KAKEN — Research Projects | Researcher Number: 20091506

1. General epidemiological study of wildlife and domestic animal rabies in Brazil

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Applied veterinary science
Research Institution	Nihon University
Principal Investigator	SAKAI Takeo Nihon University, College of Bioresource Sciences, Professor
Project Period (FY)	2002 – 2004Completed
Keywords	Rabies virus / Brazil / Molecular epidemiology / Wildlife / Domestic animal / Dog / Bat / Diagnosis
Research Abstract	Molecular epidemiological analysis of rabies virus (RV) nucleoprotein gene isolated from Brazilian wildlife and domestic animals was performed. Livest ...

Research Products of this project	Journal Article (19 results) Publications (5 results)

2. Studies on the epidemiology of Bartonellosis in Japan and pathogenicity of Bartonella henselae

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Applied veterinary science
Research Institution	Nihon University
Principal Investigator	MARUYAMA Soichi Nihon University, Professor
Project Period (FY)	2002 – 2005Completed
Keywords	Bartonella henselae / cat / cytokine / epidemiology / flea / persistent infection / serogiagnosis / humoral immunity
Research Abstract	We isolated Bartonella henselae from an inguinal lymph node of a 36-year-old male patient with cat-scratch disease for the first time in Japan. The di ...

Research Products of this project	Journal Article (36 results) Book (11 results) Publications (13 results)

3. Epidemiological investigation of protozoan diseases in China

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Applied veterinary science
Research Institution	Obihiro University of Agriculture and Veterinary Medicine
Principal Investigator	XUAN Xuenan Obihiro University, Associate Professor
Project Period (FY)	2001 – 2003Completed
Keywords	Epidemiology / recombinant antigens / T.gondii / N.canunim / C.parvum / B.caballi / B.equi / B.gibsoni
Research Abstract	1)Cloning of genes encoding immunodominant antigens of protozoan parasites

Research Products of this project	Publications (34 results)

4. Development of methods that facilitate generation of recombinant herpesviruses using BAC system

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Basic veterinary science/Basic zootechnical science
Research Institution	Nagoya University (2002) Tokyo Medical and Dental University (2000-2001)
Principal Investigator	KAWAGUCHI Yasushi Nagoya University, Graduate School of Medicine, Associate Professor
Project Period (FY)	2000 – 2002Completed
Keywords	herpesviruses / reverse genetics / BAC system
Research Abstract	In recent years, several laboratories have reported on the cloning of herpesvirus genomes as bacterial artificial chromosomes (BACs) in E. coli and on ...

Research Products of this project	Publications (68 results)

5. Induction mechanisms of mucosal immune response in intramucosal parasitic protozoan infection

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Applied veterinary science
Research Institution	OBIHIRO UNIVERSITY OF AGRICULTURE AND VETERINARY MEDICINE
Principal Investigator	OMATA Yoshitaka Obihiro University of Agriculture and Veterinary Medicine, Department of Veterinary Physiology, Associated Professor
Project Period (FY)	2000 – 2002Completed
Keywords	Infection / Mucosal immunity / Defense mechanism / Immune response / Cryptosporidium parvum / Eimeria stiedai / Toxoplasma gondii / Neospora caninum
Research Abstract	This study was aimed to clarify induction mechanism of mucosal immune responses in tissues invaded by parasitic protozoa and relationship between syst ...

Research Products of this project	Publications (38 results)

6. Epidemiology on piroplasmosis of demestic animals in Mongolia

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Applied veterinary science
Research Institution	Obihiro University of Agriculture and Veterinary Medicine
Principal Investigator	IGARASHI Ikuo Obihiro Univ., Research Center for Protozoan Diseases, Professor
Project Period (FY)	1999 – 2000Completed
Keywords	piroplasmosis / Mongolia / horse / cattle / antibody survey / isolation of parasites / diagnostic antigens / genetic analysis
Research Abstract	Babesiosis in domestic animals causes enormous economic losses throughout most of the world. In Mongolia, high prevalence of babesiosis was observed i ...

