KAKEN — Research Projects | Researcher Number: 10271032

Search Results: 40 results / Researcher Number: 10271032

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1. Multi Regulatory System for Gut Homeostasis and Inflammation

Research Project

Research Category	Grant-in-Aid for Scientific Research (S)
Review Section	Broad Section I
Research Institution	Chiba University (2022) The University of Tokyo
Principal Investigator	Hiroshi Kiyono 千葉大学, 未来医療教育研究機構, 卓越教授
Project Period (FY)	2018-06-11 – 2023-03-31Completed
Keywords	炎症性腸疾患 / 臓器連関 / 上皮細胞 / 腸内細菌 / 慢性炎症 / 粘膜免疫 / パネート細胞 / 線維芽細胞 / 蠕動運動 / 抗菌ペプチド / 膵臓 / 間葉系細胞 / 陰窩 / 腸間膜脂肪
Outline of Final Research Achievements	Inflammatory bowel disease (IBD) and its complications are chronic and difficult　to treat. In addition, the complete mechanism underlying their pathog ...
Ex-post Assessment Comments (Rating)	A: In light of the aim of introducing the research area into the research categories, expected outcomes of research have been produced.
Interim Assessment Comments (Rating)	A: In light of the aim of introducing the research area into the research categories, the expected progress has been made in research.

Research Products of this project	Int'l Joint Research (4 results) Journal Article (47 results, of which Int'l Joint Research: 9 results, Peer Reviewed: 28 results, Open Access: 22 results) Presentation (45 results, of which Int'l Joint Research: 11 results, Invited: 21 results) Book (7 results) Remarks (4 results) Patent(Industrial Property Rights) (1 results)

2. 消化管の階層的粘膜支持連関システムによる粘膜防御機構の解明

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Review Section	Medium-sized Section 53:Organ-based internal medicine and related fields
Research Institution	The University of Tokyo
Principal Investigator	清野宏東京大学, 医科学研究所, 特任教授
Project Period (FY)	2018-04-01 – 2019-03-31Discontinued
Keywords	消化管 / 間葉系細胞 / 膵臓 / 平滑筋 / パネート細胞 / 炎症性腸疾患 / 腸管粘膜 / 階層的粘膜支持連関システム
Outline of Annual Research Achievements	本研究課題では腸管における、①腸-膵連関、②粘膜―間葉連関、③粘膜―筋層連関という3種類の「階層的粘膜支持連関システム」の解析を目的とし研究活動を行った。

Research Products of this project	Journal Article (2 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 2 results, Open Access: 1 results) Presentation (3 results, of which Int'l Joint Research: 1 results, Invited: 3 results)

3. Investigation of the role of mucosal inductive site and indigenous bacteria on the NSAID-induced enteropathy

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Gastroenterology
Research Institution	Osaka University
Principal Investigator	IIJIMA Hideki 大阪大学, 医学(系)研究科(研究院), 講師
Project Period (FY)	2011 – 2013Completed
Keywords	小腸粘膜傷害 / NSAID / 粘膜免疫 / パイエル板 / 樹状細胞 / ＮＳＡＩＤ / 小腸粘膜障害 / ＮＳＡＩＤｓ / CD103陽性樹状細胞 / NSAIDｓ
Research Abstract	We investigated the role of Peyer's patches (PPs) in mouse model of non-steroidal anti-inflammatory drug (NSAID)-induced enteropathy. We found PP-null ...

Research Products of this project	Journal Article (17 results, of which Peer Reviewed: 5 results) Presentation (16 results) Remarks (1 results)

4. 顎顔面免疫と生殖器免疫のクロストーク

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Immunology
Research Institution	The University of Tokyo
Principal Investigator	清野宏東京大学, 医科学研究所, 教授
Project Period (FY)	2011Completed
Keywords	経鼻・経鼻免疫 / 性感染症 / 粘膜ワクチン / 粘膜指向性
Research Abstract	一個所の粘膜関連リンパ組織(MALT)に抗原投与することで遠隔の粘膜面に抗原特異的免疫応答が誘導されることは現象論として知られているものの、その分子・細胞機構については不明であった。近年、パイエル板において誘導される抗原特異的免疫担当細胞の腸管粘膜指向性決定分子群が同定されたが、経鼻免疫および経眼免 ...

