KAKEN — Research Projects | Researcher Number: 50011937

Search Results: 17 results / Researcher Number: 50011937

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1. Identification of the origin of urinary peptides and the assessment of protein nutrition as its application

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	食品科学・栄養科学
Research Institution	Chubu University
Principal Investigator	NOGUCHI Tadashi Chubu University, College of Bioscience and Biotechnology, Professor
Project Period (FY)	2002 – 2004Completed
Keywords	Urinary peptide / protein nutrition / nutritional evaluation / Protein degradation / peptide analysis
Research Abstract	Human urine contains a significant amount of peptides. It has been proved by the present author and his coworkers that the rate of body protein degrad ...

2. Amino Acids as Signaling Factors and the Molecular Network Transducing Their Information

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	食品科学・栄養科学
Research Institution	THE UNIVERSITY OF TOKYO
Principal Investigator	KATO Hisanori Graduate School of Agriculture and Life Sciences, Associate Professor
Project Period (FY)	2000 – 2002Completed
Keywords	amino acid / transcription factor / IGF binding protein / DNA microarray / insulin receptor / mTOR / leucine / translation factor
Research Abstract	The mechanism whereby amino acids regulate gene expression was studied with a major focus on the gene for insulin-like growth factor binding protein-1 ...

Research Products of this project	Publications (29 results)

3. Effect of Diet and Hormone on the Regulation of Body Protein Synthesis

Research Project

Research Category	Grant-in-Aid for Scientific Research (B).
Research Field	食品科学・栄養科学
Research Institution	THE UNIVERSITY OF TOKYO
Principal Investigator	NOGUCHI Tadashi Graduate School of Agriculture and life Sciences THE UNIVERSITY OF TOKYO Professor
Project Period (FY)	1998 – 2000Completed
Keywords	Insulin-like growth factor-1 / IGF-binding protein / insulin / translation initiation factor / transcription factor / protein deficiency
Research Abstract	Protein metabolism is regulated by many factors including hormonal and nutritional factors. The author showed that body protein gain or loss is well e ...

Research Products of this project	Publications (18 results)

4. 経口シグナル応答における内分泌系および神経系の機能

Research Project

Research Category	Grant-in-Aid for Exploratory Research
Research Field	食品科学・栄養科学
Research Institution	The University of Tokyo
Principal Investigator	野口忠東京大学, 大学院・農学生命科学研究科, 教授
Project Period (FY)	1997 – 1998Completed
Keywords	経口シグナル / 必須アミノ酸欠乏 / トランスサイレチン / C4アナフィラトキシン / コレシストキニン
Research Abstract	食物を摂取するということは、生体に多くの応答を誘起する。それらには、神経系を介した応答、内分泌系を介した応答などが複雑に関係していると考えられている。本研究では、必須アミノ酸欠乏食を摂取すると、急速に食欲が低下する減少に注目し、その条件下で、どのような応答が生体に誘起されるかについて、いくつかの側面 ...

Research Products of this project	Publications (1 results)

5. Mechanism of regulation of protein metabolism by insulin-like growth factor-I

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	食品科学・栄養科学
Research Institution	The University of Tokyo
Principal Investigator	NOGUCHI Tadashi The University of Tokyo, Graduate School of Agricultural and Life Sciences, Professor
Project Period (FY)	1996 – 1997Completed
Keywords	IGF-I / IGFBP-1 / protein metabolism / dexamethasone / streptozotocin / IGF-binding protein / diabetes / insulin-like growth factor-I
Research Abstract	Insulin-like growth factor-I (IGF-I) is a hormone the structure and function of which are similar to those of insulin. However, as we and others have ...

Research Products of this project	Publications (18 results)

6. 機能性食品の解析と分子設計

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Research Institution	The University of Tokyo
Principal Investigator	荒井綜一東京大学, 農学部, 教授
Project Period (FY)	1995Completed
Keywords	機能性食品 / 食品の三次機能 / 生体調節因子 / 生体防御因子 / 機能性蛋白質 / 食品機能 / 食品の内因性物質 / 食品の外因性物質
Research Abstract	平成4年4月.同補助金による重点領域研究「機能性食品の解析と分子設計」が発足した。これは、既設の2つの大型研究の思想をプリンシプルとして継承しながらも、"機能性食品"という実体を具体的研究対象として念頭に置きつつ解析から設計までを網羅し、研究の新たな展開を意図したものであった。新機軸としては、生体の ...