Research Products of this project	Publications (19 results)

7. Studies on control of animal protozoan diseases by recombinant herpesvirus vector vaccines

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Applied veterinary science
Research Institution	Nihon University (2001-2002) Obihiro University of Agriculture and Veterinary Medicine (1999-2000)
Principal Investigator	MIKAMI Takeshi Nihon University, Professor
Project Period (FY)	1999 – 2002Completed
Keywords	herpe virus vector / recombinant vaccine / T. gondii / N. caninum / C. parvum / B. caballi / B. equi / B. gibsoni
Research Abstract	1) Development of animal herpesvirus vectors

Research Products of this project	Publications (50 results)

8. Control of toxoplasmosis by inducing Th1 helper cells

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Basic veterinary science/Basic zootechnical science
Research Institution	Nihon University (2001-2002) Obihiro University of Agriculture and Veterinary Medicine (1999-2000)
Principal Investigator	MIKAMI Takeshi Nihon University, Professor
Project Period (FY)	1999 – 2002Completed
Keywords	T. gondii / IL-12 / FHV-1 / recombinant vaccine / TgSAG1 / TgSAG2 / TgROP2 / TgSRS2
Research Abstract	1) Cloning and expression of feline IL-12 gene

Research Products of this project	Publications (49 results)

9. Analysis on protective antigen of Babesia parasites by developmental engineering

Research Project

Research Category	Grant-in-Aid for Scientific Research (B).
Research Field	Applied veterinary science
Research Institution	Obihiro University Agriculture and Veterinary Medicine
Principal Investigator	IGARASHI Ikuo Obihiro Univ., Research Center for Protozoan Diseases, Professor
Project Period (FY)	1997 – 2000Completed
Keywords	Babesia parasites / protective immunity / cytokine knock-out mice / recombinant antigen / gene engineering / diagnostic antigens / Monoclonal antibody / developmental engineering
Research Abstract	1. Babesia microti produces a self-limiting infection in mice, and recovered mice are resistant to reinfection. In the present study, the protective m ...

Research Products of this project	Publications (33 results)

10. Studies on origin of retroviruses from wild carnivore

Research Project

Research Category	Grant-in-Aid for international Scientific Research
Research Field	Basic veterinary science/Basic zootechnical science
Research Institution	The University of Tokyo
Principal Investigator	MIYAZAWA Takayuki (1998) the Univ.of Tokyo, Grad Sch.of Agri.And Life Sci., Assistant Professor 見上彪 (1997) 東京大学, 大学院・農学生命科学研究科, 教授
Project Period (FY)	1997 – 1998Completed
Keywords	Vietnam / feline immunodeficiency virus / feline herpesvirus type 1 / feline leukemia virus / feline svncvtial virus / feline calicivirus / feline parvovirus / leopard cat
Research Abstract	In Socialist Republic of Vietnam (Vietnam), there are lots of camivors (feuds) which are not present in Japan. Three retroviruses (feline leukemia vir ...

Research Products of this project	Publications (17 results)

11. MUTATIONS IN ALPHAHERPESVIRUSES WITH VARIOUS GENOMIC GC CONTENTS.

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Basic veterinary science/Basic zootechnical science
Research Institution	The University of Tokyo
Principal Investigator	OTSUKA Haruki GRADUATE SCHOOL OF AGRICULTURALAND LIFE SCIENCE. The University of Tokyo, PROFESSOR
Project Period (FY)	1996 – 1998Completed
Keywords	GC content / CHV / PRV / Gb / deoxyribonucleotide triphosphate / pool / HPLC / BHV
Research Abstract	It has been known that there are wide variety in the base composition of the genome DNA of viruses which belong to the alphaherpesvirus subfamily. For ...

Research Products of this project	Publications (18 results)

12. ウシヘルペスウイルス1型をベクターとするウシ用組み換え多価ワクチンの開発

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Applied animal science
Research Institution	The University of Tokyo
Principal Investigator	大塚治城東京大学, 大学院・農学生命科学研究科, 教授
Project Period (FY)	1995 – 1997Completed
Keywords	BHV-1 / タイレリア / ピロプラズマ病 / P32 / ワクチニアウイルス / CHV / 狂犬病ウイルス / Gタンパク / p32 / SV40 / プロモータ / RSV / ペクターワクチン / チミジンキナーゼ / PRV糖タンパク / マウス / 中和抗体
Research Abstract	日本におけるウシの小型ピロプラズマ病の病原体であるTheileria sergentj原虫は千歳型と池田型の2種に大別される。原虫の主表面タンパクであるp32は宿主の免疫応答に最も重要な役割を持つと考えられているが、千歳型と池田型では異なった抗原性を示す。ウシピロプラズマ病に対する組み換えワクチンの ...

