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Middle molecular strategy: Creation of higher bio-functional molecules by integrated synthesis

International Activities Supporting Group

Project AreaMiddle molecular strategy: Creation of higher bio-functional molecules by integrated synthesis.
Project/Area Number 15K21713
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeMulti-year Fund
Review Section Science and Engineering
Research InstitutionOsaka University

Principal Investigator

Koichi Fukase  大阪大学, 大学院理学研究科, 教授 (80192722)

Project Period (FY) 2015-11-06 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥79,820,000 (Direct Cost: ¥61,400,000、Indirect Cost: ¥18,420,000)
Fiscal Year 2019: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2018: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2017: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2015: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Keywords中分子 / 反応集積 / 生体機能制御 / 糖鎖 / 免疫 / 反応集積化 / 生物機能制御 / 機能集積
Outline of Final Research Achievements

Reaction integration, which sustains the synthesis of middle-molecules, is rapidly developing in both academia and industry as a key technology supporting a new era of synthetic processes in the industrial manufacture of pharmaceuticals and fine chemicals. In this research field, we aim to advance "reaction integration" to a higher level to dramatically improve the efficiency of functional molecule synthesis, and furthermore, to expand it to the practical material production. This International Support Group aims to promote international collaboration and the formation of research networks, to help our research area become an international hub for the creation of middle-molecular functions, and to demonstrate the significant presence of our research area and Japan, in the international community.

Academic Significance and Societal Importance of the Research Achievements

現代社会では、環境に負荷をかけず物質変換効率を向上させるとともに、諸問題を解決する高効率機能性物質を創製する合成化学が強く求められている。本領域研究は、様々な機能性物質の合成効率を飛躍的に向上させ、将来的には医農薬などの生物機能分子製造にも大きく貢献する。このように極めて重要な研究領域において、国際共同研究を主導し、日本のプレゼンスを示すことができた。これにより、日本において、本分野がますます発展し、大きな社会貢献が期待できる。例えば、生物機能分子研究を飛躍的に進展させ、新たな医農薬開発への貢献が期待できる。

Report

(9 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (36 results)

All 2021 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (16 results) Remarks (2 results) Funded Workshop (18 results)

  • [Int'l Joint Research] ナポリフェデリコ二世大学(イタリア)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Academia Sinica (台湾)(中国)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] The University of Naples Federico II/University of Milano-Bicocca(イタリア)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] University of Cambridge(英国)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] Research Center Borstel(ドイツ)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] Spanish National Research Council(スペイン)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] Academia Sinica/精華大学(中国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] University of Napoli Federico II(イタリア)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] University of Napoli Federico II(イタリア)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Academia Sinica/精華大学(台湾)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] ナポリフェデリコ 2 世大学(イタリア)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Academia Sinica(台湾)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] 精華大学(台湾)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] University of Napoli Federico II(イタリア)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] Academia sinica(台湾)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] University of Michigan(米国)

    • Related Report
      2015 Research-status Report
  • [Remarks] 反応集積が導く中分子戦略:高次生物機能分子の創製

    • URL

      http://www.chem.sci.osaka-u.ac.jp/lab/fukase/middle-molecule/

    • Related Report
      2020 Research-status Report
  • [Remarks] 反応集積化が導く中分子戦略:高次生物機能分子の創製

    • URL

      http://www.middle-molecule.jp/index.html

    • Related Report
      2015 Research-status Report
  • [Funded Workshop] 16th Meeting of the International Endotoxin and Innate Immunity Innate Immunity Society2021

    • Related Report
      2021 Research-status Report
  • [Funded Workshop] The 6th International Symposium on Middle Molecular Strategy(ISMMS-6)2020

    • Related Report
      2020 Research-status Report
  • [Funded Workshop] International Joint Symposium on Synthetic Organic Chemistry2019

    • Related Report
      2019 Research-status Report
  • [Funded Workshop] The 18th International Symposium on Novel Aromatic Compounds (ISNA-18)2019

    • Related Report
      2019 Research-status Report
  • [Funded Workshop] The 27th International Society of Heterocyclic Chemistry Congress2019

    • Related Report
      2019 Research-status Report
  • [Funded Workshop] 第14回アジア最先端有機化学国際会議ICCEOCA-142019

    • Related Report
      2019 Research-status Report
  • [Funded Workshop] The 4th International Symposium on Middle Molecular Strategy(ISMMS-4)2018

    • Related Report
      2018 Research-status Report
  • [Funded Workshop] The 1st International Symposium on Middle Molecular Strategy for Young Scientists (ISMMSys-1)2018

    • Related Report
      2018 Research-status Report
  • [Funded Workshop] International Symposium on Main Group Chemistry Directed towards Organic Synthesis(MACOS)2018

    • Related Report
      2018 Research-status Report
  • [Funded Workshop] The 10th International Peptide Symposium2018

    • Related Report
      2018 Research-status Report
  • [Funded Workshop] The 3rd International Symposium on Middle Molecular Strategy(ISMMS-3)2017

    • Related Report
      2017 Research-status Report
  • [Funded Workshop] The 11th International Symposium on Integrated Synthesis(ISONIS-11)2017

    • Related Report
      2017 Research-status Report
  • [Funded Workshop] 7thCCS-CSJ Young Chemists Forum 2017;Frontier in Organic Synthesis toward Middle Molecular Strategy2017

    • Place of Presentation
      横浜
    • Related Report
      2016 Research-status Report
  • [Funded Workshop] The 10th International Symposium on Integrated Synthesis(ISONIS-10)2016

    • Place of Presentation
      淡路
    • Year and Date
      2016-11-18
    • Related Report
      2016 Research-status Report
  • [Funded Workshop] The 12th International Symposium on Organic Reactions (ISOR-12)2016

    • Place of Presentation
      京都
    • Year and Date
      2016-04-22
    • Related Report
      2016 Research-status Report
  • [Funded Workshop] The 1st International Symposium on Middle Molecular Strategy (ISMMS-1)2016

    • Place of Presentation
      Osaka
    • Year and Date
      2016-02-06
    • Related Report
      2015 Research-status Report
  • [Funded Workshop] The 2nd International Symposium on Middle Molecular Strategy(ISMMS-2)2016

    • Place of Presentation
      豊中
    • Related Report
      2016 Research-status Report
  • [Funded Workshop] Satellite International Mini Symposium on Middle Molecular Strategy in Sendai2016

    • Place of Presentation
      仙台
    • Related Report
      2016 Research-status Report

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Published: 2015-11-10   Modified: 2024-01-30  

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