KAKEN — Research Projects | Researcher Number: 40109517

Search Results: 6 results / Researcher Number: 40109517

Display:

1. Studies on the Machanism of Memory Disturbances in Senescence-Accelerated Mouse and the Application to Screening of Nootropics

Research Project

Research Category	Grant-in-Aid for Developmental Scientific Research (B)
Research Field	応用薬理学・医療系薬学
Research Institution	Hokkaido University
Principal Investigator	NOMURA Yasuyuki Hokkaido University, Faculty of Pharmaceutical Sciences Professor
Project Period (FY)	1992 – 1994Completed
Keywords	Aging / Mouse / Memory disturbance / Therapeutics / Herbs / Screening / Pharmacology / Neurochmistry
Research Abstract	Senescence-accelerated mouse (SAM) has been esstablihed as a murine model showing accelerating aging. Memory impairment with aging is also observed in ...

Research Products of this project	Publications (40 results)

2. A study of the alpha-subunits of brain GTP-binding proteins from patients suffering schizophrenic, or Alzheimer's disease

Research Project

Research Category	Grant-in-Aid for General Scientific Research (B)
Research Field	Psychiatric science
Research Institution	Hokkaido University
Principal Investigator	OKADA Fumihiko Hokkaido University, Health Administration Center, Associate Professor
Project Period (FY)	1991 – 1992Completed
Keywords	schizophrenia / Hippocampus / GTP-binding protein, Goalpha, Gi2alpha / conformation / asymmetry / diagnosis x side interaction / SAS analysis / pertussis toxin
Research Abstract	Concentrations of the alpha subunits of GTP-binding protein, Go (Goalpha) and of Gi2 (Gi2alpha) in 6 areas of control and schizophrenic post-mortem br ...

Research Products of this project	Publications (12 results)

3. 細胞膜情報伝達原解析による精神分裂病脳のド-パミン神経過剰活動説の検討

Research Project

Research Category	Grant-in-Aid for General Scientific Research (B)
Research Institution	Hokkaido University
Principal Investigator	岡田文彦北海道大学, 保健管理センター, 助教授
Project Period (FY)	1990Completed
Keywords	精神分裂病剖検脳 / ADPリボシル化反応 / 百日咳トキシン / Gi / Go / エンザイム・イム / アッセイ / Goα / Gi2α / hypofrontality
Research Abstract	左側の側脳室下角の拡大を確認した精神分裂病剖検脳と年令,性を一致させた対照群の剖検脳を用いて,各々9の脳部位について,百日咳トキシンによるADPリボシル化反応を行い,G/Go量を測定した。さらにそのうちの各々6部位についてエンザイム・イムノアッセイ法により,GoαとGi2αを測定した。精神分裂病群で ...

Research Products of this project	Publications (6 results)

4. ラット脳線状体細胞膜を介する情報伝達系の解析による向精神薬の作用機序研究

Research Project

Research Category	Grant-in-Aid for General Scientific Research (B)
Research Field	Psychiatric science
Research Institution	Hokkaido University
Principal Investigator	岡田文彦北海道大学, 保健管理センター, 助教授
Project Period (FY)	1989Completed
Keywords	向精神薬 / 脳線状体細胞膜 / 情報伝達系 / G蛋白質 / 精神分裂病
Research Abstract	代表的な向精神薬であるクロ-ルプロマジン(CP)10mg、20mg/kg、ハロペリド-ル(HD)1mg、2mg/kgをそれぞれ1日2回3週間ラット腹腔内に投与、大脳皮質、海馬及び線状体より膜画分を作製、次項に記す研究成果をえた。

Research Products of this project	Publications (2 results)

5. Physiological roles of GTP binding protein associated with pertussis toxin (IAP) for the study of medicinal and diagnostic functions

Research Project

Research Category	Grant-in-Aid for Developmental Scientific Research
Research Field	Biological pharmacy
Research Institution	Hokkaido University
Principal Investigator	TOKUMITSU Yukiko Faculty of Pharmaceutical Sciences, Hokkaido University
Project Period (FY)	1986 – 1988Completed
Keywords	IAP / GTP binding protein / Proliferation and differentiation of cells / Phospholipase A_2 / Signal transduction / NIH3T3^<ras> / Adenylate cyclase system
Research Abstract	Many kinds of hormones and neurotransmitters interact with their specific receptors coupled to guanine nucleotide-binding protein (G protein) and lead ...

Research Products of this project	Publications (23 results)

6. 神経細胞における情報伝達機構と抗精神病薬の薬理作用発現との関連

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	Biological pharmacy
Research Institution	Hokkaido University
Principal Investigator	徳光幸子北海道大学, 薬学部, 助教授
Project Period (FY)	1986Completed
Keywords	NIE-115細胞 / ラット大脳皮質 / アデニレートシクラーゼ系 / グアニレートシクラーゼ系 / 抗うつ薬 / セロトニン受容体 / 【Ca^(2+)】依存性 / リン脂質代謝回転
Research Abstract	1.ラットに抗うつ薬を長期間投与すると、大脳皮質膜アデニレートシクラーゼのアゴニストによる活性化が一部抑制されることを見出した。これはまずGTP結合蛋白質の機能低下が発現し、さらに受容体数の減少を伴うことが推定された。

Research Products of this project	Publications (3 results)