KAKEN — Research Projects | Researcher Number: 10237711

Search Results: 12 results / Researcher Number: 10237711

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1. Development and application of the environmental friendly and highly efficient organic synthesis using characteristics of the heterocycle

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Chemical pharmacy
Research Institution	Mukogawa Women's University
Principal Investigator	KAWASAKI Ikuo 武庫川女子大学, 薬学部, 教授
Project Period (FY)	2011 – 2013Completed
Keywords	複素環 / イオン化合物 / キラルリガンド / 不斉合成 / 環境調和型 / 複素環化合物 / 有機合成反応 / リサイクル / 触媒的不斉水素移動型還元反応 / 有機合成 / 高効率的
Research Abstract	Various novel chiral ionic ligands which has the structure of the quaternary ammonium salt in the nitrogen containing heterocycle were prepared. There ...

Research Products of this project	Journal Article (7 results, of which Peer Reviewed: 4 results) Presentation (36 results) Book (2 results) Remarks (2 results)

2. Development and application of the environmental friendly organic synthesis using characteristics of the heterocycle

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Chemical pharmacy
Research Institution	Mukogawa Women's University
Principal Investigator	KAWASAKI Ikuo Mukogawa Women's University
Project Period (FY)	2008 – 2010Completed
Keywords	有機合成 / 複素環 / 不斉還元 / リサイクル / イオン性化合物 / イオン液体 / リガンド / 触媒
Research Abstract	A novel chiral ionic ligand which has the structure of the quaternary ammonium salt in the nitrogen containing heterocycle was prepared, and asymmetri ...

Research Products of this project	Journal Article (10 results, of which Peer Reviewed: 10 results) Presentation (29 results) Book (5 results) Remarks (2 results)

3. 無臭チオール・スルフィドの開発とその有機反応への応用

Research Project

Research Category	Grant-in-Aid for Exploratory Research
Research Field	Chemical pharmacy
Research Institution	Hiroshima International University (2004-2005) Kyoto Pharmaceutical University (2003)
Principal Investigator	西出喜代治広島国際大学, 薬学部, 教授
Project Period (FY)	2003 – 2005Completed
Keywords	グリーンケミストリー / 無臭ボランスルフィド錯体 / 無臭有機セレン反応剤 / ビス(4-トリメチルシリルフェニル)ジセレニド / 無臭フェニルメタンチオール / 無臭ベンゼンチオール / 無臭1,3-プロパンジチオール / チオ糖 / 無臭硫黄反応剤 / ドデシルメチルスルフィド(Dod-S-Me) / ドデシルメチルスルホキシド(Dod-S(O)-Me) / メチルモルホリノヘキシルスルフィド(MMS) / メチルモルホリノヘキシルスルホキシド(MMSO) / 無臭Corey-Kim酸化 / 無臭Swern酸化 / 無臭チオール / 1-ドデカンチオール / 脱アルキル化反応 / TMSBM / TMSBT / 無臭スルフィド
Research Abstract	グリーンケミストリーに分類できる「無臭チオール・スルフィドの開発とその有機反応への応用」と題した研究を行い、以下の成果を得た。

Research Products of this project	Journal Article (9 results) Publications (6 results)

4. Studies on the construction of multi-contiguous asymmetric synthesis using mercapto alcohol as a chiral template

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Chemical pharmacy
Research Institution	Kyoto Pharmaceutical University
Principal Investigator	NODE Manabu Kyoto Pharmaceutical University, Dept.of Pharmaceutical Sciences, Professor
Project Period (FY)	2001 – 2003Completed
Keywords	mercapto alcohol / Michael addition / MPV reduction / dimethylchloroaluminum / three contiguous chiral centers / pentafluorobenzoic acid / odorless thiol / odorless sulfide
Research Abstract	We report herein the highly stereoselective construction of three contiguous stereogenic centers in tandem Michael addition and Meerwein-Ponndorff-Ver ...

Research Products of this project	Publications (24 results)

5. 新しい作用機序を有する新規ピリミジン系抗ガン剤の開発研究

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas (C)
Review Section	Biological Sciences
Research Institution	Kyoto Pharmaceutical University
Principal Investigator	野出學京都薬科大学, 薬学部, 教授
Project Period (FY)	2000Completed
Keywords	新規ピリミジン系抗癌剤 / シクロブタン骨格 / 環式アミノアルコール / ヒト乳癌MDA-MB-231 / II型トポイソメラーゼ / 選択的阻害 / NF-1147
Research Abstract	(A)方法と結果

6. Studies on the Through Space n_0 → π^* and n_0 → σ^* Interaction

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Chemical pharmacy
Research Institution	Kyoto Pharmaceutical University
Principal Investigator	NISHIDE Kiyoharu Kyoto Pharmaceutical University, Associate Professor
Project Period (FY)	1999 – 2000Completed
Keywords	Fluoro group / Cyano group / X-Ray Crystallographic Analysis / Through Space n_F → π^* Interaction / Stereoselective Protonation / Aliphatic Fluorocyanides / Diels-Alder Reaction / Nucleophile-Electrophile Interaction
Research Abstract	We have investigated novel through-space n → π^* interactions to provide a new idea for regulation of the conformation of acyclic alkane compounds hav ...

