KAKEN — Research Projects | Researcher Number: 70724277

Search Results: 8 results / Researcher Number: 70724277

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1. Therapeutic Potential of Vitamin K and Its Derivatives in Alzheimer's Disease Treatment: A Novel Approach to Inhibit Ferroptosis

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Review Section	Basic Section 59040:Nutrition science and health science-related
Research Institution	Shibaura Institute of Technology
Principal Investigator	廣田佳久芝浦工業大学, システム理工学部, 准教授
Project Period (FY)	2024-04-01 – 2027-03-31Granted
Keywords	ビタミンK / アルツハイマー病 / フェロトーシス / 疾患モデルマウス / 治療薬創製
Outline of Research at the Start	ビタミンKは他の臓器と比較して脳に多く存在するが、脳内での役割は未だ明らかではない。申請者はアルツハイマー病のヒト脳内ビタミンK濃度が著しく低下することを見出した。近年の研究よりアルツハイマー病の発症は細胞死フェロトーシスの亢進が一因であること、ビタミンKがフェロトーシスを強力に抑制することが報告さ ...

2. Elucidation of the mechanism of central nervous system regeneration by vitamin K for the treatment of cerebrovascular diseases

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Review Section	Basic Section 59040:Nutrition science and health science-related
Research Institution	Shibaura Institute of Technology
Principal Investigator	Hirota Yoshihisa 芝浦工業大学, システム理工学部, 准教授
Project Period (FY)	2021-04-01 – 2024-03-31Completed
Keywords	ビタミンK / 神経変性疾患 / L型Ca2+チャネル / 代謝型グルタミン酸受容体 / 神経修復促進効果 / 誘導体創製 / 分子動力学シュミレーション / 脳血管障害 / 中枢神経再生 / 疾患モデルマウス / 治療薬創製 / 神経損傷マウスモデル / 誘導体合成
Outline of Research at the Start	ビタミンKが脳内でどのような役割を担っているかは未だ明らかではない。申請者は、これまでに脳内に存在するビタミンKが神経幹細胞をニューロンへ選択的に分化誘導することを報告し、網羅的な遺伝子解析からニューロン分化に関与する重要な遺伝子を見出した。そこで本研究では脳内におけるビタミンKの役割を明らかにする ...
Outline of Final Research Achievements	We reported that vitamin K in the brain selectively induces neural stem cells to differentiate into neurons. Our comprehensive genetic analysis identi ...

Research Products of this project	Int'l Joint Research (2 results) Journal Article (13 results, of which Int'l Joint Research: 6 results, Peer Reviewed: 13 results, Open Access: 13 results) Presentation (81 results, of which Int'l Joint Research: 9 results, Invited: 10 results)

3. Biosynthesis of terpenoid natural products involving non-enzymatic reactions of ROS

Research Project

Research Category	Grant-in-Aid for Challenging Research (Exploratory)
Review Section	Medium-sized Section 38:Agricultural chemistry and related fields
Research Institution	Niigata University
Principal Investigator	Sato Tsutomu 新潟大学, 自然科学系, 教授
Project Period (FY)	2019-06-28 – 2022-03-31Completed
Keywords	テルペノイド / イソプレノイド / 生合成 / 活性酸素 / ビタミンK / 非酵素
Outline of Research at the Start	天然物生合成の包括的な理解には，酵素系のみならず，「非酵素」系の解析と理解が必要であるが，ゲノムからのアプローチは，本研究の主題となる「非酵素」が関与する経路の解析には適用することができない。本研究では，テルペノイド系天然物の生合成における非酵素系の関与を明らかにすることによって，これまで手付かずで ...
Outline of Final Research Achievements	Biosynthesis involving 'non-enzymatic' systems is largely unknown for the terpenoid system, which is the most abundant of natural products. In this st ...

4. Regulatory mechanisms of vitamin K metabolism through GTP metabolic sensors and their application to cancer therapy.

Research Project

Research Category	Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
Review Section	Basic Section 59040:Nutrition science and health science-related
Research Institution	Shibaura Institute of Technology
Principal Investigator	Hirota Yoshihisa 芝浦工業大学, システム理工学部, 准教授
Project Period (FY)	2019 – 2022Completed
Keywords	GTPセンサー / PI5P4Kβ / 糖尿病 / 健康寿命 / ビタミンK / UBIAD1 / GTP代謝センサー / がん治療 / ゲノム編集 / プロテオミクス解析 / UBIAD1プロモーター
Outline of Final Research Achievements	Vitamin K has been reported to have two functions: anti-tumour and prevention of cancer recurrence, but the mechanisms of these effects are not clear. ...

