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Brain Protein Aging and Dementia Control(International Research Activities Supporting Program)

International Activities Supporting Group

Project AreaPrevention of brain protein aging and dementia
Project/Area Number 15K21714
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeMulti-year Fund
Review Section Biological Sciences
Research InstitutionNagoya University

Principal Investigator

Sobue Gen  名古屋大学, 医学系研究科, 特任教授 (20148315)

Research Collaborator YANAI kazuhiko  
TAKASHIMA akihiko  
HASEGAWA masato  
ONODERA osamu  
OKANO hideyuki  
SAHARA naruhiko  
ADACHI hiroaki  
ANDO kanae  
AKAMATSU wado  
UCHIYAMA keiji  
OHTA etsuro  
OKADA yohei  
ONO masahiro  
KAIBUCHI kozo  
KATO koichi  
SAKAGUCHI suehiro  
TAINAKA kazuki  
TAKAHASHI ryosuke  
TANAKA hiromitsu  
NAGAI yoshitaka  
HASHIMOTO tadafumi  
HASEGAWA takafumi  
HAMADA kozo  
FUKADA masaki  
FUKUDA mitsunori  
FURUKAWA yoshiaki  
MATSUI hideaki  
MIZUTA kotaro  
MOCHIZUKI hideki  
YAMADA kaoru  
MORISHITA hideaki  
HISANAGA shinichi  
Project Period (FY) 2015-11-06 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥58,760,000 (Direct Cost: ¥45,200,000、Indirect Cost: ¥13,560,000)
Fiscal Year 2018: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2017: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2016: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2015: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Keywords脳タンパク質 / 認知症 / 神経変性疾患 / 国際連携 / 国際共同研究 / 国際的拠点形成 / 国際ネットワークの構築 / 若手研究者の育成 / 若手研究者育成
Outline of Final Research Achievements

Firstly, we established the secretariat and relating committees in order to promote the international joint research and global communications.During the past four years, 43 researchers presented their research achievements abroad, and 24 distinguished foreign researchers were invited to Japan by our programs. With more than 500 participants in total, we held two international symposiums, the international workshop, the international tau symposium as well as the joint meeting with PACTALS to promote the joint research and the establishment of research networks on a global basis.
Notably, we succeeded to publish eBook composed by 22 papers in “Frontiers in Neuroscience.” This was highly effective to appeal our research achievements to the world. Through our original website, annual reports of research activities and annual newsletters, our research achievements were also effectively and successfully notified to researchers, especially those of relating to our research fields.

Academic Significance and Societal Importance of the Research Achievements

国際シンポジウムやワークショップを通じて、個人ならびに施設間の共同研究ネットワーク体制が飛躍的に発展した。これらを契機に、多くの研究成果を一流誌に出す事が出来、若手の育成や研究者のプロモーションへとつながり、さらには参加した国内外の研究者の執筆により、Frontiers in Neuroscience- Neurodegenerationに「Brain Protein Aging and Dementia Control」として研究を発信出来たことは極めて大きな学術的意義がある。また複数の市民公開講座、メディア発信、学生との交流などを通じて領域の研究成果を紹介し、社会貢献にも務めた。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (34 results)

All 2019 2017 2016 Other

All Int'l Joint Research (6 results) Journal Article (22 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 22 results,  Open Access: 22 results) Remarks (3 results) Funded Workshop (3 results)

  • [Int'l Joint Research] Max Planck Florida(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Max Planck Institute of Psychiatry(Germany)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] IBENS(France)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Ryan Institute for Stem Cell Biology(Iran)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Karolinska Institute(Sweden)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] DZNE Bonn(Germany)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Pathogenesis of frontotemporal lobar degeneration: insights from loss of function theory and early involvement of the caudate nucleus2019

    • Author(s)
      Gen Sobue* ;Shinsuke Ishgaki and Hirohisa Watanabe
    • Journal Title

      Frontiers

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Imaging Brain Misfolding in the Brain Using-sheet Ligands2019

    • Author(s)
      Ryuichi Harada1, Nobuyuki Okamura2, Shozo Furumoto3, Kazuhiko Yanai1
    • Journal Title

      Frontiers

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tau Depletion in APP Transgenic Mice Attenuates Task-Related Hyperactivation of the Hippocampus and Differentially Influences Locomotor Activity and Spatial Memory2019

    • Author(s)
      Misato Yoshikawa, Yoshiyuki Soeda, Makoto MIchikawa, Osborne F Almeida and Akihiko Takashima*
    • Journal Title

      Frontiers

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease2019

    • Author(s)
      Fuyuki Kametani and Masato Hasegawa
    • Journal Title

      Frontiers

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Robustness and Vulnerability of the Autoregulatory System That Maintains Nuclear TDP-43 Levels A Trade-off Hypothesis for ALS Pathology Based on in Silico Data2019

    • Author(s)
      Akihiro Sugai, Taisuke Kato,Akihide Koyama,Yuka Koike, Sou Kasahara, Takuya Konno, Tomohiko Ishihara and Osamu Onodera
    • Journal Title

      Frontiers

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nitrative Stress and Tau Accumulation in Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC) in the Kii Peninsula, Japan2019

    • Author(s)
      Yukiko Hata, Ning Ma, Misao Yoneda, Satoru Morimoto, Hideyuki Okano*, Shigeo Murayama, Shosuke Kawanishi, Shigeki Kuzuhara and Yasumasa Kokubo
    • Journal Title

