| Budget Amount *help |
¥83,720,000 (Direct Cost: ¥64,400,000、Indirect Cost: ¥19,320,000)
Fiscal Year 2016: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2015: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2014: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2013: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2012: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
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| Outline of Final Research Achievements |
Many bacteria migrate through the environment using the flagellar apparatus which is a motion organelle. Until now, the flagellar motor was known to be driven by an ion motive force such as proton and sodium ion. In this study, we succeeded to isolate Paenibacillus sp. TCA20 with flagellar motors driven by divalent cations such as calcium ions and magnesium ions for the first time in the world. Besides this, we also characterized nonconventional cation-coupled flagellar motors derived from the alkaliphilic Bacillus. Differences in ion selective permeability between these flagellar motors and conventional motors were elucidated using molecular biological techniques. Based on the results of this study, it is expected to create artificial nanomachines and molecular switches that can selectively use driving energy.
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