KAKEN — Research Projects | Researcher Number: 40161062

1. A retrospective cohort study to evaluate the impact of dual infection of HGV and HTLV-1 on the maternal infection of HTLV-1

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Public health/Health science
Research Institution	Nagasaki University
Principal Investigator	YAMAMOTO Taro Nagasaki University
Project Period (FY)	2008 – 2010Completed
Keywords	疫学 / 感染症疫学
Research Abstract	This study has been to evaluate, with retrospective cohort, the impact of dual infection of HTLV-1 and Hepatitis G virus on maternal to child infectio ...

Research Products of this project	Journal Article (44 results, of which Peer Reviewed: 42 results) Presentation (7 results) Remarks (3 results)

2. 異常型プリオン蛋白結合性化合物の探索とその分子イメージングへの応用

Research Project

Research Category	Grant-in-Aid for Exploratory Research
Research Field	Radiation science
Research Institution	Nagasaki University
Principal Investigator	中山守雄 Nagasaki University
Project Period (FY)	2006 – 2007Completed
Keywords	プリオン病 / アルツハイマー病 / アミロイド / ベンゾフラン / イメージング / アルツハィマー病
Research Abstract	プリオン病は致死性の感染性神経変性疾患であり、脳内で生成する異常型プリオン蛋白質(PrP^<Sc>)の蓄積が発症原因と考えられている。PrP^<Sc>は、アルツハイマー病の病原物質であるアミロイドb蛋白質(Aβ)と同様に、アミロイド凝集体として脳内に沈着することから、我々がこれまでに開発を進めてきた ...

Research Products of this project	Journal Article (3 results, of which Peer Reviewed: 3 results) Presentation (1 results) Patent(Industrial Property Rights) (1 results)

3. プリオン株間干渉によるBSE感染抑制効果

Research Project

Research Category	Grant-in-Aid for Exploratory Research
Research Field	Nerve anatomy/Neuropathology
Research Institution	Nagasaki University
Principal Investigator	片峰茂長崎大学, 大学院医歯薬学総合研究科, 教授
Project Period (FY)	2006Completed
Keywords	プリオン病 / プリオン蛋白 / 干渉 / 海綿状変性
Research Abstract	1.目的

Research Products of this project	Journal Article (5 results)

4. Trial of development of therapeutic using PPS modified penetrating efficacy into brain.

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Neurology
Research Institution	Nagasaki University
Principal Investigator	SHIRABE Susumu Nagasaki University, Hospital of Medicine and Dentistry, Professor
Project Period (FY)	2005 – 2006Completed
Keywords	prion / PPS / low-molecular weight PPS / BBB
Research Abstract	The aim of this study was a trial of of development of therapeutic using PPS modified penetrating efficacy into brain. So far, Pentosan polysalfate (P ...

Research Products of this project	Journal Article (17 results)

5. Structure-based drug designs for the treatment of prion disease

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Virology
Research Institution	Nagasaki University
Principal Investigator	KATAMINE Shigeru Nagasaki University, Graduate School of Biomedical Sciences, Department of Microbiology and Immunology, Professor
Project Period (FY)	2004 – 2006Completed
Keywords	prion diseases / prion strain / conformation / NMR / drug discovery
Research Abstract	The conversion of the normal form of prion protein (PrP^c) to a disease-associated form (PrP^<Sc>) is a key molecular event in the pathogenesis of Tra ...

Research Products of this project	Journal Article (28 results) Book (2 results)

6. Biological studies on prions

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Review Section	Biological Sciences
Research Institution	Nagasaki University
Principal Investigator	KATAMINE Shigeru Nagasaki University, Graduate School of Biomedical Sciences, Professa
Project Period (FY)	2004 – 2005Completed
Keywords	prion diseases / prion strain / prion protein / variant / structural conversion / cell culture
Research Abstract	Pathogenic agents of prion diseases, namely prions, have diverse strains each of which results in a characteristic clinical course and pathology in th ...

