KAKEN — Research Projects | Researcher Number: 60130415

1. Genetic diversity and evolutionary history of HCV genotype 6 variants in Southeast Asia

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Experimental pathology
Research Institution	National Institute of Infectious Diseases
Principal Investigator	ABE KENJI 国立感染症研究所, その他部局等, 研究員
Project Period (FY)	2013-04-01 – 2016-03-31Completed
Keywords	B型肝炎 / C型肝炎 / 肝癌 / ウイルス変異株 / ウイルスゲノタイプ / エマージング感染症 / ベトナム / 東南アジア / HBVゲノタイプ / HCVゲノタイプ / 麻疹流行 / C型肝炎ウイルス / HCVゲノタイプ6変異株 / 風疹 / カンボジア
Outline of Final Research Achievements	In Vietnam and Cambodia, we confirmed 3 different genotypes consists of genotypes 1, 2 and 6 were prevalent. In both countries, genotype 6 variants we ...

Research Products of this project	Int'l Joint Research (6 results) Journal Article (10 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 10 results, Open Access: 2 results, Acknowledgement Compliant: 6 results) Presentation (1 results, of which Int'l Joint Research: 1 results, Invited: 1 results)

2. Comparative pathological study on H5N1 infection between humans and animals

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Experimental pathology
Research Institution	National Institute of Infectious Diseases
Principal Investigator	ABE Kenji 国立感染症研究所, 感染病理部, 主任研究官
Project Period (FY)	2009 – 2011Completed
Keywords	インフルエンザ / H5N1 / 比較病理 / 感染動物 / 国際協力 / 分子疫学 / 国際研究 / H1N1
Research Abstract	We investigated autopsy cases of tigers and cats infected with H5N1.The animals had eaten fresh chicken or dead pigeon carcass infected with H5N1 and ...

Research Products of this project	Journal Article (13 results, of which Peer Reviewed: 4 results) Presentation (13 results) Book (2 results)

3. Geographic pathology of HBV-related hepatitis and liver cancers based on characterization of HBV genome variant

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Human pathology
Research Institution	National Institute of Infectious Diseases
Principal Investigator	ABE Kenji 国立感染症研究所, 感染病理部, 主任研究官
Project Period (FY)	2009 – 2012Completed
Keywords	アジア / 国際連携 / 国際研究 / B型肝炎ウイルス(HBV) / ウイルス肝炎 / ウイルス肝癌 / 地理病理学 / 分子疫学 / ウイルスゲノタイプ / ウイルス変異株 / 肝癌 / 小児肝癌 / 東南アジア / ベトナム / 台湾 / B型肝炎 / HBV / 胆管癌 / 台湾アボリジン
Research Abstract	(1) HBV DNA in HCC tissues from children patients was detected in 36 of 42 (86%) cases tested. Surprisingly, very high prevalence of HBV pre-S deletio ...

Research Products of this project	Journal Article (17 results, of which Peer Reviewed: 5 results) Presentation (20 results, of which Invited: 1 results) Book (2 results)

4. Epidemiological survey of water-borne hepatitis virus infection and study on an improvement in public health

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	国際保健医療研究
Research Institution	National Institute of Infectious Diseases
Principal Investigator	ABE Kenji National Institute of Infectious Diseases
Project Period (FY)	2007 – 2008Completed
Keywords	肝炎ウイルス / A型肝炎 / E型肝炎 / 劇症肝炎 / 小児肝炎 / 非B非C型肝炎 / 国際保健 / 疫学 / 成因不明肝炎
Research Abstract	東南アジア4カ国におけるHEVの血清疫学調査を実施した結果、HEV-IgG抗体陽性率はタイ(バンコク)・27%、ベトナム(ホーチミン)・42%、ミャンマー(ヤンゴン)・35%、ネパール(カトマンズ)・66%といずれも高値を示した。年代別抗体獲得率は、16~30歳代で既に20%を越えていた。ネパールで ...

Research Products of this project	Journal Article (16 results, of which Peer Reviewed: 12 results) Presentation (4 results)

5. The study of the development of diagnostic methods, molecular epidemiology and risk assessment for viral infections diseases.