Research Products of this project	Publications (24 results)

7. Physiological role of IGF-I in the nutrition of central nervous system

Research Project

Research Category	Grant-in-Aid for General Scientific Research (B)
Research Field	食品科学・栄養科学
Research Institution	The University of Tokyo
Principal Investigator	NOGUCHI Tadashi The University of Tokyo, Professor
Project Period (FY)	1994 – 1995Completed
Keywords	IGF-I / IGF-II / IGF-binding protein / Protein nutrition / Insulin-like growth factor
Research Abstract	To elucidate the physiological role of IGF-I in the nutrition of central nervous system, the following studies were performed. ...

Research Products of this project	Publications (6 results)

8. インスリン様成長因子Iおよびその関連遺伝子の食餌による発現調節機構の解析

Research Project

Research Category	Grant-in-Aid for General Scientific Research (B)
Research Field	食品科学・栄養科学
Research Institution	The University of Tokyo
Principal Investigator	野口忠東京大学, 農学部, 教授
Project Period (FY)	1993Completed
Keywords	インスリン様成長因子I / IGF-I / インスリン様成長因子結合タンパク質 / 転写調節因子 / ゲルシフトアッセイ
Research Abstract	インスリン様成長因子-I(IGF-I)は、血漿中の濃度がよく応答するホルモンである。また、このホルモンは、血漿中で特異的な結合タンパク質(複数が知られている;IGFBP)と結合して存在しており、このIGFBPの血漿中の濃度も、食餌条件によく応答して変化する。この濃度変化によく対応して、IGF-IやI ...

Research Products of this project	Publications (3 results)

9. Protein Nutrition and IGF-I and IGF-related Proteins Nutritional Regulation of Biosynthesis and Biological Action of IGF-I and IGF-related Proteins.

Research Project

Research Category	Grant-in-Aid for international Scientific Research
Research Institution	The University of Tokyo
Principal Investigator	NOGUCHI Tadashi The University of Tokyo, Faculty of Agriculture, Professor
Project Period (FY)	1993 – 1994Completed
Keywords	Insulin-like growth factors / Insulin-like growth factor binding proteins / Insulin-like growth factor-I receptor / Tyrosine phosphorylation / Protein nutrition / Protein metabolism
Research Abstract	1) Plasma concentrations and gene expression of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding proteins (IGFBPs) under va ...

Research Products of this project	Publications (25 results)

10. A new nutrition with the knowledges of life science and molecular biology

Research Project

Research Category	Grant-in-Aid for Co-operative Research (A)
Research Field	応用生物化学・栄養化学
Research Institution	KYOTO UNIVERSITY
Principal Investigator	SUGIMOTO Etsuro Kyoto Univ., Agric., Prof.
Project Period (FY)	1991 – 1992Completed
Keywords	Cell proliferation and differentiation / Adipocytes / Serum cholesterol / Dietary fiber / Apo A-I / IGF-I / Pancreatic enzymes / Xenobiotics
Research Abstract	Studies of new style of nutrition were performed with a cutting edge of a life science and molecular biology. It includes the interaction between nutr ...

Research Products of this project	Publications (25 results)

11. Role of somatomedin C in anabolism and catabolism of body proteins

Research Project

Research Category	Grant-in-Aid for General Scientific Research (B)
Research Field	応用生物化学・栄養化学
Research Institution	The University of Tokyo
Principal Investigator	NOGUCHI Tadashi The University of Tokyo, Faculty of Agriculture, Professor
Project Period (FY)	1990 – 1992Completed
Keywords	Somatomedin C / Insulin-like growth factor-I / Protein nutrition / IGF-binding proteins / Insulin / Growth / IGF-I / IGF-I mRNA
Research Abstract	Somatomedin C, or insulin-like growth factor-I (IGF-I), is a peptide hormone which has been suggested to play an important role in growth and protein ...

Research Products of this project	Publications (11 results)

12. 生体における食品成分の受容・応答の機作

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Research Institution	Kyoto University
Principal Investigator	井村裕夫京都大学, 医学部, 教授
Project Period (FY)	1988Completed
Keywords	味覚 / 食欲 / 膵酵素 / インスリン / 糖代謝 / 成長因子 / 血圧 / 自律神経
Research Abstract	食品成分に対する生体の受容・応答の機構について検討を行った。まずイヌにおいて味覚応答の機構を研究し、甘味が塩によって増強されることを見出した。またコンブ中の中性画分に摂食を促進する物質が存在することを明らかにした。次に食品成分に対する膵酵素の応答について検討し、モニターペプチドが膵液分泌調節に関与す ...

