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Integral Understanding of Life-regulation Mechanism from "SPACE"

International Activities Supporting Group

Project Area"LIVING IN SPACE" - Integral Understanding of life-regulation mechanism from "SPACE"
Project/Area Number 15K21745
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeMulti-year Fund
Review Section Complex systems
Research InstitutionJapan Aerospace EXploration Agency

Principal Investigator

Furukawa Satoshi  国立研究開発法人宇宙航空研究開発機構, 有人宇宙技術部門, 上席研究開発員 (20726260)

Project Period (FY) 2015-11-06 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥74,100,000 (Direct Cost: ¥57,000,000、Indirect Cost: ¥17,100,000)
Fiscal Year 2019: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2018: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2017: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2016: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2015: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Keywords宇宙 / 微小重力 / ストレス / 放射線 / 微生物 / 無重力
Outline of Final Research Achievements

During a long-term stay in space, physical stress of zero gravity causes muscle atrophy and bone loss, psychological stress by an enclosed environment brings about biological rhythm dysfunction, environmental risks like space radiation exposure induce DNA mutation. These issues need to be resolved in an era of challenging an ultra-long-term stay in space with human exploration to Mars. At the same time, deep understanding of the issues will help contribute to maintaining homeostasis of life in our super-aged, stressful society on Earth, leading to healthy aging and longevity.
Our team of experts attempted to integrally understand the plasticity and failure of life forms on Earth. In the 5-year research period, total of 37 researchers were sent abroad, and total of 64 foreign researchers were invited to Japan. More than 30 peer-reviewed scientific papers were published.

Academic Significance and Societal Importance of the Research Achievements

重力影響による骨・筋・前庭・循環系・免疫機能の恒常性維持と破綻を、宇宙・地上実験にて、細胞、組織から器官、それらのネットワーク、個体レベルで、重力感受と適応応答機構ならびにその分子基盤を特定した。また、ストレスと関連が深い睡眠・覚醒の領域において新たな睡眠診断デバイス(簡易であり、地上の生活にも大いに役立つ)、不眠症治療薬の評価分析、眠気の分子的実体を捉えるなど世界トップレベルでの研究を展開・達成した。さらに、無重力と閉鎖環境の複合影響を研究するため、新規装置開発、メタゲノム解析、蛍光プローブやバイオイメージングなど新たなモニタリングシステムの開発も行った。

Report

(7 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (148 results)

All 2021 2020 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (27 results) Journal Article (73 results) (of which Int'l Joint Research: 44 results,  Peer Reviewed: 68 results,  Open Access: 42 results,  Acknowledgement Compliant: 11 results) Presentation (30 results) (of which Int'l Joint Research: 26 results,  Invited: 15 results) Book (12 results) Remarks (4 results) Funded Workshop (2 results)

  • [Int'l Joint Research] バージニア大学/コロラド州立大学/Prairie View A&M University(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] ドイツ航空宇宙センター(ドイツ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] パスツール研究所(フランス)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] バルセロナ大学/Pompeu Fabra University(スペイン)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] ベルゲン大学(ノルウェー)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] バージニア大学/コロラド州立大学/Prairie View A&M University(米国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] ドイツ航空宇宙センター/マックスプランク研究所(ドイツ)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] パスツール研究所(フランス)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] University of Bristol(英国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] シンガポール国立大学(シンガポール)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research]

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] バージニア大学/コロラド州立大学/Prairie View A&M University(米国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] ドイツ航空宇宙センター(ドイツ)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] パスツール研究所(フランス)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] バルセロナ大学/Pompeu Fabra University(スペイン)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] ベルゲン大学(ノルウェー)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research]

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] スタンフォード大学/ハーバード大学/バージニア大学(米国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] ドイツ航空宇宙センター/マールブルグ大学/Institute of Aerospace Medicine(ドイツ)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] パスツール研究所(フランス)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Institute of Science and Technology(オーストリア)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] スウェーデン農業科学大学(スウェーデン)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] スタンフォード大学/フロリダ州立大学/バージニア大学(米国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] German Aerospace Center/マールブルグ大学/Institute of Aerospace Medicine(ドイツ )

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] パスツール研究所(フランス)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Institute of Science and Technology(オーストリア)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Identification of fungi isolated from astronaut nasal and pharyngeal smears and saliva2021

    • Author(s)
      Kazuo Satoh , Takashi Yamazaki , Satoshi Furukawa , Chiaki Mukai , Koichi Makimura
    • Journal Title

      Microbiol Immunol

      Volume: 65 Issue: 2 Pages: 89

    • DOI

      10.1111/1348-0421.12872

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] How does spaceflight affect acquired immune system?2020

    • Author(s)
      T. Akiyama, K. Horie, E. Hinoi, M. Hiraiwa, A. Kato, Y. Maekawa, A. Takahashi, S. Furukawa
    • Journal Title

      NPJ Microgravity.

