KAKEN — Research Projects | Researcher Number: 90160663

Search Results: 19 results / Researcher Number: 90160663

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1. Developmental study for the control of enzootic bovine leukosis~Improvement of prognosis method and development of vaccine~

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Veterinary medical science
Research Institution	Health Sciences University of Hokkaido
Principal Investigator	OKAZAKI Katsunori 北海道医療大学, 薬学部, 教授
Project Period (FY)	2016-04-01 – 2020-03-31Completed
Keywords	地方病性牛白血病 / 牛白血病ウイルス / Tax蛋白質 / アネキシンA3 / 予後診断 / ワクチン / Taxタンパク質 / 発症前診断 / モノクローナル抗体 / 発症前診断法 / 持続性ウイルス産生細胞株 / 血管新生 / 病原性 / リアルタイムPCR / 感染性クローン / ウィルス / 獣医学 / 免疫学
Outline of Final Research Achievements	Bovine leukemia virus is a causative agent of enzootic bovine leukosis (EBL). Cattle infected with the virus carrying Tax with Pro at aa233 (P-type vi ...

Research Products of this project	Journal Article (3 results, of which Int'l Joint Research: 3 results, Peer Reviewed: 3 results, Open Access: 1 results) Presentation (13 results, of which Invited: 2 results)

2. Development research on the control of enzootic bovine leukosis

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Applied veterinary science
Research Institution	Health Sciences University of Hokkaido
Principal Investigator	Okazaki Katsunori 北海道医療大学, 薬学部, 教授
Project Period (FY)	2012-04-01 – 2016-03-31Completed
Keywords	enzootic bovine leucosis / bovine leukemia virus / control / Tax / colostrum / 地方病性牛白血病 / 牛白血病ウイルス / Taxタンパク質 / RNaseH / 逆転写酵素 / ワクチン / 発症前診断 / 弱毒生ワクチン / ドミナント・ネガティブ効果 / がん関連遺伝子 / 転写調節 / 母子感染 / 診断
Outline of Final Research Achievements	Bovine leukemia virus (BLV) is a causative agent of enzootic bovine leucosis. Cattle infected with the virus carrying Tax with Pro at amino acid posit ...

Research Products of this project	Journal Article (12 results, of which Peer Reviewed: 11 results, Acknowledgement Compliant: 2 results) Presentation (16 results, of which Invited: 1 results) Book (1 results)

3. Development of antiviral drugs inhibiting fusion between viral envelope and cellular membrane

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Virology
Research Institution	Health Sciences University of Hokkaido
Principal Investigator	OKAZAKI Katsunori Health Sciences University of Hokkaido, Dept of Pharmaceutical Sciences, Professor
Project Period (FY)	2006 – 2007Completed
Keywords	influenza virus / hemaaelutinin / α-helix / synthetic peptide / pandemic / monoclonal antibod / MHC class II molecule
Research Abstract	We found that each subtype (H1-H16) of influenza virus hemagglutinin (HA) contained the consensus sequence in a-helix region of HA2 subunit of the gly ...

Research Products of this project	Journal Article (8 results, of which Peer Reviewed: 4 results) Presentation (7 results)

4. Studies on the mechanism of entry of the envelope virus and its inhibitor.

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Basic veterinary science/Basic zootechnical science
Research Institution	Health Sciences University of Hokkaido (2005) Hokkaido University (2004)
Principal Investigator	OKAZAKI Katsunori Health Sciences University of Hokkaido, Dept of Pharmaceutical Sciences, Professor
Project Period (FY)	2004 – 2005Completed
Keywords	Virus envelope / Membrane fusion / Cell entry / Herpesviru / gB glycoprotein / Proteolytic enzyme / Endothelial cells / Endosome
Research Abstract	Glycoprotein B (gB) is the most conserved glycoprotein of herpesviruses and plays important roles in virus infectivity. The glycoprotein of most herpe ...

