2010 Fiscal Year Final Research Report
New procedure of evaluation of molecular mechanism in skin cancer : adequate diagnosis and reconstruction.
Project/Area Number |
20592099
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Plastic surgery
|
Research Institution | Ehime University |
Principal Investigator |
MORI Hideki Ehime University, 医学部附属病院, 助教 (60325389)
|
Co-Investigator(Kenkyū-buntansha) |
HIRAKAWA Satoshi 愛媛大学, 医学部附属病院, 講師 (50419511)
|
Project Period (FY) |
2008 – 2010
|
Keywords | リンパ管新生 / Paget病 |
Research Abstract |
In extramammary Paget disease(EMPD), lymphangiogenesis appeared in a early stage. We found that Paget cells adopt an invasive phenotype during epithelial-mesenchymal transition (EMT) seen in tumor progression. We found that invasive Paget cells in patient N-cadherin, a mesenchymal marker indicative of EMT, suggesting a molecular mechanism underlying tumour invasion. EMT is reportedly required for invasive phenotypes of tumour cells of epithelial origin, including EMPD.
|
Research Products
(3 results)