5. Immunological crosstalk between nasal and reproductive mucosal tissue

Research Project

Research Category	Grant-in-Aid for Scientific Research (S)
Research Field	Immunology
Research Institution	The University of Tokyo
Principal Investigator	Kiyono Hiroshi 東京大学, 医科学研究所, 教授
Project Period (FY)	2011-04-01 – 2016-03-31Completed
Keywords	粘膜免疫 / 経鼻ワクチン / HSV2 / アジュバント / 生殖免疫 / 性感染症 / ワクチン / ケモカイン / 細胞遊走 / 経鼻免疫 / 膣粘膜感染症 / 膣粘膜指向性関連分子 / エフェクターT細胞
Outline of Final Research Achievements	The antigen administration to the nasal mucosa induces not only the immune responses in the nasal mucosa but reproductive tissue even its distant part ...
Verification Result (Rating)	B
Result (Rating)	A-: Progress in the research is steadily towards the initial goal. However, further efforts are necessary as a part of the research progress is delayed.

Research Products of this project	Journal Article (90 results, of which Int'l Joint Research: 15 results, Peer Reviewed: 83 results, Acknowledgement Compliant: 19 results, Open Access: 24 results) Presentation (71 results, of which Int'l Joint Research: 13 results, Invited: 61 results) Book (7 results) Remarks (1 results)

6. Analysis of antigen-uptake network at mucosal epithelial layer

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Immunology
Research Institution	The University of Tokyo
Principal Investigator	KIYONO Hiroshi The University of Tokyo
Project Period (FY)	2008 – 2010Completed
Keywords	粘膜免役 / M細胞 / 上皮細胞 / 抗原取り込み / 共生細菌 / 粘膜免疫 / UEA-1 / フコシル化
Research Abstract	M (Microfold) cells and related subpopulation cells are known as specialized cells for antigen uptake. To reveal the extracellular regulating factors ...

Research Products of this project	Journal Article (40 results, of which Peer Reviewed: 40 results) Presentation (32 results) Book (3 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

7. Immunological Self Recognition and its Disorders

Administrative Group

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Review Section	Biological Sciences
Research Institution	Kyoto University
Principal Investigator	MINATO Nagahiro 京都大学, 医学研究科, 教授
Project Period (FY)	2007 – 2011Completed
Keywords	自己認識 / 免疫制御 / 胸腺 / 自己免疫病 / 炎症 / がん / 免疫系自己 / 自己識別 / 免疫病態 / 自己寛容 / 免疫組織 / がん免疫 / 獲得免疫 / 免疫老化 / 白血病 / T細胞 / アナジー / G蛋白 / 自己免疫
Research Abstract	To understand the mechanisms of immunological self-recognition, we organized three research groups, (A01) basic immunological mechanisms, (A02) immuno ...
Project Area	Immunological Self Recognition and its Disorders

Research Products of this project	Journal Article (54 results, of which Peer Reviewed: 35 results) Presentation (16 results) Book (2 results) Remarks (4 results) Patent(Industrial Property Rights) (5 results, of which Overseas: 2 results)

8. Mucosal Immunology and self‐discrimination

Planned Research

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Review Section	Biological Sciences
Research Institution	The University of Tokyo
Principal Investigator	KIYONO Hiroshi 東京大学, 医科学研究所, 教授
Project Period (FY)	2007 – 2011Completed
Keywords	共生細菌 / パイエル板 / Alcaligenes / フコシル化 / IgA / 孤立リンパ濾胞 / M細胞 / Tfh細胞 / 腸管IgA / 胚中心 / 濾胞性ヘルパーT細胞 / Foxp3+制御性T細胞 / PD-1 / 絨毛上皮細胞 / 自然免疫担当細胞 / 濾胞性樹状細胞 / レチノイン酸 / Alcaligrnes / 孤立性リンパ濾胞 / FoxP3^+制御性T細胞 / 樹状細胞
Research Abstract	In this study, we found some gut commensal bacteria, which habit at the inside of gut-associated lymphoid tissue such as Peyer’s patches. To make a co ...
Project Area	Immunological Self Recognition and its Disorders

