KAKEN — Research Projects | Researcher Number: 40283014

Search Results: 17 results / Researcher Number: 40283014

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1. Visualization of microenvironments of malignant glioma utilizing 7T-MRI and 3D tissue clearing technology

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Review Section	Basic Section 56010:Neurosurgery-related
Research Institution	Niigata University
Principal Investigator	藤井幸彦新潟大学, 脳研究所, 非常勤講師
Project Period (FY)	2021-04-01 – 2024-03-31Granted
Keywords	腫瘍微小環境 / 7T-MRI詳細画像 / 3次元病理解析 / 摘出脳組織透明化 / 新規治療法開発 / グリオーマ / 7T-MRI / 組織透明化 / 微小環境
Outline of Research at the Start	悪性神経膠腫の新しい治療開発の標的として、腫瘍微小環境が重要である。しかしその微小環境は、個々の患者により大きく異なり、また免疫応答が多大なる影響を及ぼすため、実験系で再現することは極めて困難である。
Outline of Annual Research Achievements	悪性神経膠腫の新しい治療開発の標的として、腫瘍微小環境が重要である。しかしその微小環境は、個々の患者により大きく異なり、また免疫応答が多大なる影響を及ぼすため、実験系で再現することは極めて困難である。
Current Status of Research Progress	2: Research has progressed on the whole more than it was originally planned.

Research Products of this project	Journal Article (13 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 13 results, Open Access: 2 results) Presentation (13 results, of which Int'l Joint Research: 1 results, Invited: 11 results)

2. Pathomechanisms and Control of Epileptogenic Foci: Imaging Practices for Surgical Specimens

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Review Section	Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Research Institution	Niigata University
Principal Investigator	Kakita Akiyoshi 新潟大学, 脳研究所, 教授
Project Period (FY)	2019-04-01 – 2022-03-31Completed
Keywords	てんかん / 神経回路 / 3D / 脳透明化 / フラビン蛍光イメージング / 脳機能外科 / 神経病理
Outline of Research at the Start	てんかん焦点では、どのように異常な神経興奮が惹起され伝播するのか？この命題はいわば、臨床てんかん学における古典的かつ本質的命題である。本研究では、この命題に対する明確な‘解’を提供し、難治てんかん患者に対する新たな外科的/内科的治療戦略を開発する。研究戦略の柱は、外科的に切除されたてんかん焦点脳組織 ...
Outline of Final Research Achievements	How is abnormal neural excitation elicited and propagated in epileptogenic brain lesions? In this study, we performed physiological analysis using fre ...

Research Products of this project	Int'l Joint Research (1 results) Journal Article (15 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 14 results, Open Access: 1 results) Presentation (17 results, of which Int'l Joint Research: 2 results, Invited: 10 results) Book (2 results)

3. Identification of targeted gene mutations for precision based medicine in malignant meningioma

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Review Section	Basic Section 56010:Neurosurgery-related
Research Institution	Niigata University
Principal Investigator	HIRAISHI TETSUYA 新潟大学, 脳研究所, 助教
Project Period (FY)	2018-04-01 – 2022-03-31Completed
Keywords	悪性髄膜腫 / 独自培養細胞株 / 精密医療 / 遺伝子パネル検査 / プレシジョンメディシン / 遺伝子パネル / ドライバー遺伝子 / 腫瘍細胞培養
Outline of Final Research Achievements	We designed this study based on the hypothesis that a gene panel could be used to identify driver mutations of unique to malignant meningiomas. Tumor ...

Research Products of this project	Journal Article (3 results) Presentation (13 results)

4. Visualization of epileptogenic foci of MRI non-lesional neocortical epilepsy patients by 7T-MRI

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Neurosurgery
Research Institution	Niigata University
Principal Investigator	Fujii Yukihiko 新潟大学, 脳研究所, 教授
Project Period (FY)	2017-04-01 – 2022-03-31Completed
Keywords	MRI陰性新皮質てんかん / ７テスラMRI / 機能的脳疾患 / 診療教育拠点 / 教育的診療教育拠点形成 / 教育的診療研究拠点形成 / 7テスラMRI
Outline of Final Research Achievements	This three-year prospective study was intended to visualize epileptogenic foci, as organic lesions, of non-lesional neocortical epilepsy patients by m ...

Research Products of this project	Journal Article (84 results, of which Int'l Joint Research: 10 results, Peer Reviewed: 83 results, Open Access: 21 results) Presentation (28 results, of which Int'l Joint Research: 5 results, Invited: 17 results)

5. Elucidation of pathophysiology of iNPH by dynamics analysis of water molecule

Research Project

Research Category	Grant-in-Aid for Challenging Exploratory Research
Research Field	Neurosurgery
Research Institution	Niigata University
Principal Investigator	Suzuki Yuji 新潟大学, 脳研究所, 准教授
Project Period (FY)	2016-04-01 – 2019-03-31Completed
Keywords	iNPH / 水PET / Glymphatic System / アクアポリン / 正常圧水頭症 / PET / 水動態 / glymphatic system / 特発性正常圧水頭症 / PET画像 / アクアポリンPET / 脳神経疾患 / 神経画像診断学 / ＰＥＴ
Outline of Final Research Achievements	The purpose of this study is to directly evaluate the dynamics of water molecules in CNS in idiopathic normal pressure hydrocephalus (iNPH) for elucid ...