Research Products of this project	Publications (6 results)

7. Exploitation of a New Method for the Reductive Desulfurization without Racemization of a Secondary Alcohol

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Chemical pharmacy
Research Institution	Kyoto Pharmaceutical University
Principal Investigator	NISHIDA Kiyoharu Kyoto Pharmaceutical University Associate Professor
Project Period (FY)	1997 – 1998Completed
Keywords	Raney nickel / hypophosphite / reductive desulfurization / thio ether / sulfoxide / optically active alcohol / retention of configuration / alpha, beta-unsaturated ketone
Research Abstract	Raney nickel is commonly used for the reduction of the carbon-sulfur bonds of sulfides, sulfoxides, and sulfones to the carbon-hydrogen bonds, Seconda ...

Research Products of this project	Publications (12 results)

8. Studies on the Development of Novel Asymmetric Multi-Functional MPV Reduction

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Chemical pharmacy
Research Institution	Kyoto Pharmaceutical University
Principal Investigator	NODE Manabu Kyoto Pharmaceutical University, Professor
Project Period (FY)	1997 – 1999Completed
Keywords	α,β-Unsaturated Compounds / Chinal Mercapto Alcohols / Asymmetric Tandem Michael-MPV Reaction / Anymmetric 1,7-Hydride Shift / Dynamic Kinetic Resolution / Asymmetric Protonation / Asymmetric Bifunctional Group Exchange Reaction / Optically Active Alcohols
Research Abstract	The introduction of a thiol group into a chiral alcohol regent for asymmetric Meerwein-Ponndorf-Verley (MPV) reductions allows asymmetric reduction of ...

Research Products of this project	Publications (20 results)

9. 官能基交換型新規不斉合成反応の開発研究

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	Chemical pharmacy
Research Institution	Kyoto Pharmaceutical University
Principal Investigator	西出喜代治京都薬科大学, 薬学部, 講師
Project Period (FY)	1995Completed
Keywords	不斉Tandem Michael-MPV反応 / 高選択的不斉還元反応 / 光学活性二級アルコール / キラルメルカプトアルコール / 還元的脱硫反応 / Raney Nickel-Combination System / 光学活性モノチオアセタール / 光学活性α-ヒドロキシアルデヒド
Research Abstract	1.Meerwein-Ponndorf-Verley(MPV)還元は古い反応であるがガルボニル基の重要な還元反応の一つである。しかしながらキラルアルコールを不斉源として用いた不斉MPV反応の鏡像体過剰率は20%以下であることが報告され、高選択的な不斉還元反応は実現されていなかった。高選択的不斉MPV ...

Research Products of this project	Publications (1 results)

10. Design of Immunosuppressant Possessing Novel Mechanisms

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Bioorganic chemistry
Research Institution	Setsunan University, Faculty of Pharmaceutical Sciences
Principal Investigator	FUJITA Tetsuro Setsunan University, Faculty of Pharmaceutical Sciences, Professor
Project Period (FY)	1995 – 1996Completed
Keywords	immunosuppresant / ISP-I / vegetable wasps plant worms / mycestericin / 2-alkyl-2-amino-1,3-propanediol / cyclosporin / FK506 / FTY720
Research Abstract	Immunosuppressants are clinically important for organ transplantations and the treatment of autoimmune diseases. Since cyclosporin A (CsA) and FK-506 ...

Research Products of this project	Publications (39 results)

11. 新しい脱モノチオアセタール化反応剤の開発とその不斉合成への応用

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	Chemical pharmacy
Research Institution	Kyoto Pharmaceutical University
Principal Investigator	野出學京都薬科大学, 薬学部, 教授
Project Period (FY)	1994Completed
Keywords	silver salt-iodine / demonothioacetalization / dedithioacetalization / chiral 3-mercaptoalcohol / Lewis acid / intramoleculat MPV reduction / optically active sec-alcohol
Research Abstract	A)新しい脱モノチオアセタール化反応剤の開発

12. beta位にヘテロ原子を有する不飽和エステル類のalpha及びgamma選択的不斉アルキル化反応の開発

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	Chemical pharmacy
Research Institution	Kyoto Pharmaceutical University
Principal Investigator	西出喜代治京都薬科大学, 薬学部, 助手
Project Period (FY)	1993Completed
Keywords	Tetronic Acid / (S)-2-Methoxymethylpyrrolidine / Alkhlation / (+)-Blastmycinone / (+)-1,1′-Binaphthol / Quaternary Carbon / (-)-Aphanorphine / (-)-Eptazocine
Research Abstract	1.alpha位の不斉アルキル化法:二環性ベンゾシクロアルカンカルボン酸(R)-2,2′-ビナフチルエステルのメチル化反応を用いてalpha位の四級不斉炭素の構築法を開発した。この基湿にもcomplex inducedproximity効果が観察され、収率は満足のいくものではなかったが92:8の高立 ...

Research Products of this project	Publications (1 results)