KAKEN — Research Projects | Researcher Number: 70270527

Search Results: 17 results / Researcher Number: 70270527

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1. Individual differences in the effect of vitamin D on improving physical and mental health and prevention of vitamin D deficiency using apps

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Review Section	Basic Section 59040:Nutrition science and health science-related
Research Institution	Wayo Women's University
Principal Investigator	鈴木敏和和洋女子大学, 家政学部, 教授
Project Period (FY)	2023-04-01 – 2026-03-31Granted
Keywords	ビタミンD / 心身的健康 / 遺伝子一塩基多型 / ビタミンD結合タンパク質 / 個人差
Outline of Research at the Start	これまでに、ビタミンD (VD)の不足とうつ病の発症や心身的健康レベルの低下の関連が示されている。本研究では、VDの体内充足の程度と心身的健康レベル、ならびにVD代謝の個人差やVD作用と関連のある10個の遺伝子一塩基多型 (SNP) の関連について明らかにする。またVDサプリメントによる心身的健康レ ...
Outline of Annual Research Achievements	18～22歳の女性を対象に、「ビタミンDサプリメント摂取の心身的健康状態改善効果およびその個人差の検討」という名のビタミンD摂取試験を行った。介入前の試験は、2023年12月に実施し、2024年1月より3か月間、1日当たり25μg (1000U)のビタミンDサプリメントを参加者に摂取してもらった。介 ...
Current Status of Research Progress	2: Research has progressed on the whole more than it was originally planned.

Research Products of this project	Journal Article (1 results, of which Peer Reviewed: 1 results, Open Access: 1 results)

2. Study onthe anti-aging effct of coenzyme Q10 with considering individual differences

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Review Section	Basic Section 59040:Nutrition science and health science-related
Research Institution	Wayo Women's University
Principal Investigator	鈴木敏和和洋女子大学, 家政学部, 教授
Project Period (FY)	2019-04-01 – 2025-03-31Granted
Keywords	補酵素Q10 / サプリメント / 遺伝子一塩基多型 / アンチエイジング / 食品 / 補酵素10 / SF-36 / 吸収 / 個人差
Outline of Research at the Start	補酵素Q10 (CoQ10) は、アンチエイジングの食品機能性成分として期待されているが、体感の個人差の大きいことが課題である。本研究では、CoQ10の吸収に関連した遺伝子上の個人差から、「体感しやすい」群と「体感しにくい」群に分けられるか検証する。さらに、CoQ10の吸収を上げるような食品成分を見 ...
Outline of Annual Research Achievements	昨年度に引き続き、「還元型CoQ10含有食品摂取による健康維持・増進効果の遺伝的個人差」という臨床試験を愛媛県上島町および新居浜市で実施しているQ10ヨーグルト健診参加者を対象に継続実施した。CoQ10を100mg含むヨーグルトを毎日摂取した参加者に、半年後の2023年5月および1年後の11月に健診 ...
Current Status of Research Progress	3: Progress in research has been slightly delayed.

Research Products of this project	Journal Article (5 results, of which Peer Reviewed: 4 results, Open Access: 4 results) Presentation (6 results)

3. Study of nutritional guidance methods with coenzyme Q10 intake considering genetic variation aimed at healthy longevity

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Eating habits
Research Institution	Wayo Women's University
Principal Investigator	Suzuki Toshikazu 和洋女子大学, 生活科学系, 教授
Project Period (FY)	2015-04-01 – 2018-03-31Completed
Keywords	補酵素Q10 / 遺伝子多型 / 健康長寿 / 栄養強化食品 / 吸収
Outline of Final Research Achievements	Coenzyme Q10 (CoQ10) is a candidate functional component expected to preserve and increase human’s health and prevent and retard aging and related dis ...

Research Products of this project	Journal Article (8 results, of which Int'l Joint Research: 2 results, Peer Reviewed: 6 results, Open Access: 3 results, Acknowledgement Compliant: 1 results) Presentation (13 results, of which Int'l Joint Research: 3 results)

4. Development of novel detection method of bioactibity of injured tissue from biological specimen

Research Project

Research Category	Grant-in-Aid for Challenging Exploratory Research
Research Field	Applied health science
Research Institution	Chiba University
Principal Investigator	NOMURA JUN 千葉大学, 教育学部, 教授
Project Period (FY)	2012-04-01 – 2015-03-31Completed
Keywords	メカニカルストレス / 創傷治癒 / ハーブ抽出成分 / スカーレスヒーリング / メディカルハーブ / 生理活性検出 / 運動療法 / 炎症制御 / 細胞運動 / 炎症反応 / 検出系
Outline of Final Research Achievements	We aimed to develop novel detection method for bioactive materials from various biological specimens which has healing activity of tissue injury. We ...