Research Products of this project	Journal Article (17 results) Book (2 results)

5. Ecology and pandemic planning of animal influenza virus

Research Project

Research Category	Grant-in-Aid for Scientific Research (S)
Research Field	Applied veterinary science
Research Institution	Hokkaido University
Principal Investigator	KIDA Hiroshi Hokkaido University, Graduate School of Veterinary Medicine, Professor
Project Period (FY)	2003 – 2006Completed
Keywords	influenza viruses / global surveillance / vaccine / antiviral / diagnosis
Research Abstract	H5N1 highly pathogenic avian influenza (HPAI) virus has spread in poultry from Southeast Asia to the north, Europe, and Africa. We have been conductin ...

Research Products of this project	Journal Article (27 results) Book (1 results) Patent(Industrial Property Rights) (1 results) Publications (6 results)

6. Ecological study of animal influenza viruses : To prepare for the emergence of pandemic influenza

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Applied veterinary science
Research Institution	Hokkaido University
Principal Investigator	KIDA Hiroshi Hokkaido University, Hokkaido University, Graduate School of Veterinary Medicine, Professor
Project Period (FY)	2000 – 2002Completed
Keywords	Influenza / migratory waterfowls / Pigs / Chickens / Epidemiological surveillance / Receptor specificity / Interspecies transmission
Research Abstract	To provide information on the precursor genes of the next pandemic influenza, epidemiological surveillance of animal and avian influenza viruses was p ...

Research Products of this project	Journal Article (44 results) Publications (24 results)

7. Analysis of virus-receptor interaction and its application in veterinary science

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Applied veterinary science
Research Institution	National Institute of Neutoscience, NCNP
Principal Investigator	TAGUCHI Fumihiro National Institute of Neuroscience, NCNP Section chief
Project Period (FY)	1999 – 2001Completed
Keywords	virus-receptor interation / mouse hepatitis virus (MHV) / murine leukemia virus / influenza virus
Research Abstract	We have investigated the interaction of mouse hepatitis virus (MHV) and its receptor CEACAM1 (MHVR) by using soluble form of MHVR (soMHVR). soMHVR1 de ...

Research Products of this project	Publications (38 results)

8. G蛋白欠失VSVを用いたウイルス表面糖蛋白の機能解析

Research Project

Research Category	Grant-in-Aid for Exploratory Research
Research Field	Virology
Research Institution	Hokkaido University
Principal Investigator	岡崎克則北海道大学, 大学院・獣医学研究科, 助教授
Project Period (FY)	1998 – 1999Completed
Keywords	VSV / 糖蛋白 / ヘルペスウイルス / gB / gC / グルコサミノグリカン / リセプター / gD / GFP / cell-to-cell感染
Research Abstract	ヘルペスウイルス主要糖蛋白の機能を明らかにするためウシヘルペスウイルス1(BHV1)の糖蛋白gBあるいはgCを発現する株化細胞を樹立し、これらにG蛋白遺伝子を欠失した水疱性口炎ウイルス(VSVdelG-G)を感染させて表現型混合ウイルスの回収を試みた。培養上清中に放出されたウイルス粒子をMDBK細胞 ...

Research Products of this project	Publications (3 results)

9. Molecular mechanisms of infection and pathogenesis of viruses

Research Project

Research Category	Grant-in-Aid for Scientific Research (A).
Research Field	Basic veterinary science/Basic zootechnical science
Research Institution	HOKKAIDO UNIVERSITY
Principal Investigator	KIDA Hiroshi Grad. School of Vet. Medicine, Hokkaido University, Professor
Project Period (FY)	1998 – 1999Completed
Keywords	influenza virus / duck / pig / Siberia / Hong Kong / H5N1 / vaccine / surveillance
Research Abstract	Influenza A viruses of different subtypes were isolated from fecal samples of ducks in their nesting areas in Siberia. Phylogenetic analysis of the NP ...