Research Products of this project	Journal Article (29 results) Book (3 results)

7. Experimental-therapeutic potency of pentosan pofysulfate as an anti-prion and anti-dementia drug

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	General pharmacology
Research Institution	Nagasaki University
Principal Investigator	NIWA Masami Nagasaki University, Graduate School of Biomedical Sciences, Professor
Project Period (FY)	2003 – 2004Completed
Keywords	blood-brain barrier(BBB) / pentosan polysulfate / heparin / prion disease / Alzheimer disease / conformation diseaase
Research Abstract	We investigated therapeutic potency of pentosan polysulfate(PPS) as an anti-prion and-dementia drug, exprimentally and clinically. In our in vitro stu ...

Research Products of this project	Journal Article (58 results) Publications (6 results)

8. プリオン病感染因子の本体と複製分子機構の解明

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Review Section	Biological Sciences
Research Institution	Nagasaki University
Principal Investigator	片峰茂長崎大学, 大学院・医歯薬学総合研究科, 教授
Project Period (FY)	2003Completed
Keywords	プリオン病 / プリオン株 / プリオン蛋白 / 変異体 / 構造変換 / 培養細胞
Research Abstract	プリオン株の分子機構解明に向けて、種々のPrP変異体のPrP^<Sc>への変換効率と、正常型プリオン蛋白(PrP^C)のPrP^<Sc>への変換に及ぼす各変異体の抑制作用(Dominant-negative効果)について、Chandler株あるいは22L株感染N2a58細胞(Ch-N2a58,22L ...

Research Products of this project	Publications (3 results)

9. 非通常病原体プリオンの分子機構

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Virology
Research Institution	Nagasaki University
Principal Investigator	片峰茂長崎大学, 大学院・医歯薬学総合研究科, 教授
Project Period (FY)	2002Completed
Keywords	プリオン / プリオン蛋白 / 神経変異 / 培養神経細胞 / 抗体
Research Abstract	本邦におけるプリオン研究者の情報交換の促進と将来の共同研究プロジェクト立ち上げのための準備を目的に本研究を遂行した。情報交換に関しては、平成14年10月21日に長崎において班会議を開催し、班員に加えて数名の内外のプリオン研究者による情報交換と討議の場をもった。その結果、個々の班員間の往来及び研究材料 ...

10. Producing and Certification of Recombinant Antigen with LCMV Isolated in Japan for Diagnosis of LCMV Infection in Mice.

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Laboratory animal science
Research Institution	Nagasaki University
Principal Investigator	OHSAWA Kazutaka Nagasaki University, Center for Frontier Life Sciences, Division of Comparative Medicine, Associate Professor
Project Period (FY)	2002 – 2003Completed
Keywords	LCMV / Recombinant antigen
Research Abstract	In 1996, six different LCMV strains (OQ28,OQ32,OQ38,OQ48,OQ49 & OQ52) were isolated from wild mice of a port in Japan. Nucleotide sequence analysis of ...

Research Products of this project	Journal Article (12 results) Publications (9 results)

11. A COHORT STUDY ON THE CANCER INCIDENCE IN AN AREA WHERE HTLV I, HCV AND HBV ARE ENDEMIC

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Public health/Health science
Research Institution	Nagasaki University
Principal Investigator	ARISAWA Kokichi Nagasaki University, Graduate School of Biomedical Sciences (Department of Molecular Microbiology and Immunology), Associate Professor
Project Period (FY)	2002 – 2003Completed
Keywords	HTLV-1 / HCV / HBV / Cohort study / Cancer Incidence / Liver cancer
Research Abstract	(1) Interleukin-10 promoter polymorphism and liver fibrosis progression in patients with chronic hepatitis C in Japan. ...

Research Products of this project	Publications (25 results)

12. Proteome Analysis for Early Diagnosis of Prion Disease

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Laboratory medicine
Research Institution	Nagasaki University
Principal Investigator	YAMAMOTO Kazuo Nagasaki University, Graduate School of Biomedical Sciences, Associate Professor
Project Period (FY)	2002 – 2003Completed
Keywords	prion / early diagnosis / proteome
Research Abstract	Purpose :

Research Products of this project	Publications (10 results)

13. プリオン病感染因子の本体と複製分子機構の解明

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Review Section	Biological Sciences
Research Institution	Nagasaki University
Principal Investigator	片峰茂長崎大学, 大学院・医歯薬学総合研究科, 教授
Project Period (FY)	2002Completed
Keywords	プリオン病 / プリオン蛋白 / 培養神経細胞 / プリオン株
Research Abstract	マウス脳で継代された生物学的個性(発症までの潜伏期、症状、病理変化)の異なる3プリオン株(Fukuoka-1,22L, Chandler)を2種の培養細胞株(1C11,GT1-7)に感染・増殖させ、培養細胞中でも株の個性が維持されるか否かを、ddyマウス脳に感染細胞抽出液を接種することにより検討した ...