Research Products of this project	Journal Article (75 results, of which Peer Reviewed: 47 results) Presentation (36 results) Book (2 results)

9. 生体防御と免疫病制御の統合的パラダイム

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Immunology
Research Institution	Kyoto University
Principal Investigator	湊長博京都大学, 生命科学研究科, 教授
Project Period (FY)	2006Completed
Keywords	生体防御 / 免疫病 / 免疫応答 / 生体恒常性
Research Abstract	免疫特定領域研究「免疫監視」の終了にあたり、新たに免疫領域における定研究を推進する妥当性、必要性、およびその領域研究内容につき、3回にわたる全班員による全体会議、その他有志班員による数回の個別テーマ会議を開き、十分な議論を検証を行った。今日残された最も重要な免疫研究課題の一つは免疫応答における自己識 ...

Research Products of this project	Journal Article (6 results)

10. Identification of the crosstalk between Notch signaling and Wnt signaling in the differentiation of the intestinal epithelial cells.

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Gastroenterology
Research Institution	Tokyo Medical and Dental University
Principal Investigator	WATANABE Mamoru Tokyo Medical and Dental University, Department of Gastroenterology and Hepatology, Professor
Project Period (FY)	2005 – 2006Completed
Keywords	Differentiation / Regenerative medicine / Translational research / Signal transduction / Atoh1 / Hath1 / Wnt / Notch
Research Abstract	In this study, we revealed the crosstalk between Ant and Notch signaling in the regulation of the intestinal differentiation via Hath1 gene that plays ...

Research Products of this project	Journal Article (18 results)

11. 粘膜免疫監視の場としてのGALT・NALTを介した免疫制御誘導の解明

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Review Section	Biological Sciences
Research Institution	The University of Tokyo
Principal Investigator	清野宏東京大学, 医科学研究所, 教授
Project Period (FY)	2005 – 2006Completed
Keywords	鼻咽腔関連リンパ組織 / バイエル板 / リンフォイドケモカイン / 原基 / 胚中心 / 経鼻ワクチン / 粘膜免疫 / 粘膜ワクチン / AIDSワクチン / 分泌型IgA / 経口ワクチン
Research Abstract	鼻咽腔関連リンパ組織(nasopharynx-associated lymphoid tissue ; NALT)は、腸管におけるパイエル板と同様の粘膜関連リンパ組織の一つである。上気道の免疫監視機構の解明にはNALTの形成メカニズムを明らかにする事が不可欠である。

Research Products of this project	Journal Article (22 results)

12. Regulation of Intestinal Mucosal Immunity in a Mouse Model on Inflammatory Bowel Disease

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Digestive surgery
Research Institution	Osaka University
Principal Investigator	ITO Toshinori Osaka University, Graduate School of Medicine, Endowed Chair Professor
Project Period (FY)	2004 – 2005Completed
Keywords	Inflammatory Bowel Disease / IL-10 knock out mouse / Bcl transgenic mouse / Intestinal epithelium / apoptosis / Th1
Research Abstract	Interleukin-10 gene-deficient (IL-10^<-/->) mice spontaneously develop an intestinal inflammation characterized by multifocal lesions throughout the g ...

Research Products of this project	Journal Article (9 results)

13. 粘膜免疫監視の場としてのGALT・NALTを介した免疫制御誘導の解明

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Review Section	Biological Sciences
Research Institution	The University of Tokyo
Principal Investigator	清野宏東京大学, 医科学研究所, 教授
Project Period (FY)	2004 – 2005Completed
Keywords	粘膜免疫 / 粘膜ワクチン / AIDSワクチン / 分泌型IgA / 経鼻ワクチン / 経口ワクチン
Research Abstract	粘膜免疫応答誘導の場として重要な役割を果たしている腸管関連リンパ組織群、パイエル板、腸間膜リンパ節などがこれにあたる。例えばパイエル板は経口免疫応答の誘導組織として知られ、抗原特異的なT細胞やB細胞はここで抗原に感作される。我々は腸管孤立リンパ小節(ILF : J.Immunol.168:57,20 ...