Research Products of this project	Publications (32 results)

10. Studies on the T-cell epitopes of herpesviruses

Research Project

Research Category	Grant-in-Aid for Scientific Research (B)
Research Field	Basic veterinary science/Basic zootechnical science
Research Institution	HOKKAIDO UNIVERSITY
Principal Investigator	OKAZAKI Katsunori Hokkaido University, Graduate School of Veterinary Medicine, Associate Professor
Project Period (FY)	1996 – 1997Completed
Keywords	bovine herpesvirus 1 / glycoprotein / monoclonal antibody / T-cell epitope / lbaculovirus / Aujeszky's disease virus / DNA vaccine / cellular immunity
Research Abstract	An escape mutant of bovine herpesvirus 1 (BHV1) was obtained in the presence of monoclonal antibody against glycoprotein B (gB) , which required compl ...

Research Products of this project	Publications (14 results)

11. Molecular mechanisms of infection and pathogenesis of viruses

Research Project

Research Category	Grant-in-Aid for Scientific Research (A)
Research Field	Applied veterinary science
Research Institution	HOKKAIDO UNIVERSITY
Principal Investigator	KIDA Hiroshi Grad.School of Veterinary Medicine, Hokkaido University, Professor
Project Period (FY)	1996 – 1998Completed
Keywords	influenza virus / pathogenicity / host cell factor / vascular endothelial cell / blood coagulation factor / disseminated intravascular coagulation / chicken
Research Abstract	Intravenous injection into chickens with the virus-free extracts from the allantoic membrane of chicken embryos infected with influenza viruses result ...

Research Products of this project	Publications (47 results)

12. Prediction of new pandemic influenza viruses -Distribution of the viruses in waterfowls in their nesting places in Siberia

Research Project

Research Category	Grant-in-Aid for international Scientific Research
Research Field	Basic veterinary science/Basic zootechnical science
Research Institution	Hokkaido University
Principal Investigator	KIDA Hiroshi Hokkaido Univ., Graduate School of Vet.Medicine, Professor
Project Period (FY)	1995 – 1997Completed
Keywords	influenza virus / migratory ducks / feces / breeding areas / Siberia / lake water / The River Lena / Southern China
Research Abstract	In each summer of 1995-1997,3,000 fecal materials of waterfowls and lake-water samples were collected in Kamchatka, Khabarovsk, and Saha Republic. In ...

Research Products of this project	Publications (53 results)

13. 動物ヘルペスウイルスの吸着・細胞内侵入機構の解析

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	Basic veterinary science/Basic zootechnical science
Research Institution	Tokyo University of Agriculture and Technology
Principal Investigator	岡崎克則東京農工大学, 農学部, 助手
Project Period (FY)	1994Completed
Keywords	ウシヘルペスウイルス1型 / 吸着 / 侵入 / バキュロウイルス / gIII / gIV / エンドサイトーシス
Research Abstract	一般的に、エンベロープウイルスでは宿主細胞への吸着・侵入反応には糖蛋白が関与するとされている。標準的なヘルペスウイルスであるヒト単純ヘルペスウイルスでは少なくとも11種の糖蛋白が同定されており、これらが複雑なカスケードを形成して細胞内に侵入し、感染が成立するものと考えられている。一方、動物のヘルペス ...

Research Products of this project	Publications (2 results)

14. ヘルペスウイルス吸着および侵入反応に関与する細胞側因子の同定

Research Project

Research Category	Grant-in-Aid for Encouragement of Young Scientists (A)
Research Field	Basic veterinary science/Basic zootechnical science
Research Institution	Tokyo University of Agriculture and Technology
Principal Investigator	岡崎克則東京農工大学, 農学部, 助手
Project Period (FY)	1993 – 1994Completed
Keywords	ウシヘルペスウイルス1型 / 吸着 / 侵入 / バキュロウイルス / 糖蛋白 / リセプター / ヘパラン硫酸
Research Abstract	本研究では、ウシヘルペスウイルス1型(BHV-1)主要糖蛋白のうちgI、gIII、gIVの3種、並びに本ウイルスではこれまで存在が証明されていなかったgH糖蛋白をバキュロウイルスベクターで大量発現し、その細胞側標的分子を同定することを試みた。