Research Products of this project	Publications (2 results)

14. プリオン感染培養細胞系によるプリオン複製の分子機構解明

Research Project

Research Category	Grant-in-Aid for Exploratory Research
Research Field	Virology
Research Institution	Nagasaki University
Principal Investigator	片峰茂長崎大学, 大学院・医学研究科, 教授
Project Period (FY)	2001Completed
Keywords	プリオン / プリオン蛋白 / プリオン株 / 培養神経細胞
Research Abstract	これまでプリオン複製の実験モデルが動物個体以外に存在せず、感染実体の生化学的解析が困難であった。プリオン感染培養細胞モデルもこれまで感染複製効率の低さが致命的な欠陥であったが、最近我々は培養神経細胞に遺伝子導入によりPrPを過発現することにより高効率でプリオン感染とその複製が起こることを示した。この ...

Research Products of this project	Publications (2 results)

15. Therapeutic trial of prion infected mice by continuous infusion of anti-prion agent to brain

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Neurology
Research Institution	Graduate School of Biomedical Sciences, Nagasaki University
Principal Investigator	SHIRABE Susumu Graduate School of Biomedical Sciences, Nagasaki University, The First Internal Medicine, associate professor
Project Period (FY)	2001 – 2002Completed
Keywords	Prion / Creutz feldt・Jakob disease / Autiseuse / Monpliosimno / Treatment
Research Abstract	1) We established prion-infected cell line to evaluate in-vitro effect of anti-prion agents.

Research Products of this project	Publications (26 results)

16. Physiological and pathological functions of a novel prion-like protein, PrPLP/Dpl.

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Virology
Research Institution	Nagasaki University
Principal Investigator	KATAMINE Shigeru Nagasaki University, Graduate School of Biomedical Sciences, Professor
Project Period (FY)	2001 – 2003Completed
Keywords	prion diseases / prion protein / prion-like protein / gene-knockout mice / neurodegeneration
Research Abstract	Certain lines of mice devoid of prion protein (PrP), such as Ngsk Prnp^<0/0>, exhibit late-onset ataxia due to Purkinje cell degeneration, which is re ...

Research Products of this project	Publications (22 results)

17. プリオン病感染因子の本体と複製分子機構の解明

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas (C)
Review Section	Biological Sciences
Research Institution	Nagasaki University
Principal Investigator	片峰茂長崎大学, 大学院・医学研究科, 教授
Project Period (FY)	2001Completed
Keywords	プリオン病 / プリオン蛋白 / プリオン類似蛋白 / 遺伝子改変マウス / 培養神経細胞 / プリオン株
Research Abstract	(1)PrPLP/Dplによるプリオン病の病態修飾の可能性の検討:PrPとの相同性から、PrPLP/Dplの神経細胞における発現がプリオン病におけるPrPScの蓄積あるいは病態に影響を与える可能性があり、遺伝子改変マウスを用いて検討した。先ず、神経細胞でPrPLP/Dplを異所性に発現するマウス(N ...

Research Products of this project	Publications (2 results)

18. Producing of Recombinant Antigen with LCMV Isolated in Japan and Diagnosis of LCMV Infection in Mice

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Laboratory animal science
Research Institution	Nagasaki University
Principal Investigator	OHSAWA Kazutaka Laboratory Animal Center for Biomedical Research, Nagasaki University, Assistant Prof.
Project Period (FY)	2000 – 2001Completed
Keywords	LCMV / Recombinant antigen
Research Abstract	In 1996, six different LCMV strains (OQ28, OQ32, OQ38, OQ48, OQ49 ＆ OQ52) were isolated from wild mice of a port in Japan. Nucleotide sequence analysi ...

