Relative Biological Effectiveness of the 235 MeV Proton Beams at the National Cancer Center Hospital East
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- ANDO KOICHI
- Clinical Radiation Biology and International Space Radiation Laboratory
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- FURUSAWA YOSHIYA
- Clinical Radiation Biology and International Space Radiation Laboratory
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- SUZUKI MASAO
- Clinical Radiation Biology and International Space Radiation Laboratory
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- NOJIMA KUMIE
- Clinical Radiation Biology and International Space Radiation Laboratory
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- MAJIMA HIDEYUKI
- Clinical Radiation Biology and International Space Radiation Laboratory
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- KOIKE SACHIKO
- Clinical Radiation Biology and International Space Radiation Laboratory
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- AOKI MIZUHO
- Clinical Radiation Biology and International Space Radiation Laboratory
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- SHIMIZU WAKAKO
- Clinical Radiation Biology and International Space Radiation Laboratory
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- FUTAMI YASUYUKI
- Division of Accelerator Physics and Engineering, National Institute of Radiological Sciences
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- OGINO TAKASHI
- Department of Radiation Oncology, National Cancer Center Hospital East
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- MURAYAMA SHIGEYUKI
- Department of Radiation Oncology, National Cancer Center Hospital East
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- IKEDA HIROSHI
- Department of Radiation Oncology, National Cancer Center Hospital East
Bibliographic Information
- Other Title
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- Relative Biological Effectiveness of 235 MeV Proton Beams at the National Cancer Center Hospital East
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Abstract
A therapy-dedicated cyclotron was installed in the National Cancer Center Hospital East (NCCHE) at Kashiwa in 1997. Prior to the start of clinical use, we investigated the biological effectiveness of therapeutic proton beams for cell lethality. The proton beams accelerated up to 235 MeV were horizontally extracted from the cyclotron, and scattered by a bar-ridge filter to produce a Spread-Out-Bragg-Peak (SOBP) of 10-cm width. The biological systems used here were mouse intestinal crypt cells and three in vitro cell lines, including SCC61 human squamous cell carcinoma, NB1RGB human fibroblasts and V79 Chinese hamster cells. The dose responses after irradiation at either the entrance plateau or the middle portion of SOBP were compared with those after linac 6 MV X-ray irradiation. The fit of a linear quadratic model to survival curves showed that proton irradiation increased the α value of SCC61 and the β value of V79 cells with a least change for α/β ratio of NB1RGB cells. The isoeffect dose that reduces either cell survivals to 10% or mouse jejunum crypts to 10 per circumference was termed D10. The relative biological effectiveness (RBE) of protons obtained by comparing the D10 values between protons and X-rays ranged from 0.9 to 1.2. The depth distribution of cell lethality was measured by replating V79 cells after irradiation from a "cell stack chamber" that received a single dose of 7 Gy at the middle position of SOBP. The thus-obtained cell survivals at various depths coincided well with the estimated survivals, but tended to decrease at the distal end of SOBP . We conclude that an RBE of 1.1 would be appropriate for 235 MeV proton beams at the NCCHE.
Journal
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- Journal of Radiation Research
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Journal of Radiation Research 42 (1), 79-89, 2001
Journal of Radiation Research Editorial Committee
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Details
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- CRID
- 1390282680194677248
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- NII Article ID
- 110002328742
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- NII Book ID
- AA00705792
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- COI
- 1:STN:280:DC%2BD3MzislWmtw%3D%3D
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- ISSN
- 13499157
- 04493060
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- NDL BIB ID
- 5733338
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- PubMed
- 11393892
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- NDL-Digital
- CiNii Articles
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- Abstract License Flag
- Disallowed