KAKEN — Research Projects | Researcher Number: 70025584

1. STUDY ON THREE DIMENTIONAL CULTURE OF REPITONAL RESIDENT CELLS(AETIFICIAL PERITONEUM)

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Biomedical engineering/Biological material science
Research Institution	UNIVERSITY OF EAST ASIA
Principal Investigator	HORIUCHI Takashi FAC. OF ENG PROF
Project Period (FY)	1999 – 2001Completed
Keywords	腹膜透析 / 腹膜硬化症 / 細胞培養 / 三次元培養 / 画像解析 / 腹膜修復 / 細胞増殖 / 細胞遊走 / サイトカイン / RT-PCR / VEGF / TGF-β1
Research Abstract	Extracellular matrices layered with collagen and hyaluronan was formed in the Transwell (Corstar ; 0.3 μm pore size) and utilized for a solute-transfe ...

Research Products of this project	Publications (24 results)

2. Study of constitution of postgraduate clinical training programs in the university hospital

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Institution	Chiba University
Principal Investigator	ISONO Kaichi Chiba University School of Medicine, President
Project Period (FY)	1997 – 1998Completed
Keywords	Postgraduate clinical training / Objectives to be achieved / Training systems / Evaluation systems / Training programs / University hospital
Research Abstract	We have clarified the role of university hospital as the place for residents' clinical training and investigated postgraduate clinical trainings inclu ...

3. Study on the plasticity of ion-channel in the bladder afferent and efferent neurons associated with bladder hypesrefl

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Urology
Research Institution	KYOTO UNIVERSITY
Principal Investigator	KAKEHI Yoshiyuki Kyoto University Graduate School of Medicine, Assistant Professor
Project Period (FY)	1996 – 1997Completed
Keywords	micturition reflex / ion-channel / plasticity / neurotransmitter / nitric oxide / bladder efferent pathway / whole-cell patch clamp / nerve growth factor
Research Abstract	(1) Primary afferent neurons in dorsal root ganglia (DRG) and efferent neurons in major pelvic ganglia innervating the urinary bladder were labeled by ...

Research Products of this project	Publications (23 results)

4. Analysis of the telomerase activity in renal cell carcinoma

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Urology
Research Institution	KYOTO UNIVERSITY
Principal Investigator	TERACHI Toshiro Kyoto University, Urology, Assistant professor
Project Period (FY)	1996 – 1997Completed
Keywords	telomerase / renal cell carcinoma / chromophobe cell type / bladder cancer
Research Abstract	In malignant tumors, telomerase reactivation plays an important role in the acquisition of cellular immortality. We examined the telomerase activity i ...

Research Products of this project	Publications (6 results)

5. Analysis of the pathogenesis of bacterial prostatitis

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Urology
Research Institution	KYOTO UNIVERSITY
Principal Investigator	OKADA Yusaku Kyoto University, Urology, Associate professor
Project Period (FY)	1996 – 1997Completed
Keywords	bacterial prostatitis / Escherichia coli / virulence factors
Research Abstract	Escherichia coli is the most frequent pathogen in acute bacterial prostatitis as well as in acute uncomplicated urinary infections. To assess the viru ...

Research Products of this project	Publications (9 results)

6. Nationwide survey of urolithiasis in Japan

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Urology
Research Institution	KYOTO UNIVERSITY
Principal Investigator	YOSHIDA Osamu Kyoto University, Urology, Professor
Project Period (FY)	1996 – 1997Completed
Keywords	urinary calculi / upper urinary tract / epidemiology / nationwide survey / annual incidence / retrospective cohort
Research Abstract	A nationwide survey of urolithiasis in Japan was made that succeeded previous studies done in 1955, 1966, 1979, and 1990, in order to evaluate the chr ...

7. 排尿筋過反射に伴う頻尿、尿失禁の発生機序に関する基礎的研究

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	Urology
Research Institution	Kyoto University
Principal Investigator	吉村直樹京都大学, 医学研究科, 助手
Project Period (FY)	1995Completed
Keywords	MPTP / パーキンソン病 / D1受容体 / 脊髄損傷 / 排尿筋過反射 / neurofilament / パッチクランプ
Research Abstract	1)中脳黒質のドーパミン神経に対する神経毒であるMPTPの静脈内投与によってパーキンソン病状態を呈したサルでは、膀胱内圧測定上、膀胱収縮は正常サルに比べて有意に少ない膀胱容量で引き起こされ、パーキンソン病に伴う排尿反射亢進が確認され尿失禁のモデル動物として有用であると考えられた。

Research Products of this project	Publications (5 results)

8. Basic and Climicol Research for BCG Immunatherapy agoinst Bledd-Caner

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Urology
Research Institution	KYOTO UNIVERSITY
Principal Investigator	MIZUTANI Youichi Kyoto University, Urology, Lecturer
Project Period (FY)	1995 – 1996Completed
Keywords	Bladdr cancer / BCG / Immunity / Lymphocyte / Cytotoxicity / Autologors tumor / Fas / ADR
Research Abstract	The resistance of bladder cancer to anticancer chemotherapeutic agents remains a major problem. Hence, several immunotherapeutic approaches have been ...

