KAKEN — Research Projects | Researcher Number: 50171616

Search Results: 13 results / Researcher Number: 50171616

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1. Development of versatile antiviral medicines using advanced decoy particles for topical mucosal formulations

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Review Section	Basic Section 47060:Clinical pharmacy-related
Research Institution	Gifu Pharmaceutical University
Principal Investigator	Tahara Kohei 岐阜薬科大学, 薬学部, 教授
Project Period (FY)	2018-04-01 – 2021-03-31Completed
Keywords	リポソーム / ナノ粒子 / ウイルス
Outline of Final Research Achievements	We have found that liposomes and polymeric nanoparticles can potently inhibit viral infection of host cells. This phenomenon suggested that the nanopa ...

Research Products of this project	Journal Article (4 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 3 results, Open Access: 1 results)

2. Studies on topical application of BONAC nucleic with liposomal formulation for advanced clinical treatment

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Physical pharmacy
Research Institution	Gifu Pharmaceutical University
Principal Investigator	Takeuchi Hirofumi 岐阜薬科大学, 薬学部, 教授
Project Period (FY)	2013-04-01 – 2016-03-31Completed
Keywords	リポソーム / 核酸医薬 / 点眼 / 網膜 / 肺疾患 / 前臨床試験 / ボナック核酸 / 経肺 / DDS
Outline of Final Research Achievements	For the purpose of design of the topical formulations of BONAC nucleic, the optimal liposomal formulation with the fluorescent substance, selected as ...

Research Products of this project	Journal Article (9 results, of which Peer Reviewed: 7 results, Acknowledgement Compliant: 2 results, Open Access: 2 results) Presentation (20 results, of which Int'l Joint Research: 3 results, Invited: 3 results) Book (1 results)

3. Novel Dosage form design for ocular and pulmonary drug delivery based on analysis of behavior of nano-particle as drug carrier

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Physical pharmacy
Research Institution	Gifu Pharmaceutical University
Principal Investigator	TAKEUCHI Hirofumi 岐阜薬科大学, 薬学部, 教授
Project Period (FY)	2009 – 2011Completed
Keywords	製剤学 / リポソーム / 局所体内挙動 / 網膜 / 点眼剤 / 微粒子 / リモートローディング / 経肺投与 / 抗炎症薬 / ステロイド / ペプチド
Research Abstract	The purpose of this research project is development of noninvasive drug delivery systems to promote drug delivery in several administration routes. Tw ...

Research Products of this project	Journal Article (26 results, of which Peer Reviewed: 23 results) Presentation (45 results) Book (8 results) Patent(Industrial Property Rights) (3 results, of which Overseas: 1 results)

4. Development of a new topical treatment system for the eye

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Ophthalmology
Research Institution	Osaka University
Principal Investigator	OHGURO Nobuyuki Osaka University, Graduate School of Medicine, Associate professor
Project Period (FY)	2005 – 2006Completed
Keywords	drug delivery system / chitosan / lipid nanosphere / eye drop / hierarchial cluster analysis / EAU
Research Abstract	We evaluated chitosan-coated lipid nanosphere (CS-LNS) as a new topical eye drop system which can target the posterior pole of the eye. First, we did ...

Research Products of this project	Journal Article (11 results) Patent(Industrial Property Rights) (1 results)

5. Studies on nano-particulate systems and their bio-response for drug delivery

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Physical pharmacy
Research Institution	Gifu Pharmaceutical University
Principal Investigator	TAKEUCHI Hirofumi Gifu Pharmaceutical University, Pharmaceutical Science, Associate Professor
Project Period (FY)	2002 – 2004Completed
Keywords	nanoparticles / liposomes / mucoadhesion / Caco2 cell / chitosan / drug permeability
Research Abstract	1. Assessment of bio-compatibility of nano-particles

Research Products of this project	Journal Article (9 results) Book (1 results) Publications (8 results)

6. Organization of nanoparticulate system by spherical crystallization for poorly absorbable drug

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	広領域
Research Institution	Gifu Pharmaceutical University
Principal Investigator	KAWASHIMA Yoshiaki Gifu Pharmaceutical University Faculty of Pharmaceutical Science, Professor
Project Period (FY)	2001 – 2003Completed
Keywords	D,L-lactide / glycolide copolymer / spherical crystallization / nanosphere / pulmonary administration / intra-articular injection / surface modification / chitosan / plasmid DNA
Research Abstract	The aim of this project is to design surface and size controlled nanoparticulate carrier for delivering poorly absorbable drug by the spherical crysta ...