Research Products of this project	Publications (6 results)

13. 生体における食品成分の受容・応答の機作

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Research Institution	Kyoto University
Principal Investigator	井村裕夫京都大学, 医学部, 教授
Project Period (FY)	1988 – 1990Completed
Keywords	嗅覚・味覚 / 摂食 / インスリン作用 / インスリン分泌 / 増殖因子レセプタ- / 血圧 / 成長ホルモン / IGF
Research Abstract	食品成分に対する生体の応答を、感覚,消化管、内分泌・代謝,自律神経・血圧などいくつかのレベルで研究した。種々の物質に対する嗅覚の識別能を慣れの現象で見ると,温度によって相異があり、膜の構造が関与する可能性が示された。また糖に対する味覚応答の食塩による促進機構で新しい知見を得た。次にラットにおいて香気 ...

Research Products of this project	Publications (6 results)

14. 生体における食品成分の受容・応答の機作

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Research Institution	Kyoto University
Principal Investigator	井村裕夫京都大学, 医学部, 教授
Project Period (FY)	1988 – 1990Completed
Keywords	味覚応答 / 嗅覚応答 / 食欲促進物質 / インスリン分泌 / インスリン受容体 / インスリン様成長因子 / 血圧 / 食品成分
Research Abstract	食品成分の味、においの感覚への影響を神経系の応答を指標として検査する方法を確立し、この方法を用いて嗅覚の応答における慣れの現象と化学構造の関係を明らかにした。また昆布の成分中にラットの摂食行動を促進する物質を見出し、その精製を行って構造を解析した。次に食品成分の糖代謝への影響を、インスリン分泌、作用 ...

Research Products of this project	Publications (7 results)

15. Production of low-gizzerosine fish meal

Research Project

Research Category	Grant-in-Aid for Developmental Scientific Research
Research Field	応用生物化学・栄養化学
Research Institution	Faculty of Agriculture, The University of Tokyo
Principal Investigator	NOGUCHI Tadashi (1988-1989) Univ. of Tokyo, Faculty of Agric. Professor 内藤博 (1987) 東京大学, 農学部, 教授
Project Period (FY)	1987 – 1989Completed
Keywords	Gizzerosine / Gizzard erosion / Supplementation of lysine / Fish meal
Research Abstract	Gizzerosine is a causative compound of chicken gizzard erosion induced by over-heated fish meals. Gizzerosine is not contained in fresh fish meat but ...

Research Products of this project	Publications (7 results)

16. Somatomedin C in protein and amino acid nutrition

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	応用生物化学・栄養化学
Research Institution	The University of Tokyo
Principal Investigator	NOGUCHI Tadashi Faculty of Agric., The Univ. of Tokyo Professor
Project Period (FY)	1987 – 1989Completed
Keywords	Somatomedin C / Insulin-like growth factor-I / Protein nutrition / Whole-body protein synthesis rate / somatomedin C-mRNA
Research Abstract	Somatomedin C (or insulin-like growth factor-I, IGF-I) is a peptide hormone, the structure of which is known to be similar to insulin. However, IGF-I ...

Research Products of this project	Publications (12 results)

17. 機能性食品の設計・構成に関する研究

Research Project

Research Category	Grant-in-Aid for Special Project Research
Research Institution	The University of Tokyo
Principal Investigator	山内邦男東大, 農学部, 教授
Project Period (FY)	1986Completed
Keywords	牛乳アレルギー / フェニルケトン尿症 / β-ラクトグロブリン / エリスロポエチン / インスリン様成長因子【I】 / 高度不飽和脂肪酸 / 脂質酸化 / 乳酸菌
Research Abstract	山内(東大農)は牛乳アレルギーの主要原因物質であるβ-ラクトグロブリン(β-LG)に対する数種のモノクローナル抗体を用いて、β-LGの高次構造におけるβ-ストランドA上に1ヵ所、ランダムコイル上に2ヵ所のエピトープを決定した。T細胞によって認識させるエピトープも3ヵ所限局化し、これらの結果に基づいて ...

Research Products of this project	Publications (6 results)