Research Products of this project	Publications (2 results)

15. Origin and Evolution of Influenza Viruses

Research Project

Research Category	Grant-in-Aid for international Scientific Research
Research Institution	Hokkaido University
Principal Investigator	KIDA Hiroshi Hokkaido University, School of Veterinary Medicine
Project Period (FY)	1993 – 1994Completed
Keywords	Influenza virus / Migratory duck / Nesting lake / Flyway / Perpetuation of virus / Phylogenetic tree / Freezing preservation / Water-born transmission
Research Abstract	To provide information how influenza A viruses are maintained among waterfowl reservoirs at their nesting areas in the northern territory and on the m ...

Research Products of this project	Publications (31 results)

16. Evolution and Prediction of Influenza Viruses

Research Project

Research Category	Grant-in-Aid for international Scientific Research
Research Institution	Hokkaido University School of Veterinary Medicine
Principal Investigator	KIDA Hiroshi Associate Professor Hokkaido University School of Veterinary Medicine
Project Period (FY)	1991 – 1992Completed
Keywords	New pandemic influenza virus / Prediction / Migratory duck / Nesting point / Frozen lake water / Perpetuation of virus / Evolution / Newcastle disease virus
Research Abstract	On the basis of the results of epidemiological studies of influenza in birds, animals, and humans, we have proposed the route of introduction of the h ...

Research Products of this project	Publications (16 results)

17. Nucleotide sequence analysis and expression of bovid herpesvirus 1 glycoproteins

Research Project

Research Category	Grant-in-Aid for General Scientific Research (C)
Research Field	基礎獣医学
Research Institution	Tokyo University of Agriculture/Technology
Principal Investigator	OKAZAKI Katsunori Tokyo University of Agriculture/Technology, Faculty of agriculture, Assistant Professor
Project Period (FY)	1990 – 1991Completed
Keywords	bovid herpesvirus 1 / glycoprotein / gI / gIII / gIV / heparin / hemadsorption
Research Abstract	Bovid herpesvirus I(BBY-1)was prevented from adsorbing to and infecting cells by addition of heparin to the virus inoculus and by treatment of the cel ...

Research Products of this project	Publications (5 results)

18. Comparative studies on the immunogenic proteins of animal herpesviruses

Research Project

Research Category	Grant-in-Aid for Co-operative Research (A)
Research Field	基礎獣医学
Research Institution	The University of Tokyo
Principal Investigator	TAKAHASHI Eiji Fac. of Agri., Univ. of Tokyo, Professor
Project Period (FY)	1990 – 1992Completed
Keywords	Herpesvirus / Virus glycoprotein / Expression of gene / Feline herpesvirus type 1 / Canine herpes virus / Pseudorabies virus
Research Abstract	This research project was designed to elucidate the immunogenic characteristics of virus glycoproteins among several animal herpesviruses using molecu ...

Research Products of this project	Publications (26 results)

19. Preventive measures of Mark's desease (MD) vaccine break caused by very virulent MD virus.

Research Project

Research Category	Grant-in-Aid for Developmental Scientific Research
Research Field	Applied veterinary science
Research Institution	The university of Tokyo
Principal Investigator	MIKAMI Takeshi Univ. of Tokyo, Fac. of Agr., Professor
Project Period (FY)	1989 – 1991Completed
Keywords	very virulent Marek's disease virus / vaccine / Marek's disease / CD4-depleted chicken / CD-8depleted chicken / mechanism of vaccine protection / mechanism of tumorigenesis / preventive measure
Research Abstract	For prevention of Marek's disease (MD) caused by Marek's disease virus (MDV), monovalent vaccine of herpesvirus of turkey has been widely used for chi ...

Research Products of this project	Publications (43 results)