Letter to the Editor
Numb chin syndrome as initial manifestation of bisphosphonate-related osteomyelitis of the jaw and methotrexate-associated lymphoproliferative disorders: a rare case

https://doi.org/10.1016/j.bjoms.2015.10.031Get rights and content

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Conflict of interest

We have no conflicts of interest.

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Patient permission was obtained.

References (3)

  • N. Horie et al.

    Methotrexate-related lymphoproliferative disorder arising in the gingiva of a patient with rheumatoid arthritis

    Aust Dent J

    (2015)
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Cited by (4)

  • Clinical utility of contact heat evoked potentials (CHEPs) in a case of mentalis nerve lesion

    2018, Clinical Neurophysiology Practice
    Citation Excerpt :

    The case presented here shares clinical features with the well-known numb-chin syndrome (Smith et al., 2015). Our patient had a clear iatrogenic cause of her symptoms, in relation to dental procedures, as in other reported cases (Elahi et al., 2014; Mishima et al., 2016; Brooks et al., 2017). Although numbness is the main symptom in many instances, allodynia may also be present, which develops slowly after an acute episode of pain (Elahi et al., 2014).

  • Methotrexate-related osteonecrosis of the jaw: Report of two cases

    2017, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
    Citation Excerpt :

    Histopathologically, we did not recognize the variety of atypical lymphocytes typically present in MTX-LPD or abnormal lymphocytes present in hematopoietic tumor in the specimen from Case 2. Several cases of MTX-LPD accompanied by osteonecrosis of the jaw have been reported [4]. Bone necrosis in MTX-LPD may occur as a result of an opportunistic infection and malignant invasion of bone.

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