Research Products of this project	Publications (48 results)

7. Studies on controlled biodistribution of submicron-sized drug-carriers with surface modification and its controlling mechanism

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Physical pharmacy
Research Institution	Gifu Pharmaceutical University
Principal Investigator	TALEUCHI Hirofumi Gifu Pharmaceutical University, Pharmaceutical Sciences, Associate Professor
Project Period (FY)	2000 – 2001Completed
Keywords	surface modification / liposome / nanosphere / mires adhesion / Targeting / cancer cell
Research Abstract	1. Mucoadhesive property of chitosan-coated liposomes (CS-Lip) was much improved by reducing their size to sub-micron. Penetration of the submicron-si ...

Research Products of this project	Publications (24 results)

8. Development of pulmonary drug delivery system with dry powder and aqueous suspension aerosols

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Physical pharmacy
Research Institution	GIFU PHARMACEUTICAL UNIVERSITY
Principal Investigator	KAWASHIMA Yoshiaki Gifu Pharmaceutical University, Pharmacy, Professor
Project Period (FY)	1996 – 1998Completed
Keywords	dry powder inhalation / pulmonary delivery / aerosolized aqueous suspension / nanocapsule / lactide / glycolide copolymer / nebulizer / insulin / surface modification
Research Abstract	The evaluation methods for the dry powder inhalation dosage forms (DPI) were developed by using cascade impactor and twinimpinger, which have been uti ...

Research Products of this project	Publications (32 results)

9. DESIGN AND EVALUATION OF MUCOADHESIVE MICROPARTICULATE DRUG CARRIERS FOR ORAL ADMINISTRATION OF PEPTIDE DRUGS

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Physical pharmacy
Research Institution	GIFU PHARMACEUTICAL UNIVERSITY
Principal Investigator	TAKEUCHI Hirofumi GIFU PHARMACEUTICAL UNIVERSITY,PHARMACY,ASSOCIATE PROFESSOR
Project Period (FY)	1995 – 1997Completed
Keywords	liposome / nanosphere / oral administration / mucoadhesive / insulin / peptide
Research Abstract	1.Design of mucoadhesive microparticulate drug carriers

Research Products of this project	Publications (16 results)

10. Development and application of novel w/o/w emulsion for the chemoembolization therapy of hepatocellular carcinoma

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Physical pharmacy
Research Institution	Gifu Pharmaceutical University
Principal Investigator	HINO Tomoaki Gifu Pharmaceutical University, Faculty of Pharmaceutical Sciences, Assistant Professor
Project Period (FY)	1995 – 1996Completed
Keywords	w / o / w emulsion / transcatheter arterial ambolization therapy / epirubicin hydrochloride / lipiodol / acute toxicity / hemolysis
Research Abstract	W/o/w emulsion (WOWE) encapsulating water-soluble anticancer agent (epirubicin hydrochloride, EPI) was prepared by two-step amulsification method. Aqu ...

Research Products of this project	Publications (4 results)

11. Development of novel controlled drug release system with floating micro-hollow sphere

Research Project

Research Category	Grant-in-Aid for General Scientific Research (A)
Research Field	広領域
Research Institution	Gifu Pharmaceutical University
Principal Investigator	KAWASHIMA Yoshiaki Gifu Pharmaceutical University, Professor
Project Period (FY)	1989 – 1991Completed
Keywords	controlled release system / floating system / microballoon / emulsion-solvent-diffusion method / drug release rate / residence time in stomach / spherical crystallization / particle design
Research Abstract	A novel controlled drug release floating system with micro-hollow spheres of polymer, termed microballoons, was developed for pharmaceutical, chemical ...

Research Products of this project	Publications (37 results)

12. Development of a Novel Preparation Method of High Energy Microsphere

Research Project

Research Category	Grant-in-Aid for General Scientific Research (B)
Research Field	広領域
Research Institution	Gifu Pharmaceutical University
Principal Investigator	KAWASHIMA Y Gifu Pharmaceutical University
Project Period (FY)	1987 – 1988Completed
Keywords	Microspher / Amorphous / Controlled release / Bioavailability / Suspension
Research Abstract	Novel preparation methods of high energy microspheres of pharmaceutics have been developed. Ibuprofen was molecularly dispersed in acrylic polymer sph ...

Research Products of this project	Publications (20 results)

13. Freeze-Drying and Stabilization of Liposomes Encapsulating Drug and Enzyme

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	Physical pharmacy
Research Institution	Gifu Pharmaceutical University
Principal Investigator	HANDA Tetsurou Gifu Pharmaceutical University ・ Associate Professor
Project Period (FY)	1985 – 1986Completed
Keywords	Lyophilization of Liposomes / Size Control of Liposomes / Fluidity of Liposomes / Modified REV Method / Freeze-Thawing of Liposomes
Research Abstract	Liposomes have been considered to have great potential as drug delivery vehicles. From pharmaceutical stand-point, the chemical and physical stabiliti ...

Research Products of this project	Publications (8 results)