Identification of low-dose stress-responsive pathways
Project/Area Number |
15K14449
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Molecular biology
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Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | ストレス反応 / 分裂酵母 / 変異体スクリーニング / ストレス / ミトコンドリア / 暦寿命 / ミトコンドリアDNA / 制限酵素 |
Outline of Final Research Achievements |
All organisms live in ever-changing environments. Subtle environmental stresses, although not recognized consciously, may alert organisms to prepare for prospective severe stress. This study is aimed for elucidating molecular pathways, if any, that recognizes low-dose stress, which causes adaptive response in organisms. We have screened fission yeast a mutant library for mutants that are resistant to severe stress, but sensitive to low-dose stress. We have identified mutants and their responsible genes. These results suggest that there is pathawys that respond specifically to low-dose stresses.
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Report
(3 results)
Research Products
(14 results)
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[Presentation] Hormesis2016
Author(s)
Fuyuki Ishikawa
Organizer
第75回癌学会学術総会
Place of Presentation
パシフィコ横浜
Year and Date
2016-10-06
Related Report
Invited
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[Presentation] Mitohormesis2016
Author(s)
Fuyuki Ishikawa
Organizer
The 32th International Symposium “Growing Edge of Radiation Biology, from principles to applications”
Place of Presentation
京都コープイン
Year and Date
2016-09-01
Related Report
Int'l Joint Research / Invited
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[Presentation] Mitohormesis2015
Author(s)
石川 冬木
Organizer
島根大学大学院セミナー
Place of Presentation
島根県出雲市、島根大学大学院医学系研究科
Year and Date
2015-11-17
Related Report
Invited
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