KAKEN — Research Projects | Researcher Number: 80271633

1. Drug-associated progressive multifocal leukoencephalopathy: Establishment of early diagnostic criteria with understanding of the anti-viral host response

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Review Section	Basic Section 49020:Human pathology-related
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	宍戸由紀子 (宍戸ー原由紀子) 京都府立医科大学, 医学(系)研究科(研究院), 准教授
Project Period (FY)	2023-04-01 – 2026-03-31Granted
Keywords	進行性多巣性白質脳症 / JCウイルス / 薬剤関連 / 脳生検 / 鑑別診断 / 炎症 / 悪性リンパ腫 / PML / JCV / 免疫再構築症候群 / 免疫抑制剤 / 早期診断
Outline of Research at the Start	進行性多巣性白質脳症(PML)は、JCウイルス(JCV)感染による脱髄脳症である。人口の大半に持続・潜伏感染するJCVは、宿主免疫能の低下に伴い再活性化する。1980年代、PMLは後天性免疫不全症候群(AIDS)に合併する致死的疾患として知られていたが、2004年以降、多発性硬化症の疾患修飾薬など、 ...
Outline of Annual Research Achievements	進行性多巣性白質脳症(progressive multifocal leukoencephalopathy: PML)はJCウイルス(JCV)感染による脱髄脳症である。JCVは人口の大半に持続・潜伏感染し、宿主免疫能の低下に伴い再活性化してPMLを発症する。かつてPMLは後天性免疫不全症候群(AID ...
Current Status of Research Progress	2: Research has progressed on the whole more than it was originally planned.

Research Products of this project	Journal Article (3 results, of which Peer Reviewed: 3 results, Open Access: 2 results)

2. Development of spike protein CpG-ODN nasal vaccine against COVID-19

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Review Section	Basic Section 55060:Emergency medicine-related
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	佐和貞治京都府立医科大学, 医学(系)研究科(研究院), 教授
Project Period (FY)	2022-04-01 – 2026-03-31Granted
Keywords	COVID-19 / 経鼻ワクチン / CpG ODN / SARS-CoV2 / 肺炎 / 新型コロナウイルス感染症 / SARS-CoV2ウイルス / スパイクタンパク / CpG ODNアジュバント / スパイク蛋白 / 免疫 / ウイルス感染 / 抗体免疫 / CpGアジュバント / Oligodeoxynucleotide / ワクチン / 経鼻
Outline of Research at the Start	新型コロナウイルス感染(COVID-19)は， SARS-CoV-2の経気道感染による急性肺傷害発生が重症化の起点となる．経鼻ワクチン投与で有効な気道粘膜における免疫力を高めることが可能であれば，投与が簡便で，かつ副作用も少ない有効な免疫の確立が期待できる可能性がある．そこで，粘膜刺激ワクチン用とし ...
Outline of Annual Research Achievements	新型コロナウイルス感染(COVID-19)は， SARS-CoV-2の経気道感染による急性肺傷害発生が重症化の起点となる．経鼻ワクチン投与で有効な気道粘膜における免疫力を高めることが可能であれば，投与が簡便で，かつ副作用も少ない有効な免疫の確立が期待できる可能性がある．そこで，粘膜刺激ワクチン用とし ...
Current Status of Research Progress	2: Research has progressed on the whole more than it was originally planned.

