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Search Results: 29 results / Researcher Number: 10109506

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  • 1. Investigation of the mechanism of inducing the original antigenic sin phenomenon associated with influenza virus infection

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Review Section Basic Section 49060:Virology-related
    Research Institution Hokkaido University
    Principal Investigator

    SHINGAI Masashi 北海道大学, 人獣共通感染症国際共同研究所, 准教授

    Project Period (FY) 2018-04-01 – 2021-03-31Completed
    Keywords インフルエンザ / ウイルス / ワクチン / 免疫 / 抗原原罪 / インフルエンザウイルス / レパトア解析
    Outline of Final Research Achievements Using a mouse model of influenza virus infection, we confirmed that the original antigenic sin does indeed occur. Repertoire analysis of immunoglobuli ...
    Research Products of this project Journal Article (4 results, of which Int'l Joint Research: 3 results, Peer Reviewed: 4 results)   Presentation (3 results, of which Int'l Joint Research: 2 results, Invited: 2 results)
  • 2. Development of a new influenza vaccine of global standard.

    Research Project

    Research Category

    Grant-in-Aid for JSPS Fellows

    Research Field Immunology
    Research Institution Hokkaido University
    Principal Investigator

    喜田 宏 北海道大学, 人獣共通感染症リサーチセンター, 特別招へい教授

    Project Period (FY) 2015-11-09 – 2018-03-31Discontinued
    Keywords インフルエンザ / 全粒子ワクチン / ワクチン / エクソソーム
    Outline of Annual Research Achievements 「世界基準の季節性インフルエンザ不活化ウイルス全粒子ワクチンの開発」において、不活化ウイルス全粒子ワクチンが、現行のエーテルスプリットワクチン(HAワクチン)より、遥かに高い免疫をマウスおよびサルに誘導することが明らとなった。
    Research Products of this project Int'l Joint Research (1 results)
  • 3. Development of measles virus vector-based vaccine against highly pathogenic avian influenza virus

    Research Project

    Research Category

    Grant-in-Aid for Young Scientists (B)

    Research Field Veterinary medical science
    Virology
    Research Institution The University of Tokyo
    Principal Investigator

    Fujiyuki Tomoko 東京大学, 医科学研究所, 助教

    Project Period (FY) 2014-04-01 – 2017-03-31Completed
    Keywords 高病原性鳥インフルエンザウイルス / 麻疹ウイルス / カニクイザル / 感染モデル / 発症防御 / ワクチン / ベクター / 組換えウイルス / ウイルスベクター / H5N1
    Outline of Final Research Achievements We generated recombinant measles virus (rMV) expressing the hemagglutinin (HA) protein of HPAIV (H5), and examined protective efficacy of the candidat ...
    Research Products of this project Presentation (6 results)
  • 4. Establishment of novel preventive/therapeutic measures and demonstration of a mechanism of neural spread of pathogens in neurotropic zoonotic diseases

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (B)

    Research Field Applied veterinary science
    Research Institution Hokkaido University
    Principal Investigator

    UMEMURA Takashi Hokkaido University

    Project Period (FY) 2007 – 2009Completed
    Keywords 狂犬病 / 鞘内免疫 / インフルエンザウイルス / 小児脳症 / オーエスキー病 / 血球凝集性脳脊髄炎ウイルス / インフルエンザ脳症 / 野兎病 / 人獣共通感染症 / 脳内免疫 / LPS / 経神経伝播 / ワクチン / 人畜共通感染症
    Research Abstract Specific antibodies detected in cerebrospinal fluid by intrathecal vaccination (vaccination by an inoculating antigen into subarachnoidal space) were  ...
    Research Products of this project Journal Article (24 results, of which Peer Reviewed: 21 results)   Presentation (12 results)
  • 5. Studies on the mechanism of entry of the envelope virus and its inhibitor.

