KAKEN — Research Projects | Researcher Number: 10109506

1. Investigation of the mechanism of inducing the original antigenic sin phenomenon associated with influenza virus infection

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Review Section	Basic Section 49060:Virology-related
Research Institution	Hokkaido University
Principal Investigator	SHINGAI Masashi 北海道大学, 人獣共通感染症国際共同研究所, 准教授
Project Period (FY)	2018-04-01 – 2021-03-31Completed
Keywords	インフルエンザ / ウイルス / ワクチン / 免疫 / 抗原原罪 / インフルエンザウイルス / レパトア解析
Outline of Final Research Achievements	Using a mouse model of influenza virus infection, we confirmed that the original antigenic sin does indeed occur. Repertoire analysis of immunoglobuli ...

Research Products of this project	Journal Article (4 results, of which Int'l Joint Research: 3 results, Peer Reviewed: 4 results) Presentation (3 results, of which Int'l Joint Research: 2 results, Invited: 2 results)

2. Development of a new influenza vaccine of global standard.

Research Project

Research Category	Grant-in-Aid for JSPS Fellows
Research Field	Immunology
Research Institution	Hokkaido University
Principal Investigator	喜田宏北海道大学, 人獣共通感染症リサーチセンター, 特別招へい教授
Project Period (FY)	2015-11-09 – 2018-03-31Discontinued
Keywords	インフルエンザ / 全粒子ワクチン / ワクチン / エクソソーム
Outline of Annual Research Achievements	「世界基準の季節性インフルエンザ不活化ウイルス全粒子ワクチンの開発」において、不活化ウイルス全粒子ワクチンが、現行のエーテルスプリットワクチン（HAワクチン）より、遥かに高い免疫をマウスおよびサルに誘導することが明らとなった。

Research Products of this project	Int'l Joint Research (1 results)

3. Development of measles virus vector-based vaccine against highly pathogenic avian influenza virus

Research Project

Research Category	Grant-in-Aid for Young Scientists (B)
Research Field	Veterinary medical science Virology
Research Institution	The University of Tokyo
Principal Investigator	Fujiyuki Tomoko 東京大学, 医科学研究所, 助教
Project Period (FY)	2014-04-01 – 2017-03-31Completed
Keywords	高病原性鳥インフルエンザウイルス / 麻疹ウイルス / カニクイザル / 感染モデル / 発症防御 / ワクチン / ベクター / 組換えウイルス / ウイルスベクター / H5N1
Outline of Final Research Achievements	We generated recombinant measles virus (rMV) expressing the hemagglutinin (HA) protein of HPAIV (H5), and examined protective efficacy of the candidat ...

Research Products of this project	Presentation (6 results)

4. Establishment of novel preventive/therapeutic measures and demonstration of a mechanism of neural spread of pathogens in neurotropic zoonotic diseases

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Applied veterinary science
Research Institution	Hokkaido University
Principal Investigator	UMEMURA Takashi Hokkaido University
Project Period (FY)	2007 – 2009Completed
Keywords	狂犬病 / 鞘内免疫 / インフルエンザウイルス / 小児脳症 / オーエスキー病 / 血球凝集性脳脊髄炎ウイルス / インフルエンザ脳症 / 野兎病 / 人獣共通感染症 / 脳内免疫 / LPS / 経神経伝播 / ワクチン / 人畜共通感染症
Research Abstract	Specific antibodies detected in cerebrospinal fluid by intrathecal vaccination (vaccination by an inoculating antigen into subarachnoidal space) were ...

Research Products of this project	Journal Article (24 results, of which Peer Reviewed: 21 results) Presentation (12 results)

5. Studies on the mechanism of entry of the envelope virus and its inhibitor.

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Basic veterinary science/Basic zootechnical science
Research Institution	Health Sciences University of Hokkaido (2005) Hokkaido University (2004)
Principal Investigator	OKAZAKI Katsunori Health Sciences University of Hokkaido, Dept of Pharmaceutical Sciences, Professor
Project Period (FY)	2004 – 2005Completed
Keywords	Virus envelope / Membrane fusion / Cell entry / Herpesviru / gB glycoprotein / Proteolytic enzyme / Endothelial cells / Endosome
Research Abstract	Glycoprotein B (gB) is the most conserved glycoprotein of herpesviruses and plays important roles in virus infectivity. The glycoprotein of most herpe ...