Research Products of this project	Publications (28 results)

9. Analysis of Genomic Imprinting in Human Testicular Tumors

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Urology
Research Institution	KYOTO UNIVERSITY
Principal Investigator	OGAWA Osamu Kyoto Univ.Urology, Instructor
Project Period (FY)	1995 – 1996Completed
Keywords	Testicular Tumor / Gemomic Imprinting
Research Abstract	Recent molecular analyzes have demonstrated that epigenetic alterations such as genomic imprinting might have an important role in human tumorigenesis ...

Research Products of this project	Publications (10 results)

10. Establishment of criteria and technique for molecular genetical diagnosis of urothelial cancer

Research Project

Research Category	Grant-in-Aid for General Scientific Research (B)
Research Field	Urology
Research Institution	KYOTO UNIVERSITY
Principal Investigator	YOSHIDA Osamu Kyoto Univ., Faculty of Medicine Professor
Project Period (FY)	1994 – 1995Completed
Keywords	Urothelial cancer / Genetic alteration / Urine cytology / p53 / p16 / MTS1, MTS2 / MDR1, MRP / Primary culture / MASA
Research Abstract	We have reported the losses of heterozygosity on chromosome 9 and 17 are clinically important and now we try to examine several molecular markers to a ...

Research Products of this project	Publications (32 results)

11. A stydy of standarization of criteria for severity and treatment efficacy in Benign Prostate hyperplasia (BPH)

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Urology
Research Institution	NARA MEDICAL UNIVERSITY
Principal Investigator	OKAJIMA Eigoro NARA MEDICAL UNIV.PROFESSOR
Project Period (FY)	1994 – 1996Completed
Keywords	benign prostate hyperplasis / ethiology / criteria for diagnosis and severity / criteria for treatment efficacy
Research Abstract	The objectives of this research are to establish the standard criteria for severity and treatment efficacy in Benign Prostate hyperplasia (BPH) which ...

Research Products of this project	Publications (226 results)

12. 泌尿器科領域悪性腫瘍の発生、進展に関与する遺伝子変異の検索とその臨床的応用

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	Urology
Research Institution	Kyoto University
Principal Investigator	水谷陽一京都大学, 医学部, 助手
Project Period (FY)	1993Completed
Keywords	膀胱癌 / 腎癌 / 染色体 / ヘテロ接合性 / 癌抑制遺伝子 / PCR
Research Abstract	尿路上皮癌において、従来の病理組織学的な悪性度の評価では不十分な症例がしばしば観察されるため、より的確な悪性進展に関わる遺伝子変化の検出を確立し、これを臨床の場に応用することを目的とし、研究を進めてきた。

Research Products of this project	Publications (6 results)

13. 泌尿器科悪性腫瘍の発生・悪性進展に関与する遺伝子異常の検索とその臨床応用

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	Urology
Research Institution	Kyoto University
Principal Investigator	寺地敏郎京都大学, 医学部, 助手
Project Period (FY)	1992Completed
Keywords	尿路上皮癌 / 癌抑制遺伝子 / 悪性度 / p53遺伝子 / 染色体 / ヘテロ接合性の消失
Research Abstract	尿路上皮癌の発生、進展に於いて癌抑制遺伝子の不活化がどの様に関与しているかを調べる目的で、多様な病期と異型度を伴う尿路上皮癌を対象に病理学的所見と対比させ、遺伝子の変化を調べた。癌抑制遺伝子が不活化される際に対立遺伝子の欠失が生じる現象を利用し、50例以上の尿路上皮癌を対象に、ヘテロ接合性の消失(以 ...

Research Products of this project	Publications (5 results)

14. Study on the induction of cytotoxic lymphocytes that act on urological tumors and its clinical application

Research Project

Research Category	Grant-in-Aid for General Scientific Research (B)
Research Field	Urology
Research Institution	KYOTO UNIVERSITY
Principal Investigator	YOSHIDA Osamu Kyoto Univesity, Faculty of Medicine, Professor
Project Period (FY)	1991 – 1993Completed
Keywords	Urological tumor / Cytotoxic Lymphocyte / BCG / CK-432 / CDDP / PSK / TNF / BSO
Research Abstract	We demonstrate the following results :

Research Products of this project	Publications (80 results)

15. 本邦尿路結石症の分析疫学的研究

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	Urology
Research Institution	Kyoto University
Principal Investigator	吉田修京都大学, 医学部, 教授
Project Period (FY)	1990Completed
Keywords	尿路結石症 / 疫学
Research Abstract	昭和60年の尿路結石症年間有病率(対10万人口)は92.5で、生涯罹患率は5.4%と算定された。年齢・性別頻度では、男女比は2.4:1と男性に多く、20才代から50才代に多く、ピ-クは40才代で前回調査時に比べ幅広くなる傾向がみられた。有病率の地域的比較を見ると、近畿・四国・北海道・沖縄地域で頻度が ...