Research Products of this project	Publications (16 results)

19. A NESTED CASE-CONTROL STUDY ON THE INTERACTION BETWEEN HCV AND HTLV-I IN THE DEVELOPMENT OF LIVER CANCER

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Public health/Health science
Research Institution	Nagasaki University
Principal Investigator	ARISAWA Kokichi Nagasaki University, Department of Preventive Medicine and Health Promotion, Associate Professor
Project Period (FY)	2000 – 2001Completed
Keywords	HTLV-I / HCV / Liver cancer / Biliary tract cancer / Interaction / Nested Case-control study / Ecologic study / Adult T-cell leukemia / lymphoma
Research Abstract	(1) Geographic Distribution of the Incidence of Adult T-cell Leukemia/lymphoma and Other Malignancies in Nagasaki Prefecture, Japan ...

Research Products of this project	Publications (24 results)

20. EFFECTS OF HEALTH EDUCATION ON BEHAVIORAL CHANGES IN, PREVENTION OF HIV/AIDS AND URINARY SCHISTOSOMIASIS

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Public health/Health science
Research Institution	Nagasaki University
Principal Investigator	MOJI Kazuhiko Nagasaki University, Institute of Tropical Medicine, Professor
Project Period (FY)	2000 – 2003Completed
Keywords	health education / school health / Schistosomaisis / HIC / AIDS / behavioral change / KAP study / Africa
Research Abstract	HIV/AIDS epidemic in Sub-Saharan Africa is a very serious public health problem. Although, some approachs for adults like VCT (voluntary, counseling a ...

Research Products of this project	Publications (10 results)

Project Period (Start Year [FY])

1. A retrospective cohort study to evaluate the impact of dual infection of HGV and HTLV-1 on the maternal infection of HTLV-1 Research Project

YAMAMOTO Taro Nagasaki University

2. 異常型プリオン蛋白結合性化合物の探索とその分子イメージングへの応用 Research Project

中山 守雄 Nagasaki University

3. プリオン株間干渉によるBSE感染抑制効果 Research Project

片峰 茂 長崎大学, 大学院医歯薬学総合研究科, 教授

4. Trial of development of therapeutic using PPS modified penetrating efficacy into brain. Research Project

SHIRABE Susumu Nagasaki University, Hospital of Medicine and Dentistry, Professor

5. Structure-based drug designs for the treatment of prion disease Research Project

KATAMINE Shigeru Nagasaki University, Graduate School of Biomedical Sciences, Department of Microbiology and Immunology, Professor

6. Biological studies on prions Research Project

KATAMINE Shigeru Nagasaki University, Graduate School of Biomedical Sciences, Professa

7. Experimental-therapeutic potency of pentosan pofysulfate as an anti-prion and anti-dementia drug Research Project

NIWA Masami Nagasaki University, Graduate School of Biomedical Sciences, Professor

8. プリオン病感染因子の本体と複製分子機構の解明 Research Project

片峰 茂 長崎大学, 大学院・医歯薬学総合研究科, 教授

9. 非通常病原体プリオンの分子機構 Research Project

片峰 茂 長崎大学, 大学院・医歯薬学総合研究科, 教授

10. Producing and Certification of Recombinant Antigen with LCMV Isolated in Japan for Diagnosis of LCMV Infection in Mice. Research Project

OHSAWA Kazutaka Nagasaki University, Center for Frontier Life Sciences, Division of Comparative Medicine, Associate Professor

11. A COHORT STUDY ON THE CANCER INCIDENCE IN AN AREA WHERE HTLV I, HCV AND HBV ARE ENDEMIC Research Project

ARISAWA Kokichi Nagasaki University, Graduate School of Biomedical Sciences (Department of Molecular Microbiology and Immunology), Associate Professor

12. Proteome Analysis for Early Diagnosis of Prion Disease Research Project

YAMAMOTO Kazuo Nagasaki University, Graduate School of Biomedical Sciences, Associate Professor