Research Products of this project	Publications (8 results)

13. DEVELOPMENT OF POLYVALENT RECOMBINANT VACCINES FOR CATS.

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Applied veterinary science
Research Institution	The University of Tokyo
Principal Investigator	MIKAMI Takeshi Univ.of Tokyo, Grad.Sch.of Agri.and Life Sci., Professor
Project Period (FY)	1995 – 1997Completed
Keywords	recombinant vaccine / feline herpesvirus 1 / feline calicivirus / feline immunodeficiency virus / gag protein / capsid protein / thymidine kinase gene / immunoblot analysis
Research Abstract	The aim of the present studies is to develop polyvalent recombinant (rec) vaccines which are superior to safeness, inexpensiveness and effctiveness to ...

Research Products of this project	Publications (28 results)

14. Molecular and Immunological Studies on Feline Immunodeficiency Virus

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Basic veterinary science/Basic zootechnical science
Research Institution	The University of Tokyo
Principal Investigator	MIKAMI Takeshi Univ. of Tokyo, Grad. Sch. of Agri. and Life Sci., Professor
Project Period (FY)	1995 – 1996Completed
Keywords	FIV / evolution / quantification / neutralizing antibody / AP-1 / vif / ORF-A / CD8
Research Abstract	The purpose of the project is to clarify the genetic properties of feline immunodeficiency virus (FIV) and to know the pathogenetic mechanism of the v ...

Research Products of this project	Publications (25 results)

15. エイズの病態と制御に関する基礎研究エイズの動物モデル

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Research Institution	Kyoto University
Principal Investigator	速水正憲京都大学, ウイルス研究所, 教授
Project Period (FY)	1995 – 1997Completed
Keywords	サル免疫不全ウイルス / ネコ免疫不全ウイルス / キメラウイルス / トランスジェニックマウス / スキッドマウス / ヒト免疫不全ウイルス / マウスエイズ / 後天性免疫不全症 / ヒト免疫不全ウィルス / サル免疫不全ウィルス / ネコ免疫不全ウィルス / チロシンキナーゼ
Research Abstract	HIVの感染・発症機序の解明さらに治療薬・ワクチン開発の為に以下の動物モデルを用いた研究を実施した。

Research Products of this project	Publications (69 results)

16. Studies on the mechanisms of persistent infection and reactivation of animal viruses.

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Applied veterinary science
Research Institution	The University of Tokyo
Principal Investigator	MIKAMI Takeshi Univ.of Tokyo, Grad.Sch.of Agri.and Life Sci., Professor
Project Period (FY)	1994 – 1999Completed
Keywords	FIV / MDV / FHV-1 / CDV / ICP4 / immediate early transcript / B95a cells / MOLT-4 cells
Research Abstract	In persistent infection, virus can hidden in body and escape from immunological pressure, in spite of the presence of immunity. However, the virus is ...

Research Products of this project	Publications (36 results)

17. エイズ制圧に向けての基礎研究・エイズの動物モデル

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Research Institution	Kyoto University
Principal Investigator	速水正憲京都大学, ウイルス研究所, 教授
Project Period (FY)	1994Completed
Keywords	サル免疫不全ウイルス / ネコ免疫不全ウイルス / マウスエイズ / トランスジェニックマウス / 組換えウイルス / エイズ / 動物モデル
Research Abstract	速水班員は、種々のHIV-1のenv遺伝子を組み込んだSIVとのキメラウイルスを作成し、その感染性を調べた。従来のIIIb型とは異なるMNのSF-13envのキメラウイルスがサルPBMCに感染・増殖したことからサルを使ってのMN型のワクチン評価が可能になった。また好マクロファジ-性のHIV-1 en ...

