宇宙からひも解く新たな生命制御機構の統合的理解

• Project Area: "LIVING IN SPACE" - Integral Understanding of life-regulation mechanism from "SPACE"
• Project/Area Number: 15K21745
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Multi-year Fund
• Review Section: Complex systems
• Research Institution: Japan Aerospace EXploration Agency
• Principal Investigator: 古川 聡 国立研究開発法人宇宙航空研究開発機構, 有人宇宙技術部門, 上席研究開発員 (20726260)
• Project Period (FY): 2015-11-06 – 2020-03-31
• Project Status: Granted (Fiscal Year 2018)
• Budget Amount: ¥74,100,000 (Direct Cost: ¥57,000,000、Indirect Cost: ¥17,100,000); Fiscal Year 2019: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000); Fiscal Year 2018: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000); Fiscal Year 2017: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000); Fiscal Year 2016: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000); Fiscal Year 2015: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
• Keywords: 宇宙 / 無重力 / ストレス / 放射線 / 微生物

Outline of Annual Research Achievements

H30年度は研究代表者枠派遣5件、若手研究者派遣5件、海外研究者招聘10件、海外若手研究者招聘8件を実施した。H30年度は本基金による国際共同研究で新たに9本の論文が発表された。更に国際共同研究が始まっている。また、同時に若手交流促進や人材育成に貢献している。
[A01]宇宙からひも解かれる生命分子基盤の理解を達成目標に、重力はじめ力学的ストレスに対する細胞、神経―筋の細胞間、筋や腱組織のメカノセンシング機構からの適応応答、発達制御、長期無重力や加齢による萎縮・破綻に至る仕組みについて、バイオイメージングやトランスクリプトーム、プロテオーム等先端手法を用いて解析を進めている。
[A02]生命体が個体として有する高次恒常性・適応機構と生命医学への展開として、重力と閉鎖環境に対する循環系、前庭系、精神・自律神経系、睡眠・覚醒、統合的理解を、ヒトを主な研究対象とし、生理・生化学的データ、遺伝子発現、エピゲノム解析、さらにはメンタルストレスに対する新たな客観的評価分析法を開発するなど、基礎医学的解析を中心に実施している。
[A03]宇宙環境によるリスク因子研究とその克服として、宇宙放射線の中でも特に単位面積当たりとして少ないが、高いエネルギーを付与する重粒子放射線、重力変化と宇宙放射線の複合作用、太陽紫外線を含む様々な宇宙放射線、無重力に伴うバイオフィルム形成や遺伝子伝播を含めた微生物間相互作用への影響について評価・分析し、リスク対策方法の開発を展開している。
領域課題の横断・補完的研究[B01]で、放射線被ばくによる細胞ダメージや細胞周期の可視化等を行っている。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

国際活動支援班基金開始から4年経ち、H30年度は本基金による国際共同研究で新たに9本の論文が発表された。また、H30年度は外国への研究者派遣や、外国からの研究者招聘件数が前年度より増加し、それに伴いさらに多くの国際共同研究が始まっており、当初計画よりもわずかに遅れ気味なレベルにまで取り戻している。
以上の理由により、現状おおむね順調に進展していると考える。

Strategy for Future Research Activity

新たに選定された公募班研究者や関連若手研究者を対象に、H31年度も約10名の研究者を派遣、約25名の研究者を招聘予定である。多くの国際共同研究が期待され、基金を有効活用できる見込みである。

Research Products

• [Int'l Joint Research] バージニア大学/コロラド州立大学/Prairie View A&M University(米国)
• [Int'l Joint Research] ドイツ航空宇宙センター(ドイツ)
• [Int'l Joint Research] パスツール研究所(フランス)
• [Int'l Joint Research] バルセロナ大学/Pompeu Fabra University(スペイン)
• [Int'l Joint Research] ベルゲン大学(ノルウェー)
• [Int'l Joint Research]
• [Int'l Joint Research] スタンフォード大学/ハーバード大学/バージニア大学(アメリカ合衆国)
• [Int'l Joint Research] ドイツ航空宇宙センター/マールブルグ大学/Institute of Aerospace Medicine(ドイツ)
• [Int'l Joint Research] パスツール研究所(フランス)
• [Int'l Joint Research] Institute of Science and Technology(オーストリア)
• [Int'l Joint Research] スウェーデン農業科学大学(スウェーデン)
• [Int'l Joint Research] スタンフォード大学/フロリダ州立大学/バージニア大学(アメリカ合衆国)
• [Int'l Joint Research] German Aerospace Center/マールブルグ大学/Institute of Aerospace Medicine(ドイツ )
• [Int'l Joint Research] パスツール研究所(フランス)
• [Int'l Joint Research] Institute of Science and Technology(オーストリア)
• [Journal Article] Non-canonical cholinergic anti-inflammatory pathway-mediated activation of peritoneal macrophages induces Hes1 and blocks ischemia/reperfusion injury in the kidney (2019)
  • Author(s): Inoue T,Abe C, Kohro T, Tanaka S, Huang L, Yao J, Zheng S, Ye H, Inagi R, Stornetta RL, Rosin DL, Nangaku M, Wada Y, Okusa MD
  • Journal Title: Kidney International Volume: 95(3) Pages: 563-576
  • DOI: 10.1016/j.kint.2018.09.020
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Enhancing endogenous adenosine A2A receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function (2019)