Research Products of this project	Journal Article (11 results, of which Peer Reviewed: 7 results, Open Access: 5 results) Presentation (5 results, of which Int'l Joint Research: 3 results)

3. Transmission of SARS-CoV-2 and influenza viruses

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Review Section	Basic Section 58020:Hygiene and public health-related: including laboratory approach
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	中屋隆明京都府立医科大学, 医学(系)研究科(研究院), 教授
Project Period (FY)	2021-04-01 – 2024-03-31Completed
Keywords	インフルエンザウイルス / 伝播機構 / SARS-CoV-2 / コロナウイルス / COVID-19 / 薬剤耐性機構 / ウイルス / 薬剤耐性ウイルス / 飛沫 / インフルエンザ / ウイルス粒子構造
Outline of Research at the Start	本研究ではコロナウイルス（SARS-CoV-2）およびインフルエンザウイルスのヒト間伝播機構の解明を研究目的とする。
Outline of Annual Research Achievements	１．「コロナウイルスの生体（皮膚）表面および環境中におけるウイルス粒子安定性の解析」綿、ポリエステル製の乾燥スワブ（乾燥条件）と回収液に浸したスワブ（湿潤条件）での擦過回収について、種々の物体表面（1～400cm2）に対しインフルエンザウイルス等を塗布し、ウイルスRNA、感染性ウイルスの回収率を比較 ...

Research Products of this project	Journal Article (15 results, of which Peer Reviewed: 15 results, Open Access: 14 results) Presentation (4 results, of which Invited: 1 results) Book (1 results)

4. Development of CAR-T cell therapy complementary system for rhabdomyosarcoma using oncolytic virus

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Review Section	Basic Section 50020:Tumor diagnostics and therapeutics-related
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	Hosoi Hajime 京都府立医科大学, 医学(系)研究科(研究院), 特任教授
Project Period (FY)	2020-04-01 – 2023-03-31Completed
Keywords	腫瘍溶解性アデノウイルス / 小児がん / 腫瘍溶解性ウイルス / CAR-T療法 / プロモーター制御 / CAR-T / エフェクターサイトカイン / 制御性T細胞 / エクソソーム / T-reg
Outline of Research at the Start	本研究では、我々の研究を発展させる形で、エフェクターサイトカインを分泌し、CAR-T細胞を活性化させるOAdを開発することでRMSに対する特異的CAR-T細胞治療の効果を強化する。また、sh-Foxp3を分泌しTregの機能を低下させるOAdを開発し、これらを組み合わせることで、より効果的な抗腫瘍作 ...
Outline of Final Research Achievements	We initially aimed to develop an oncolytic adenovirus (OAd) to enhance CAR-T therapy, but the acquisition of the essential plasmid for OAd production ...

5. Study on the transmission system of influenza virus due to the viscosity of aerosol

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Review Section	Basic Section 58020:Hygiene and public health-related: including laboratory approach
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	NAKAYA TAKAAKI 京都府立医科大学, 医学(系)研究科(研究院), 教授
Project Period (FY)	2018-04-01 – 2021-03-31Completed
Keywords	インフルエンザウイルス / 飛沫感染 / エアロゾル / COVID-19 / SARS-CoV-2 / 伝播機構 / 飛沫 / ウイルス / インフルエンザ / 呼吸器ウイルス / 空気感染 / 呼吸器感染ウイルス / 粘性 / 手指衛生 / レオロジー / 粘弾性 / 腸管感染
Outline of Final Research Achievements	We demonstrated that the efficacy of hand-washing using ethanol-based disinfectant against mucus is greatly reduced until infectious mucus adhering to ...

Research Products of this project	Journal Article (11 results, of which Int'l Joint Research: 2 results, Peer Reviewed: 11 results, Open Access: 9 results) Presentation (2 results, of which Int'l Joint Research: 1 results, Invited: 2 results) Remarks (1 results)

6. Monitoring possible emergence of H5N1 influenza variants with higher pandemic potential in Egypt

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Infectious disease medicine
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	Watanabe Yohei 京都府立医科大学, 医学(系)研究科(研究院), 講師
Project Period (FY)	2015-04-01 – 2020-03-31Completed
Keywords	ウイルス学 / 感染症内科学 / インフルエンザウイルス / 国際感染症
Outline of Final Research Achievements	Egypt has had the highest numbers of human infection cases of H5N1 influenza viruses. In this study, we performed comprehensive surveillance for avian ...