Research Products of this project	Journal Article (17 results) Book (2 results)

6. Ecology and pandemic planning of animal influenza virus

Research Project

Research Category	Grant-in-Aid for Scientific Research (S)
Research Field	Applied veterinary science
Research Institution	Hokkaido University
Principal Investigator	KIDA Hiroshi Hokkaido University, Graduate School of Veterinary Medicine, Professor
Project Period (FY)	2003 – 2006Completed
Keywords	influenza viruses / global surveillance / vaccine / antiviral / diagnosis
Research Abstract	H5N1 highly pathogenic avian influenza (HPAI) virus has spread in poultry from Southeast Asia to the north, Europe, and Africa. We have been conductin ...

Research Products of this project	Journal Article (27 results) Book (1 results) Patent(Industrial Property Rights) (1 results) Publications (6 results)

7. Ecological study of animal influenza viruses : To prepare for the emergence of pandemic influenza

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Applied veterinary science
Research Institution	Hokkaido University
Principal Investigator	KIDA Hiroshi Hokkaido University, Hokkaido University, Graduate School of Veterinary Medicine, Professor
Project Period (FY)	2000 – 2002Completed
Keywords	Influenza / migratory waterfowls / Pigs / Chickens / Epidemiological surveillance / Receptor specificity / Interspecies transmission
Research Abstract	To provide information on the precursor genes of the next pandemic influenza, epidemiological surveillance of animal and avian influenza viruses was p ...

Research Products of this project	Journal Article (44 results) Publications (24 results)

8. Molecular basis for highly pathogenesis of avian influenza virus in humans.

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Virology
Research Institution	The University of Tokyo
Principal Investigator	KAWAOKA Yoshihiro The University of Tokyo, IMS, Professor
Project Period (FY)	2000 – 2002Completed
Keywords	avian influenza virus / H5N1 / reverse genetics
Research Abstract	Influenza is an example of a disease for which the viral pathogen has emerged into the human population many times over past centuries, sometimes with ...

Research Products of this project	Journal Article (10 results) Publications (12 results)

9. Origin and Mutations of Hong Kong New H5 Influenza Viruses

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Applied veterinary science
Research Institution	Tottori University
Principal Investigator	ITO Toshihiro Tottori University, Faculty of Agriculture, Professor
Project Period (FY)	1999 – 2001Completed
Keywords	influenza virus / fowl plague / host range / pathogenicity / chicken / H5 / pandemic / recerse genetics
Research Abstract	An H5N1 avian influenza A virus was transmitted to humans in Hong Kong in 1997. Although the virus causes systemic infection and is highly lethal in c ...

Research Products of this project	Publications (87 results)

10. G蛋白欠失VSVを用いたウイルス表面糖蛋白の機能解析

Research Project

Research Category	Grant-in-Aid for Exploratory Research
Research Field	Virology
Research Institution	Hokkaido University
Principal Investigator	岡崎克則北海道大学, 大学院・獣医学研究科, 助教授
Project Period (FY)	1998 – 1999Completed
Keywords	VSV / 糖蛋白 / ヘルペスウイルス / gB / gC / グルコサミノグリカン / リセプター / gD / GFP / cell-to-cell感染
Research Abstract	ヘルペスウイルス主要糖蛋白の機能を明らかにするためウシヘルペスウイルス1(BHV1)の糖蛋白gBあるいはgCを発現する株化細胞を樹立し、これらにG蛋白遺伝子を欠失した水疱性口炎ウイルス(VSVdelG-G)を感染させて表現型混合ウイルスの回収を試みた。培養上清中に放出されたウイルス粒子をMDBK細胞 ...

Research Products of this project	Publications (3 results)

11. Preparation of peptide vaccines according to the cassette theory against newly emerged influenza virus

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Experimental pathology
Research Institution	SHIGA UNIVERSITY OF MEDICAL SCIENCE (1999) Hokkaido University (1998)
Principal Investigator	OGASAWARA Kazumasa SHIGA UNIVERSITY OF MEDICAL SCIENCE, DEPARTMENT OF 2nd PATHOLOGY, PROFESSOR
Project Period (FY)	1998 – 1999Completed
Keywords	MHC / peptide vaccine / newly emerged influenza virus / HA / cassette theory / CTL / NP / anti-CD40 antibody
Research Abstract	1. According to the cassette theory, we prepared a synthetic peptide vaccine against H5 subtype influenza viruses. The peptide, however, could not ind ...

