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New gallstone solvent with dissolving action for mucin in the gallstone.

Research Project

Project/Area Number 04807089
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionTohoku University

Principal Investigator

ISE Hideo  School of medicine, Tohoku University assistant professor, 医学部, 講師 (10150260)

Co-Investigator(Kenkyū-buntansha) MORIYASU Akihito  University medical center assistant professor, 医学部・附属病院, 助手 (10241621)
KITAYAMA Osamu  University medical center assistant professor, 医学部・附属病院, 助手 (80214823)
臼井 律郎  東北大学, 医学部・附属病院, 助手
Project Period (FY) 1992 – 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1994: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1992: ¥800,000 (Direct Cost: ¥800,000)
KeywordsGallstone / mucin / Acetylcystein / 胆石溶解剤 / 胆石中ムチン / 胆石切片標本 / 酸性ムチン
Research Abstract

We performed the analysis of the composition of gallstones, and obtained the results that ; (1)there were the nucine-network structures into the gallstones, which carried out the Constructive role of the gallstone, (2)nucin into the gallstones were the sulfated glyeoprotein as a acidic nucin.
In this result, we tried to dissolve the gallstone nucin by ascetylcystein as a nucous solvent.
Acetylcystein disintegrated theall Rind of gallstones in vitro prompthy.
Acelytystein was acidic substunce and neutrized by NaltCO_3 in use.
Disintegrating action of acetylcystein was best under the Condition of pH 7.5-8.0. We examined the toxicity of acetylystein injecting into the bete duct. Gcute and chronic toxicity was not observed in histochemicaly and blood demically.
Conculusion, we think the acetylcystein is a gallstone solvent, by mechanism of the dissolved nucin network in the gallstone.

Report

(4 results)
  • 1994 Annual Research Report   Final Research Report Summary
  • 1993 Annual Research Report
  • 1992 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] 森安章人ほか: "アゼチルシステインを用いた胆石の直接溶解・崩壊療法" 胆と膵. 14. 1277-1286 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 森安章人ほか: "Treatment of cholelithiasis with acetylcystein:a new gallstone solvent" J.hepato-leiliray pancrealic surgery. 4. 406-412 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] Akihito Moriyasu et al.: "Treatment of cholelitheasis with acetylcystein, a new gallstone solvent." J.of hepato-biliary-pancreatic surgery. Vol 4. 406-412 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1994 Final Research Report Summary
  • [Publications] 森安章人 ほか: "アセチルシステインを用いた胆石の直接溶解崩治療法" 胆と膵. 14. 1277-1286 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 森安章人 ほか: "Treatment of cholelilhiasis with acetifaystein:a new gallstone solueu" J.hepato biliauy pancreatic surgevy. 4. 406-412 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 森安章人ほか: "胆石中ムチンの分布とその意義-胆石薄切標本の観察-" 胆と膵. 13. 85-89 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 森安 章人 ほか: "胆石中ムチンの分布とその意義ー胆石薄切標本の観察ー" 胆と膵. 13. 85-89 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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