Research Products of this project	Journal Article (17 results, of which Peer Reviewed: 16 results, Open Access: 8 results) Presentation (1 results, of which Int'l Joint Research: 1 results)

6. Development of an innovative treatment for pediatric diffuse intrinsic pontine glioma: Convection enhanced drug delivery methods against rat brainstem glioma model

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Neurosurgery
Research Institution	Niigata University
Principal Investigator	YOSHIMURA Junichi 新潟大学, 医歯学総合病院, 特任教授
Project Period (FY)	2015-04-01 – 2018-03-31Completed
Keywords	脳幹グリオーマ / 小児脳腫瘍 / 動物モデル / 新規治療法開発 / 対流強化型送達法（CED） / 新規治療法 / ヒト脳幹グリオーマ細胞株 / CED法 / 臨床研究 / 国際学会発表 / 論文発表 / 培養細胞株 / CED
Outline of Final Research Achievements	The aim of this study is innovation of a new treatment for pediatric malignant brainstem glioma, especially diffuse intrinsic pontine glioma (DIPG) wh ...

Research Products of this project	Journal Article (7 results, of which Peer Reviewed: 6 results, Open Access: 5 results, Acknowledgement Compliant: 1 results) Presentation (10 results, of which Int'l Joint Research: 3 results, Invited: 1 results) Book (1 results)

7. Development of novel therapy based on functional reorganization in brain tumor patients

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Neurosurgery
Research Institution	Niigata University
Principal Investigator	Fujii Yukihiko 新潟大学, 脳研究所, 教授
Project Period (FY)	2013-04-01 – 2017-03-31Completed
Keywords	脳腫瘍 / 脳機能再構築 / fMRI / NIRS / 新規治療 / 機能的再構築 / TMS / 新規治療法
Outline of Final Research Achievements	Motor functions in brain tumor patients were assessed by fMRI. The locus of primary sensory motor activation during contralesional hand grasp was disp ...

Research Products of this project	Journal Article (52 results, of which Peer Reviewed: 51 results, Acknowledgement Compliant: 1 results, Open Access: 2 results) Presentation (24 results, of which Invited: 12 results) Book (1 results)

8. Pathomechanisms underlying human temporal lobe epilepsy

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Nerve anatomy/Neuropathology
Research Institution	Niigata University
Principal Investigator	KAKITA Akiyoshi 新潟大学, 脳研究所, 教授
Project Period (FY)	2013-04-01 – 2017-03-31Completed
Keywords	てんかん / 脳神経疾患 / 海馬硬化症 / カリウムチャネル / 海馬 / 神経病理学 / 神経回路 / 細胞病理学
Outline of Final Research Achievements	Mesial temporal lobe epilepsy (MTLE) is the most frequent focal epileptic syndrome in adults, and the majority of seizures originate primarily from th ...

Research Products of this project	Journal Article (20 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 16 results, Acknowledgement Compliant: 3 results) Presentation (29 results, of which Int'l Joint Research: 1 results, Invited: 9 results) Book (8 results)

9. A stepwise study to develop therapies for patients with subcortical hemiparesis using fMRI guided near-infrared spectroscopy

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Cerebral neurosurgery
Research Institution	Niigata University
Principal Investigator	FUJII Yukihiko 新潟大学, 脳研究所, 教授
Project Period (FY)	2009 – 2011Completed
Keywords	脳血管障害学 / NIRS / 脳機能再構築 / 機能回復 / 片麻痺 / fMRI
Research Abstract	This study is considered as the first step of a stepwise study to develop therapies for patients with subcortical hemiparesis using functional MRI gui ...

Research Products of this project	Journal Article (97 results, of which Peer Reviewed: 90 results) Presentation (44 results) Book (8 results)

10. Magnetic Resonance Molecular Microimaging

Research Project

Research Category	Grant-in-Aid for Scientific Research (S)
Research Field	Neuroscience in general
Research Institution	Niigata University
Principal Investigator	NAKADA Tsutomu 新潟大学, 脳研究所, 教授
Project Period (FY)	2009-05-11 – 2014-03-31Completed
Keywords	MRI / 7テスラ / MR microscopy / 解剖学的解像度 / 超高磁場 / MR spectroscopy / hyperpolarization / 機能画像 / magnetic resonance spectroscopy / 超候磁場
Research Abstract	The research project was one of the most ambitious proposals aiming to develop ligand based MRI molecular imaging, a goal that has eluded world scient ...
Verification Result (Rating)	A-