Research Products of this project	Journal Article (10 results)

14. エイズ粘膜ワクチン開発へ向けて:HIV特異的分泌型IgA誘導システムの開発

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Review Section	Biological Sciences
Research Institution	The University of Tokyo
Principal Investigator	清野宏東京大学, 医科学研究所, 教授
Project Period (FY)	2004 – 2005Completed
Keywords	粘膜免疫 / 粘膜ワクチン / AIDSワクチン / 分泌型IgA / 経鼻ワクチン / 経口ワクチン
Research Abstract	「研究目的」エイズ・バイオテロに代表される新興・再興感染症に対するワクチンの開発は、これらの感染源が主に粘膜面を介して侵入してくるという点からも重要であり、その開発は急務である。粘膜面に有効な抗原特異抗体を誘導するためには粘膜アジュバントの応用は必須である。しかしながらその有効性と安全性を兼ね備えた ...

Research Products of this project	Journal Article (21 results)

15. Development of a novel therapy for the treatment of chronic colitis based on the manipulation of mucosal immune response and the clarification of tissue specific system for epithelial regeneration.

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Gastroenterology
Research Institution	Tokyo Medical and Dental University
Principal Investigator	WATANABE Mamoru Tokyo Medical and Dental University, Department of Gastroenterology and Hepatology, Professor
Project Period (FY)	2003 – 2004Completed
Keywords	mucosal immunity / IL-7 / intestinal epithelial cell / cell differentiation / chronic colitis / transcriptional factor / bone marrow cell / regenerative medicine
Research Abstract	The present study was a sprouting study following our original findings of the IL-7/IL-7 receptor system within the intesine, and provided successful ...

Research Products of this project	Journal Article (12 results) Publications (6 results)

16. HIV特異的分泌型IgA誘導粘膜ワクチン開発へ向けての基礎研究

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Review Section	Biological Sciences
Research Institution	The University of Tokyo
Principal Investigator	清野宏東京大学, 医科学研究所, 教授
Project Period (FY)	2003Completed
Keywords	粘膜免疫 / 粘膜ワクチン / AIDSワクチン / 分泌型IgA / 経鼻ワクチン / 経口ワクチン
Research Abstract	粘膜免疫システムを駆使してHIVに対する第一線のバリアをその侵入門戸である生殖器粘膜に構築するには、経口・経鼻ワクチンが有効であり、その鍵を握っているのが粘膜免疫増強効果のある粘膜アジュバントや新型粘膜ワクチンデリバリーシステムの開発である。そこで第一世代としてコレラ毒素(CT)を無毒化した変異型( ...

Research Products of this project	Publications (6 results)

17. 粘膜ワクチンへの基礎研究:HIV特異的分泌型IgA誘導システムの開発

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Review Section	Biological Sciences
Research Institution	The University of Tokyo
Principal Investigator	清野宏東京大学, 医科学研究所, 教授
Project Period (FY)	2002Completed
Keywords	粘膜免疫 / 粘膜ワクチン / 粘膜アジュバント / HIVワクチン / 分泌型IgA
Research Abstract	粘膜免疫システムを駆使してHIVに対する第一線のバリアを構築するには、経口・経ワクチンが有効であり、その鍵を握っているのが安全で免疫増強作用の強い粘膜アジュバントと粘膜ワクチンデリバリー法の開発である。

Research Products of this project	Publications (19 results)

18. Study of mucosal immune response in the murine model of inflammatory bowel disease -Therapeutic effect of a new immunosuppressive reagent FTY720-

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Digestive surgery
Research Institution	Osaka University
Principal Investigator	ITO Toshinori Osaka University Graduate School of Medicine, Associate Professor
Project Period (FY)	2001 – 2002Completed
Keywords	inflammatory bowel disease / Interleukin-10 gene-deficient mice / FTY720 / Colonic lamina propria lymphocyte / Peyer's patch / Mesenteric lymph node / Lamina propria
Research Abstract	Background & Aims: FTY72O is a novel lymphocyte homing agent that possesses potent immunosuppressive activity. The immunosuppression induced by FTY72O ...