  • Author(s): Korkutata M, Saitoh T, Cherasse Y, Ioka S, Duo F, Qin R, Murakoshi N, Fujii S, Zhou X, Sugiyama F, Chen JF, Kumagai H, Nagase H, Lazarus M
  • Journal Title: Neuropharmacology Volume: 144 Pages: 122-132
  • DOI: 10.1016/j.neuropharm.2018.10.022
  • NAID: 120006583051
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Radiobiological Characterization of Canine Malignant Melanoma Cell Lines with Different Types of Ionizing Radiation and Efficacy Evaluation with Cytotoxic Agents. (2019)
  • Author(s): Yoshikawa Hiroto、Sunada Shigeaki、Hirakawa Hirokazu、Fujimori Akira、Elmegerhi Suad、Leary Del、Kato Takamitsu
  • Journal Title: International Journal of Molecular Sciences Volume: 20 Pages: 1-12
  • DOI: 10.3390/ijms20040841
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Extracellular adenosine and slow-wave sleep are increased after ablation of nucleus accumbens core astrocytes and neurons in mice (2019)
  • Author(s): Zhou X, Oishi Y, Cherasse Y, Korkutata M, Fujii S, Lee CY, Lazarus M
  • Journal Title: Neurochem Int Volume: 124 Pages: 256-263
  • DOI: 10.1016/j.neuint.2019.01.020
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Increased chromosome aberrations in cells exposed simultaneously to simulated microgravity and radiation. (2019)
  • Author(s): Hada M, Ikeda H, Rhone JR, Beitman AJ, Plante I, Souda H, Yoshida Y, Held KD, Fujiwara K, Saganti PB, Takahashi A.
  • Journal Title: Int J Mol Sci Volume: 20 Pages: 43-43
  • DOI: 10.3390/ijms20010043
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Progression of peripheral vestibular dysfunctions in patients with a mitochondrial A3243G mutation. (2019)
  • Author(s): Inoue Aki、Iwasaki Shinichi、Fujimoto Chisato、Kinoshita Makoto、Yamasoba Tatsuya
  • Journal Title: Otol Neurotol Volume: 40 Pages: 359-364
  • DOI: 10.1097/mao.0000000000002091
  • Peer Reviewed / Open Access
• [Journal Article] Sleep and Wakefulness Are Controlled by Ventral Medial Midbrain/Pons GABAergic Neurons in Mice (2018)
  • Author(s): Takata Y, Oishi Y, Zhou XZ, Hasegawa E, Takahashi K, Cherasse Y, Sakurai T, Lazarus M
  • Journal Title: J Neurosci Volume: 0598-18 Pages: 10080-10092
  • DOI: 10.1523/jneurosci.0598-18.2018
  • NAID: 120006582772
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Palmitoyl ascorbic acid 2-glucoside has the potential to protect mammalian cells from high-LET carbon-ion radiation (2018)
  • Author(s): Alexis H. Haskins, Dylan J. Buglewicz, Hirakawa Hirokazu, Akira Fujimori, Yasushi Aizawa, Takamitsu A. Kato
  • Journal Title: Scientific Reports Volume: 8(1) Pages: 1-7
  • DOI: 10.1038/s41598-018-31747-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Role of C1 neurons in anti-inflammatory reflex: Mediation between afferents and efferents. (2018)
  • Author(s): Chikara Abe, Tsuyoshi Inoue
  • Journal Title: Neuroscience Research Volume: 136 Pages: 6-12
  • DOI: 10.1016/j.neures.2018.05.001
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Histone deacetylase inhibitor induced radiation sensitization effects on human cancer cells after photon and hadron radiation exposure (2018)
  • Author(s): Ariungerel Gerelchuluun, Junko Maeda, Akira Fujimori et al.
  • Journal Title: Int J Mol Sci Volume: 19(2) Pages: 496-496
  • DOI: 10.3390/ijms19020496
  • NAID: 120006460182
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cryptoendolithic Antarctic Black Fungus Cryomyces antarcticus Irradiated with Accelerated Helium Ions: Survival and Metabolic Activity, DNA and Ultrastructural Damage (2017)
  • Author(s): Claudia Pacelli, Ralf Moeller, Akira Fujimori et al.