Research Products of this project	Publications (68 results)

18. A new approach for the control of Aujeszky's disease by using germ-line transformation

Research Project

Research Category	Grant-in-Aid for Developmental Scientific Research (A)
Research Field	Basic veterinary science/Basic zootechnical science
Research Institution	HOKKAIDO UNIVERSITY
Principal Investigator	KIDA Hiroshi (1994-1995) Hokkaido Univ., Grad. Sch. of Vet. Med., Pro. 清水悠紀臣 (1993) 北海道大学, 獣医学部, 教授
Project Period (FY)	1993 – 1995Completed
Keywords	Aujeszky's disease virus / Herpesvirus / Transcription / Transcriptional repression
Research Abstract	Intracellular immunization using dominant-negative mutants of viral proteins is prorposed as a new approach to antiviral therapy in humans and to germ ...

Research Products of this project	Publications (39 results)

19. Study of Immunopathogenesis of FIV Infected cats

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	基礎獣医学
Research Institution	Toyama Medical & Pharmaceutical University
Principal Investigator	YAMAMOTO Hiroshi Toyama Medical & Pharmaceutical University, Laboratory Animal Research Center, Associate Professor
Project Period (FY)	1992 – 1993Completed
Keywords	Feline immunodeficiency virus(FIV) / T lymphoblastoid cell line(TLCL) / Cellular immunity / Antibody / ELIZA / Natural killer cells / PCR / Recombinant virus
Research Abstract	The feline immunodeficiency virus (FIV) specific cell-mediated immunity was investigated with experimentally FIV infected cats by ^<51>Cr-release assa ...

Research Products of this project	Publications (2 results)

20. Development of polyvalent recombinant vaccines for chickens and companion animals

Research Project

Research Category	Grant-in-Aid for Developmental Scientific Research (B)
Research Field	Applied veterinary science
Research Institution	The University of Tokyo
Principal Investigator	MIKAMI Takeshi Univ.of Tokyo, Fac.of Agr., Professor
Project Period (FY)	1992 – 1994Completed
Keywords	Recombinant vaccine / Vector virus / Feline herpesvirus type 1 (FHV-1) / Marek's disease virus (MDV) / Fowlpox virus (FPV) / Newcastle disease virus (NDV) / Chicken infections bursal disease virus (IBDV) / Feline calicivirus (FCV)
Research Abstract	The aim of the present studies is to develop polyvalent recombinant (rec) vaccines which are superior to safeness, inexpensiveness and effectiveness t ...

Research Products of this project	Publications (26 results)

Project Period (Start Year [FY])

1. General epidemiological study of wildlife and domestic animal rabies in Brazil Research Project

SAKAI Takeo Nihon University, College of Bioresource Sciences, Professor

2. Studies on the epidemiology of Bartonellosis in Japan and pathogenicity of Bartonella henselae Research Project

MARUYAMA Soichi Nihon University, Professor

3. Epidemiological investigation of protozoan diseases in China Research Project

XUAN Xuenan Obihiro University, Associate Professor

4. Development of methods that facilitate generation of recombinant herpesviruses using BAC system Research Project

KAWAGUCHI Yasushi Nagoya University, Graduate School of Medicine, Associate Professor

5. Induction mechanisms of mucosal immune response in intramucosal parasitic protozoan infection Research Project

OMATA Yoshitaka Obihiro University of Agriculture and Veterinary Medicine, Department of Veterinary Physiology, Associated Professor

6. Epidemiology on piroplasmosis of demestic animals in Mongolia Research Project

IGARASHI Ikuo Obihiro Univ., Research Center for Protozoan Diseases, Professor

7. Studies on control of animal protozoan diseases by recombinant herpesvirus vector vaccines Research Project

MIKAMI Takeshi Nihon University, Professor

8. Control of toxoplasmosis by inducing Th1 helper cells Research Project

MIKAMI Takeshi Nihon University, Professor

9. Analysis on protective antigen of Babesia parasites by developmental engineering Research Project

IGARASHI Ikuo Obihiro Univ., Research Center for Protozoan Diseases, Professor

10. Studies on origin of retroviruses from wild carnivore Research Project

MIYAZAWA Takayuki (1998) the Univ.of Tokyo, Grad Sch.of Agri.And Life Sci., Assistant Professor 見上 彪 (1997) 東京大学, 大学院・農学生命科学研究科, 教授

11. MUTATIONS IN ALPHAHERPESVIRUSES WITH VARIOUS GENOMIC GC CONTENTS. Research Project

OTSUKA Haruki GRADUATE SCHOOL OF AGRICULTURALAND LIFE SCIENCE. The University of Tokyo, PROFESSOR

