KAKEN — Research Projects | Researcher Number: 70280873

Search Results: 18 results / Researcher Number: 70280873

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1. Clinical and Pathophysiological analysis of myelin Oligodendrocyte Glycoprotein antibody-Associated Neurologic Disease

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Neurology
Research Institution	Tohoku University
Principal Investigator	FUJIHARA KAZUO 東北大学, 医学系研究科, 大学院非常勤講師
Project Period (FY)	2017-04-01 – 2020-03-31Completed
Keywords	ミエリンオリゴデンドロサイト糖タンパク / 脱髄疾患 / 自己抗体 / 自己免疫性脳炎 / 多発性硬化症 / 非典型例 / 抗MOG抗体 / 視神経脊髄炎 / アストロサイトパチー
Outline of Final Research Achievements	We analyzed the clinical and pathophysiological aspects of myelin oligodendrocyte glycoprotein (MOG)-antibody-associated disease,(MOGAD).1) Clinical f ...

Research Products of this project	Int'l Joint Research (18 results) Journal Article (40 results, of which Int'l Joint Research: 12 results, Peer Reviewed: 39 results, Open Access: 19 results) Presentation (45 results, of which Int'l Joint Research: 45 results, Invited: 45 results) Book (6 results)

2. Clinical and Pathophysiological Analysis of Atypical Multiple Sclerosis

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Neurology
Research Institution	Tohoku University
Principal Investigator	FUJIHARA KAZUO 東北大学, 医学(系)研究科(研究院), 非常勤講師
Project Period (FY)	2014-04-01 – 2017-03-31Completed
Keywords	多発性硬化症 / 非典型例 / 抗MOG抗体 / 視神経脊髄炎 / 脱髄疾患 / アストロサイトパチー / 脳神経疾患 / 神経免疫学
Outline of Final Research Achievements	Some cases with multiple sclerosis (MS) are atypical, and they may include unique clinical entities which can be distinguishable from typical MS in te ...

Research Products of this project	Int'l Joint Research (10 results) Journal Article (51 results, of which Int'l Joint Research: 20 results, Peer Reviewed: 51 results, Open Access: 21 results, Acknowledgement Compliant: 51 results) Presentation (42 results, of which Int'l Joint Research: 33 results, Invited: 42 results) Book (10 results) Remarks (2 results)

3. Clinical, pathological and immunological investigation in idiopathic inflammatory myopathies

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Neurology
Research Institution	Tohoku University
Principal Investigator	Tateyama Maki 東北大学, 医学(系)研究科(研究院), 非常勤講師
Project Period (FY)	2013-04-01 – 2016-03-31Completed
Keywords	特発性炎症性筋疾患 / 皮膚筋炎 / 多発筋炎 / 筋生検 / FDG PET / 筋病理 / 免疫組織化学 / リンパ管 / FDG-PET,PET/CT
Outline of Final Research Achievements	Idiopathic inflammatory myopathy (IIM) is an immune-mediated heterogeneous group of disorders characterized by inflammation and muscle fiber necrosis ...

Research Products of this project	Journal Article (2 results, of which Peer Reviewed: 2 results, Acknowledgement Compliant: 2 results, Open Access: 1 results) Presentation (3 results)

4. Establishment of a new disease entity as astrocytopathy, and studies on the pathogenesis and treatment for neuromyelitis optica

Research Project

Research Category	Grant-in-Aid for Scientific Research (S)
Research Field	Neurology
Research Institution	International University of Health and Welfare (2014) National Center of Neurology and Psychiatry (2010-2013)
Principal Investigator	ITOYAMA Yasuto 国際医療福祉大学, 公私立大学の部局等, 教授
Project Period (FY)	2010-04-01 – 2015-03-31Completed
Keywords	視神経脊髄炎 / アクアポリン4抗体 / アストロサイトパチー / 多発性硬化症 / 脱髄疾患 / 脳神経疾患 / デビック病
Outline of Final Research Achievements	We clarified the clinical and laboratory features of aquaporin (AQP) 4-antibody-positive neuromyelitis optica (NMO), and contributed to the new intern ...
Verification Result (Rating)	A-
Result (Rating)	A-: Progress in the research is steadily towards the initial goal. However, further efforts are necessary as a part of the research progress is delayed.

Research Products of this project	Journal Article (128 results, of which Peer Reviewed: 78 results, Acknowledgement Compliant: 17 results) Presentation (87 results, of which Invited: 51 results) Book (17 results) Remarks (2 results)

5. Clarification of aquaporin-4 related molecular and cellular pathomechanism in neuromyelitis optica (Devic's disease)

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Neurology
Research Institution	Tohoku University
Principal Investigator	FUJIHARA Kazuo 東北大学, 大学院・医学系研究科, 教授
Project Period (FY)	2008 – 2010Completed
Keywords	脳神経疾患 / 視神経脊髄炎 / デビック病
Research Abstract	Neuromyelitis optica (NMO)is an intractable neurologic disease characterized by recurrent severe optic neuritis and transverse myelitis. The present s ...