  • Journal Title: Frontiers in Microbiology Volume: 8 Pages: 2002-2002
  • DOI: 10.3389/fmicb.2017.02002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice. (2017)
  • Author(s): Oishi Yo、Xu Qi、Wang Lu、Zhang Bin-Jia、Takahashi Koji、Takata Yohko、Luo Yan-Jia、Cherasse Yoan、Schiffmann Serge N.、de Kerchove d’Exaerde Alban、Urade Yoshihiro、Qu Wei-Min、Huang Zhi-Li、Lazarus Michael
  • Journal Title: Nat. Commun Volume: 8 Pages: 1-12
  • DOI: 10.1038/s41467-017-00781-4
  • NAID: 120006355834
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Microgravity elicits reproducible alterations in cytoskeletal and metabolic gene and protein expression in space-flown Caenorhabditis elegans. (2016)
  • Author(s): Higashibata A., Hashizume T., Nemoto K., Higashitani N., Etheridge T., Mori C., Harada S., Sugimoto T., Szewczyk NJ., Baba SA., Mogami Y., Fukui K., Higashitani A.
  • Journal Title: npj Microgravity Volume: 2 Pages: 15022-15022
  • DOI: 10.1038/npjmgrav.2015.22
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Fluid dynamics alter Caenorhabditis elegans body length via TGF-β/DBL-1 neuromuscular signaling. (2016)
  • Author(s): Harada S., Hashizume T., Nemoto K., Shao Z., Higashitani N., Etheridge T., Szewczyk NJ., Fukui K., Higashibata A., Higashitani A.
  • Journal Title: npj Microgravity Volume: 2 Pages: 16006-16006
  • DOI: 10.1038/npjmgrav.2016.6
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The relationship between widespread changes in gravity and cerebral blood flow. (2016)
  • Author(s): Ogawa Y, Yanagida R, Ueda K, Aoki K, Iwasaki K
  • Journal Title: Environmental Health and Preventive Medicine Volume: in press
  • DOI: 10.1007/s12199-016-0513-7
  • NAID: 210000000435
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Intrathecal morphine-3-glucuronide-induced nociceptive behavior via Delta-2 opioid receptors in the spinal cord (2016)
  • Author(s): Takaaki Komatsu, Soh Katsuyama, Hiroshi Nagase, Hirokazu Mizoguchi, Chikai Sakurada, Minoru Tsuzuki, Shinobu Sakurada, Tsukasa Sakurada
  • Journal Title: Pharmacol. Biochem. Be. Volume: 140 Pages: 68-74
  • DOI: 10.1016/j.pbb.2015.10.010
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Opioid System in the Lateral Hypothalamus Regulate Feeding Behavior Through Orexin and GABA Neurons (2016)
  • Author(s): Ardianto C, Yonemochi N, Yamamoto S, Yang L, Takenoya F, Shioda S, Nagase H, Ikeda H, Kamei J.
  • Journal Title: NeuroScience Volume: 320 Pages: 183-193
  • DOI: 10.1016/j.neuroscience.2016.02.002
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] High-fat diet feeding alters olfactory-, social- and reward-related behaviors of mice independent of obesity (2016)
  • Author(s): Takase K, Tsuneoka Y, Oda S, Kuroda M, Funato H
  • Journal Title: Obesity (Silver Spring, Md.) Volume: 4 Pages: 886-894
  • DOI: 10.1002/oby.21441
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Sleep as a biological problem: an overview of frontiers in sleep research. (2016)
  • Author(s): Kanda T, Tsujino N, Kuramoto E, Koyama Y, Susaki EA, Chikahisa S, Funato H
  • Journal Title: The Journal of Physiological Sciences Volume: 66 Pages: 1-13
  • DOI: 10.1007/s12576-015-0414-3
  • NAID: 40020697820
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Nighttime Administration of Nicotine Improves Hepatic Glucose Metabolism via the Hypothalamic Orexin System in Mice (2016)
  • Author(s): Tsuneki H, Nagata T, Fujita M, Kon K, Wu N, Takatsuki M, Yamaguchi K, Wada T, Nishijo H, Yanagisawa M, Sakurai T, Sasaoka T.
  • Journal Title: Endocrinology Volume: 157 Pages: 195-206
  • DOI: 10.1210/en.2015-1488
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Plant nuclei move to escape ultraviolet-induced DNA damage and cell death (2016)
  • Author(s): Iwabuchi K., Hidema J., Tamura K., Takagi S., and Hara-Nishimura I.