12. ウシヘルペスウイルス1型をベクターとするウシ用組み換え多価ワクチンの開発 Research Project

大塚 治城 東京大学, 大学院・農学生命科学研究科, 教授

13. DEVELOPMENT OF POLYVALENT RECOMBINANT VACCINES FOR CATS. Research Project

MIKAMI Takeshi Univ.of Tokyo, Grad.Sch.of Agri.and Life Sci., Professor

14. Molecular and Immunological Studies on Feline Immunodeficiency Virus Research Project

MIKAMI Takeshi Univ. of Tokyo, Grad. Sch. of Agri. and Life Sci., Professor

15. エイズの病態と制御に関する基礎研究 エイズの動物モデル Research Project

速水 正憲 京都大学, ウイルス研究所, 教授

16. Studies on the mechanisms of persistent infection and reactivation of animal viruses. Research Project

MIKAMI Takeshi Univ.of Tokyo, Grad.Sch.of Agri.and Life Sci., Professor

17. エイズ制圧に向けての基礎研究・エイズの動物モデル Research Project

速水 正憲 京都大学, ウイルス研究所, 教授

18. A new approach for the control of Aujeszky's disease by using germ-line transformation Research Project

KIDA Hiroshi (1994-1995) Hokkaido Univ., Grad. Sch. of Vet. Med., Pro. 清水 悠紀臣 (1993) 北海道大学, 獣医学部, 教授

19. Study of Immunopathogenesis of FIV Infected cats Research Project

YAMAMOTO Hiroshi Toyama Medical & Pharmaceutical University, Laboratory Animal Research Center, Associate Professor

20. Development of polyvalent recombinant vaccines for chickens and companion animals Research Project

MIKAMI Takeshi Univ.of Tokyo, Fac.of Agr., Professor

1. General epidemiological study of wildlife and domestic animal rabies in Brazil

Research Project

2. Studies on the epidemiology of Bartonellosis in Japan and pathogenicity of Bartonella henselae

Research Project

3. Epidemiological investigation of protozoan diseases in China

Research Project

4. Development of methods that facilitate generation of recombinant herpesviruses using BAC system

Research Project

5. Induction mechanisms of mucosal immune response in intramucosal parasitic protozoan infection

Research Project

6. Epidemiology on piroplasmosis of demestic animals in Mongolia

Research Project

7. Studies on control of animal protozoan diseases by recombinant herpesvirus vector vaccines

Research Project

8. Control of toxoplasmosis by inducing Th1 helper cells

Research Project

9. Analysis on protective antigen of Babesia parasites by developmental engineering

Research Project

10. Studies on origin of retroviruses from wild carnivore

Research Project

MIYAZAWA Takayuki (1998) the Univ.of Tokyo, Grad Sch.of Agri.And Life Sci., Assistant Professor
見上彪 (1997) 東京大学, 大学院・農学生命科学研究科, 教授

11. MUTATIONS IN ALPHAHERPESVIRUSES WITH VARIOUS GENOMIC GC CONTENTS.

Research Project

12. ウシヘルペスウイルス1型をベクターとするウシ用組み換え多価ワクチンの開発

Research Project

大塚治城東京大学, 大学院・農学生命科学研究科, 教授

13. DEVELOPMENT OF POLYVALENT RECOMBINANT VACCINES FOR CATS.

Research Project

14. Molecular and Immunological Studies on Feline Immunodeficiency Virus

Research Project

15. エイズの病態と制御に関する基礎研究エイズの動物モデル

Research Project

速水正憲京都大学, ウイルス研究所, 教授

16. Studies on the mechanisms of persistent infection and reactivation of animal viruses.

Research Project

17. エイズ制圧に向けての基礎研究・エイズの動物モデル

Research Project

速水正憲京都大学, ウイルス研究所, 教授

18. A new approach for the control of Aujeszky's disease by using germ-line transformation

Research Project

KIDA Hiroshi (1994-1995) Hokkaido Univ., Grad. Sch. of Vet. Med., Pro.
清水悠紀臣 (1993) 北海道大学, 獣医学部, 教授

19. Study of Immunopathogenesis of FIV Infected cats

Research Project

20. Development of polyvalent recombinant vaccines for chickens and companion animals

Research Project