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Mechanisms for Coelom formation : Binary dicision of the lateral plate mesoderm

Research Project

Project/Area Number 14570027
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General anatomy (including Histology/Embryology)
Research InstitutionRIKEN (The Institute of Physical and Chemical Research)

Principal Investigator

FUNAYAMA Noriko  RIKEN (The Institute of Physical and Chemical Research), Group for Evolutionary Regeneration Biology, Researcher, 進化再生研究グループ, 研究員 (30276175)

Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsLateral plate mesoderm / Somatopleural mesoderm / Splanchnopleural mesoderm / Epithelialization / SHH / Chick embryo / Cyclopamin / RNAi / 2本鎖RNA / knock down / cadherin6B / Pax6
Research Abstract

Most triploblastic animals including vertebrates have a coelomic cavity that separates the outer and inner components of the body. The coelom is lined by two different tissue components, somatopleure and splanchnopleure, which are derived from the lateral plate region. Thus, the coelom is constructed as a result of a binary decision during early specification of the lateral plate. In this report we studied the molecular mechanisms of this binary decision. We first demonstrate that the splitting of the lateral plate into the two cell sheets progresses in an anteroposterior order and this progression is not coordinated with that of the somitic segmentation. By a series of embryological manipulations we found that the ectoderm underneath the primitive lateral plate is also required for the Splanchnopleural mesoderm. From the barrier experiment, it was suggested that this inductive activity is depend on the secreting factor(s) from lateral plate endoderm. We also show that the inductive activity is mediated by SHH molecules that are localized in the lateral endoderm. Evolutionary aspects of the coelom formation are also considered.

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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