Research Products of this project	Publications (26 results)

19. Elucidation of the mechanism for regurating mucosal immune response and application for the treatment of chronic colitis and food allergy.

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Gastroenterology
Research Institution	Tokyo Medical and Dental University
Principal Investigator	WATANABE Mamoru Tokyo Medical and Dental University, Department of Gastroenterology and Hepatology, Professor
Project Period (FY)	2001 – 2002Completed
Keywords	IL-7 / IL-7 receptor / mucosal jmmunity / regenerative medicine / intestinal epithelial cell / bone marrow cell / chronic cohtis / food allergy
Research Abstract	We have established a concept of intramucosal network system composed of IL-7-producing epithelial cells and IL-7R-expressing lymphoid cells, and clar ...

Research Products of this project	Publications (22 results)

20. 粘膜ワクチンへの基礎研究:HIV特異的分泌型IgA誘導型アジュバント開発

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas (C)
Review Section	Biological Sciences
Research Institution	Osaka University
Principal Investigator	清野宏大阪大学, 微生物病研究所, 教授
Project Period (FY)	2001Completed
Keywords	粘膜免疫 / 粘膜ワクチン / 粘膜アジュバント / HIVワクチン / キメラ型無毒化毒素 / 経口免疫 / 経鼻ワクチン / IgA
Research Abstract	粘膜免疫システムを駆使してHIVに対する第一線のバリアを構築する為に、経口・経鼻ワクチンが有効であり、その鍵を握っているのが粘膜免疫増強効果のある粘膜アジュバントの開発である。そこで、本研究計画ではHIV粘膜ワクチンに向けて新規アジュバント開発の為の基礎研究を展開している。新規粘膜アジュバントとして ...

Research Products of this project	Publications (13 results)

Project Period (Start Year [FY])

1. Multi Regulatory System for Gut Homeostasis and Inflammation Research Project

Hiroshi Kiyono 千葉大学, 未来医療教育研究機構, 卓越教授

2. 消化管の階層的粘膜支持連関システムによる粘膜防御機構の解明 Research Project

清野 宏 東京大学, 医科学研究所, 特任教授

3. Investigation of the role of mucosal inductive site and indigenous bacteria on the NSAID-induced enteropathy Research Project

IIJIMA Hideki 大阪大学, 医学(系)研究科(研究院), 講師

4. 顎顔面免疫と生殖器免疫のクロストーク Research Project

清野 宏 東京大学, 医科学研究所, 教授

5. Immunological crosstalk between nasal and reproductive mucosal tissue Research Project

Kiyono Hiroshi 東京大学, 医科学研究所, 教授

6. Analysis of antigen-uptake network at mucosal epithelial layer Research Project

KIYONO Hiroshi The University of Tokyo

7. Immunological Self Recognition and its Disorders Administrative Group

MINATO Nagahiro 京都大学, 医学研究科, 教授

8. Mucosal Immunology and self‐discrimination Planned Research

KIYONO Hiroshi 東京大学, 医科学研究所, 教授

9. 生体防御と免疫病制御の統合的パラダイム Research Project

湊 長博 京都大学, 生命科学研究科, 教授

10. Identification of the crosstalk between Notch signaling and Wnt signaling in the differentiation of the intestinal epithelial cells. Research Project

WATANABE Mamoru Tokyo Medical and Dental University, Department of Gastroenterology and Hepatology, Professor

11. 粘膜免疫監視の場としてのGALT・NALTを介した免疫制御誘導の解明 Research Project

清野 宏 東京大学, 医科学研究所, 教授

12. Regulation of Intestinal Mucosal Immunity in a Mouse Model on Inflammatory Bowel Disease Research Project

ITO Toshinori Osaka University, Graduate School of Medicine, Endowed Chair Professor