  • Journal Title: Plant Physiol. Volume: 170 Issue: 2 Pages: 678-685
  • DOI: 10.1104/pp.15.01400
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A critical role of Dectin-1 in hypersensitivity pneumonitis. (2016)
  • Author(s): Higashino-Kameda M, Yabe-Wada T, Matsuba S, Takeda K, Anzawa K, Mochizuki T, Makimura K, Saijo S, Iwakura Y, Toga H, Nakamura A
  • Journal Title: Inflamm Res. Volume: 65 Pages: 235-244
  • DOI: 10.1007/s00011-015-0910-1
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Comprehensive analysis of the skin fungal microbiota of astronauts during a half-year stay at the International Space Station (2016)
  • Author(s): Sugita T, Yamazaki T, Makimura K, Cho O, Yamada S, Ohshima H, Mukai C
  • Journal Title: Medical Mycology Volume: published online Pages: 232-239
  • DOI: 10.1093/mmy/myv121
  • Peer Reviewed / Open Access
• [Journal Article] Phylogenetic analysis of dermatophyte species using DNA sequence polymorphism in calmodulin gene (2016)
  • Author(s): Ahmadi B, Mirhendi H, Makimura K, de Hoog GS, Shidfar MR, Nouripour-Sisakht S, Jalalizand N
  • Journal Title: Med Mycol Volume: published online
  • DOI: 10.1093/mmy/myw004
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Fatal Cyberlindnera fabianii fungemia in a patient with mixed phenotype acute leukemia after umbilical cord blood transplantation (2016)
  • Author(s): Katagiri S, Gotoh M, Tone K, Akahane D, Ito Y, Ohyashiki K, Makimura K
  • Journal Title: Int J Hematol Volume: published online
  • DOI: 10.1007/s12185-016-1953-y
  • Peer Reviewed
• [Journal Article] Epidemiological aspects of Dermatophytosis in Khusestan, southwestern Iran, an update (2016)
  • Author(s): Razaei-Matehkolaei A, Rafiei A, Makimura K, Graser Y, Gharghani M, Sadeghi-Nejad B
  • Journal Title: Mycopathologia Volume: published online
  • DOI: 10.1007/s11046-016-9990-x
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Mest but not miR-335 affects skeletal muscle growth and regeneration (2015)
  • Author(s): Hiramuki Y, Sato T, Furuta Y, Surani A, Sehara-Fujisawa A
  • Journal Title: PLoS One Volume: 10
  • DOI: 10.1371/journal.pone.0130436
  • NAID: 120005756262
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] High-resolution live imaging reveals axon-glia interactions during peripheral nerve injury and repair (2015)
  • Author(s): Xiao Y, Faucherre A, Pola-Morell L, Heddleston J, Liu T, Chew T, Sato F, Sehara-Fujisawa A, Kawakami K, Lopez-Schier H
  • Journal Title: Disease Models & Mechanisms Volume: 8 Pages: 553-564
  • DOI: 10.1242/dmm.018184
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Early pathogenesis of Duchenne muscular dystrophy modelled in patient-derived human induced pluripotent stem cells. (2015)
  • Author(s): Shoji E, Sakurai H, Nishino T, Nakahata T, Heike T, Awaya T, Fujii N, Manabe Y, Matsuo M, Sehara-Fujisawa A
  • Journal Title: Scientific Reports. Volume: 5 Pages: 12831-12831
  • DOI: 10.1038/srep12831
  • NAID: 120005649326
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Molecular dynamics study on protein–water interplay in the mechanogating of the bacterial mechanosensitive channel MscL (2015)
  • Author(s): Sawada Y, Sokabe M
  • Journal Title: Eur J Biophys Volume: 44 Pages: 531-43
  • DOI: 10.1007/s00249-015-1065-2
  • Peer Reviewed / Open Access
• [Journal Article] Unidirectional incorporation of a bacterial mechanosensitive channel into liposomal membranes (2015)
  • Author(s): Nomura T, Cox CD, Bavi N, Sokabe M and Martinac B
  • Journal Title: FASEB J Volume: 29 Pages: 4334-4345
  • DOI: 10.1096/fj.15-275198
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Ion Channels Activated by Mechanical Forces in Bacterial and Eukaryotic Cells (2015)
  • Author(s): Sokabe M, Sawada M, Kobayashi T
  • Journal Title: Subcell Biochem: high Pressure Bioscience-Basic Concepts, Applications and Frontiers Volume: 72 Pages: 613-26
  • DOI: 10.1007/978-94-017-9918-8_28
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Hypergravity Provokes a Temporary Reduction in CD4+CD8+ Thymocyte Number and a Persistent Decrease in Medullary Thymic Epithelial Cell Frequency in Mice. (2015)
  • Author(s): Tateishi R, Akiyama N, Miyauchi M, Yoshinaga R, Sasanuma H, Kudo T, Shimbo M, Shinohara M, Obata K, Inoue J, Shirakawa M, Shiba D, Asahara H, Yoshida N, Takahashi S, Morita H, Akiyama T
  • Journal Title: PLoS One Volume: 10 Pages: 1-17
  • DOI: 10.1371/journal.pone.0141650
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Feasibility of a Short-Arm Centrifuge for Mouse Hypergravity Experiments. (2015)
  • Author(s): Morita H, et al.