Research Products of this project	Journal Article (92 results, of which Peer Reviewed: 51 results) Presentation (46 results) Book (14 results) Remarks (1 results)

6. Optic-spinal multiple sclerosis : clarification of pathogenesis, establishment of new disease entity and treatment

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Neurology
Research Institution	Tohoku University
Principal Investigator	ITOYAMA Yasuto Tohoku University
Project Period (FY)	2007 – 2009Completed
Keywords	多発性硬化症 / 脱髄疾患 / 視神経脊髄炎 / 脳神経疾患
Research Abstract	Optic-spinal multiple sclerosis (OSMS) is an intractable neurologic disease characterized by recurrent severe optic neuritis and transverse myelitis, ...

Research Products of this project	Journal Article (79 results, of which Peer Reviewed: 51 results) Presentation (30 results) Book (8 results) Remarks (1 results)

7. A Study of the Regulation of Dendritic Cells and Immunological Memory by Immunoglobulins in Multiple Sclerosis

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Neurology
Research Institution	Tohoku University
Principal Investigator	FUJIHARA Kazuo Tohoku University, TOHOKU UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, PROFESSOR
Project Period (FY)	2006 – 2007Completed
Keywords	Multiple Sclerosis / Demyelinating Disease / Immunoglobulin / Dendritic Cell
Research Abstract	Intravenous immunoglobulin preparations (IVIg) are reportedly effective in inhibiting the relapseof multiple sclerosis (MS), but few reports have inve ...

Research Products of this project	Journal Article (116 results, of which Peer Reviewed: 36 results) Presentation (31 results) Book (9 results)

8. A Study on the Pathogenesis and Therapy of Optic-Spinal Multiple Sclerosis

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Neurology
Research Institution	TOHOKU UNIVERSITY
Principal Investigator	ITOYAMA Yasuto TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE, PROFESSOR
Project Period (FY)	2005 – 2006Completed
Keywords	Multiple Sclerosis / Demyelinating disease / Optic-spinal MS / Conventional MS / Neuromyelitis optica / Anti-aquaporin-4 antibody
Research Abstract	In Japan, multiple sclerosis (MS) has been classified into two subtypes, 1) conventional MS (CMS) in which demyelinating lesions are disseminated in t ...

Research Products of this project	Journal Article (112 results) Book (5 results)

9. プロテインチップを用いた多発性硬化症髄液バイオマーカーの検索

Research Project

Research Category	Grant-in-Aid for Exploratory Research
Research Field	Neurology
Research Institution	Tohoku University
Principal Investigator	糸山泰人東北大学, 大学院・医学系研究科, 教授
Project Period (FY)	2004 – 2005Completed
Keywords	多発性硬化症 / バイオマーカー / プロテインチップ / 髄液 / シスタチンC / SELDI-TOF / 液体クロマトグラフ・タンデム質量分析装置 / ELISA / プロテオミクス / 蛋白質
Research Abstract	前年度までの研究結果により、多発性硬化症の髄液において13.4kDaの蛋白質の上昇と12.6kDaの蛋白質の低下が有意であることが示された。本年度は該当する蛋白質の同定を行った。

Research Products of this project	Journal Article (3 results)

10. DYNAMIC ANALYSIS OF MEMORY T GEELs IN RELAPSE AND CHRONIC PROGRESSION IN THE PATHOGENESIS OF MULTIPLE SCLEROSIS

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Neurology
Research Institution	TOHOKU UNIVERSITY
Principal Investigator	FUJIHARA Kazuo TOHOKU UNIVERSITY, HOSPITAL, ASSOCIATE PROFESSOR
Project Period (FY)	2003 – 2004Completed
Keywords	multiple sclerosis / demyelinating disease / optic-spinal MS / conventional MS / memory T cells / CCR7 / immunological memory / antigen presentation
Research Abstract	In multiple sclerosis (MS), immunological memories to cause inflammatory demyelination are renewed and retained for long periods, and they are critica ...

Research Products of this project	Journal Article (78 results) Book (8 results) Publications (17 results)

11. COMPARATIVE ANALYSIS OF CLINICAL AND MOLECULAR IMMUNOLOGICAL PATHOGENESES IN SUBTYPES OF MULTIPLE SCLEROSIS IN JAPAN

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Neurology
Research Institution	TOHOKU UNIVERSITY
Principal Investigator	ITOYAMA Yasuto TOHOKU UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, PROFESSOR
Project Period (FY)	2003 – 2004Completed
Keywords	multiple sclerosis / demyelinating disease / optic-spinal MS / conventional MS / oligoconal band / cerebral white matter lesions / Th1 / Th2 balance
Research Abstract	Multiple sclerosis (MS) is classified into two subtypes, 1)conventional MS (CMS) in which demyelinating lesions are disseminated in the central nervou ...

