Mesogenin causes embryonic mesoderm progenitors to differentiate during development of zebrafish tail somites
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Graphical Abstract
Highlights
► Msgn and spadetail are redundantly required for PSM differentiation in the tail. ► Msgn is cell-autonomously required for the differentiation of MPCs to the PSM. ► Msgn acts as a transcriptional activator in PSM differentiation. ► Misexpression of Msgn causes PSM differentiation in ntl-expressing cells. ► Coexpression of msgn and ntl can induce efficient differentiation to the PSM.
Keywords
Zebrafish
Mesodermal progenitor cells (MPCs)
Presomatic mesoderm (PSM)
Mesogenin1
Spadetail/Tbx16
Cell differentiation
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