  • Journal Title: PLoS One Volume: 10(7): e133981 Pages: 1-14
  • DOI: 10.1371/journal.pone.0133981
  • NAID: 120005656590
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Role of osteoclasis in the heterotopic ossification enhanced by fobrodysplasia ossificans progressiva-related activin-like kinase 2 mutation in mice (2015)
  • Author(s): Kawao N, Yano M, Tamura Y, Okumoto K, Okada K, Kaji H
  • Journal Title: J Bone Miner Metab Volume: epub
  • Peer Reviewed
• [Journal Article] Clinical charasteristics of patients with abnornal ocular/cervical vestibular evoked myogenic potentials in the presence of normal caloric responses (2015)
  • Author(s): Iwasaki S, Fujimoto C, Kinoshita M, Kamogashira T, Egami N, Yamasoba T
  • Journal Title: Ann Otol Rhinol Laryngol Volume: 124 Pages: 458-65
  • Peer Reviewed
• [Journal Article] The effect of aging on the center-of-pressure power spectrum in foam posturography (2015)
  • Author(s): Fujimoto C, Egami N, Demura S, Yamasoba T, Iwasaki S.
  • Journal Title: Neuroscience letters Volume: 585 Pages: 92-7
  • DOI: 10.1016/j.neulet.2014.11.033
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Transformation of naltrexone into mesembrane and investigation of the binding properties of its intermediate derivatives to opioid receptors (2015)
  • Author(s): Konoura K, Fujii H, Imaide S, Gouda H, Hirayama S, Hirono S, Nagase H
  • Journal Title: Bioorg. Med. Chem. Volume: 23 Pages: 439-448
  • DOI: 10.1016/j.bmc.2014.12.032
  • NAID: 120005555623
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Peripheral opioid antagonist enhances the effect of anti-tumor drug by blocking a cell growth-suppressive pathway in vivo. (2015)
  • Author(s): Masami Suzuki, Fumiko Chiwaki, Yumi Sawada, Maho Ashikawa, Kazuhiko Aoyagi, Takeshi Fujita, Kazuyoshi Yanagihara, Masayuki Komatsu, Minoru Narita, Tsutomu Suzuki, Hiroshi Nagase, Ryoji Kushima, Hiromi Sakamoto, Takeo Fukagawa, Hitoshi Katai, Hitoshi Nakagama, Teruhiko Yoshida, Yasuhito Uezono, Hiroki Sasaki
  • Journal Title: PLoS One. Volume: 10(4) Pages: 1-18
  • DOI: 10.1371/journal.pone.0123407
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Naltrindole derivatives with fluorinated ethyl substituents on 17-nitrogen as delta opioid receptor inverse agonist (2015)
  • Author(s): Nemoto T, Iihara Y, Hirayama S, Iwai T, Higashi E, Fujii H, Nagase H
  • Journal Title: Bioorg Med Chem Lett Volume: 25 Pages: 2927-30
  • DOI: 10.1016/j.bmcl.2015.05.038
  • Peer Reviewed
• [Journal Article] Naltrindole derivatives with fluorinated ethyl substituents on 17-nitrogen as δ opioid receptor inverse agonist (2015)
  • Author(s): Kutsumura, N.; Nakajima, R.; Koyama, Y.; Miyata, Y.; Saitoh, T.; Yamamoto, N.; Iwata, S.; Fujii, H.; Nagase, H.
  • Journal Title: Bioorg. Med. Chem. Lett Volume: 25 Pages: 4890-2
  • DOI: 10.1016/j.bmcl.2015.06.002
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Inhibition of opioid systems in the hypothalamus as well as the mesolimbic area suppresses feeding behavior of mice (2015)
  • Author(s): Ikeda H, Ardianto C, Yonemochi N, Yang L, Ohashi T, Ikegami M, Nagase H, Kamei J
  • Journal Title: NeuroScience Volume: 311 Pages: 9-21
  • DOI: 10.1016/j.neuroscience.2015.10.002
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Design and synthesis of non-peptide, selective orexin receptor 2 agonists (2015)
  • Author(s): Nagahara T, Saitoh T, Kutsumura N, Irukayama-Tomobe Y, Ogawa Y, Kuroda D, Gouda H, Kumagai H, Fujii H, Yanagisawa M, Nagase H
  • Journal Title: J Med Chem. Volume: 58 Pages: 7931-37
  • DOI: 10.1021/acs.jmedchem.5b00988
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain (2015)
  • Author(s): Nakajima R, Yamamoto N, Hirayama S, Iwai T, Saitoh A, Nagumo Y, Fujii H, Nagase H.