Research Products of this project	Publications (7 results)

16. 受容体チロシンキナ-ゼによる細胞増殖の制御機構: mi突然変異マウスを利用した解析

Research Project

Research Category	Grant-in-Aid for Cancer Research
Research Institution	Kyoto University
Principal Investigator	藤田潤京都大学, 医学部, 教授
Project Period (FY)	1990Completed
Keywords	癌遺伝子 / 細胞増殖 / チロシンキナ-ゼ / 突然変異マウス / 増殖因子 / シグナル伝達 / 細胞間相互作用
Research Abstract	1.肥満細胞が欠損する小眼球症突然変異マウスmi/miを用いて、cーkit蛋白をレセプタ-とする増殖シグナル伝達経路の解析を行なった。その結果

Research Products of this project	Publications (6 results)

17. 前立腺潜在癌の顕性化

Research Project

Research Category	Grant-in-Aid for Cancer Research
Research Institution	Chiba University
Principal Investigator	島崎淳千葉大学, 医学部, 教授
Project Period (FY)	1990Completed
Keywords	前立腺がん / 潜在がん / 偶発がん / 潜在がん顕性化 / がんの進行 / ras p21 / 成長因子 / シオノギがん115
Research Abstract	前立腺潜在癌は高齢男子の約20%に認められるが、顕性化するものはその1%であり、欧米に比しきわめて低率である。この理由を解明するため、多方面より検討された。

Research Products of this project	Publications (6 results)

18. Expression of Growth Factors in the Human Prostate and Identification of the Cells Producing Them (Analysis by Molecular Biological Method)

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	Urology
Research Institution	Kyoto University
Principal Investigator	OISHI Kenji Kyoto University Urology Assistant Professor
Project Period (FY)	1989 – 1990Completed
Keywords	Prostate / Growth Factor / Benign Prostatic Hyperplasia / Northern Blot Method / Molecular Biology
Research Abstract	Using a Northern blot analysis, we examined human normal (3 cases) and benign hyperplastic (12 cases) prostates for expressions of basic fibroblast gr ...

Research Products of this project	Publications (6 results)

19. 泌尿器科領域癌の転移予測指標としてのLーmyc遺伝子DNA多型の解析

Research Project

Research Category	Grant-in-Aid for Cancer Research
Research Institution	Kyoto University
Principal Investigator	吉田修京都大学, 医学部・泌尿器科, 教授
Project Period (FY)	1989Completed
Keywords	Lーmyc / RFLP解析 / 転移のしやすさ / 腎細胞癌 / 前立腺癌
Research Abstract	1.腎臓癌患者におけるLーmyc DNA多型と易転移性について

Research Products of this project	Publications (1 results)

20. 前立腺潜在癌の顕性化

Research Project

Research Category	Grant-in-Aid for Cancer Research
Research Institution	Chiba University
Principal Investigator	島崎淳千葉大学, 医学部, 教授
Project Period (FY)	1988Completed
Keywords	前立腺癌 / 潜在癌 / ホルモン依存性増殖 / 成長因子
Research Abstract	1.潜在癌の頻度と経過

Research Products of this project	Publications (6 results)

Project Period (Start Year [FY])

1. STUDY ON THREE DIMENTIONAL CULTURE OF REPITONAL RESIDENT CELLS(AETIFICIAL PERITONEUM) Research Project

HORIUCHI Takashi FAC. OF ENG PROF

2. Study of constitution of postgraduate clinical training programs in the university hospital Research Project

ISONO Kaichi Chiba University School of Medicine, President

3. Study on the plasticity of ion-channel in the bladder afferent and efferent neurons associated with bladder hypesrefl Research Project

KAKEHI Yoshiyuki Kyoto University Graduate School of Medicine, Assistant Professor