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Pediatrics
Research Institution	The International University of Kagoshima (2007) The University of Tokyo (2006)
Principal Investigator	USHIJIMA Hiroshi The International University of Kagoshima, Graduate School of Welfare Society, Professor
Project Period (FY)	2006 – 2007Completed
Keywords	virus / infectious disease / diagnosis / epidemiology / pathophysiology
Research Abstract	1)Norovirus polyclonal and monoclonal antibodies were produced by using norovirus-like particles as antigen. Immunoclomatography test kit for noroviru ...

Research Products of this project	Journal Article (168 results, of which Peer Reviewed: 86 results) Presentation (68 results) Book (4 results)

6. Molecular epidemiology of hepatitis E virus in Japan and study on animal host of virus.

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Experimental pathology
Research Institution	National Institute of Infectious Diseases
Principal Investigator	ABE Kenji National Institute of Infectious Diseases, Department of Pathology, Senior Research Scientist
Project Period (FY)	2004 – 2005Completed
Keywords	Hepatitis E / HEV / Animal host / International study
Research Abstract	I conducted seroepidemiological studies on antibody prevalence to hepatitis E virus (HEV) in 5,233 sera from 11 countries to ascertain the present sta ...

Research Products of this project	Journal Article (16 results)

7. The study of infectious diseases in infants and children in Asia

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Pediatrics
Research Institution	The University of Tokyo
Principal Investigator	USHIJIMA Hiroshi The University of Tokyo, Graduate School of Medicine, Professor
Project Period (FY)	2004 – 2006Completed
Keywords	viral gastroenteritis / viral hepatitis / HIV / mother to child infection / diagnosis / molecular epidemiology / Asia
Research Abstract	Development of diagnosis and molecular epidemiological study have done in Asian children mainly with viral gastroenteritis, viral hepatitis and HIV in ...

Research Products of this project	Journal Article (184 results) Book (13 results)

8. アジアにおけるHBVゲノタイプ分布および変異株流行様式と肝発癌との開連

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Review Section	Biological Sciences
Research Institution	National Institute of Infectious Diseases
Principal Investigator	阿部賢治国立感染症研究所, 感染病理部, 主任研究官
Project Period (FY)	2004Completed
Keywords	アジア / B型肝炎ウイルス / HBVゲノタイプ / ウイルス変異株 / 肝癌
Research Abstract	アジア地域を中心として、HBV変異株の流行実態を調査した結果、preS gene変異株はベトナムでの検出率が36%と最も高く、次いでネパール(27.3%)、ミャンマー(23.3%)、中国(22.4%)、韓国(14.3%)、タイ(10.5%)、日本(7.7%)であった。高い検出率を示したのは、いずれも ...

Research Products of this project	Journal Article (5 results)

9. Study of simian TT virus (s-TTV) infection and its pathogenesis to humans

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Experimental pathology
Research Institution	National Institute of Infectious Diseases
Principal Investigator	ABE Kenji National Institute of Infectious Diseases, Department of Pathology, Senior Researcher
Project Period (FY)	2002 – 2003Completed
Keywords	TT virus (TTV) / simian TTV (s-TTV) / molecular epidemiology / zoonosis
Research Abstract	Recently, we identified TTV isolates from nonhuman primates and named them simian TTV (s-TTV). To investigate the prevalence of s-TTV in humans, we ex ...

Research Products of this project	Publications (34 results)

10. Research of genetic analysis. of hepatitis C virus clones and immune response in reinfection experiment using chimpanzees.

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Experimental pathology
Research Institution	Nihon University
Principal Investigator	SUGITANI Masahiko Nihon University, School of Medicine, Associate Professor
Project Period (FY)	2002 – 2003Completed
Keywords	Hepatitis C virus (HCV) / Hypervariable region-1 / Chimpanzee / Reinfection experiment / HCV cloning / Anti-HCV antibody
Research Abstract	To investigate whether the genetically same hepatitis C virus (HCV) could twice reinfect the same chimpanzee or not, we analyzed amino acid sequences ...

Research Products of this project	Publications (4 results)

11. Molecular epidemiological research of maternal and child infection (mainly focused on blood and oral transmission)

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Pediatrics
Research Institution	The University of Tokyo
Principal Investigator	USHIJIMA Hiroshi The University of Tokyo, Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, Professor
Project Period (FY)	2001 – 2003Completed
Keywords	Asia / molecular epidemiology / diarrheal virus / hepatitis virus / HIV
Research Abstract	We have been studying on molecular epidemiologies of diarrheal viruses, hepatitis viruses and HIV. We developed first the techniques of multiplex PCR ...