  • Journal Title: Bioorg. Med. Chem. Volume: 23 Pages: 6271-6279
  • DOI: 10.1016/j.bmc.2015.08.036
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Endothelin-1 as a master regulator of whole-body Na+ homeostasis (2015)
  • Author(s): Speed JS, Heimlich JB, Hyndman KA, Fox BM, Patel V, Yanagisawa M, Pollock JS, Titze JM, Pollock DM
  • Journal Title: FASEB J Volume: 29 Pages: 4937-44
  • DOI: 10.1096/fj.15-276584
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Functional ETA-ETB receptor cross-talk in basilar artery in situ from ETB receptor deficient rats (2015)
  • Author(s): Yoon S, Gariepy CE, Yanagisawa M, Zuccarello M, Rapoport RM
  • Journal Title: J Cardiovasc Pharmacol Volume: epub
  • Peer Reviewed
• [Journal Article] 長期宇宙滞在時に解決すべき医学的課題～循環制御関連を中心に～ (2015)
  • Author(s): 古川聡
  • Journal Title: 循環制御 Volume: 36 Pages: 66-8
  • Open Access
• [Journal Article] UV-B-Induced CPD Photolyase Gene Expression is Regulated by UVR8-Dependent and -Independent Pathways in Arabidopsis (2015)
  • Author(s): Li N, Teranishi M, Yamaguchi Ｈ, Matsushita T, Watahiki MK, Tsuge T, Li SS, Hidema J
  • Journal Title: Plant Cell Physiol. Volume: 56 Pages: 2014-2023
  • DOI: 10.1093/pcp/pcv121
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] From Arabidopsis to cereal crops: Conservation of chloroplast protein degradation by autophagy indicates its fundamental role in plant productivity (2015)
  • Author(s): Izumi M, Hidema J, Ishida H
  • Journal Title: Plant Signal Behav. Volume: 10
  • DOI: 10.1080/15592324.2015.1101199
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells (2015)
  • Author(s): Ma H, Takahashi A, Yoshida Y, Adachi A, Kanai T, Ohno T, Nakano T.
  • Journal Title: Radiat Oncol Volume: 10 Pages: 225-225
  • DOI: 10.1186/s13014-015-0536-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Targeting of Carbon Ion-Induced G2 Checkpoint Activation in Lung Cancer Cells Using Wee-1 Inhibitor MK-1775 (2015)
  • Author(s): Ma H, Takahashi A, Sejimo Y, Adachi A, Kubo N, Isono M, Yoshida Y, Kanai T, Ohno T, Nakano T.
  • Journal Title: Radiat Res Volume: 184 Pages: 660-669
  • DOI: 10.1667/rr14171.1
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Genetic and phenotypic analyses of Calcineurin A subunit in Arthroderma vanbreuseghemii (2015)
  • Author(s): Alshahni MM, Shimizu K, Yoshimoto M, Yamada T, Nishiyama Y, Arai T, Makimura K
  • Journal Title: Med Mycol Volume: 54 Pages: 207-18
  • DOI: 10.1093/mmy/myv088
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Dermatophytosis due to Microsporum incurvatum: notification and identification of a neglected pathogenic species (2015)
  • Author(s): Rezaei-Matehkolaei A, Makimura K, Graser Y, Seyedmousavi S, Abastabar M, Rafiei A, Zhan P, Ronagh A, Jafarpour S
  • Journal Title: Mycopathologia Volume: 181 Pages: 107-13
  • DOI: 10.1007/s11046-015-9946-6
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Microbes and crewed space habitat (2015)
  • Author(s): Yamaguchi N, Nasu M
  • Journal Title: J Dis Res Volume: 10 Pages: 1022-4
• [Journal Article] Microbial observatory research in the International Space Station and Japanese Experiment Module "Kibo" (2015)
  • Author(s): Shirakawa M, Tanigaki F, Yamazaki T
  • Journal Title: J Dis Res Volume: 10 Pages: 1025-30
• [Journal Article] Significance of changes in the skin fungal microbiomes of astronauts staying on the International Space Station (2015)
  • Author(s): Sugita T, Cho O
  • Journal Title: J Dis Res Volume: 10 Pages: 1031-4
• [Journal Article] Bacterial Monitoring in the International Space Station (2015)
  • Author(s): Ichijo T, Yamaguchi N, nasu M
  • Journal Title: J Dis Res Volume: 10 Pages: 1035-9
• [Presentation] Increased chromosome aberrations in cells exposed simultaneously to simulated microgravity and radiation. (2019)
  • Author(s): Rhone JR, Beitman A, Ikeda H, Souda H, Yoshida Y, Held KD, Fujiwara K, Takahashi A, Saganti PB, Hada M.
  • Organizer: 2019 NASA Human Research Program Investigators' Workshop
  • Int'l Joint Research
• [Presentation] Study on gravity-dependent skeletal muscle maintenance mechanisms using Zebrafish, aquatic organisms (2018)
  • Author(s): Fuminori Sato, Minyong Choi, Zi Wang, Kiyomi Imamura, Terumi Horiuchi, Wu Quan, Ikumi Fujita, Satoko Uchida, Mitsuyasu Kato, Fumiaki Tanigaki, Akira Higashibata, Masafumi Muratani, Junya Kobayashi, Akihisa Takahashi, Sumio Sugano, Fumio Matsuzaki, Yutaka Suzuki, Koichi Kawakami, Atsuko Sehara-Fujisawa
  • Organizer: 2018 ASCB EMBO Meeting
  • Int'l Joint Research
• [Presentation] Effects from chronic restraint-induced stress and total body Fe irradiation on the hematopoietic system in Trp53-heterozygous mice. (2018)
  • Author(s): Bing Wang, Kaoru Tanaka, Takanori Katsube, Yasuharu Ninomiya, Hirokazu Hirakawa, Cuihua Liu, Kouichi Maruyama, Guillaume Vares, Qing Liu, Tetsuo Nakajima, Akira Fujimori, Mitsuru Nenoi
  • Organizer: The 64th Annual Radiation Research Society Meeting
  • Int'l Joint Research
• [Presentation] Effects from chronic restraint-induced stress and total body Fe-particle irradiation on the induction of chromosomal aberrations in splenocytes of Trp53-heterozygous mice (2018)
  • Author(s): Takanori Katsube, Bing Wang, Kaoru Tanaka, Yasuharu Ninomiya, Hirokazu Hirakawa, Cuihua Liu, Kouichi Maruyama, Guillaume Vares, Qing Liu, Tetsuo Nakajima, Akira Fujimori, Mitsuru Nenoi
  • Organizer: The 64th Annual Radiation Research Society Meeting
  • Int'l Joint Research
• [Presentation] Residual Genotoxic Damage Induced by Accelerated Heavy Iron Particles in Bone Marrow Erythrocytes in Mice: Reduction of genotoxic effects by radioadaptive response and mild diet restriction? (2018)
  • Author(s): Bing Wang, Kaoru Tanaka, Takanori Katsube, Yasuharu Ninomiya, Hirokazu Hirakawa, Cuihua Liu, Kouichi Maruyama, Guillaume Vares, Tetsuo Nakajima, Akira Fujimori, Mitsuru Nenoi
  • Organizer: The 3rd Global Chinese Congress of Radiation Research
  • Int'l Joint Research / Invited
• [Presentation] Effects of chronic restraint-induced psychological stress and ionizing radiation on mouse spleen cells (2018)
  • Author(s): Takanori Katsube, Bing Wang, Kaoru Tanaka, Yasuharu Ninomiya, Hirokazu Hirakawa, Cuihua Liu, Kouichi Maruyama, Guillaume Vares, Tetsuo Nakajima, Aiko Nagamatsu, Kenshi Suzuki, Taiki Kawagoshi, Naoko Shiomi, Yoshihisa Kubota, Qiang Liu, Akinori Morita, Akira Fujimori, Mitsuru Nenoi
  • Organizer: The 3rd Global Chinese Congress of Radiation Research
  • Int'l Joint Research / Invited
• [Presentation] Reduction of high-dose-radiation-induced delayed genotoxic effects by induction of radioadaptive response and mild diet restriction in mice:The Superiority of The Mechanism of Heavy Ion Therapy in Institute of Modern Physic (2018)
  • Author(s): Bing Wang, Kaoru Tanaka, Takanori Katsube, Yasuharu Ninomiya, Mitsuru Nenoi
  • Organizer: Institute of Modern Physic
  • Int'l Joint Research / Invited
• [Presentation] FISH analysis of chromosomal aberrations in mouse splenocytes following total body irradiation with heavy ions (iron-56 ions) and X-rays. The Superiority of The Mechanism of Heavy Ion Therapy in Institute of Modern Physic (2018)