Research Products of this project	Int'l Joint Research (9 results) Journal Article (34 results, of which Int'l Joint Research: 17 results, Peer Reviewed: 33 results, Open Access: 18 results, Acknowledgement Compliant: 5 results) Presentation (40 results, of which Int'l Joint Research: 13 results, Invited: 8 results) Book (1 results) Remarks (5 results)

7. Characterizing avian influenza H5N1 viruses in Egypt

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Hygiene and public health
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	NAKAYA Takaaki 京都府立医科大学, 医学(系)研究科(研究院), 教授
Project Period (FY)	2015-04-01 – 2018-03-31Completed
Keywords	インフルエンザ / H5N1 / エジプト / ペプチド核酸 / ウイルス / 検出系 / Ｈ５Ｎ１
Outline of Final Research Achievements	We reported that highly pathogenic avian influenza H5N1 viruses, isolated from naturally infected pigeons in Egypt, have several unique mutations in v ...

Research Products of this project	Int'l Joint Research (3 results) Journal Article (16 results, of which Int'l Joint Research: 5 results, Peer Reviewed: 15 results, Acknowledgement Compliant: 4 results) Presentation (8 results, of which Int'l Joint Research: 1 results, Invited: 6 results) Book (1 results) Patent(Industrial Property Rights) (1 results)

8. Preclinical study of Pseudomonas aeruginosa PcrV-CpG(K3)-SPG Vaccine

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Emergency medicine
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	Sawa Teiji 京都府立医科大学, 医学(系)研究科(研究院), 教授
Project Period (FY)	2015-04-01 – 2018-03-31Completed
Keywords	緑膿菌 / ワクチン / 三型分泌システム / PcrV / CpG oligonucleotide / 肺炎 / 動物モデル / 前臨床試験 / 経鼻 / アジュバント / 経鼻ワクチン / Ⅲ型分泌システム / 急性肺傷害 / 細菌性肺炎 / CpG
Outline of Final Research Achievements	An effective vaccine against Pseudomonas aeruginosa would be hugely beneficial to people who are susceptible to the serious infections caused by it. V ...

Research Products of this project	Journal Article (23 results, of which Peer Reviewed: 12 results, Acknowledgement Compliant: 2 results) Presentation (21 results, of which Int'l Joint Research: 3 results, Invited: 12 results) Book (4 results) Patent(Industrial Property Rights) (1 results) Funded Workshop (1 results)

9. Establishment of a procedure to eliminate viral sequences by means of the chromosome editing

Research Project

Research Category	Grant-in-Aid for Challenging Exploratory Research
Research Field	Infectious disease medicine
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	KISHIDA Tsunao 京都府立医科大学, 医学(系)研究科(研究院), 准教授
Project Period (FY)	2014-04-01 – 2015-03-31Completed
Keywords	感染症治療学
Outline of Final Research Achievements	For the treatment of HIV infection, some medicines that suppress particular viral proteins are commonly used and have improved clinical outcomes. Howe ...

Research Products of this project	Journal Article (4 results, of which Peer Reviewed: 4 results) Presentation (1 results)

10. Infection kinetics of avian H5N1 influenza viruses in human airway epithelial cells by bio-imaging analysis

Research Project

Research Category	Grant-in-Aid for Challenging Exploratory Research
Research Field	Infectious disease medicine
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	NAKAYA Takaaki 京都府立医科大学, 医学(系)研究科(研究院), 教授
Project Period (FY)	2012-04-01 – 2014-03-31Completed
Keywords	インフルエンザウイルス / H5N1 / 呼吸器上皮細胞 / バイオイメージング / ウイルス
Research Abstract	Highly pathogenic avian influenza H5N1 viruses have spread across Eurasia and into Africa; however, the mechanism underlying the pathogenesis of H5N1 ...