Research Products of this project	Publications (191 results)

12. 国際間比較からみた新規ウイルスおよびウイルス変異株の病因論の展開

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas (C)
Review Section	Biological Sciences
Research Institution	National Institute of Infectious Diseases
Principal Investigator	阿部賢治国立感染症研究所, 感染病理部, 主任研究官
Project Period (FY)	2001Completed
Keywords	新規ウイルス / TTV / TTVゲノタイプ / 分子疫学 / 分子系統樹
Research Abstract	本研究の目的は、近年新たに登場した新規ウイルスの分子疫学、成因不明とされる疾患との関連を分子レベルで解明することである。また、既知ウイルスとその変異株の流行様式も分子レベルで解析し、病態との関連を追及した上で、その病因論の展開を試みる。この目的を達成するため、多くの発展途上国を含む世界14カ国との国 ...

Research Products of this project	Publications (5 results)

13. Pathological and molecular-based virological studies of TTV and s-TTV infection

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Experimental pathology
Research Institution	National Institute of Infectious Diseases
Principal Investigator	ABE Kenji National Institute of Infectious Diseases, Department of Pathology, Senior Researcher
Project Period (FY)	2000 – 2001Completed
Keywords	TTV / Simian TTV (s-TTV) / TTV DNA / TTV particle / Molecular epidemiology
Research Abstract	1) Detection of TTV DNA in body fluids : ...

Research Products of this project	Journal Article (18 results, of which Peer Reviewed: 9 results) Presentation (4 results) Publications (11 results)

14. 持続感染ウイルスと発癌に関する民族疫学的研究

Research Project

Research Category	Grant-in-Aid for Scientific Research on Priority Areas (C)
Review Section	Biological Sciences
Research Institution	National Institute of Infectious Diseases
Principal Investigator	阿部賢治国立感染症研究所, 感染病理部, 主任研究官
Project Period (FY)	2000Completed
Keywords	G型肝炎ウイルス / HGV / 肝癌 / 民族疫学 / ゲノタイプ / PCRゲノタイピング / 分子疫学 / HGV4型
Research Abstract	G型肝炎ウイルス(HGV)の民族疫学について解析した結果、健常人におけるHGV陽性率は、いわゆる先進国では1〜1.4%であったのに対し、発展途上国では8〜14.6%であった。これら諸国から収集したHGV株の塩基配列を決定し、分子系統樹解析にてゲノタイプ分類を行った結果、ミャンマー、ベトナムにおいて、 ...

Research Products of this project	Publications (6 results)

15. Molecular epidemiology of hepatitis G virus infection

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Experimental pathology
Research Institution	National Institute of Infectious Diseases
Principal Investigator	ABE Kenji Nat. Inst. Inf. Dis., Pathology, Senior Researcher
Project Period (FY)	1998 – 1999Completed
Keywords	Hepatitis G / Hepatitis G virus / HGV genotype / HGV type 4 / Myanmar / Vietnam / Molecular epidemiology / phylogenetic analysis
Research Abstract	We recently identified a novel genotype of hepatitis G virus (HGV) in Southeast Asian countries. To characterize the viral genome in more detail, we c ...

Research Products of this project	Publications (28 results)

16. STUDY ON MOLECULAR EPIDEMIOLOGY OF HIV AND HEPATITIS VIRUS INFECTIONS IN ASIA

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Virology
Research Institution	NATIONAL INSTITUTE OF INFECTIOUS DISEASES
Principal Investigator	TAKEBE Yutaka NATIONAL INSTITUTE OF INFECTIOUS DISEASES, AIDS RESEARCH CENTER, CHIEF
Project Period (FY)	1998 – 2000Completed
Keywords	ASIA / AIDS / HIV / HBV / HCV / HGV / MOLECULAR EPIDEMIOLOGY / SURVEILLANCE
Research Abstract	(A)Molecular epidemiology of HIV in Asia

Research Products of this project	Journal Article (24 results) Publications (46 results)

17. C型肝炎の病態解明に関する実験病理および分子ウイルス学的研究

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	Experimental pathology
Research Institution	国立予防衛生研究所
Principal Investigator	阿部賢治国立予防衛生研究所, 感染病理部, 主任研究員
Project Period (FY)	1995Completed
Keywords	C型肝炎ウイルス / チンパンジー実験 / 遺伝子変異 / 慢性C型肝炎 / Escape mutant / ウイルスキャリア
Research Abstract	C型肝炎ウイルス(HCV)感染症は高率にキャリア化することが知られているが、そのメカニズムは未だ明確にされていない。そこで本年度は、HCV遺伝子の変異と肝炎の進展の関係についてチンパンジー実験から解析した。方法は、HCV-F株の接種により感染が成立した6頭のチンパンジーから経時的に採取した血清を用い ...