13. プリオン病感染因子の本体と複製分子機構の解明 Research Project

片峰 茂 長崎大学, 大学院・医歯薬学総合研究科, 教授

14. プリオン感染培養細胞系によるプリオン複製の分子機構解明 Research Project

片峰 茂 長崎大学, 大学院・医学研究科, 教授

15. Therapeutic trial of prion infected mice by continuous infusion of anti-prion agent to brain Research Project

SHIRABE Susumu Graduate School of Biomedical Sciences, Nagasaki University, The First Internal Medicine, associate professor

16. Physiological and pathological functions of a novel prion-like protein, PrPLP/Dpl. Research Project

KATAMINE Shigeru Nagasaki University, Graduate School of Biomedical Sciences, Professor

17. プリオン病感染因子の本体と複製分子機構の解明 Research Project

片峰 茂 長崎大学, 大学院・医学研究科, 教授

18. Producing of Recombinant Antigen with LCMV Isolated in Japan and Diagnosis of LCMV Infection in Mice Research Project

OHSAWA Kazutaka Laboratory Animal Center for Biomedical Research, Nagasaki University, Assistant Prof.

19. A NESTED CASE-CONTROL STUDY ON THE INTERACTION BETWEEN HCV AND HTLV-I IN THE DEVELOPMENT OF LIVER CANCER Research Project

ARISAWA Kokichi Nagasaki University, Department of Preventive Medicine and Health Promotion, Associate Professor

20. EFFECTS OF HEALTH EDUCATION ON BEHAVIORAL CHANGES IN, PREVENTION OF HIV/AIDS AND URINARY SCHISTOSOMIASIS Research Project

MOJI Kazuhiko Nagasaki University, Institute of Tropical Medicine, Professor

1. A retrospective cohort study to evaluate the impact of dual infection of HGV and HTLV-1 on the maternal infection of HTLV-1

Research Project

2. 異常型プリオン蛋白結合性化合物の探索とその分子イメージングへの応用

Research Project

中山守雄 Nagasaki University

3. プリオン株間干渉によるBSE感染抑制効果

Research Project

片峰茂長崎大学, 大学院医歯薬学総合研究科, 教授

4. Trial of development of therapeutic using PPS modified penetrating efficacy into brain.

Research Project

5. Structure-based drug designs for the treatment of prion disease

Research Project

6. Biological studies on prions

Research Project

7. Experimental-therapeutic potency of pentosan pofysulfate as an anti-prion and anti-dementia drug

Research Project

8. プリオン病感染因子の本体と複製分子機構の解明

Research Project

片峰茂長崎大学, 大学院・医歯薬学総合研究科, 教授

9. 非通常病原体プリオンの分子機構

Research Project

片峰茂長崎大学, 大学院・医歯薬学総合研究科, 教授

10. Producing and Certification of Recombinant Antigen with LCMV Isolated in Japan for Diagnosis of LCMV Infection in Mice.

Research Project

11. A COHORT STUDY ON THE CANCER INCIDENCE IN AN AREA WHERE HTLV I, HCV AND HBV ARE ENDEMIC

Research Project

12. Proteome Analysis for Early Diagnosis of Prion Disease

Research Project

13. プリオン病感染因子の本体と複製分子機構の解明

Research Project

片峰茂長崎大学, 大学院・医歯薬学総合研究科, 教授

14. プリオン感染培養細胞系によるプリオン複製の分子機構解明

Research Project

片峰茂長崎大学, 大学院・医学研究科, 教授

15. Therapeutic trial of prion infected mice by continuous infusion of anti-prion agent to brain

Research Project

16. Physiological and pathological functions of a novel prion-like protein, PrPLP/Dpl.

Research Project

17. プリオン病感染因子の本体と複製分子機構の解明

Research Project

片峰茂長崎大学, 大学院・医学研究科, 教授

18. Producing of Recombinant Antigen with LCMV Isolated in Japan and Diagnosis of LCMV Infection in Mice

Research Project

19. A NESTED CASE-CONTROL STUDY ON THE INTERACTION BETWEEN HCV AND HTLV-I IN THE DEVELOPMENT OF LIVER CANCER

Research Project

20. EFFECTS OF HEALTH EDUCATION ON BEHAVIORAL CHANGES IN, PREVENTION OF HIV/AIDS AND URINARY SCHISTOSOMIASIS

Research Project