4. Analysis of the telomerase activity in renal cell carcinoma Research Project

TERACHI Toshiro Kyoto University, Urology, Assistant professor

5. Analysis of the pathogenesis of bacterial prostatitis Research Project

OKADA Yusaku Kyoto University, Urology, Associate professor

6. Nationwide survey of urolithiasis in Japan Research Project

YOSHIDA Osamu Kyoto University, Urology, Professor

7. 排尿筋過反射に伴う頻尿、尿失禁の発生機序に関する基礎的研究 Research Project

吉村 直樹 京都大学, 医学研究科, 助手

8. Basic and Climicol Research for BCG Immunatherapy agoinst Bledd-Caner Research Project

MIZUTANI Youichi Kyoto University, Urology, Lecturer

9. Analysis of Genomic Imprinting in Human Testicular Tumors Research Project

OGAWA Osamu Kyoto Univ.Urology, Instructor

10. Establishment of criteria and technique for molecular genetical diagnosis of urothelial cancer Research Project

YOSHIDA Osamu Kyoto Univ., Faculty of Medicine Professor

11. A stydy of standarization of criteria for severity and treatment efficacy in Benign Prostate hyperplasia (BPH) Research Project

OKAJIMA Eigoro NARA MEDICAL UNIV.PROFESSOR

12. 泌尿器科領域悪性腫瘍の発生、進展に関与する遺伝子変異の検索とその臨床的応用 Research Project

水谷 陽一 京都大学, 医学部, 助手

13. 泌尿器科悪性腫瘍の発生・悪性進展に関与する遺伝子異常の検索とその臨床応用 Research Project

寺地 敏郎 京都大学, 医学部, 助手

14. Study on the induction of cytotoxic lymphocytes that act on urological tumors and its clinical application Research Project

YOSHIDA Osamu Kyoto Univesity, Faculty of Medicine, Professor

15. 本邦尿路結石症の分析疫学的研究 Research Project

吉田 修 京都大学, 医学部, 教授

16. 受容体チロシンキナ-ゼによる細胞増殖の制御機構: mi突然変異マウスを利用した解析 Research Project

藤田 潤 京都大学, 医学部, 教授

17. 前立腺潜在癌の顕性化 Research Project

島崎 淳 千葉大学, 医学部, 教授

18. Expression of Growth Factors in the Human Prostate and Identification of the Cells Producing Them (Analysis by Molecular Biological Method) Research Project

OISHI Kenji Kyoto University Urology Assistant Professor

19. 泌尿器科領域癌の転移予測指標としてのLーmyc遺伝子DNA多型の解析 Research Project

吉田 修 京都大学, 医学部・泌尿器科, 教授

20. 前立腺潜在癌の顕性化 Research Project

島崎 淳 千葉大学, 医学部, 教授

1. STUDY ON THREE DIMENTIONAL CULTURE OF REPITONAL RESIDENT CELLS(AETIFICIAL PERITONEUM)

Research Project

2. Study of constitution of postgraduate clinical training programs in the university hospital

Research Project

3. Study on the plasticity of ion-channel in the bladder afferent and efferent neurons associated with bladder hypesrefl

Research Project

4. Analysis of the telomerase activity in renal cell carcinoma

Research Project

5. Analysis of the pathogenesis of bacterial prostatitis

Research Project

6. Nationwide survey of urolithiasis in Japan

Research Project

7. 排尿筋過反射に伴う頻尿、尿失禁の発生機序に関する基礎的研究

Research Project

吉村直樹京都大学, 医学研究科, 助手

8. Basic and Climicol Research for BCG Immunatherapy agoinst Bledd-Caner

Research Project

9. Analysis of Genomic Imprinting in Human Testicular Tumors

Research Project

10. Establishment of criteria and technique for molecular genetical diagnosis of urothelial cancer

Research Project

11. A stydy of standarization of criteria for severity and treatment efficacy in Benign Prostate hyperplasia (BPH)

Research Project

12. 泌尿器科領域悪性腫瘍の発生、進展に関与する遺伝子変異の検索とその臨床的応用

Research Project

水谷陽一京都大学, 医学部, 助手

13. 泌尿器科悪性腫瘍の発生・悪性進展に関与する遺伝子異常の検索とその臨床応用

Research Project

寺地敏郎京都大学, 医学部, 助手

14. Study on the induction of cytotoxic lymphocytes that act on urological tumors and its clinical application

Research Project

15. 本邦尿路結石症の分析疫学的研究

Research Project

吉田修京都大学, 医学部, 教授

16. 受容体チロシンキナ-ゼによる細胞増殖の制御機構: mi突然変異マウスを利用した解析

Research Project

藤田潤京都大学, 医学部, 教授

17. 前立腺潜在癌の顕性化

Research Project

島崎淳千葉大学, 医学部, 教授

18. Expression of Growth Factors in the Human Prostate and Identification of the Cells Producing Them (Analysis by Molecular Biological Method)

Research Project

19. 泌尿器科領域癌の転移予測指標としてのLーmyc遺伝子DNA多型の解析

Research Project

吉田修京都大学, 医学部・泌尿器科, 教授

20. 前立腺潜在癌の顕性化

Research Project

島崎淳千葉大学, 医学部, 教授