Research Products of this project	Journal Article (7 results, of which Peer Reviewed: 3 results) Presentation (13 results, of which Invited: 4 results) Remarks (2 results)

11. Use of peptide nucleic acid probes for pathogen-targeted metagenomics

Research Project

Research Category	Grant-in-Aid for Challenging Exploratory Research
Research Field	Laboratory medicine
Research Institution	Osaka University
Principal Investigator	YASUNAGA Teruo 大阪大学, 微生物病研究所, 教授
Project Period (FY)	2012Completed
Keywords	遺伝子検査学 / 遺伝子診断
Research Abstract	Metagenomics is becoming an important tool for comprehensive pathogen detection from clinical specimens. So far, using this methodology, we have detec ...

Research Products of this project	Journal Article (1 results, of which Peer Reviewed: 1 results) Presentation (5 results) Remarks (1 results)

12. Development of PNA-based chromatography for rapid detection of respiratory viruses

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Laboratory medicine
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	NAKAYA TAKAAKI 京都府立医科大学, 医学(系)研究科(研究院), 教授
Project Period (FY)	2012-04-01 – 2015-03-31Completed
Keywords	迅速診断 / デバイス / インフルエンザウイルス / ペプチド核酸 / ウイルス検出 / マイクロ流体システム / ウイルス / クロマトデバイス / オンチップ / 感染症
Outline of Final Research Achievements	In this study, we developed a novel chromatography kit for the subtype-specific detection of influenza A viruses. Azobenzene-tethered hairpin-type pep ...

Research Products of this project	Journal Article (11 results, of which Peer Reviewed: 10 results, Open Access: 2 results, Acknowledgement Compliant: 1 results) Presentation (6 results, of which Invited: 2 results) Book (1 results)

13. Basis research in evolutionary mechanism of H5N1 highly pathogenic avian influenza viruses

Research Project

Research Category	Grant-in-Aid for Young Scientists (B)
Research Field	Infectious disease medicine
Research Institution	Osaka University
Principal Investigator	WATANABE Yohei 大阪大学, 微生物病研究所, 助教
Project Period (FY)	2011-04-28 – 2015-03-31Completed
Keywords	国際感染症 / ウイルス学 / 人獣共通感染症 / インフルエンザウイルス / インフルエンザ / 鳥インフルエンザウイルス / 人獣共同感染症 / 変異 / ヒト適応性 / エジプト / H5N1
Outline of Final Research Achievements	We have searched mutations that H5N1 highly pathogenic avian influenza viruses acquired during their dissemination in Egypt. The results showed that s ...

Research Products of this project	Journal Article (5 results, of which Peer Reviewed: 5 results) Presentation (10 results, of which Invited: 3 results) Remarks (2 results)

14. Development of method for comprehensive isolation and purification of viral particles from clinical specimens

Research Project

Research Category	Grant-in-Aid for Challenging Exploratory Research
Research Field	Laboratory medicine
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	NAKAYA Takaaki 京都府立医科大学, 大学院・医学研究科, 教授
Project Period (FY)	2011 – 2012Completed
Keywords	ウイルス / ウイルス粒子精製 / インフルエンザウイルス / ニューカッスル病ウイルス / メタゲノム
Research Abstract	A more effective method to purify viral paricles from clinical specimens is required in metagenomic analysis of pathogens using a high-throughput DNA ...

Research Products of this project	Journal Article (7 results, of which Peer Reviewed: 4 results) Presentation (7 results, of which Invited: 2 results) Book (2 results) Remarks (3 results)

15. Metagenomic research of virus infections in human clinical specimens by high-throughput DNA sequencing in Thailand

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Infectious disease medicine
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	NAKAYA Takaaki 京都府立医科大学, 医学(系)研究科(研究院), 教授
Project Period (FY)	2011-04-01 – 2014-03-31Completed
Keywords	ウイルス / メタゲノム / 次世代シーケンサー / タイ / タイ王国 / ハイスループットシーケンサー / 感染症 / タイ国 / ウイルス感染症 / ハイスループットシークエンサー / インフルエンザウイルス
Research Abstract	Newly developed next-generation sequencing (NGS) technologies can be used to generate large amounts of unbiased data (gigabases) in a single round of ...