Research Products of this project	Journal Article (3 results, of which Peer Reviewed: 1 results) Presentation (4 results) Book (1 results)

5. Study of the mechanism of obesity-associated infertility in male and search for nutrient component improving obesity associated infertility

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Integrated Nutrition Science
Research Institution	Wayo Women's University
Principal Investigator	SUZUKI Toshikazu 和洋女子大学, 生活科学系, 准教授
Project Period (FY)	2011 – 2013Completed
Keywords	雄性不妊 / 肥満 / 高脂肪食 / 精巣 / 精巣上体 / 遺伝子解析
Research Abstract	Human studies have shown a direct relationship between obesity and infertility in men and women. In the present study, we examined the mechanism of in ...

Research Products of this project	Journal Article (10 results, of which Peer Reviewed: 2 results) Presentation (21 results)

6. The role of chaperones and micro RNA on regulation of radiation-induced mutation in human physiological functions.

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Risk sciences of radiation/Chemicals
Research Institution	Chiba University
Principal Investigator	SUZUKI Nobuo Chiba University
Project Period (FY)	2008 – 2010Completed
Keywords	ヒト / 放射線 / 変異 / シャペロン / プロテアーゼ / 血清 / 細胞 / DNA修復 / ヒト細胞 / マイクロRNA
Research Abstract	The following two points were mainly identified in mechanisms which regulate mutability in human. (1) When the HSP27 and annexin II complex is involve ...

Research Products of this project	Journal Article (44 results, of which Peer Reviewed: 21 results) Presentation (24 results) Book (2 results) Patent(Industrial Property Rights) (2 results)

7. Complex of annexin II with cytoplasmic molecular chaperons is involved in novel DNA repair-regulating mechanisms

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Risk sciences of radiation/Chemicals
Research Institution	Chiba University
Principal Investigator	KITA Kazuko Chiba University
Project Period (FY)	2007 – 2008Completed
Keywords	ヒト細胞 / 紫外線(UVC)抵抗性 / HSP27結合タンパク質 / annexin II / 損傷DNA修復 / シャペロン / 安定化 / 紫外線抵抗性 / annexinII
Research Abstract	短波長紫外線(UVC)ストレスに対応し、annexin II を実行因子、HSP27をシャペロンとするDNA損傷ストレス防御複合体が、UVC抵抗性に関わるとの仮説を立証すべく解析を行った。その結果、1) annexin II はHSP27 と複合体を形成すること、2) 両者の複合体は紫外線照射に応じ ...

Research Products of this project	Journal Article (18 results, of which Peer Reviewed: 18 results) Presentation (4 results) Patent(Industrial Property Rights) (2 results)

8. The study of modulating effects on X-ray induced cell mutability by chaperons and autophagy

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Risk sciences of radiation/Chemicals
Research Institution	Chiba University
Principal Investigator	SUZUKI Nobuo Chiba University, Graduate School of Medicine, PROFESSOR
Project Period (FY)	2006 – 2007Completed
Keywords	annexin II / aldolase A / human serum / chaperon / autophagy / X-ray / human cell / UV (ultraviolet)
Research Abstract	The present work is designed to investigate the role of chaperons and autophagy on the suppressive physiological functions for radiation-induced mutag ...

Research Products of this project	Journal Article (30 results, of which Peer Reviewed: 16 results) Presentation (28 results)

9. Molecular mechanisms of GRP78-involving process to repair UVC-damaged DNA

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Risk sciences of radiation/Chemicals
Research Institution	Chiba University
Principal Investigator	KITA Kazuko Chiba University, Graduate School of Medicine, Lecturer
Project Period (FY)	2005 – 2006Completed
Keywords	human cells / UV / DNA damage / DNA repair / ER molecular chaperone / GRP78 / sensitivity to cell death
Research Abstract	There are only a few reports about the roles of the 78-kDa glucose-regulated protein (GRP78) in human cell response to DNA-damaging stresses. We previ ...

Research Products of this project	Journal Article (32 results)

10. DNA脱メチル化による細胞老化誘導機構の解析

Research Project

Research Category	Grant-in-Aid for Young Scientists (B)
Research Field	Biological pharmacy
Research Institution	Chiba University
Principal Investigator	鈴木敏和千葉大学, 大学院・医学研究院, 助手
Project Period (FY)	2004 – 2005Completed
Keywords	細胞老化 / DNAメチル化 / ヘテロクロマチン
Research Abstract	細胞の老化に伴うDNAのシトシンメチル化量の減少が、約20年前以上前より知られている。しかし、その生理的意義はよく分かっていない。一方で私たちは、細胞の老化に伴って、古典的サテライト配列を含むヘテロクロマチン領域DNAが損傷を受けること、およびその領域のDNAメチル化が減少することを報告してきた。最 ...

Research Products of this project	Journal Article (1 results)

11. The study of modulating effects on X-ray induced cell mutability by chaperons and SUMO.

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Risk sciences of radiation/Chemicals
Research Institution	Chiba University
Principal Investigator	SUZUKI Nobuo Chiba University, Graduate School of Medicine, PROFESSOR
Project Period (FY)	2004 – 2005Completed
Keywords	GENE MUTATION / HUMAN CELL / HUMAN SERUM / CHAPERON / UBIQUITIN-LIKE-PROTEIN / X-RAY / OXIDATIVE STRESS / HYDROPEROXIDE
Research Abstract	We previously reported that modulation of cell mutability by human serum factors is associated with increased levels of protease activity. The present ...

