Theoretical Study on Oligomerization of Cytochrome <i>c</i>
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- MOTOKI Hideyoshi
- Department of Chemistry, Biology, and Marine Science, Graduate School of Engineering and Science,University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan
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- YOSHIDA Norio
- Department of Chemistry, Graduate School of Science, Kyushu University, 744 Motooka,Nishiku, Fukuoka 819-0395, Japan
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- HIROTA Shun
- Graduate School of Materials Science, Nara Institute of Science and Technology,8916-5 Takayama, Ikoma, Nara 630-0192, Japan
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- HIGASHI Masahiro
- Department of Chemistry, Biology, and Marine Science, Faculty of Science, University of the Ryukyus,1 Senbaru, Nishihara, Okinawa 903-0213, Japan
Bibliographic Information
- Other Title
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- シトクロム<i>c</i>の多量体形成に関する理論的研究
Abstract
<p>Cytochrome c is a hemoprotein that plays an important role in electron transport in the mitochondrial respiratory chain. Cytochrome c forms oligomers by successive domain swapping, where the C-terminal α helices are replaced by the corresponding helices of other cytochrome c molecules, leading to a loss in the electron transfer function. However, the detailed mechanism of domain swapping of cytochrome c is still unclear. To clarify the mechanism of the oligomerization, we have analyzed the thermodynamic stabilities of the domain-swapped dimer. In this paper, we introduce our recent progress.</p>
Journal
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- Journal of Computer Chemistry, Japan
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Journal of Computer Chemistry, Japan 17 (1), 8-13, 2018
Society of Computer Chemistry, Japan
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Details
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- CRID
- 1390001205178090240
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- NII Article ID
- 130006528632
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- ISSN
- 13473824
- 13471767
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed