 / ヒト発生 / ３次元再構成 / 位相CT / 分岐構造
Outline of Annual Research Achievements	ヒト気管支の３次元的な発生の法則性を知るために本研究を行った。
Project Area	Multidisciplinary computational anatomy and its application to highly intelligent diagnosis and therapy

Research Products of this project	Journal Article (25 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 23 results, Open Access: 19 results, Acknowledgement Compliant: 25 results) Presentation (17 results) Book (1 results) Remarks (1 results)

8. Developmental dynamics of human brain from pattern formation to generation of behaviors

Research Project

Research Category	Grant-in-Aid for Scientific Research (S)
Research Field	Life / Health / Medical informatics
Research Institution	The University of Tokyo
Principal Investigator	Taga Gentaro 東京大学, 大学院教育学研究科(教育学部), 教授
Project Period (FY)	2014-05-30 – 2019-03-31Completed
Keywords	生命情報 / ダイナミクス / 脳 / 発達 / 胚発生 / 乳児 / fNIRS / MRI / 胎児 / 睡眠 / NIRS / 複雑系 / ネットワーク / 新生児 / 形態形成
Outline of Final Research Achievements	We aimed to elucidate the dynamics of early development from morphogenesis of human brain to action generation. Three-dimensional information of the b ...
Verification Result (Rating)	A-
Result (Rating)	A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Research Products of this project	Journal Article (28 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 26 results, Acknowledgement Compliant: 13 results, Open Access: 2 results) Presentation (100 results, of which Int'l Joint Research: 11 results, Invited: 25 results) Book (7 results) Remarks (2 results)

9. Analysis of normal and abnormal development of human embryos using 3D imaging data

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Embryonic/Neonatal medicine
Research Institution	Kyoto University
Principal Investigator	Takakuwa Tetsuya 京都大学, 医学(系)研究科(研究院), 教授
Project Period (FY)	2013-04-01 – 2016-03-31Completed
Keywords	ヒト胚子 / 形態形成 / 発生 / ３次元画像 / MRI / 位相CT / 先天異常 / 発生解剖
Outline of Final Research Achievements	Insights into the dynamic and complex processes during organogenesis will require accurate 3D morphologic data with dynamic modeling of embryonic stru ...

Research Products of this project	Int'l Joint Research (1 results) Journal Article (37 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 32 results, Acknowledgement Compliant: 28 results, Open Access: 7 results) Presentation (67 results, of which Int'l Joint Research: 3 results, Invited: 7 results) Book (3 results) Remarks (7 results)

10. Exercise intervention for the improvement of cognitive function in patients with Alzheimer's disease or mild cognitive impairment

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Rehabilitation science/Welfare engineering
Research Institution	Kyoto University
Principal Investigator	HIDENORI Arai 京都大学, 医学(系)研究科(研究院), 教授
Project Period (FY)	2011-04-01 – 2014-03-31Completed
Keywords	介護予防・支援技術 / 認知機能 / 認知機能障害 / MRI / 多重課題 / 転倒予防 / サルコペニア / PET
Research Abstract	The aim of this study is to address whether or not exercise intervention is effective for the improvement of cognitive function in patients with Alzhe ...

Research Products of this project	Journal Article (29 results, of which Peer Reviewed: 29 results) Presentation (53 results, of which Invited: 1 results)

11. A multi-modal rehabilitation approach that used cartilage stem cell as a subject

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Rehabilitation science/Welfare engineering
Research Institution	Kyoto University
Principal Investigator	AOYAMA Tomoki 京都大学, 医学(系)研究科(研究院), 准教授
Project Period (FY)	2011-04-01 – 2014-03-31Completed
Keywords	リハビリテーション / マルチモダル / 軟骨幹細胞 / 生体内シグナル / 関節軟骨 / 物理療法 / 理学療法 / 運動療法 / 再生医療 / PGE2
Research Abstract	In the field of rehabilitation, the analysis was carried out mainly for an individual and the group. It was hard to build the evidence not to adjust t ...

Research Products of this project	Journal Article (20 results, of which Peer Reviewed: 10 results) Presentation (37 results, of which Invited: 1 results) Book (1 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

12. Morphology and Morphometry of the human embryos by magnetic resonance microscopic imaging

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Embryonic/Neonatal medicine
Research Institution	Kyoto University
Principal Investigator	TAKAKUWA Tetsuya 京都大学, 大学院・医学研究科, 教授
Project Period (FY)	2010 – 2012Completed
Keywords	3次元画像 / MR顕微鏡 / ヒト胚子 / 形態形成 / 発生 / 先天異常学 / 発生解剖学 / 病理学 / 胎児診断学 / 画像診断学
Research Abstract	Insights into the dynamic and complex processes during organogenesis will require accurate morphologic data with dynamic modeling of embryonic structu ...

Research Products of this project	Journal Article (30 results, of which Peer Reviewed: 30 results) Presentation (41 results, of which Invited: 8 results) Book (5 results) Remarks (9 results)

13. 鼻腔NK/T細胞リンパ腫発生要因の系統的解析

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Review Section	Biological Sciences
Research Institution	Osaka University
Principal Investigator	青笹克之 Osaka University
Project Period (FY)	2008 – 2009Completed
Keywords	鼻腔リンパ腫 / NK / T細胞 / EBウイルス / 農薬
Research Abstract	末梢性T/NK細胞腫瘍の一つである鼻腔NK/T細胞リンパ腫は全悪性リンパ腫の2～3パーセントを占める比較的稀なものであるが、その発生には地域差がある。つまりアジア、南米に多く発生し、EBウイルスが腫瘍細胞核内に検出される特有の疾患である。私共の2000～2005年の疫学研究により、本疾患発生と農薬使 ...

Research Products of this project	Journal Article (5 results, of which Peer Reviewed: 5 results) Book (1 results)

14. 鼻腔NK/T細胞リンパ腫発生要因の系統的解析

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Review Section	Biological Sciences
Research Institution	Osaka University
Principal Investigator	青笹克之 Osaka University
Project Period (FY)	2006 – 2007Completed
Keywords	鼻腔リンパ腫 / NK / T 細胞 / EBウィルス / 農薬 / 癌遺伝子 / 癌抑制遺伝子 / T細胞 / 疫学調査
Research Abstract	鼻腔NK/T細胞性リンパ腫(NKTCL)の発症要因としてはEBウィルス他に社会環境要因が考えられる。研究者はビニールハウス内で大量の農薬使用を行ってきた父と息子に発生したNKTCLについて報告した。この例は疾患発生状況から農薬使用の影響が強く疑われた。そこで2000〜2005年に本邦、韓国の疫学調査 ...

Research Products of this project	Journal Article (9 results, of which Peer Reviewed: 3 results) Presentation (1 results)

15. Impairment of DNA repair in lymphoma developing in chronic inflammation

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Experimental pathology
Research Institution	Osaka University
Principal Investigator	TAKAKUWA Tetsuya Osaka University, Graduate School of Medicine, Associate Professor
Project Period (FY)	2005 – 2006Completed
Keywords	lymphoma / DNA repair / ATM / ATR / chronic inflammtaion / MRE-11 / genome instability
Research Abstract	Double-strand breaks (DSBs), which are extremely cytotoxic DNA lesions, activate an extensive array of responses that lead to repair of the damage and ...

Research Products of this project	Journal Article (22 results)

16. Study on patho-epidemiology of malignant lymphoma in Japan

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Human pathology
Research Institution	Osaka University
Principal Investigator	AOZASA Katsuyuki Osaka University, Graduate School of Medicine, professor
Project Period (FY)	2004 – 2006Completed
Keywords	malignant lymphoma / etiology / EB virus / rheumatoid arthritis / prognosis
Research Abstract	The study based on the cases with malignant lymphomas registered in the Osaka Lymphoma Study Group and the cases with pyothorax-associated lymphoma (P ...

Research Products of this project	Journal Article (27 results) Book (1 results)

17. Cloning of Epstein-Barr virus integration sites in lymphoma cell lines

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Experimental pathology
Research Institution	Osaka University
Principal Investigator	TAKAKUWA Tetsuya Osaka University, Graduate School of Medicine, Associate Professor
Project Period (FY)	2003 – 2004Completed
Keywords	Epstein-Barr virus / integration / lymphoma / Raji / lymphoblastoid cell line / Rel / Bcl-11A / Bach2
Research Abstract	Epstein-Barr virus (EBV) initially isolated from cultured Burkitt lymphoma (BL) cells, is one of well-known oncogenic virus. The Raji cell line was es ...

Research Products of this project	Journal Article (10 results) Publications (3 results)

18. Patho-epidemiological study on the nasal NK/T cell lymphoma.

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Human pathology
Research Institution	Osaka University
Principal Investigator	AOZASA Katsuyuki Osaka University, Grad Sch Med, Prof.
Project Period (FY)	2003 – 2005Completed
Keywords	malignant lymphoma / NK / T cell / EB virus / pesticide / epidemiology / gene mutation
Research Abstract	1. PCR-SSCP method followed with direct sequencing revealed the different frequency and pattern of p53, c-kit, k-ras, and β-catenin gene mutations in ...

Research Products of this project	Journal Article (20 results) Book (1 results) Publications (7 results)

19. 甲状腺リンパ腫におけるFas遺伝子異常の解析

Research Project

Research Category	Grant-in-Aid for Encouragement of Young Scientists (A)
Research Field	Human pathology
Research Institution	Osaka University
Principal Investigator	高桑徹也大阪大学, 医学系研究科, 助手
Project Period (FY)	2000 – 2001Completed
Keywords	悪性リンパ腫 / Fas / apoptosis / 橋本病 / 甲状腺 / 慢性炎症 / Fas ligand / loss of function mutation / Fas遺伝子 / 甲状腺リンパ腫 / 慢性甲状腺炎 / 遺伝子異常 / アポトーシス / lymphomagenesis
Research Abstract	FasはTNF receptor familyに属するtransmenbrane proteinで、Fas ligand(FasL)とcross-linkしapoptosisのシグナル伝達に関与する。Fasの異常はリンパ球細胞の蓄積をもたらす。甲状腺リンパ腫は、慢性甲状腺炎を背景に発症するリンパ腫で ...

Research Products of this project	Publications (5 results)

20. Analysis of DNA sequence of immunoglobulin heavy chain variable region gene in lymphomas developing from chronic inflammation

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Human pathology
Research Institution	Osaka University
Principal Investigator	AOZASA Katsuyuki Osaka Univ Graduate Sch Med, Professor
Project Period (FY)	2000 – 2001Completed
Keywords	immunoglobulin gene / thyroid lymphoma / Hashimoto's thyroiditis / pyothorax-associated lymphoma
Research Abstract	Immunoglobulin heavy chain variable region gene was analyzed in lymphomas developing from chonic inflammation of different etiology to evaluate whethe ...

Research Products of this project	Publications (24 results)

Project Period (Start Year [FY])

1. 拡散MRI法を用いた妊娠第1三半期胎児の脳神経ネットワーク形成過程の解析 Research Project

高桑 徹也 京都大学, 医学研究科, 教授

2. hierarchical database for better understanding of human fetal morphogenesis Research Project

Takakuwa Tetsuya 京都大学, 医学研究科, 教授

3. ヒト胎児脳神経系、骨格器系の多元計算解剖学的解析 Publicly Offered Research

高桑 徹也 京都大学, 医学研究科, 教授

4. Myocardial fiber formation in the human fetus detected by diffusion tensor imaging Research Project

Takakuwa Tetsuya 京都大学, 医学研究科, 教授

5. Three-dimensional analyses of human embryos using phase-contrast X-ray computed tomography Research Project

Zhao Langying 京都大学, 医学研究科, 研究員

6. Digitization, Histological Analyses and Making Web Atlas of Blechschmidt Collection Research Project

YAMADA SHIGEHITO 京都大学, 医学研究科, 教授

7. ヒト器官形成期において分岐構造を有する器官の３次元分枝パターンを解析する Publicly Offered Research

高桑 徹也 京都大学, 医学研究科, 教授

8. Developmental dynamics of human brain from pattern formation to generation of behaviors Research Project

Taga Gentaro 東京大学, 大学院教育学研究科(教育学部), 教授

9. Analysis of normal and abnormal development of human embryos using 3D imaging data Research Project

Takakuwa Tetsuya 京都大学, 医学(系)研究科(研究院), 教授

10. Exercise intervention for the improvement of cognitive function in patients with Alzheimer's disease or mild cognitive impairment Research Project