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Basic veterinary science/Basic zootechnical science
    Research Institution Health Sciences University of Hokkaido (2005)
    Hokkaido University (2004)
    Principal Investigator

    OKAZAKI Katsunori Health Sciences University of Hokkaido, Dept of Pharmaceutical Sciences, Professor

    Project Period (FY) 2004 – 2005Completed
    Keywords Virus envelope / Membrane fusion / Cell entry / Herpesviru / gB glycoprotein / Proteolytic enzyme / Endothelial cells / Endosome
    Research Abstract Glycoprotein B (gB) is the most conserved glycoprotein of herpesviruses and plays important roles in virus infectivity. The glycoprotein of most herpe ...
    Research Products of this project Journal Article (17 results)   Book (2 results)
  • 6. Ecology and pandemic planning of animal influenza virus

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (S)

    Research Field Applied veterinary science
    Research Institution Hokkaido University
    Principal Investigator

    KIDA Hiroshi Hokkaido University, Graduate School of Veterinary Medicine, Professor

    Project Period (FY) 2003 – 2006Completed
    Keywords influenza viruses / global surveillance / vaccine / antiviral / diagnosis
    Research Abstract H5N1 highly pathogenic avian influenza (HPAI) virus has spread in poultry from Southeast Asia to the north, Europe, and Africa. We have been conductin ...
    Research Products of this project Journal Article (27 results)   Book (1 results)   Patent(Industrial Property Rights) (1 results)   Publications (6 results)
  • 7. Ecological study of animal influenza viruses : To prepare for the emergence of pandemic influenza

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (A)

    Research Field Applied veterinary science
    Research Institution Hokkaido University
    Principal Investigator

    KIDA Hiroshi Hokkaido University, Hokkaido University, Graduate School of Veterinary Medicine, Professor

    Project Period (FY) 2000 – 2002Completed
    Keywords Influenza / migratory waterfowls / Pigs / Chickens / Epidemiological surveillance / Receptor specificity / Interspecies transmission
    Research Abstract To provide information on the precursor genes of the next pandemic influenza, epidemiological surveillance of animal and avian influenza viruses was p ...
    Research Products of this project Journal Article (44 results)   Publications (24 results)
  • 8. Molecular basis for highly pathogenesis of avian influenza virus in humans.

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (A)

    Research Field Virology
    Research Institution The University of Tokyo
    Principal Investigator

    KAWAOKA Yoshihiro The University of Tokyo, IMS, Professor

    Project Period (FY) 2000 – 2002Completed
    Keywords avian influenza virus / H5N1 / reverse genetics
    Research Abstract Influenza is an example of a disease for which the viral pathogen has emerged into the human population many times over past centuries, sometimes with ...
    Research Products of this project Journal Article (10 results)   Publications (12 results)
  • 9. Origin and Mutations of Hong Kong New H5 Influenza Viruses

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (A)

    Research Field Applied veterinary science
    Research Institution Tottori University
    Principal Investigator

    ITO Toshihiro Tottori University, Faculty of Agriculture, Professor

    Project Period (FY) 1999 – 2001Completed
    Keywords influenza virus / fowl plague / host range / pathogenicity / chicken / H5 / pandemic / recerse genetics
    Research Abstract An H5N1 avian influenza A virus was transmitted to humans in Hong Kong in 1997. Although the virus causes systemic infection and is highly lethal in c ...
    Research Products of this project Publications (87 results)
  • 10. G蛋白欠失VSVを用いたウイルス表面糖蛋白の機能解析

    Research Project

    Research Category

    Grant-in-Aid for Exploratory Research

    Research Field Virology
    Research Institution Hokkaido University
    Principal Investigator

    岡崎 克則 北海道大学, 大学院・獣医学研究科, 助教授

    Project Period (FY) 1998 – 1999Completed
    Keywords VSV / 糖蛋白 / ヘルペスウイルス / gB / gC / グルコサミノグリカン / リセプター / gD / GFP / cell-to-cell感染
    Research Abstract ヘルペスウイルス主要糖蛋白の機能を明らかにするためウシヘルペスウイルス1(BHV1)の糖蛋白gBあるいはgCを発現する株化細胞を樹立し、これらにG蛋白遺伝子を欠失した水疱性口炎ウイルス(VSVdelG-G)を感染させて表現型混合ウイルスの回収を試みた。培養上清中に放出されたウイルス粒子をMDBK細胞 ...
    Research Products of this project Publications (3 results)
  • 11. Preparation of peptide vaccines according to the cassette theory against newly emerged influenza virus