Research Products of this project	Int'l Joint Research (1 results) Journal Article (16 results, of which Int'l Joint Research: 5 results, Peer Reviewed: 16 results, Open Access: 16 results) Presentation (103 results, of which Int'l Joint Research: 50 results, Invited: 13 results)

5. Metabolic dynamics of vitamin K by elucidation of vitamin K side chain cleavage enzyme

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Review Section	Basic Section 59040:Nutrition science and health science-related
Research Institution	Shibaura Institute of Technology
Principal Investigator	Hirota Yoshihisa 芝浦工業大学, システム理工学部, 准教授
Project Period (FY)	2018-04-01 – 2021-03-31Completed
Keywords	ビタミンK / 側鎖切断機構 / 誘導体研究 / ゲノム編集 / プロテオミクス解析 / トランスクリプトーム解析 / 側鎖切断酵素 / UBIAD1 / オミクス解析 / 小腸上皮細胞 / ゲノム編集技術 / 代謝ダイナミクス / 誘導体解析
Outline of Final Research Achievements	Vitamin K plays an important role in blood clotting and bone formation. While PK is the main vitamin K ingested by humans through the diet, the majori ...

Research Products of this project	Journal Article (14 results, of which Int'l Joint Research: 3 results, Peer Reviewed: 14 results, Open Access: 14 results) Presentation (64 results, of which Int'l Joint Research: 23 results, Invited: 5 results)

6. Studies on the disposition of menadione, a intermediate of conversion into active form of vitamin K

Research Project

Research Category	Grant-in-Aid for Scientific Research (C)
Research Field	Eating habits
Research Institution	Kobe Pharmaceutical University
Principal Investigator	Kamao Maya 神戸薬科大学, 薬学部, 講師
Project Period (FY)	2017-04-01 – 2020-03-31Completed
Keywords	ビタミンK / menadione / menaquinone / phylloquinone / 体内動態 / 側鎖切断 / 構造活性相関 / cysteamine誘導体 / 結合タンパク質 / menaquinone-4 / 抱合体
Outline of Final Research Achievements	It was found that derivatization of cysteamine (CA) is useful for the measurement of menadione (MD), an intermediate for conversion to active form of ...

Research Products of this project	Journal Article (2 results, of which Peer Reviewed: 2 results, Open Access: 2 results) Presentation (12 results, of which Int'l Joint Research: 5 results)

7. Elucidation of vitamin K side chain cleavage enzyme aiming at unified understanding of vitamin K synthesis mechanism

Research Project

Research Category	Grant-in-Aid for Young Scientists (B)
Research Field	Environmental and hygienic pharmacy
Research Institution	Shibaura Institute of Technology
Principal Investigator	HIROTA Yoshihisa 芝浦工業大学, システム理工学部, 助教
Project Period (FY)	2016-04-01 – 2018-03-31Completed
Keywords	ビタミンK / 側鎖切断酵素 / 2',3'-PKH2 / 代謝機構 / UBIAD1 / MK-4 / MD / 遺伝子改変 / 小腸 / オミクス解析 / 遺伝子改変動物 / 腸
Outline of Final Research Achievements	In humans and mice, ingested PK is MD which has a side chain cleaved in the small intestine and has no side chains and is converted into MK-4 by UBIAD ...

Research Products of this project	Journal Article (11 results, of which Peer Reviewed: 11 results, Open Access: 11 results, Acknowledgement Compliant: 3 results) Presentation (15 results, of which Invited: 1 results) Remarks (2 results)

8. Generation of mice with bone-specific deficiency of noble vitamin K synthesis enzyme UBIAD1 and elucidation of the physiological roles of UBIAD1.

Research Project

Research Category	Grant-in-Aid for Young Scientists (B)
Research Field	Biological pharmacy
Research Institution	Suzuka University of Medical Science
Principal Investigator	HIROTA Yoshihisa 鈴鹿医療科学大学, 薬学部, 助手
Project Period (FY)	2014-04-01 – 2016-03-31Completed
Keywords	ビタミンK / UBIAD1 / 骨代謝 / 骨特異的遺伝子欠損マウス / タンパク質機能解析 / タンパク質構造解析 / 骨特異的ノックアウトマウス
Outline of Final Research Achievements	We have generated mice with bone-specific deficiency of noble vitamin K synthesis enzyme UBIAD1, using mice expressing Cre downstream of the osterix p ...

Research Products of this project	Journal Article (6 results, of which Peer Reviewed: 6 results, Open Access: 6 results, Acknowledgement Compliant: 3 results) Presentation (14 results, of which Invited: 1 results) Remarks (1 results)