Archival ReportIncreased Occipital Gyrification and Development of Psychotic Disorders in Individuals With an At-Risk Mental State: A Multicenter Study
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Participants
One hundred four individuals with ARMS were recruited from domestic specialized clinical services for ARMS at Toyama University Hospital, The University of Tokyo Hospital, Toho University Hospital, and Tohoku University Hospital 30, 31. Each individual fulfilled the criteria of ARMS according to the Comprehensive Assessment of At-Risk Mental States (CAARMS) (32) (Toyama and Tohoku) or the Structured Interview for Prodromal Symptoms/the Scale of Prodromal Symptoms (SIPS/SOPS) (33) (Tokyo and
Demographic Background
There were no group differences in age and gender, but the healthy control subjects had attained a higher level of education compared with ARMS-T (p < .001), ARMS-NT (p < .001), and those individuals with unknown outcome because of dropout within 2 years (p < .001) (Table 1) groups. The ARMS-T and ARMS-NT individuals did not differ in their symptom severity on the basis of CAARMS scores and the medication dose (Table 1).
Group Comparison of LGI Between the ARMS and Control Subjects
Compared with the healthy control subjects, the ARMS individuals as a whole
Discussion
To the best of our knowledge, this is the first MRI study to examine the gyrification pattern of the entire cortex among individuals with clinical high risk for psychotic disorders using vertexwise analysis of the LGI. The present study analyzed the multicenter structural MRI dataset of high-risk individuals from Eastern Asia where the prevalence of cannabis use is particularly low, which could be a notable advantage for research of psychotic disorders by minimizing the possible confounding
Acknowledgments and Disclosures
This work was supported by Kiban C Grant No. 26461738 (to YT), Kiban C Grant No. 26461739 (to TT), and Kiban B Grant No. 24390281 (to MS) from the Japanese Society for the Promotion of Science; Health and Labour Sciences Research Grants for Comprehensive Research on Persons with Disabilities from the Japan Agency for Medical Research and Development (to MS, KM, and MM); the SENSHIN Medical Research Foundation (to YT); JSPS KAKENHI Grant Nos. JP16H06395, 16H06399, 16K21720, and 16H06280
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