Research Products of this project	Journal Article (12 results, of which Peer Reviewed: 7 results) Presentation (8 results, of which Invited: 3 results) Book (2 results) Remarks (2 results)

16. Surveillance study tracking the changing nature of influenza viruses derived from domestic animals and birds in Egypt and Thailand

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Laboratory medicine
Research Institution	Osaka University
Principal Investigator	Ikuta Kazuyoshi 大阪大学, 医学(系)研究科(研究院), 招へい教授
Project Period (FY)	2011-04-01 – 2016-03-31Completed
Keywords	ウイルス学 / インフルエンザ / 人獣共通感染症 / 検査 / 国際研究者交流 / エジプト / 病態検査学 / 疫学 / 感染症 / ウイルス / 高病原性鳥インフルエンザ / 変異 / 鳥インフルエンザウイルス / タイ / アレキサンドリア大学 / ダマンフール大学 / マヒドン大学 / ヒト病原性 / 迅速診断キット / 病原性 / 遺伝子配列
Outline of Final Research Achievements	H5N1 highly pathogenic avian influenza viruses have become endemic in birds in Southeast Aria and Egypt. In particular, Egypt has a substantially　high ...

Research Products of this project	Int'l Joint Research (3 results) Journal Article (30 results, of which Int'l Joint Research: 1 results, Peer Reviewed: 29 results, Open Access: 1 results, Acknowledgement Compliant: 4 results) Presentation (24 results, of which Invited: 3 results) Book (1 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results, of which Overseas: 1 results)

17. A study to solve the mystery of AIDS pandemic by expeditions into the most remote areas in the Congo basin.

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Virology
Research Institution	Tokyo Medical and Dental University
Principal Investigator	IDO Eiji 東京医科歯科大学, 医歯(薬)学総合研究科, 特任教授
Project Period (FY)	2010-04-01 – 2014-03-31Completed
Keywords	ウイルス / HIV / 感染症 / エイズ / 進化 / アフリカ / コンゴ盆地 / コンゴ民主共和国 / 分子進化 / コンゴ民主 / コンゴ / 分子疫学 / コンゴ共和国 / 起源
Research Abstract	The purpose of this study is to clarify the mystery of AIDS pandemic (when, where and how did it occur?) as well as the origin of HIV. To do so, we ha ...

Research Products of this project	Journal Article (30 results, of which Peer Reviewed: 29 results) Presentation (23 results, of which Invited: 1 results) Book (2 results)

18. 次世代型シーケンサによる未知病原体同定システム構築に必要な新技術開発

Research Project

Research Category	Grant-in-Aid for Challenging Exploratory Research
Research Field	Infectious disease medicine
Research Institution	Osaka University
Principal Investigator	中屋隆明大阪大学, 微生物病研究所, 特任准教授
Project Period (FY)	2009 – 2010Completed
Keywords	世代シーケンサー / ウイルス / 感染症 / 次世代シーケンサー
Research Abstract	希少病原体(ウイルス)によるアウトブレイクへの対応には、病原体の迅速な同定が不可欠である。しかしながら未知の病原体を同定するには数ヶ月を要する(SARSでは4ヶ月)とともに、エボラウイルス等既知の病原体に対しても検査に必要とする抗体等の検査試薬は国内にほとんど存在しない。一方、ヒトのみならず野生動物 ...