Research Products of this project	Publications (4 results)

18. Pathelogical and nualecular biological study of Hepatitis C Virus infection

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	Experimental pathology
Research Institution	National Institute of Health
Principal Investigator	ABE Kenji Natioral Institute of Health
Project Period (FY)	1993 – 1994Completed
Keywords	Hepatitis C / Hepatitis C virus / Chimpangee exparimint / Nested RT-PCR / HCV antibody / Paraffin embedded tissnes / Transmission study / Infection pattern
Research Abstract	The relationship between hepatitis C virus RNA and hepatitis C virus-associated antibodies (antibody against the putative capsid protein and C-100 ant ...

Research Products of this project	Publications (7 results)

19. Animal Experimental Model of Human Hepatocellular Carcinoma

Research Project

Research Category	Grant-in-Aid for Developmental Scientific Research
Research Field	Laboratory animal science
Research Institution	UNIVERSITY OF TOKYO
Principal Investigator	SHIGA Junji University of Tokyo Pathology Associate Professor
Project Period (FY)	1989 – 1991Completed
Keywords	Woodchuck / Woodchuck hepatitis virus / Hepatic cancer / PCR / RIA
Research Abstract	Basical problems about conditions of care and breeding woodchucks such as cages, housing or food were solved. We made stainless steel indoor cages(O. ...

Research Products of this project	Publications (35 results)

20. 非A非B型ウイルス性肝炎に関する総合的研究

Research Project

Research Category	Grant-in-Aid for Co-operative Research (A)
Research Institution	Nihon University
Principal Investigator	志方俊夫日本大学, 医学部, 教授
Project Period (FY)	1989Completed
Keywords	非A非B型肝炎 / C型肝炎 / C肝炎ウイルス遺伝子 / PCR法 / C型肝炎関連抗体 / C型肝炎ウイルス粒子 / 肝細胞癌
Research Abstract	輸血後の非A非B型肝炎の起因ウイルスの内メジャ-なものが遺伝子のクロ-ニングにより発見され、C型肝炎ウイルスと呼ばれるようになった。この仕事はアメリカのカイロン社によりなされたが、殆ど同時に全く独立して本研究班の有馬により成功されている。又志方のグル-プによりクロ-ニングされたC型肝炎ウイルスの株は ...

Research Products of this project	Publications (5 results)

Project Period (Start Year [FY])

1. Genetic diversity and evolutionary history of HCV genotype 6 variants in Southeast Asia Research Project

ABE KENJI 国立感染症研究所, その他部局等, 研究員

2. Comparative pathological study on H5N1 infection between humans and animals Research Project

ABE Kenji 国立感染症研究所, 感染病理部, 主任研究官

3. Geographic pathology of HBV-related hepatitis and liver cancers based on characterization of HBV genome variant Research Project

ABE Kenji 国立感染症研究所, 感染病理部, 主任研究官

4. Epidemiological survey of water-borne hepatitis virus infection and study on an improvement in public health Research Project

ABE Kenji National Institute of Infectious Diseases

5. The study of the development of diagnostic methods, molecular epidemiology and risk assessment for viral infections diseases. Research Project

USHIJIMA Hiroshi The International University of Kagoshima, Graduate School of Welfare Society, Professor

6. Molecular epidemiology of hepatitis E virus in Japan and study on animal host of virus. Research Project

ABE Kenji National Institute of Infectious Diseases, Department of Pathology, Senior Research Scientist

7. The study of infectious diseases in infants and children in Asia Research Project

USHIJIMA Hiroshi The University of Tokyo, Graduate School of Medicine, Professor

8. アジアにおけるHBVゲノタイプ分布および変異株流行様式と肝発癌との開連 Research Project

阿部 賢治 国立感染症研究所, 感染病理部, 主任研究官

9. Study of simian TT virus (s-TTV) infection and its pathogenesis to humans Research Project

ABE Kenji National Institute of Infectious Diseases, Department of Pathology, Senior Researcher