13. 粘膜免疫監視の場としてのGALT・NALTを介した免疫制御誘導の解明 Research Project

清野 宏 東京大学, 医科学研究所, 教授

14. エイズ粘膜ワクチン開発へ向けて:HIV特異的分泌型IgA誘導システムの開発 Research Project

清野 宏 東京大学, 医科学研究所, 教授

15. Development of a novel therapy for the treatment of chronic colitis based on the manipulation of mucosal immune response and the clarification of tissue specific system for epithelial regeneration. Research Project

WATANABE Mamoru Tokyo Medical and Dental University, Department of Gastroenterology and Hepatology, Professor

16. HIV特異的分泌型IgA誘導粘膜ワクチン開発へ向けての基礎研究 Research Project

清野 宏 東京大学, 医科学研究所, 教授

17. 粘膜ワクチンへの基礎研究:HIV特異的分泌型IgA誘導システムの開発 Research Project

清野 宏 東京大学, 医科学研究所, 教授

18. Study of mucosal immune response in the murine model of inflammatory bowel disease -Therapeutic effect of a new immunosuppressive reagent FTY720- Research Project

ITO Toshinori Osaka University Graduate School of Medicine, Associate Professor

19. Elucidation of the mechanism for regurating mucosal immune response and application for the treatment of chronic colitis and food allergy. Research Project

WATANABE Mamoru Tokyo Medical and Dental University, Department of Gastroenterology and Hepatology, Professor

20. 粘膜ワクチンへの基礎研究:HIV特異的分泌型IgA誘導型アジュバント開発 Research Project

清野 宏 大阪大学, 微生物病研究所, 教授

1. Multi Regulatory System for Gut Homeostasis and Inflammation

Research Project

2. 消化管の階層的粘膜支持連関システムによる粘膜防御機構の解明

Research Project

清野宏東京大学, 医科学研究所, 特任教授

3. Investigation of the role of mucosal inductive site and indigenous bacteria on the NSAID-induced enteropathy

Research Project

4. 顎顔面免疫と生殖器免疫のクロストーク

Research Project

清野宏東京大学, 医科学研究所, 教授

5. Immunological crosstalk between nasal and reproductive mucosal tissue

Research Project

6. Analysis of antigen-uptake network at mucosal epithelial layer

Research Project

7. Immunological Self Recognition and its Disorders

Administrative Group

8. Mucosal Immunology and self‐discrimination

Planned Research

9. 生体防御と免疫病制御の統合的パラダイム

Research Project

湊長博京都大学, 生命科学研究科, 教授

10. Identification of the crosstalk between Notch signaling and Wnt signaling in the differentiation of the intestinal epithelial cells.

Research Project

11. 粘膜免疫監視の場としてのGALT・NALTを介した免疫制御誘導の解明

Research Project

清野宏東京大学, 医科学研究所, 教授

12. Regulation of Intestinal Mucosal Immunity in a Mouse Model on Inflammatory Bowel Disease

Research Project

13. 粘膜免疫監視の場としてのGALT・NALTを介した免疫制御誘導の解明

Research Project

清野宏東京大学, 医科学研究所, 教授

14. エイズ粘膜ワクチン開発へ向けて:HIV特異的分泌型IgA誘導システムの開発

Research Project

清野宏東京大学, 医科学研究所, 教授

15. Development of a novel therapy for the treatment of chronic colitis based on the manipulation of mucosal immune response and the clarification of tissue specific system for epithelial regeneration.

Research Project

16. HIV特異的分泌型IgA誘導粘膜ワクチン開発へ向けての基礎研究

Research Project

清野宏東京大学, 医科学研究所, 教授

17. 粘膜ワクチンへの基礎研究:HIV特異的分泌型IgA誘導システムの開発

Research Project

清野宏東京大学, 医科学研究所, 教授

18. Study of mucosal immune response in the murine model of inflammatory bowel disease -Therapeutic effect of a new immunosuppressive reagent FTY720-

Research Project

19. Elucidation of the mechanism for regurating mucosal immune response and application for the treatment of chronic colitis and food allergy.

Research Project

20. 粘膜ワクチンへの基礎研究:HIV特異的分泌型IgA誘導型アジュバント開発

Research Project

清野宏大阪大学, 微生物病研究所, 教授