Research Products of this project	Publications (26 results)

12. Molecular mechanisms of infection and pathogenesis of viruses

Research Project

Research Category	Grant-in-Aid for Scientific Research (A).
Research Field	Basic veterinary science/Basic zootechnical science
Research Institution	HOKKAIDO UNIVERSITY
Principal Investigator	KIDA Hiroshi Grad. School of Vet. Medicine, Hokkaido University, Professor
Project Period (FY)	1998 – 1999Completed
Keywords	influenza virus / duck / pig / Siberia / Hong Kong / H5N1 / vaccine / surveillance
Research Abstract	Influenza A viruses of different subtypes were isolated from fecal samples of ducks in their nesting areas in Siberia. Phylogenetic analysis of the NP ...

Research Products of this project	Publications (32 results)

13. トリから哺乳動物へのインフルエンザウイルス伝播の機構

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Basic veterinary science/Basic zootechnical science
Research Institution	Tottori University
Principal Investigator	伊藤寿啓鳥取大学, 農学部・獣医学科, 助教授
Project Period (FY)	1996Completed
Keywords	インフルエンザウイルス / 種間伝播 / 宿主域 / ヘマグルチニン / シアル酸 / レセプター / 変異株 / 感染実験
Research Abstract	インフルエンザウイルス(IFV)は哺乳動物や鳥類に広く感染する。すべてのIFVは野生水禽のウイルスに由来すると考えられている。しかし、ウイルスが異なる動物種間を伝播する機序が解明されていない.IFVはHA蛋白を介して細胞表面のシアル酸を末端にもつ糖鎖レセプターに結合して感染する。そこで、本研究ではI ...

Research Products of this project	Publications (4 results)

14. Studies on the T-cell epitopes of herpesviruses

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Basic veterinary science/Basic zootechnical science
Research Institution	HOKKAIDO UNIVERSITY
Principal Investigator	OKAZAKI Katsunori Hokkaido University, Graduate School of Veterinary Medicine, Associate Professor
Project Period (FY)	1996 – 1997Completed
Keywords	bovine herpesvirus 1 / glycoprotein / monoclonal antibody / T-cell epitope / lbaculovirus / Aujeszky's disease virus / DNA vaccine / cellular immunity
Research Abstract	An escape mutant of bovine herpesvirus 1 (BHV1) was obtained in the presence of monoclonal antibody against glycoprotein B (gB) , which required compl ...

Research Products of this project	Publications (14 results)

15. Molecular mechanisms of infection and pathogenesis of viruses

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Applied veterinary science
Research Institution	HOKKAIDO UNIVERSITY
Principal Investigator	KIDA Hiroshi Grad.School of Veterinary Medicine, Hokkaido University, Professor
Project Period (FY)	1996 – 1998Completed
Keywords	influenza virus / pathogenicity / host cell factor / vascular endothelial cell / blood coagulation factor / disseminated intravascular coagulation / chicken
Research Abstract	Intravenous injection into chickens with the virus-free extracts from the allantoic membrane of chicken embryos infected with influenza viruses result ...

Research Products of this project	Publications (47 results)

16. Prediction of new pandemic influenza viruses -Distribution of the viruses in waterfowls in their nesting places in Siberia

Research Project

Research Category	Grant-in-Aid for international Scientific Research
Research Field	Basic veterinary science/Basic zootechnical science
Research Institution	Hokkaido University
Principal Investigator	KIDA Hiroshi Hokkaido Univ., Graduate School of Vet.Medicine, Professor
Project Period (FY)	1995 – 1997Completed
Keywords	influenza virus / migratory ducks / feces / breeding areas / Siberia / lake water / The River Lena / Southern China
Research Abstract	In each summer of 1995-1997,3,000 fecal materials of waterfowls and lake-water samples were collected in Kamchatka, Khabarovsk, and Saha Republic. In ...

Research Products of this project	Publications (53 results)

17. STUDY ON RECEPTOR SPECIFICITY OF ANIMAL INFLUENZA VIRUSES

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	Basic veterinary science/Basic zootechnical science
Research Institution	HOKKAIDO UNIVERSITY
Principal Investigator	ITO Toshihiro Hokkaido Univ., Graduate School of Vet. Med., Res. Assoc.
Project Period (FY)	1994 – 1995Completed
Keywords	Influenza virus / Receptor specificity / Sialic acid / Host range / Tissue tropism / Hemagglutinin / Interspecies transmission / Inhibitor
Research Abstract	The receptor specificity of the HA differs amongsinfluenza viruses : most avian influenza viruses preferentially bind the sialic acid-alpha-2,3-galact ...

Research Products of this project	Publications (6 results)

18. Enhancement of non-specific antiviral immunity induced by mucosal administration of immunoadijivant in infant animal

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Laboratory animal science
Research Institution	Hokkaido University
Principal Investigator	ARIKAWA Jiro Hokkaido University School of Medicine, Institute for Animal Experimentation, Professor
Project Period (FY)	1994 – 1996Completed
Keywords	Influenzavirus / Rotavirus / Hantavirus / Adjuvant / MDP / Pseudorabies / Mucosal immunity / Animal experiment
Research Abstract	1. Animal models for studying respiratory infection, enteric infection and systemic infections were established by using mice and Sendai virus, rotavi ...

Research Products of this project	Publications (39 results)

19. 中国の兎の出血病の病因並びに病態-特に韓国の例との比較研究

Research Project

Research Category	Grant-in-Aid for international Scientific Research
Research Institution	Hokkaido University
Principal Investigator	板倉智敏北海道大学, 獣医学部, 教授
Project Period (FY)	1994Completed
Keywords	兎 / 出血病 / カリシウイルス / 肝炎 / 急死 / 肝細胞壊死
Research Abstract	兎の出血病(RHD)は,1984年中国で初めて発生し,以後韓国をはじめ多くの養兎を行っている国々に発生した。我々は,1989年から韓国で発生したRHDに関する研究を行い,多くの成果をあげた。この成果には以下の点が含まれる。RHDの原因ウイルスはカルシウイルスで,肝細胞に親和性が強い。この原因ウイルス ...

Research Products of this project	Publications (2 results)

20. A new approach for the control of Aujeszky's disease by using germ-line transformation

Research Project

Research Category	Grant-in-Aid for Developmental Scientific Research (A)
Research Field	Basic veterinary science/Basic zootechnical science
Research Institution	HOKKAIDO UNIVERSITY
Principal Investigator	KIDA Hiroshi (1994-1995) Hokkaido Univ., Grad. Sch. of Vet. Med., Pro. 清水悠紀臣 (1993) 北海道大学, 獣医学部, 教授
Project Period (FY)	1993 – 1995Completed
Keywords	Aujeszky's disease virus / Herpesvirus / Transcription / Transcriptional repression
Research Abstract	Intracellular immunization using dominant-negative mutants of viral proteins is prorposed as a new approach to antiviral therapy in humans and to germ ...

Research Products of this project	Publications (39 results)

Project Period (Start Year [FY])

1. Investigation of the mechanism of inducing the original antigenic sin phenomenon associated with influenza virus infection Research Project

SHINGAI Masashi 北海道大学, 人獣共通感染症国際共同研究所, 准教授

2. Development of a new influenza vaccine of global standard. Research Project

喜田 宏 北海道大学, 人獣共通感染症リサーチセンター, 特別招へい教授

3. Development of measles virus vector-based vaccine against highly pathogenic avian influenza virus Research Project

Fujiyuki Tomoko 東京大学, 医科学研究所, 助教

4. Establishment of novel preventive/therapeutic measures and demonstration of a mechanism of neural spread of pathogens in neurotropic zoonotic diseases Research Project

UMEMURA Takashi Hokkaido University

5. Studies on the mechanism of entry of the envelope virus and its inhibitor. Research Project

OKAZAKI Katsunori Health Sciences University of Hokkaido, Dept of Pharmaceutical Sciences, Professor

6. Ecology and pandemic planning of animal influenza virus Research Project

KIDA Hiroshi Hokkaido University, Graduate School of Veterinary Medicine, Professor

7. Ecological study of animal influenza viruses : To prepare for the emergence of pandemic influenza Research Project

KIDA Hiroshi Hokkaido University, Hokkaido University, Graduate School of Veterinary Medicine, Professor

8. Molecular basis for highly pathogenesis of avian influenza virus in humans. Research Project

KAWAOKA Yoshihiro The University of Tokyo, IMS, Professor

9. Origin and Mutations of Hong Kong New H5 Influenza Viruses Research Project

ITO Toshihiro Tottori University, Faculty of Agriculture, Professor

10. G蛋白欠失VSVを用いたウイルス表面糖蛋白の機能解析 Research Project

岡崎 克則 北海道大学, 大学院・獣医学研究科, 助教授

11. Preparation of peptide vaccines according to the cassette theory against newly emerged influenza virus Research Project