HIDENORI Arai 京都大学, 医学(系)研究科(研究院), 教授

11. A multi-modal rehabilitation approach that used cartilage stem cell as a subject Research Project

AOYAMA Tomoki 京都大学, 医学(系)研究科(研究院), 准教授

12. Morphology and Morphometry of the human embryos by magnetic resonance microscopic imaging Research Project

TAKAKUWA Tetsuya 京都大学, 大学院・医学研究科, 教授

13. 鼻腔NK/T細胞リンパ腫発生要因の系統的解析 Research Project

青笹 克之 Osaka University

14. 鼻腔NK/T細胞リンパ腫発生要因の系統的解析 Research Project

青笹 克之 Osaka University

15. Impairment of DNA repair in lymphoma developing in chronic inflammation Research Project

TAKAKUWA Tetsuya Osaka University, Graduate School of Medicine, Associate Professor

16. Study on patho-epidemiology of malignant lymphoma in Japan Research Project

AOZASA Katsuyuki Osaka University, Graduate School of Medicine, professor

17. Cloning of Epstein-Barr virus integration sites in lymphoma cell lines Research Project

TAKAKUWA Tetsuya Osaka University, Graduate School of Medicine, Associate Professor

18. Patho-epidemiological study on the nasal NK/T cell lymphoma. Research Project

AOZASA Katsuyuki Osaka University, Grad Sch Med, Prof.

19. 甲状腺リンパ腫におけるFas遺伝子異常の解析 Research Project

高桑 徹也 大阪大学, 医学系研究科, 助手

20. Analysis of DNA sequence of immunoglobulin heavy chain variable region gene in lymphomas developing from chronic inflammation Research Project

AOZASA Katsuyuki Osaka Univ Graduate Sch Med, Professor

1. 拡散MRI法を用いた妊娠第1三半期胎児の脳神経ネットワーク形成過程の解析

Research Project

高桑徹也京都大学, 医学研究科, 教授

2. hierarchical database for better understanding of human fetal morphogenesis

Research Project

3. ヒト胎児脳神経系、骨格器系の多元計算解剖学的解析

Publicly Offered Research

高桑徹也京都大学, 医学研究科, 教授

4. Myocardial fiber formation in the human fetus detected by diffusion tensor imaging

Research Project

5. Three-dimensional analyses of human embryos using phase-contrast X-ray computed tomography

Research Project

6. Digitization, Histological Analyses and Making Web Atlas of Blechschmidt Collection

Research Project

7. ヒト器官形成期において分岐構造を有する器官の３次元分枝パターンを解析する

Publicly Offered Research

高桑徹也京都大学, 医学研究科, 教授

8. Developmental dynamics of human brain from pattern formation to generation of behaviors

Research Project

9. Analysis of normal and abnormal development of human embryos using 3D imaging data

Research Project

10. Exercise intervention for the improvement of cognitive function in patients with Alzheimer's disease or mild cognitive impairment

Research Project

11. A multi-modal rehabilitation approach that used cartilage stem cell as a subject

Research Project

12. Morphology and Morphometry of the human embryos by magnetic resonance microscopic imaging

Research Project

13. 鼻腔NK/T細胞リンパ腫発生要因の系統的解析

Research Project

青笹克之 Osaka University

14. 鼻腔NK/T細胞リンパ腫発生要因の系統的解析

Research Project

青笹克之 Osaka University

15. Impairment of DNA repair in lymphoma developing in chronic inflammation

Research Project

16. Study on patho-epidemiology of malignant lymphoma in Japan

Research Project

17. Cloning of Epstein-Barr virus integration sites in lymphoma cell lines

Research Project

18. Patho-epidemiological study on the nasal NK/T cell lymphoma.

Research Project

19. 甲状腺リンパ腫におけるFas遺伝子異常の解析

Research Project

高桑徹也大阪大学, 医学系研究科, 助手

20. Analysis of DNA sequence of immunoglobulin heavy chain variable region gene in lymphomas developing from chronic inflammation

Research Project