Research Products of this project	Journal Article (44 results, of which Peer Reviewed: 44 results) Presentation (18 results, of which Invited: 6 results) Book (5 results) Remarks (4 results)

11. High-resolution Clinical lmaging on 7.0 T MR system

Research Project

Research Category	Grant-in-Aid for Scientific Research (S)
Research Field	Neuroscience in general
Research Institution	Niigata University
Principal Investigator	NAKADA Tsutomu Niigata University
Project Period (FY)	2004 – 2008Completed
Keywords	MRI / 7テスラ / MR microscopy / 解剖学的解像度 / 超高磁場 / magnetic resonance spectroscopy / hyperpolarization / 機能画像 / 3DAC / tensor imaging
Research Abstract	本研究は、本邦唯一のヒト用超高磁場(7.0T)装置を用いた高分解能画像を開発し、特定疾患における組織特性を反映するコントラスト画像法を導入することにより、組織標本に匹敵する臨床生体顕微鏡を開発することを目的とした。様々な技術開発を行い、SusceptibilityWeighted Imaging(S ...

Research Products of this project	Journal Article (60 results, of which Peer Reviewed: 23 results) Presentation (27 results) Book (2 results) Remarks (19 results) Patent(Industrial Property Rights) (3 results, of which Overseas: 1 results)

12. Mechanism of Motor Cortical Reorgationization

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Cerebral neurosurgery
Research Institution	Niigata University
Principal Investigator	FUJII Yukihiko Niigata University, Brain Research Institute, Associate Professor
Project Period (FY)	2002 – 2005Completed
Keywords	brain function / cortical reorganization / functional MRI / hemiparesis / high magnetic field / diffusion tensor analysis
Research Abstract	The objectives of this study were to assess the mechanisms of motor functional recovery and cortical reorganization, and thereby to elucidate the cort ...

Research Products of this project	Journal Article (79 results) Book (1 results) Publications (19 results)

13. Multi linguistic Neuronal Processing fMRI Study

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Neuroscience in general
Research Institution	Niigata University
Principal Investigator	NAKADA Tsutomu Niigata University Brain Research Institute, Professor
Project Period (FY)	1999 – 2001Completed
Keywords	functional MRI / language / deafness / dyslexia
Research Abstract	Functional magnetic resonance imaging (MRI) has revolutionized the investigations of higher brain function in humans. Nevertheless, the method still h ...

Research Products of this project	Publications (154 results)

14. Neuronal Substrates of Literacy : High-field Functional MRI

Research Project

Research Category	Grant-in-Aid for Scientific Research (B).
Research Field	Neuroscience in general
Research Institution	Niigata University
Principal Investigator	NAKADA Tsutomu Niigata University, Brain Research Institute, Professor
Project Period (FY)	1999 – 2000Completed
Keywords	functional MRI / language / deafness / dyslexia
Research Abstract	Blood oxygenation level dependent (BOLD) contrast functional magnetic resonance imaging (MRI) has revolutionized the investigations of higher brain fu ...

Research Products of this project	Publications (105 results)

15. Multi-Ilinguistic Neuronal Processing : fMRI Study

Research Project

Research Category	Grant-in-Aid for international Scientific Research
Research Field	Neuroscience in general
Research Institution	Niigata University
Principal Investigator	NAKADA Tsutomu Niigata University, Brain Research Institute, Professor
Project Period (FY)	1997 – 1998Completed
Keywords	Multi-linguistics / Neuronal Processing / functional MRI
Research Abstract	The project is designed based on long-standing collaboration efforts between the principle investigator, who himself has been a faculty member of Univ ...

Research Products of this project	Publications (83 results)

16. Threshold depolarization intervals for ischemic tolerance vs. expression of hsp72 and immediate early genes in gerbils.

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Cerebral neurosurgery
Research Institution	NIIGATA UNIVERSITY
Principal Investigator	ABE Hiroshi NIIGATA UNIVERSITY MEDECAL HOSPITAL,ASSISTANT
Project Period (FY)	1996 – 1998Completed
Keywords	cerebral ischemia / ischemic tolerance / immediate early gene / heat shock protein / DC potential / depolarization
Research Abstract	Brief ischemia can induce tolerance to later more severe ischemia, but reported effects are highly variable. It has been suggested that changes in gen ...

17. BASIC RESEARCH FOR CEREBRAL WHITE MATTER DEMENTIA USING MODELS OF RADIATION-INDUCED DEMENTIA RATS

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Cerebral neurosurgery
Research Institution	NIIGATA UNIVERSITY
Principal Investigator	TAKEUCHI Shigekazu NIIGATA UNIV.BRAIN RES.INST.ASSISTANT PROFESSOR
Project Period (FY)	1996 – 1997Completed
Keywords	radiation / rat / water maze / passive avordance / apoptosis
Research Abstract	A course of whole brain irradiation (30Gy (group A) or 25Gy (group B) /single dose, 40Gy/5Gy*8/4weeks (groupC)) was administered to Fischer 344 rats a ...

Research Products of this project	Publications (2 results)