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (B)

    Research Field Experimental pathology
    Research Institution SHIGA UNIVERSITY OF MEDICAL SCIENCE (1999)
    Hokkaido University (1998)
    Principal Investigator

    OGASAWARA Kazumasa SHIGA UNIVERSITY OF MEDICAL SCIENCE, DEPARTMENT OF 2nd PATHOLOGY, PROFESSOR

    Project Period (FY) 1998 – 1999Completed
    Keywords MHC / peptide vaccine / newly emerged influenza virus / HA / cassette theory / CTL / NP / anti-CD40 antibody
    Research Abstract 1. According to the cassette theory, we prepared a synthetic peptide vaccine against H5 subtype influenza viruses. The peptide, however, could not ind ...
    Research Products of this project Publications (26 results)
  • 12. Molecular mechanisms of infection and pathogenesis of viruses

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (A).

    Research Field Basic veterinary science/Basic zootechnical science
    Research Institution HOKKAIDO UNIVERSITY
    Principal Investigator

    KIDA Hiroshi Grad. School of Vet. Medicine, Hokkaido University, Professor

    Project Period (FY) 1998 – 1999Completed
    Keywords influenza virus / duck / pig / Siberia / Hong Kong / H5N1 / vaccine / surveillance
    Research Abstract Influenza A viruses of different subtypes were isolated from fecal samples of ducks in their nesting areas in Siberia. Phylogenetic analysis of the NP ...
    Research Products of this project Publications (32 results)
  • 13. トリから哺乳動物へのインフルエンザウイルス伝播の機構

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (C)

    Research Field Basic veterinary science/Basic zootechnical science
    Research Institution Tottori University
    Principal Investigator

    伊藤 寿啓 鳥取大学, 農学部・獣医学科, 助教授

    Project Period (FY) 1996Completed
    Keywords インフルエンザウイルス / 種間伝播 / 宿主域 / ヘマグルチニン / シアル酸 / レセプター / 変異株 / 感染実験
    Research Abstract インフルエンザウイルス(IFV)は哺乳動物や鳥類に広く感染する。すべてのIFVは野生水禽のウイルスに由来すると考えられている。しかし、ウイルスが異なる動物種間を伝播する機序が解明されていない.IFVはHA蛋白を介して細胞表面のシアル酸を末端にもつ糖鎖レセプターに結合して感染する。そこで、本研究ではI ...
    Research Products of this project Publications (4 results)
  • 14. Studies on the T-cell epitopes of herpesviruses

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (B)

    Research Field Basic veterinary science/Basic zootechnical science
    Research Institution HOKKAIDO UNIVERSITY
    Principal Investigator

    OKAZAKI Katsunori Hokkaido University, Graduate School of Veterinary Medicine, Associate Professor

    Project Period (FY) 1996 – 1997Completed
    Keywords bovine herpesvirus 1 / glycoprotein / monoclonal antibody / T-cell epitope / lbaculovirus / Aujeszky's disease virus / DNA vaccine / cellular immunity
    Research Abstract An escape mutant of bovine herpesvirus 1 (BHV1) was obtained in the presence of monoclonal antibody against glycoprotein B (gB) , which required compl ...
    Research Products of this project Publications (14 results)
  • 15. Molecular mechanisms of infection and pathogenesis of viruses

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (A)

    Research Field Applied veterinary science
    Research Institution HOKKAIDO UNIVERSITY
    Principal Investigator

    KIDA Hiroshi Grad.School of Veterinary Medicine, Hokkaido University, Professor

    Project Period (FY) 1996 – 1998Completed
    Keywords influenza virus / pathogenicity / host cell factor / vascular endothelial cell / blood coagulation factor / disseminated intravascular coagulation / chicken
    Research Abstract Intravenous injection into chickens with the virus-free extracts from the allantoic membrane of chicken embryos infected with influenza viruses result ...
    Research Products of this project Publications (47 results)
  • 16. Prediction of new pandemic influenza viruses -Distribution of the viruses in waterfowls in their nesting places in Siberia