10. Research of genetic analysis. of hepatitis C virus clones and immune response in reinfection experiment using chimpanzees. Research Project

SUGITANI Masahiko Nihon University, School of Medicine, Associate Professor

11. Molecular epidemiological research of maternal and child infection (mainly focused on blood and oral transmission) Research Project

USHIJIMA Hiroshi The University of Tokyo, Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, Professor

12. 国際間比較からみた新規ウイルスおよびウイルス変異株の病因論の展開 Research Project

阿部 賢治 国立感染症研究所, 感染病理部, 主任研究官

13. Pathological and molecular-based virological studies of TTV and s-TTV infection Research Project

ABE Kenji National Institute of Infectious Diseases, Department of Pathology, Senior Researcher

14. 持続感染ウイルスと発癌に関する民族疫学的研究 Research Project

阿部 賢治 国立感染症研究所, 感染病理部, 主任研究官

15. Molecular epidemiology of hepatitis G virus infection Research Project

ABE Kenji Nat. Inst. Inf. Dis., Pathology, Senior Researcher

16. STUDY ON MOLECULAR EPIDEMIOLOGY OF HIV AND HEPATITIS VIRUS INFECTIONS IN ASIA Research Project

TAKEBE Yutaka NATIONAL INSTITUTE OF INFECTIOUS DISEASES, AIDS RESEARCH CENTER, CHIEF

17. C型肝炎の病態解明に関する実験病理および分子ウイルス学的研究 Research Project

阿部 賢治 国立予防衛生研究所, 感染病理部, 主任研究員

18. Pathelogical and nualecular biological study of Hepatitis C Virus infection Research Project

ABE Kenji Natioral Institute of Health

19. Animal Experimental Model of Human Hepatocellular Carcinoma Research Project

SHIGA Junji University of Tokyo Pathology Associate Professor

20. 非A非B型ウイルス性肝炎に関する総合的研究 Research Project

志方 俊夫 日本大学, 医学部, 教授

1. Genetic diversity and evolutionary history of HCV genotype 6 variants in Southeast Asia

Research Project

2. Comparative pathological study on H5N1 infection between humans and animals

Research Project

3. Geographic pathology of HBV-related hepatitis and liver cancers based on characterization of HBV genome variant

Research Project

4. Epidemiological survey of water-borne hepatitis virus infection and study on an improvement in public health

Research Project

5. The study of the development of diagnostic methods, molecular epidemiology and risk assessment for viral infections diseases.

Research Project

6. Molecular epidemiology of hepatitis E virus in Japan and study on animal host of virus.

Research Project

7. The study of infectious diseases in infants and children in Asia

Research Project

8. アジアにおけるHBVゲノタイプ分布および変異株流行様式と肝発癌との開連

Research Project

阿部賢治国立感染症研究所, 感染病理部, 主任研究官

9. Study of simian TT virus (s-TTV) infection and its pathogenesis to humans

Research Project

10. Research of genetic analysis. of hepatitis C virus clones and immune response in reinfection experiment using chimpanzees.

Research Project

11. Molecular epidemiological research of maternal and child infection (mainly focused on blood and oral transmission)

Research Project

12. 国際間比較からみた新規ウイルスおよびウイルス変異株の病因論の展開

Research Project

阿部賢治国立感染症研究所, 感染病理部, 主任研究官

13. Pathological and molecular-based virological studies of TTV and s-TTV infection

Research Project

14. 持続感染ウイルスと発癌に関する民族疫学的研究

Research Project

阿部賢治国立感染症研究所, 感染病理部, 主任研究官

15. Molecular epidemiology of hepatitis G virus infection

Research Project

16. STUDY ON MOLECULAR EPIDEMIOLOGY OF HIV AND HEPATITIS VIRUS INFECTIONS IN ASIA

Research Project

17. C型肝炎の病態解明に関する実験病理および分子ウイルス学的研究

Research Project

阿部賢治国立予防衛生研究所, 感染病理部, 主任研究員

18. Pathelogical and nualecular biological study of Hepatitis C Virus infection

Research Project

19. Animal Experimental Model of Human Hepatocellular Carcinoma

Research Project

20. 非A非B型ウイルス性肝炎に関する総合的研究

Research Project

志方俊夫日本大学, 医学部, 教授