Research Products of this project	Journal Article (5 results, of which Peer Reviewed: 5 results) Presentation (10 results) Book (2 results)

19. Epidemiological and virological studies on avian influenza virus H5N1 in Egypt

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Infectious disease medicine
Research Institution	Osaka University
Principal Investigator	IKUTA Kazuyoshi Osaka University
Project Period (FY)	2008 – 2010Completed
Keywords	鳥インフルエンザウイルス / エジプト / アレキサンドリア大学 / ニワトリ / アヒル / ハト / 遺伝子配列 / 病原性
Research Abstract	Highly pathogenic avian influenza A virus (HPAIV H5N1) is currently widespread in several areas. Although the current H1N1 pandemic may have diverted ...

Research Products of this project	Journal Article (36 results, of which Peer Reviewed: 36 results) Presentation (18 results) Remarks (3 results)

20. Analysis of the mechanisms involved in influenza virus replication and cytopathicity

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	膠原病・アレルギー・感染症内科学
Research Institution	Osaka University
Principal Investigator	NAKAYA Takaaki Osaka University
Project Period (FY)	2007 – 2008Completed
Keywords	呼吸器感染症 / インフルエンザウイルス / H5N1 / アポトーシス / SARSコロナウイルス
Research Abstract	高病原性鳥インフルエンザH5N1ウイルス(H5N1-Flu)の感染・増殖と細胞傷害性との関係については今なお不明な点が多い。本研究では、ブタ呼吸器上皮由来の初代細胞による感染実験系を確立し、H5N1-Fluの感染試験を行った。その結果、H5N1-Fluによる細胞傷害性は(カスパーゼ依存的な)アポトー ...

Research Products of this project	Journal Article (17 results, of which Peer Reviewed: 17 results) Presentation (13 results) Remarks (1 results) Patent(Industrial Property Rights) (4 results)

Project Period (Start Year [FY])

1. Drug-associated progressive multifocal leukoencephalopathy: Establishment of early diagnostic criteria with understanding of the anti-viral host response Research Project

宍戸 由紀子 (宍戸ー原由紀子) 京都府立医科大学, 医学(系)研究科(研究院), 准教授

2. Development of spike protein CpG-ODN nasal vaccine against COVID-19 Research Project

佐和 貞治 京都府立医科大学, 医学(系)研究科(研究院), 教授

3. Transmission of SARS-CoV-2 and influenza viruses Research Project

中屋 隆明 京都府立医科大学, 医学(系)研究科(研究院), 教授

4. Development of CAR-T cell therapy complementary system for rhabdomyosarcoma using oncolytic virus Research Project

Hosoi Hajime 京都府立医科大学, 医学(系)研究科(研究院), 特任教授

5. Study on the transmission system of influenza virus due to the viscosity of aerosol Research Project

NAKAYA TAKAAKI 京都府立医科大学, 医学(系)研究科(研究院), 教授

6. Monitoring possible emergence of H5N1 influenza variants with higher pandemic potential in Egypt Research Project

Watanabe Yohei 京都府立医科大学, 医学(系)研究科(研究院), 講師

7. Characterizing avian influenza H5N1 viruses in Egypt Research Project

NAKAYA Takaaki 京都府立医科大学, 医学(系)研究科(研究院), 教授

8. Preclinical study of Pseudomonas aeruginosa PcrV-CpG(K3)-SPG Vaccine Research Project

Sawa Teiji 京都府立医科大学, 医学(系)研究科(研究院), 教授

9. Establishment of a procedure to eliminate viral sequences by means of the chromosome editing Research Project

KISHIDA Tsunao 京都府立医科大学, 医学(系)研究科(研究院), 准教授

10. Infection kinetics of avian H5N1 influenza viruses in human airway epithelial cells by bio-imaging analysis Research Project

NAKAYA Takaaki 京都府立医科大学, 医学(系)研究科(研究院), 教授

11. Use of peptide nucleic acid probes for pathogen-targeted metagenomics Research Project

YASUNAGA Teruo 大阪大学, 微生物病研究所, 教授

12. Development of PNA-based chromatography for rapid detection of respiratory viruses Research Project

NAKAYA TAKAAKI 京都府立医科大学, 医学(系)研究科(研究院), 教授

13. Basis research in evolutionary mechanism of H5N1 highly pathogenic avian influenza viruses Research Project

WATANABE Yohei 大阪大学, 微生物病研究所, 助教

14. Development of method for comprehensive isolation and purification of viral particles from clinical specimens Research Project

