Structure and Reactivity of an Asymmetric Synthetic Mimic of Nitrogenase Cofactor
Abstract
The Mo nitrogenase catalyzes the ambient reduction of N2 to NH3 at its M-cluster site. A complex metallocofactor with a core composition of [MoFe7S9C], the M-cluster, can be extracted from the protein scaffold and used to facilitate the catalytic reduction of CN−, CO, and CO2 into hydrocarbons in the isolated state. Herein, we report the synthesis, structure, and reactivity of an asymmetric M-cluster analogue with a core composition of [MoFe5S9]. This analogue, referred to as the Mo-cluster, is the first synthetic example of an M-cluster mimic with Fe and Mo positioned at opposite ends of the cluster. Moreover, the ability of the Mo-cluster to reduce C1 substrates to hydrocarbons suggests the feasibility of developing nitrogenase-based biomimetic approaches to recycle C1 waste into fuel products.
Journal
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- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55 (50), 15633-15636, 2016-12-12
Wiley
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Details
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- CRID
- 1050845763735846016
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- NII Article ID
- 120005981222
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- HANDLE
- 2237/25738
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- ISSN
- 14337851
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB
- CiNii Articles