| Project Area | Dynamic chromatin structure and function |
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| Project/Area Number |
15K21730
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Biological Sciences
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| Research Institution | Waseda University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
木村 宏 東京工業大学, 科学技術創成研究院, 教授 (30241392)
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| Co-Investigator(Renkei-kenkyūsha) |
OBUSE Chikashi 大阪大学, 理学研究科, 教授 (00273855)
HARAGUCHI Tokuko 情報通信研究機構, 未来ICT研究所, 主任研究員 (20359079)
YONEDA Yoshihiro 医薬基盤健康栄養研究所, 研究所長 (80191667)
TOKUNAGA Makio 東京工業大学, 生命理工学院, 教授 (00192659)
KONO Hidetoshi 量子科学技術研究開発機構, グループリーダー (40291918)
SAITOH Noriko がん研究会, がん生物部, 部長 (40398235)
OHKAWA Yasuyuki 九州大学, 生体防御医学研究所, 教授 (80448430)
HARATA Masahiko 東北大学, 農学研究科, 教授 (70218642)
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| Project Period (FY) |
2015-11-06 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥32,890,000 (Direct Cost: ¥25,300,000、Indirect Cost: ¥7,590,000)
Fiscal Year 2017: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2016: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Keywords | エピジェネティクス / ゲノム機能 / 染色体構築・機能・分配 / ゲノム多様性 / 生体高分子構造・機能ゲノム進化・再編 / 遺伝情報複製・再編 / ゲノム維持修復 / ゲノム進化・再編 / 活性発現の分子機構 / 生体高分子構造・機能 / 構造活性相関 |
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| Outline of Final Research Achievements |
In eukaryotes, genomic DNA forms chromatin, which is generally inhibitory for transcription, replication, recombination, and repair. Structural versatility and dynamics of chromatin are important to overcome such a chromatin barrier. To understand the mechanism by which the chromatin architecture negotiates the genomic DNA activities, international collaboration is very important. Therefore, the aim of this study is to create the international research network for chromatin scientist. Eventually, the international partnership created in this study markedly boosted the chromatin research.
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