KAKEN — Research Projects | Researcher Number: 90101857

Search Results: 8 results / Researcher Number: 90101857

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1. How is immunological accommodation induced in ABO incompatible kidney transplantation?

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Urology
Research Institution	Niigata University
Principal Investigator	TAKAHASHI KOTA 新潟大学, 医歯(薬)学総合研究科, 客員研究員
Project Period (FY)	2012-04-01 – 2015-03-31Completed
Keywords	腎移植 / ABO血液型不適合 / 抗原抗体反応 / 糖鎖抗原 / 血管内皮細胞 / 交差抗原性 / 脱感作療法 / 免疫学的順応 / ホスト免疫系因子 / グラフト内皮細胞因子 / 血液型不適合 / 血液型糖鎖抗原
Outline of Final Research Achievements	We have publidhed many articles and books on elucidation of the mechanism of induction of "immunological accommodation" in ABO-incompatible kidney tra ...

Research Products of this project	Journal Article (54 results, of which Peer Reviewed: 53 results, Acknowledgement Compliant: 10 results) Presentation (95 results, of which Invited: 45 results) Book (8 results) Remarks (3 results)

2. 骨髄細胞移植による、移植腎再生治療の試み

Research Project

Research Category	Grant-in-Aid for Exploratory Research
Research Field	Urology
Research Institution	Niigata University
Principal Investigator	高橋公太新潟大学, 医歯学系, 教授
Project Period (FY)	2004 – 2005Completed
Keywords	骨髄幹細胞 / 骨髄移植 / GFPラット / 腎移植 / 虚血再灌流障害 / 腎微小循環障害 / シクロスポリン / 血管内皮細胞再生 / GFP陽性ラット
Research Abstract	GFP陽性ラット骨髄細胞の同系GFP陰性ラット腎障害モデルラットへの移植実験と、障害修復機序、血管内皮細胞キメリズムの検討、腎移植モデルにおける検討。

Research Products of this project	Journal Article (12 results) Book (1 results)

3. Restoration of renal microcirculation by eNOS gene transfection for overcoming the antibody-mediated rejection and achievement of long-term renal allograft survival

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Urology
Research Institution	Niigata University
Principal Investigator	TAKAHASHI Kota Niigata University, Institute of Medicine and Dentistry, Professor
Project Period (FY)	2003 – 2006Completed
Keywords	microcirculation injury / ischemia-reperfusion injury / renal vascular endothelial cells / rat bone marrow transplantation / GFP positive cells / stem cell transplantation
Research Abstract	1. From the clinicopathological observation of antibody-mediated rejection in living donor ABO-incompatible kidney transplantation and ischemia-reperf ...

Research Products of this project	Journal Article (25 results) Book (3 results) Publications (3 results)

4. Donor vascular endothelial regeneration and chimerism induced by recipient bone marrow transplantation

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Urology
Research Institution	Niigata University
Principal Investigator	SAITO Kazuhide Niigata University, Medical and Dental Hospital, Lecturer
Project Period (FY)	2003 – 2006Completed
Keywords	microcirculation injury / ischemia-reperfusion injury / renal vascular endothelial cells / rat bone marrow transplantation / GFP positive cells / stem cell transplantation
Research Abstract	1. From the clinicopathological observation of antibody-mediated rejection in living donor ABO-incompatible kidney transplantation and ischemia-reperf ...

Research Products of this project	Journal Article (25 results) Book (3 results) Publications (3 results)

5. アデノウイルスベクターを用いたアポトーシス抑制分子発現による移植腎拒絶回避の試み

Research Project

Research Category	Grant-in-Aid for Exploratory Research
Research Field	Urology
Research Institution	Niigata University
Principal Investigator	高橋公太新潟大学, 大学院・医歯学総合研究科, 教授
Project Period (FY)	2002 – 2003Completed
Keywords	XIAP / adenovirus vector / 尿細管上皮細胞 / 移植腎 / 急性拒絶反応 / apoptosis / adnovirus vector
Research Abstract	X-linked inhibitor of apoptosis protein (XIAP)は細胞のapoptosis実行分子であるprotease ; caspase-3及び-7のubiquitinationとproteasomal degradationを直接行っており、細胞の生存に深く関わる分 ...

6. Research of the regulation pf acute allograft rejection in ABO-blood type incompatible kidney transplantation

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Urology
Research Institution	NIIGATA UNIVERSITY
Principal Investigator	TAKAHASHI Kota NIIGATA UNIVERSITY, Graduate School of Medical and Dental Sciences, Professor
Project Period (FY)	1999 – 2001Completed
Keywords	ABO-incompatible kidney transplantation / Humoral rejection / Standarization of anti-A / B antibody titre estimation / Elimination of antibodies / Immunosuppressive therapy / Splenectomy / Pathological criteria / Anti-endothelial cell antibody
Research Abstract	ABO-blood type incompatible kidney transplantation is one of a big challenge to overcome the immunological barrier of humoral rejection caused by acqu ...

Research Products of this project	Publications (62 results)

7. オリゴペプチドによる移植腎拒絶の回避の基礎的検討-アポトーシス誘導酵素阻害ペプチド利用の可能性-

Research Project

Research Category	Grant-in-Aid for Exploratory Research
Research Field	Urology
Research Institution	Niigata University
Principal Investigator	高橋公太新潟大学, 医学部, 教授
Project Period (FY)	1998 – 1999Completed
Keywords	アポトーシス / 腎移植 / オリゴペプチド
Research Abstract	1.293cellにおけるアポトーシスの誘導

8. Trial for extending indication of kidney transplantation

Research Project

Research Category	Grant-in-Aid for General Scientific Research (A)
Research Field	General surgery
Research Institution	Tokyo Women's Medical College
Principal Investigator	OTA Kazuo Dept. of Surgery. Tokyo Women's Medical College. Professor.
Project Period (FY)	1989 – 1992Completed
Keywords	kidney function / ABO blood type / ABO-incompatibility / preformed antibody / extending indication for kidney transplantation / anti-A, anti-B antibody / rejection / splenectomy
Research Abstract	In an effort to extend the opportunity of kidney transplantation, we treated the blood of ABO-incompatible patients or the blood of preformed antibodi ...

Research Products of this project	Publications (39 results)