NAKAYA Takaaki 京都府立医科大学, 大学院・医学研究科, 教授

15. Metagenomic research of virus infections in human clinical specimens by high-throughput DNA sequencing in Thailand Research Project

NAKAYA Takaaki 京都府立医科大学, 医学(系)研究科(研究院), 教授

16. Surveillance study tracking the changing nature of influenza viruses derived from domestic animals and birds in Egypt and Thailand Research Project

Ikuta Kazuyoshi 大阪大学, 医学(系)研究科(研究院), 招へい教授

17. A study to solve the mystery of AIDS pandemic by expeditions into the most remote areas in the Congo basin. Research Project

IDO Eiji 東京医科歯科大学, 医歯(薬)学総合研究科, 特任教授

18. 次世代型シーケンサによる未知病原体同定システム構築に必要な新技術開発 Research Project

中屋 隆明 大阪大学, 微生物病研究所, 特任准教授

19. Epidemiological and virological studies on avian influenza virus H5N1 in Egypt Research Project

IKUTA Kazuyoshi Osaka University

20. Analysis of the mechanisms involved in influenza virus replication and cytopathicity Research Project

NAKAYA Takaaki Osaka University

1. Drug-associated progressive multifocal leukoencephalopathy: Establishment of early diagnostic criteria with understanding of the anti-viral host response

Research Project

宍戸由紀子 (宍戸ー原由紀子) 京都府立医科大学, 医学(系)研究科(研究院), 准教授

2. Development of spike protein CpG-ODN nasal vaccine against COVID-19

Research Project

佐和貞治京都府立医科大学, 医学(系)研究科(研究院), 教授

3. Transmission of SARS-CoV-2 and influenza viruses

Research Project

中屋隆明京都府立医科大学, 医学(系)研究科(研究院), 教授

4. Development of CAR-T cell therapy complementary system for rhabdomyosarcoma using oncolytic virus

Research Project

5. Study on the transmission system of influenza virus due to the viscosity of aerosol

Research Project

6. Monitoring possible emergence of H5N1 influenza variants with higher pandemic potential in Egypt

Research Project

7. Characterizing avian influenza H5N1 viruses in Egypt

Research Project

8. Preclinical study of Pseudomonas aeruginosa PcrV-CpG(K3)-SPG Vaccine

Research Project

9. Establishment of a procedure to eliminate viral sequences by means of the chromosome editing

Research Project

10. Infection kinetics of avian H5N1 influenza viruses in human airway epithelial cells by bio-imaging analysis

Research Project

11. Use of peptide nucleic acid probes for pathogen-targeted metagenomics

Research Project

12. Development of PNA-based chromatography for rapid detection of respiratory viruses

Research Project

13. Basis research in evolutionary mechanism of H5N1 highly pathogenic avian influenza viruses

Research Project

14. Development of method for comprehensive isolation and purification of viral particles from clinical specimens

Research Project

15. Metagenomic research of virus infections in human clinical specimens by high-throughput DNA sequencing in Thailand

Research Project

16. Surveillance study tracking the changing nature of influenza viruses derived from domestic animals and birds in Egypt and Thailand

Research Project

17. A study to solve the mystery of AIDS pandemic by expeditions into the most remote areas in the Congo basin.

Research Project

18. 次世代型シーケンサによる未知病原体同定システム構築に必要な新技術開発

Research Project

中屋隆明大阪大学, 微生物病研究所, 特任准教授

19. Epidemiological and virological studies on avian influenza virus H5N1 in Egypt

Research Project

20. Analysis of the mechanisms involved in influenza virus replication and cytopathicity

Research Project