Research Products of this project	Journal Article (79 results) Book (8 results) Publications (17 results)

12. Analysis oftarget anfigens in oerebrospinal oligoclonal bands in multiple sclerosis patients

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Neurology
Research Institution	Tohoku University
Principal Investigator	FUJIHARA Kazuo Tohoku University Hospital, Associate Professor
Project Period (FY)	2001 – 2002Completed
Keywords	demyelinating disease / neuroimmunology / neurologic intractable diseasa / multiple sclerosis / oligoclonal band
Research Abstract	Cerebrospinal fluid (CSF) oligoclonal lgG band (OS) is an important laboratory finding in multiple sclerosis (MS). Since its clinical implication and ...

Research Products of this project	Publications (112 results)

13. Comparative analysis of molecular immunopathogenesis in optic-spinal and conventional multiple sclerosis

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Neurology
Research Institution	Tohoku University
Principal Investigator	ITOYAMA Yasuto Tohoku University, Graduate School of Medicine, Professor
Project Period (FY)	2001 – 2002Completed
Keywords	demyelinating disease / neuroimmunology / neuriloqic intractable disease / multiple sclerosis / optic-spinal MS / oligoclonal band / Th1 / Th2 balance
Research Abstract	We analyzed the molecular immunopathogeneses of optic-spinal multiple sclerosis (OSMS) relatively common in Japan and conventional MS (CMS) commonly s ...

Research Products of this project	Publications (112 results)

14. Chemokine signaling in myasthenia gravis and multiple sclerosis

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Neurology
Research Institution	Tohoku University
Principal Investigator	ONODERA Hiroshi Graduate school, of medicine, associate professor
Project Period (FY)	2000 – 2002Completed
Keywords	myasthenia gravis / thymus / chemokine / multiple sclerosis / homing
Research Abstract	We studied chemokine signaling in lymphocytes of patients with myasthenia gravis and multiple sclerosis. Th1-type chemokine signaling in peripheral bl ...

Research Products of this project	Publications (24 results)

15. The Pathomechanisms of The Impaired Anti-HTLV-I Immunesurveillance by ADCC in HAM

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Neurology
Research Institution	TOHOKU UNIVERSITY
Principal Investigator	FUJIHARA Kazuo Tohoku University Hospital, Lecturer
Project Period (FY)	1998 – 1999Completed
Keywords	HTLV-I / HAM / ADCC / K cell / NK-T cell / immunesurveillance / retrovirus / myelopathy
Research Abstract	Antibody-dependent cell-mediated cytotoxicity (ADCC) is impaired in HTLV-I associated myelopathy (HAM). This defect in immune surveillance may allow t ...

Research Products of this project	Publications (12 results)

16. 多発性硬化症におけるケモカインシグナル伝達系の検討

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Neurology
Research Institution	TOHOKU UNIVERSITY
Principal Investigator	ONODERA Hiroshi Grad School of Medicine, Tohoku University, associate professor
Project Period (FY)	1998 – 1999Completed
Keywords	multiple sclerosis / endothelium / chemokine / eotaxin / PAI-1
Research Abstract	Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system and one of the earliest changes in inflammatory focus i ...

Research Products of this project	Publications (20 results)

17. Clinical epidemiology and analysis of pathomechanisms of optic-spinal form of multiple sclerosis

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Neurology
Research Institution	Tohoku University
Principal Investigator	ITOYAMA Yasuto Tohoku University School of Medicine, Professor
Project Period (FY)	1997 – 1998Completed
Keywords	multiple sclerosis / demyelinating disease / MRI / Motor evoked potentials / 4-aminopyridine / Parvovirus B19 / Devic disease
Research Abstract	We studied clinical features and pathomechanisms of multiple sclerosis (MS) in Japan, especially optic-spinal form of MS (OSMS). (l)Eighty six cases o ...

Research Products of this project	Publications (21 results)

18. HAMの臨床免疫学的病態における異常リンパ球活性化機構とOX40,gp34の役割

Research Project

Research Category	Grant-in-Aid for Exploratory Research
Research Field	Neurology
Research Institution	Tohoku University
Principal Investigator	糸山泰人東北大学, 医学部, 教授
Project Period (FY)	1996 – 1997Completed
Keywords	OX40 / gp34 / HTLV-I / HAM TSP / lymphocyte / T cell / thymus / inflammatory myopathy / HAM / TSP / activation / Tcell
Research Abstract	(A)HAM患者の末梢血リンパ球を培養すると,多くの症例でCD8陽性細胞が優位に増殖しCD4/CD8比が次第に低下した.またCD4/CD8比の低い症例ほど痙性対麻痺が重症であった.OX40,gp34はCD4,CD8いづれの培養T細胞においても経時的に発現が増加したが,IL-2RαはCD8優位に発現し ...

Research Products of this project	Publications (7 results)