Real-time precision functional network mapping of the human brain for neurosurgical applications
| Project/Area Number |
21K09149
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56010:Neurosurgery-related
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| Research Institution | Nagoya University |
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Principal Investigator |
Bagarinao E. 名古屋大学, 医学系研究科(保健), 准教授 (00443218)
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| Co-Investigator(Kenkyū-buntansha) |
礒田 治夫 名古屋大学, 脳とこころの研究センター(保健), 教授 (40223060)
前澤 聡 名古屋大学, 医学系研究科, 准教授 (90566960)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Project Status |
Granted (Fiscal Year 2022)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | precision mapping / functional connectivity / real-time fMRI / essential tremor / resting state fMRI / human connectome / neurosurgery |
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| Outline of Research at the Start |
Advances in brain imaging research have significantly improved our understanding of the brain's functions and its functional organization, yet their clinical applications remain very limited. This research aims to bridge this gap by developing a system that can be used to generate individualized, highly reliable, and reproducible functional connection profile of the human brain in real-time that can be used for neurosurgical applications including preoperative planning and during online intraoperative assessment.
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| Outline of Annual Research Achievements |
For the FY2022, we have scanned 10 more healthy volunteers, completing the MRI scans of all 20 healthy controls. All participants underwent two imaging sessions, about one month apart. Acquired MRI data includes structural T1 MRI data, an hour of resting state functional MRI data, and diffusion-weighted MRI data. Additionally, we have also acquired the MRI data from patients with essential tremor. Preliminary analysis of the acquired datasets from healthy controls have shown that the reliability of the whole-brain FCOR map exhibited an initial rapid increase as more volumes are incorporated into the analysis. With more volumes added, the reliability measure later plateaus suggesting an upper limit to the reliability as well as an optimal number of volumes to achieve this limit. We have also started the analysis of the data from patients with essential tremor. This will be completed in FY2023.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
The implementation of the project in the second year was progressing smoothly as planned. With all the data acquired, we have started the full analysis, which we plan to complete in FY2023.
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| Strategy for Future Research Activity |
For the FY2023, we will complete the full analysis of the acquired MRI data. The results of the analysis will be presented in upcoming domestic and international conferences and will be organized into a manuscript to be submitted for possible publication in international journals.
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Report
(2 results)
Research Products
(14 results)
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[Journal Article] Functional connector hubs in the cerebellum2022
Author(s)
Kawabata Kazuya、Bagarinao Epifanio、Watanabe Hirohisa、Maesawa Satoshi、Mori Daisuke、Hara Kazuhiro、Ohdake Reiko、Masuda Michihito、Ogura Aya、Kato Toshiyasu、Koyama Shuji、Katsuno Masahisa、Wakabayashi Toshihiko、Kuzuya Masafumi、Hoshiyama Minoru、Isoda Haruo、Naganawa Shinji、Ozaki Norio、Sobue Gen
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Journal Title
NeuroImage
Volume: 257
Pages: 119263-119263
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Characteristics of the aging brain of healthy older adults: A longitudinal study2022
Author(s)
Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Kazuya Kawabata, Kazuhiro Hara, Reiko Ohdake, Aya Ogura, Daisuke Mori, Shuji Koyama, Masahisa Katsuno, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Norio Ozaki, Gen Sobue
Organizer
45th Annual Meeting of the Japan Neuroscience Society
Related Report
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