Morphofimctional analysis ofGalanin-lice Peptide on regulation offeeding and enegy metabolism
| Project/Area Number |
18590176
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Showa University |
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Principal Investigator |
GUAN Jian-Lian Showa University, Dept. of Anatomy, Sch. of Med., Assistant Professor (20276538)
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| Co-Investigator(Kenkyū-buntansha) |
SHIODA Seiji Showa University, Department of Analomy School of Medicine, Professor (80102375)
ARATA Satoru Showa Univ., Center for Biotechnology, Associate Professor (20159502)
OSAKA Toshimasa National Institute of Health and Nutrition, 栄養所要量研究部, Senior Researcher (30152101)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,820,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2006: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | Galanin-like peptide / afferent neuron / energy metabolism / Transgenic mice / neuron network |
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| Research Abstract |
The hypothalamus plays a critical role in regulation of feeding behavior, energy metabolism and reproduction. A novel peptide discovered in porcine hypothalamus has 60 amino acid peptide and a non-amidated C-terminus. Since a portion of this peptide is homology with galanin, it is named galanin-like peptide (GALP). GALP is mainly produced in the hypothalamic arcuate nucleus. GALP acts in the central nervous system, where it is involved in the regulation of feeding behavior. GALP-producing neurons were shown to make neuron networks with several feeding related peptide-producing neurons in the hypothalamus. Since GALP controls food intake and energy balance, it is possible that GALP is an important factor in development of obesity. Furthermore, we have succeeded to make transgenic (Tg) mice that express enhanced green fluorescence (EGFP) in GALP-containing neurons and also to make Tg mice that express EGFP in afferent GALP neurons in brain. As a result, we have first shown that GALP-containing neurons make synaptic input from the pyriform cortex and amygdala. Therefore, GALP may involve in feeding behavior, energy metabolism and reproduction, further studies on the morphology and function of GALP should continue to demonstrate further the understanding in brain function.
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Report
(3 results)
Research Products
(31 results)
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[Journal Article] 2006 Galanin-like peptide promotes feeding behaviour via activation of orexinergic neurones in the rat lateral hypothalamus
Author(s)
Kageyama, H, Kita, T, Toshinai, K, Guan, JL, Date, Y, Takenoya, F, Kato, S, Matsumoto, H, Ohtaki, T, Nakazato M, Shioda, S
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Journal Title
J Neuroendocrinol 18
Pages: 33-41
Description
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[Journal Article] 2006 Central administration of melanin-concentrating hormone(MCH) suppresses food intake, but not locomotor activity, in the goldfish, Carassius auratus
Author(s)
Matsuda, K, Shimakura, S, Maruyama, K, Miura, T, Uchiyama, M, Kawauchi, H, Shioda, S, Takahashi, A
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Journal Title
Neurosci Lett 399
Pages: 259-63
Description
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[Journal Article] 2006 Neural interaction between galanin-like peptide(GALP)- and luteinizing hormone-releasing hormone(LHRH)-containing neurons
Author(s)
Takenoya, F, Guan, JL, Kato, M, Sakuma, Y, Kintaka, Y, Kitamura, Y, Kitamura, S, Okuda, H, Takeuchi, M, Kageyama, H, Shioda, S
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Journal Title
Peptides 27
Pages: 2885-93
Description
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[Journal Article] 2006 Peripheral ghrelin transmits orexigenic signals through the noradrenergic pathway from the hindbrain to the hypothalamus
Author(s)
Date, Y, Shimbara, T, Koda, S, Toshinai, K, Ida, T, Murakami, N, Miyazato, M, Kokame, K, Ishizuka, Y, Ishida, Y, Kageyama, H, Shioda, S, Kangawa, K, Nakazato, M
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Journal Title
Cell Metab 4
Pages: 323-31
Description
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[Journal Article] 2008 Visualization of ghrelin-producing neurons in the hypothalamic arcuate nucleus using ghrelin-EGFP transgenic mice
Author(s)
Kageyama, H, Kitamura, Y, Hosono, T, Kintaka, Y, Seki, M, Takenoya, F, Hori, Y, Nonaka, N, Arata, S, Shioda, S
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Journal Title
Regul Pept 145
Pages: 116-21
Description
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[Journal Article] 2008 Synaptic interaction between ghrelin- and ghrelin-containing neurons in the rat hypothalamus
Author(s)
Hori, Y, Kageyama, H, Guan, JL, Kohno, D, Yada, T, Takenoya, F, Nonaka, N, Kangawa, K, Shioda, S, Yoshida, T
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Journal Title
Regul Pept 145
Pages: 122-7
Description
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[Journal Article] 2008 Synaptic relationships between proopiomelanocortin- and ghrelin-containing neurons in the rat arcuate nucleus
Author(s)
Guan, JL, Okuda, H, Takenoya, F, Kintaka, Y, Yagi, M, Wang, L, Seki, M, Hori, Y, Kageyama, H, Shioda, S
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Journal Title
Regul Pept 145
Pages: 128-32
Description
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[Journal Article] 2008 Neuronal interactions between neuropeptide W- and orexin- or melanin-concentrating hormone-containing neurons in the rat hypothalamus
Author(s)
Takenoya, F, Kitamura, S, Kageyama, H, Nonaka, N, Seki, M, Itabashi, K, Date, Y, Nakazato, M, Shioda, S
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Journal Title
Regul Pept 145
Pages: 159-64
Description
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