Research Products of this project	Journal Article (26 results)

12. Role of ER stress sensor Bip/GRP78 in protection of genome stability from DNA damaging stresses

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Risk sciences of radiation/Chemicals
Research Institution	Chiba University
Principal Investigator	KITA Kazuko Chiba University, Graduated School of Medicine, Lecturer
Project Period (FY)	2003 – 2004Completed
Keywords	ER stress proteins / Bip / GRP78 / DNA damage / UV / human cells / sensitivity to cell death / DNA repair / molecular chaperone
Research Abstract	In contrast to extensive studies on the roles of molecular chaperones in mammalian cell responses to DNA-damaging stresses, there are only a few repor ...

Research Products of this project	Journal Article (20 results) Publications (4 results)

13. The relationship between molecular mechanisms of serum factors and bystander effects modulating cell mutability.

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	環境影響評価(含放射線生物学)
Research Institution	Chiba University
Principal Investigator	SUZUKI Nobuo Chiba University, Graduate School of Medicine, Professor
Project Period (FY)	2002 – 2003Completed
Keywords	GENE MUTATION / HUMAN CELL / HUMAN SERUM / BYSTANDER EFFECT / CHAPERON / ULTRAVIOLET RAY / X-RAY / DNA REPAIR
Research Abstract	We previously reported that modulation of cell mutability by human serum factors is associated with increased levels of protease activity. However, ra ...

Research Products of this project	Publications (27 results)

14. 細胞老化関連遺伝子の探索とその解析

Research Project

Research Category	Grant-in-Aid for Encouragement of Young Scientists (A)
Research Field	Biological pharmacy
Research Institution	Yokohama City University
Principal Investigator	鈴木敏和横浜市立大学, 木原生物学研究所, 助手
Project Period (FY)	2000 – 2001Completed
Keywords	細胞老化 / 遺伝子 / ブロモデオキシウリジン
Research Abstract	チミジン類似体のブロモデオキシウリジンは、正常細胞および不死化細胞の両者において速やかに、かつ同調的に細胞老化を誘導する。細胞老化関連遺伝子のカタログ化、各遺伝子の細胞老化における役割および遺伝子の共通の発現調節機構の解明を目的として、ブロモデオキシウリジンで発現が上昇する遺伝子をサブトラクション- ...

Research Products of this project	Publications (3 results)

15. ヒトD群不死化抑制遺伝子のマッピングとポジショナルクローニング

Research Project

Research Category	Grant-in-Aid for Encouragement of Young Scientists (A)
Research Field	Biological pharmacy
Research Institution	Yokohama City University
Principal Investigator	鈴木敏和横浜市立大学, 木原生物学研究所, 助手
Project Period (FY)	1998 – 1999Completed
Keywords	不死化抑制遺伝子 / マッピング / DT40
Research Abstract	昨年度は苦労の末、正常に増殖するヒト7番染色体を含むDT40由来雑種細胞(DT40ー7R)の取得に成功した。微小核細胞融合法により、この細胞のヒト7番染色体をD群不死化細胞株Met5Aへ導入したところ、分裂停止を誘導したことから、雑種細胞はD群不死化抑制遺伝子を安定に保持していることが確認された。そ ...

16. Cloning of an immortality-suppressor gene on human chromosome 7

Research Project

Research Category	Grant-in-Aid for Scientific Research (B).
Research Field	Cell biology
Research Institution	Kihara Institute for Biological Research
Principal Investigator	AYUSAWA Dai Kihara Institute for Biological Research Professor
Project Period (FY)	1997 – 1999Completed
Keywords	chromosome 7 / microcell-mediated chromosome transfer / YAC / BAC / radiation hybrid / senescence / telomerase / telomere / STS marker
Research Abstract	Approximately 50% of immortal human cell lines so far tested seem to have a mutation on a gene on human chromosome 7 since introduction of this chromo ...

Research Products of this project	Publications (24 results)

17. Molecular mechanisms for mammalian glucose transporter expression and its function associated with human tumorigenesis.

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Biological pharmacy
Research Institution	National Institute of Infectious Diseases, Tokyo, Japan.
Principal Investigator	KITAGAWA Takayuki NATIONAL INSTITUTE OF INFECTIOUS DESEASES (NIID), DEPARTMENT OF BIOCHEMISTRY AND CELL BIOLOGY,LABORATORY CHIEF
Project Period (FY)	1996 – 1997Completed
Keywords	GLUCOSE TRANSPORTER / N-LINKED GLYCOPROTEIN / TUMOR SUPPRESSOR / HUMAN TUMOR CELLS / CAVEOLIN / MEMBRANE PROTEINS
Research Abstract	Glucose uptake in mammalian cells is mediated by an integral membrane protein, glucose transporter, which is an N-linked glycoprotein with molecular m ...

Research Products of this project	Publications (4 results)