| Project Area | Mechanisms regulating gamete formation in animals |
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| Project/Area Number |
15K21736
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Biological Sciences
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| Research Institution | University of Tsukuba |
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Principal Investigator |
Kobayashi Satoru 筑波大学, 生命領域学際研究センター, 教授 (90225508)
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| Co-Investigator(Kenkyū-buntansha) |
小川 毅彦 横浜市立大学, 生命医科学研究科, 教授 (50254222)
吉田 松生 基礎生物学研究所, 生殖細胞研究部門, 教授 (60294138)
林 克彦 九州大学, 医学研究院, 教授 (20287486)
大保 和之 横浜市立大学, 医学研究科, 教授 (70250751)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUI YASUHISA 東北大学, 加齢医学研究所, 教授 (40241575)
YOSHIZAKI GORO 東京海洋大学, 海洋科学技術研究科, 教授 (70281003)
OBATA YAYOI 東京農業大学, 応用生物科学部, 教授 (70312907)
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| Project Period (FY) |
2015-11-06 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥35,100,000 (Direct Cost: ¥27,000,000、Indirect Cost: ¥8,100,000)
Fiscal Year 2017: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2016: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2015: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 配偶子産生 / 配偶子幹細胞 / 精子形成 / 始原生殖細胞 / in vitro 配偶子産生 / 国際共同研究 / 異分野間共同研究 / エピジェネティック制御 / ライブイメージング |
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| Outline of Final Research Achievements |
International joint research was performed, based on the research supported by Grant-in-Aid for Scientific Research on Innovation Area "Mechanisms regulating gamete formation in animals", which aimed to find the regulatory mechanisms of primordial germ cell (PGC) formation and gamete stem cell (GSC) function in animals. This international joint research consisted of constructing an in vitro live-imaging system for spermatogenesis, developing the method to analyze epigenetic regulation of spermatogenesis, and encouraging and supporting tight interaction with oversea researchers through international meetings. This research grant enabled us to establish a novel world-leading research community.
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