      Frontiers

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] n Vivo Tau Imaging for a Diagnostic Platform of Tauopathy Using the rTg4510 Mouse Line2019

    • Author(s)
      Naruhiko Sahara*, Masafumi Shimojo, Maiko Ono, Hiroyuki Takuwa, Makoto Higuchi, Marcelo Febo, Tetsuya Suhara
    • Journal Title

      Frontiers

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Phosphorylation of threonine 175 tau in the pathogenesis of tau pathology in amyotrophic lateral sclerosis - frontotemporal spectrum disorder (ALS-FTSD). A review.2019

    • Author(s)
      Alexander J Moszczynski, Matthew A Hintermayer and Michael Joseph Strong
    • Journal Title

      Frontiers

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between autophagy and neurodegenerative diseases2019

    • Author(s)
      Shigeomi Shimizu
    • Journal Title

      Frontiers

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] DnaJ/Hsp40 family and Parkinson’s disease2019

    • Author(s)
      Takafumi Hasegawa*, Shun Yoshida, Naoto Sugeno, Junpei Kobayashi and Masashi Aoki
    • Journal Title

      Frontiers

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ER dynamics and derangement in neurological diseases2019

    • Author(s)
      Tomoyuki Yamanaka, Nobuyuki Nukina
    • Journal Title

      Frontiers

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] mbalanced expression of tau and tubulin induces neuronal dysfunction in C. elegans models of tauopathy2019

    • Author(s)
      Tomohiro Miyasaka*, Yuki Shinzaki, Satomi Yoshimura, Sawako Yoshina, Eriko Kage-Nakadai, Shohei Mitani and Yasuo Ihara
    • Journal Title

      Frontiers

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Extracellular tau and its potential role in the propagation of tau pathology2019

    • Author(s)
      Kaoru Ymada
    • Journal Title

      Frontiers

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phospho-tau bar code: analysis of phosphoisotypes of tau and its application to tauopathy2019

    • Author(s)
      Taeko Kimura, Govinda Sharma, Koichi Ishiguro and Shin-Ichi Hisanaga*
    • Journal Title

      Frontiers

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Linking hnRNP function to ALS and FTD pathology2019

    • Author(s)
      J Paul Taylor, Maria D Purice
    • Journal Title

      Frontiers

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An overview of the role of lipofuscin in age-related neurodegeneration2019

    • Author(s)
      Alexandra Moreno-Garcia, Alejandra Kun, Olga Calero, Miguel Medina* and Miguel Calero
    • Journal Title

      Frontiers

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Safety and efficacy of scanning ultrasound treatment of aged APP23 mice2019

    • Author(s)
      Gerhard Leinenga and Jurgen Gotz*
    • Journal Title

      Frontiers

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Imaging of neuronal activity in awake mice by measurements of flavoprotein autofluorescence corrected for cerebral blood flow2019

    • Author(s)
      Manami Takahashi, Takuya Urushihata, Hiroyuki Takuwa* Kazumi Sakata, Yuhei Takado, Eiji Shimizu,
    • Journal Title

      Frontiers

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alzheimer’s disease: The role of microglia in brain homeostasis and proteopathy2019

    • Author(s)
      Kevin A Clayton, Alicia A Van Enoo and Tsuneya Ikezu*
    • Journal Title

      Frontiers

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Imbalances in the Hsp90 chaperone machinery: Implications for tauopathies2019

    • Author(s)
      Lindsey B Shelton, John Koren and Laura J Blair*
    • Journal Title

      Frontiers

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cognitive decline in neuronal aging and Alzheimer’s disease: role of NMDA receptors and associated proteins2019

    • Author(s)
      Jesus Avila, Maria Llorens Mart, Noemi Pallas Bazarra, Marta Bolos Juan Ramon Perea, Alberto Rodriguez-Matellan and Felix Hernandez
    • Journal Title

      Frontiers

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tau Filaments and the Development of Positron Emission Tomography (PET) Tracers2019

    • Author(s)
      Michel Goedert*, Yoshiki Yamaguchi, Sushil Mishra, Makoto Higuchi& and Naruhiko Sahara*
    • Journal Title

      Frontiers

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Remarks] 新学術領域研究(研究領域提案型)脳タンパク質老化と認知症制御 国際活動支援班

    • URL

      http://www.protein-dementia.jp/intl/

    • Related Report
      2018 Annual Research Report
  • [Remarks] Brain Protein Aging and Dementia Control

    • URL

      https://www.frontiersin.org/research-topics/5745/brain-protein-aging-and-dementia-control

    • Related Report
      2018 Annual Research Report
  • [Remarks] 新学術領域研究脳「タンパク質老化と認知症制御」国際活動支援班

    • URL

      http://www.protein-dementia.jp/intl/

    • Related Report
      2017 Research-status Report
  • [Funded Workshop] Joint Meeting of “Brain Protein Aging and Dementia Control” project & Pan-Asia Consortium for Treatment and Research in ALS (PACTALS)2017

    • Related Report
      2017 Research-status Report
  • [Funded Workshop] 2nd International Symposium of Brain Protein Aging and Dementia Control2017

    • Related Report
      2017 Research-status Report
  • [Funded Workshop] 国際ワークショップ20162016

    • Place of Presentation
      名古屋大学 鶴舞会館
    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-11-10   Modified: 2020-03-30  

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