OGASAWARA Kazumasa SHIGA UNIVERSITY OF MEDICAL SCIENCE, DEPARTMENT OF 2nd PATHOLOGY, PROFESSOR

12. Molecular mechanisms of infection and pathogenesis of viruses Research Project

KIDA Hiroshi Grad. School of Vet. Medicine, Hokkaido University, Professor

13. トリから哺乳動物へのインフルエンザウイルス伝播の機構 Research Project

伊藤 寿啓 鳥取大学, 農学部・獣医学科, 助教授

14. Studies on the T-cell epitopes of herpesviruses Research Project

OKAZAKI Katsunori Hokkaido University, Graduate School of Veterinary Medicine, Associate Professor

15. Molecular mechanisms of infection and pathogenesis of viruses Research Project

KIDA Hiroshi Grad.School of Veterinary Medicine, Hokkaido University, Professor

16. Prediction of new pandemic influenza viruses -Distribution of the viruses in waterfowls in their nesting places in Siberia Research Project

KIDA Hiroshi Hokkaido Univ., Graduate School of Vet.Medicine, Professor

17. STUDY ON RECEPTOR SPECIFICITY OF ANIMAL INFLUENZA VIRUSES Research Project

ITO Toshihiro Hokkaido Univ., Graduate School of Vet. Med., Res. Assoc.

18. Enhancement of non-specific antiviral immunity induced by mucosal administration of immunoadijivant in infant animal Research Project

ARIKAWA Jiro Hokkaido University School of Medicine, Institute for Animal Experimentation, Professor

19. 中国の兎の出血病の病因並びに病態-特に韓国の例との比較研究 Research Project

板倉 智敏 北海道大学, 獣医学部, 教授

20. A new approach for the control of Aujeszky's disease by using germ-line transformation Research Project

KIDA Hiroshi (1994-1995) Hokkaido Univ., Grad. Sch. of Vet. Med., Pro. 清水 悠紀臣 (1993) 北海道大学, 獣医学部, 教授

1. Investigation of the mechanism of inducing the original antigenic sin phenomenon associated with influenza virus infection

Research Project

2. Development of a new influenza vaccine of global standard.

Research Project

喜田宏北海道大学, 人獣共通感染症リサーチセンター, 特別招へい教授

3. Development of measles virus vector-based vaccine against highly pathogenic avian influenza virus

Research Project

4. Establishment of novel preventive/therapeutic measures and demonstration of a mechanism of neural spread of pathogens in neurotropic zoonotic diseases

Research Project

5. Studies on the mechanism of entry of the envelope virus and its inhibitor.

Research Project

6. Ecology and pandemic planning of animal influenza virus

Research Project

7. Ecological study of animal influenza viruses : To prepare for the emergence of pandemic influenza

Research Project

8. Molecular basis for highly pathogenesis of avian influenza virus in humans.

Research Project

9. Origin and Mutations of Hong Kong New H5 Influenza Viruses

Research Project

10. G蛋白欠失VSVを用いたウイルス表面糖蛋白の機能解析

Research Project

岡崎克則北海道大学, 大学院・獣医学研究科, 助教授

11. Preparation of peptide vaccines according to the cassette theory against newly emerged influenza virus

Research Project

12. Molecular mechanisms of infection and pathogenesis of viruses

Research Project

13. トリから哺乳動物へのインフルエンザウイルス伝播の機構

Research Project

伊藤寿啓鳥取大学, 農学部・獣医学科, 助教授

14. Studies on the T-cell epitopes of herpesviruses

Research Project

15. Molecular mechanisms of infection and pathogenesis of viruses

Research Project

16. Prediction of new pandemic influenza viruses -Distribution of the viruses in waterfowls in their nesting places in Siberia

Research Project

17. STUDY ON RECEPTOR SPECIFICITY OF ANIMAL INFLUENZA VIRUSES

Research Project

18. Enhancement of non-specific antiviral immunity induced by mucosal administration of immunoadijivant in infant animal

Research Project

19. 中国の兎の出血病の病因並びに病態-特に韓国の例との比較研究

Research Project

板倉智敏北海道大学, 獣医学部, 教授

20. A new approach for the control of Aujeszky's disease by using germ-line transformation

Research Project

KIDA Hiroshi (1994-1995) Hokkaido Univ., Grad. Sch. of Vet. Med., Pro.
清水悠紀臣 (1993) 北海道大学, 獣医学部, 教授