    Research Project

    Research Category

    Grant-in-Aid for international Scientific Research

    Research Field Basic veterinary science/Basic zootechnical science
    Research Institution Hokkaido University
    Principal Investigator

    KIDA Hiroshi Hokkaido Univ., Graduate School of Vet.Medicine, Professor

    Project Period (FY) 1995 – 1997Completed
    Keywords influenza virus / migratory ducks / feces / breeding areas / Siberia / lake water / The River Lena / Southern China
    Research Abstract In each summer of 1995-1997,3,000 fecal materials of waterfowls and lake-water samples were collected in Kamchatka, Khabarovsk, and Saha Republic. In  ...
    Research Products of this project Publications (53 results)
  • 17. STUDY ON RECEPTOR SPECIFICITY OF ANIMAL INFLUENZA VIRUSES

    Research Project

    Research Category

    Grant-in-Aid for General Scientific Research (C)

    Research Field Basic veterinary science/Basic zootechnical science
    Research Institution HOKKAIDO UNIVERSITY
    Principal Investigator

    ITO Toshihiro Hokkaido Univ., Graduate School of Vet. Med., Res. Assoc.

    Project Period (FY) 1994 – 1995Completed
    Keywords Influenza virus / Receptor specificity / Sialic acid / Host range / Tissue tropism / Hemagglutinin / Interspecies transmission / Inhibitor
    Research Abstract The receptor specificity of the HA differs amongsinfluenza viruses : most avian influenza viruses preferentially bind the sialic acid-alpha-2,3-galact ...
    Research Products of this project Publications (6 results)
  • 18. Enhancement of non-specific antiviral immunity induced by mucosal administration of immunoadijivant in infant animal

    Research Project

    Research Category

    Grant-in-Aid for Scientific Research (B)

    Research Field Laboratory animal science
    Research Institution Hokkaido University
    Principal Investigator

    ARIKAWA Jiro Hokkaido University School of Medicine, Institute for Animal Experimentation, Professor

    Project Period (FY) 1994 – 1996Completed
    Keywords Influenzavirus / Rotavirus / Hantavirus / Adjuvant / MDP / Pseudorabies / Mucosal immunity / Animal experiment
    Research Abstract 1. Animal models for studying respiratory infection, enteric infection and systemic infections were established by using mice and Sendai virus, rotavi ...
    Research Products of this project Publications (39 results)
  • 19. 中国の兎の出血病の病因並びに病態-特に韓国の例との比較研究

    Research Project

    Research Category

    Grant-in-Aid for international Scientific Research

    Research Institution Hokkaido University
    Principal Investigator

    板倉 智敏 北海道大学, 獣医学部, 教授

    Project Period (FY) 1994Completed
    Keywords 兎 / 出血病 / カリシウイルス / 肝炎 / 急死 / 肝細胞壊死
    Research Abstract 兎の出血病(RHD)は,1984年中国で初めて発生し,以後韓国をはじめ多くの養兎を行っている国々に発生した。我々は,1989年から韓国で発生したRHDに関する研究を行い,多くの成果をあげた。この成果には以下の点が含まれる。RHDの原因ウイルスはカルシウイルスで,肝細胞に親和性が強い。この原因ウイルス ...
    Research Products of this project Publications (2 results)
  • 20. A new approach for the control of Aujeszky's disease by using germ-line transformation

    Research Project

    Research Category

    Grant-in-Aid for Developmental Scientific Research (A)

    Research Field Basic veterinary science/Basic zootechnical science
    Research Institution HOKKAIDO UNIVERSITY
    Principal Investigator

    KIDA Hiroshi (1994-1995) Hokkaido Univ., Grad. Sch. of Vet. Med., Pro.
    清水 悠紀臣 (1993) 北海道大学, 獣医学部, 教授

    Project Period (FY) 1993 – 1995Completed
    Keywords Aujeszky's disease virus / Herpesvirus / Transcription / Transcriptional repression
    Research Abstract Intracellular immunization using dominant-negative mutants of viral proteins is prorposed as a new approach to antiviral therapy in humans and to germ ...
    Research Products of this project Publications (39 results)
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