  • Author(s): Takanori Katsube, Bing Wang, Kaoru Tanaka, Yasuharu Ninomiya, Hirokazu Hirakawa, Cuihua Liu, Kouichi Maruyama, Guillaume Vares, Tetsuo Nakajima, Aiko Nagamatsu, Kenshi Suzuki, Taiki Kawagoshi, Naoko Shiomi, Yoshihisa Kubota, Qiang Liu, Akinori Morita, Akira Fujimori, Mitsuru Nenoi
  • Organizer: Institute of Modern Physic
  • Int'l Joint Research / Invited
• [Presentation] The link between REM sleep loss and the desire for junk food (2018)
  • Author(s): Michael Lazarus
  • Organizer: European Sleep Research Society (ESRS)
  • Int'l Joint Research / Invited
• [Presentation] The link between REM sleep loss and the desire for junk food (2018)
  • Author(s): Michael Lazarus
  • Organizer: Federation of European Neuroscience Societies (FENS)
  • Int'l Joint Research / Invited
• [Presentation] Why do we fall asleep when bored? - The control of sleep and wakefulness by the nucleusaccumbens (2018)
  • Author(s): Michael Lazarus
  • Organizer: Japan Neuroscience Society
  • Int'l Joint Research / Invited
• [Presentation] Design and synthesis of novel ligands of opioid receptors (2015)
  • Author(s): Nagase H
  • Organizer: Pacifichem
  • Place of Presentation: Honolulu, HI, USA
  • Year and Date: 2015-12-17
  • Int'l Joint Research / Invited
• [Book] 宇宙を模擬した放射線と微小重力の複合曝露による染色体異常の増加 (2019)
  • Author(s): 髙橋昭久, 藤原敬己, 秦恵
  • Total Pages: 4
  • Publisher: ニューサイエンス社
• [Book] 4Arch Pharm Chem Life Sci「Synthesis of novel triplets with a 1,3,5-trioxazatriquinane skeleton and their pharmacologies for opioid receptors」 (2015)
  • Author(s): Nagase H, Katsunuma N
  • Total Pages: 15
  • Publisher: Wiley
• [Book] Orexin and Sleep: Molecular, Functional and Clinical Aspects「Orexin and Metabolism」 (2015)
  • Author(s): Funato H
  • Total Pages: 18
  • Publisher: Springer
• [Book] 平成27年度日本薬学会医薬化学部会賞を受賞し、Med Chem Newsに掲載「低分子オレキシン受容体アゴニストの創製」 (2015)
  • Author(s): 斉藤毅、長瀬博
  • Total Pages: 7
  • Publisher: 日本薬学会
• [Book] メカノバイオロジー：細胞が力を感じ応答する仕組み (2015)
  • Author(s): 曽我部正博（編集）
  • Total Pages: 332
  • Publisher: 化学同人
• [Book] The Lipid, vol.27「Ⅲ.サルコぺニアの予防と治療、1.筋衛星細胞活性化による骨格筋再生」 (2015)
  • Author(s): 瀬原淳子
  • Total Pages: 6
  • Publisher: メディカルレビュー社
• [Book] 日本薬学会誌ファルマシア「オピニオン：メカノバイオロジーの可能性」 (2015)
  • Author(s): 曽我部正博
  • Total Pages: 3
  • Publisher: 日本薬学会
• [Book] 日本生物物理学会誌生物物理「アクチン線維は張力を感じ、コフィリンとの相互作用を介して細胞骨格の動態を制御するメカノセンサーである」 (2015)
  • Author(s): 辰巳仁史、早川公英、曽我部正博
  • Total Pages: 5
  • Publisher: 日本生物物理学会
• [Book] 血管医学「発展するメカノセンシング研究」 (2015)
  • Author(s): 曽我部正博
  • Total Pages: 13
  • Publisher: メディカルレビュー社
• [Book] JOHNS「起立性調節障害に自律神経はどう関与するか？」 (2015)
  • Author(s): 森田啓之
  • Total Pages: 4
  • Publisher: 東京医学社
• [Book] PROGRESS IN MEDICINE「フレイルと骨粗鬆症の関連」 (2015)
  • Author(s): 梶博史
  • Total Pages: 4
  • Publisher: ライフサイエンス
• [Book] 循環制御「長期宇宙滞在時に解決すべき医学的課題～循環制御関連を中心に～」 (2015)
  • Author(s): 古川聡
  • Total Pages: 3
  • Publisher: 日本循環制御医学会
• [Remarks] 宇宙に生きる 宇宙からひも解く新たな生命制御機構の統合的理解
  • URL: http://living-in-space.jp/
• [Remarks] 宇宙に生きる 宇宙からひも解く新たな生命制御機構の統合的理
  • URL: http://living-in-space.jp/
• [Funded Workshop] International Symposium on LIVING IN SPACE (2019)
• [Funded Workshop] International Symposium on LIVING IN SPACE (2017)
  • Place of Presentation: Tokyo