      Volume: 0 Issue: 1 Pages: 1-7

    • DOI

      10.1038/s41526-020-0104-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transient and lineage-restricted requirement of Ebf3 for sternum ossification.2020

    • Author(s)
      Kuriki M, Sato F, Arai HN, Sogabe M, Kaneko M, Kiyonari H, Kawakami K, Yoshimoto Y, Shukunami C, Sehara-Fujisawa A.
    • Journal Title

      Development

      Volume: 147 Issue: 9

    • DOI

      10.1242/dev.186239

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Combined Environment Simulator for Low-Dose-Rate Radiation and Partial Gravity of Moon and Mars2020

    • Author(s)
      Takahashi Akihisa、Yamanouchi Sakuya、Takeuchi Kazuomi、Takahashi Shogo、Tashiro Mutsumi、Hidema Jun、Higashitani Atsushi、Adachi Takuya、Zhang Shenke、Guirguis Fady Nagy Lotfy、Yoshida Yukari、Nagamatsu Aiko、Hada Megumi、Takeuchi Kunihito、Takahashi Tohru、Sekitomi Yuji
    • Journal Title

      Life

      Volume: 10 Issue: 11 Pages: 274-274

    • DOI

      10.3390/life10110274

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Simultaneous Exposure of Cultured Human Lymphoblastic Cells to Simulated Microgravity and Radiation Increases Chromosome Aberrations2020

    • Author(s)
      Sakuya Yamanouchi, Jordan Rhone, Jian-Hua Mao, Keigi Fujiwara, Premkumar B. Saganti, Akihisa Takahashi, and Megumi Hada
    • Journal Title

      life

      Volume: 10(9) Issue: 9 Pages: 187-187

    • DOI

      10.3390/life10090187

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The skin mycobiome of an astronaut during a 1-year stay on the International Space Station2020

    • Author(s)
      *Takashi Sugita , Takashi Yamazaki , Otomi Cho , Satoshi Furukawa and Chiaki Mukai
    • Journal Title

      Medical Mycology

      Volume: N/A Issue: 1 Pages: 106-109

    • DOI

      10.1093/mmy/myaa067

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Iron Ladies - How Desiccated Asexual Rotifer Adineta vaga Deal With X-Rays and Heavy Ions?2020

    • Author(s)
      Hespeels B, Penninckx S, Cornet V, Bruneau L, Bopp C, Baumle V, Redivo B, Heuskin AC, Moeller R, Fujimori A, Stephane Lucas, Doninck KV.
    • Journal Title

      frontiers in Microbiology

      Volume: 11 Pages: 1-14

    • DOI

      10.3389/fmicb.2020.01792

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Responses of the Black Fungus Cryomyces Antarcticus to High Doses of Accelerated Helium Ions Radiation within Martian Regolith Simulants and Their Relevance for Mars2020

    • Author(s)
      Pacelli C, Cassaro A, Aureli L, Moeller R, Fujimori A, Onofri S.
    • Journal Title

      life

      Volume: 10 Issue: 8 Pages: 1-14

    • DOI

      10.3390/life10080130

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Space radiation biology for “Living in Space”2020

    • Author(s)
      Furukawa S, Nagamatsu A, Nenoi M, Fujimori A, Kakinuma S, Katsube T, Wang B, Tsuruoka C, Shirai T, Nakamura AJ, Sakaue-Sawano A, Miyawaki A, Harada H, Kobayashi M, Kobayashi J, Kunieda T, Funayama T, Suzuki M, Miyamoto T, Hidema J, Yoshida Y, Takahashi A.
    • Journal Title

      BioMed Res Int.

      Volume: 2020 Issue: 1 Pages: 4703286-4703286

    • DOI

      10.1155/2020/4703286

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate.2019

    • Author(s)
      Arai HN, Sato F, Yamamoto T, Woltjen K, Kiyonari H, Yoshimoto Y, Shukunami C, Akiyama H, Kist R, Sehara-Fujisawa A.
    • Journal Title

      Cell Rep

      Volume: 29 Issue: 3 Pages: 603-616

    • DOI

      10.1016/j.celrep.2019.09.019

    • NAID

      120006731597

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mitochondrial dysfunction causes Ca2+ overload and ECM degradation?mediated muscle damage in C. elegans2019

    • Author(s)
      Sudevan Surabhi、Takiura Mai、Kubota Yukihiko、Higashitani Nahoko、Cooke Michael、Ellwood Rebecca A.、Etheridge Timothy、Szewczyk Nathaniel J.、Higashitani Atsushi
    • Journal Title

      The FASEB Journal

      Volume: 33 Issue: 8 Pages: 9540-9550

    • DOI

      10.1096/fj.201802298r

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] PDH-mediated metabolic flow is critical for skeletal muscle stem cell differentiation and myotube formation during regeneration in mice2019

    • Author(s)
      Hori Shimpei、Hiramuki Yosuke、Nishimura Daigo、Sato Fuminori、Sehara-Fujisawa Atsuko
    • Journal Title

      The FASEB Journal

      Volume: - Issue: 7 Pages: 8094-8109

    • DOI

      10.1096/fj.201802479r

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Expression Profile of Cell Cycle-Related Genes in Human Fibroblasts Exposed Simultaneously to Radiation and Simulated Microgravity2019

    • Author(s)
      Ikeda Hiroko、Muratani Masafumi、Hidema Jun、Hada Megumi、Fujiwara Keigi、Souda Hikaru、Yoshida Yukari、Takahashi Akihisa
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 19 Pages: 4791-4791

    • DOI

      10.3390/ijms20194791

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Monoenergetic 290 MeV/n carbon-ion beam biological lethal dose distribution surrounding the Bragg peak2019

    • Author(s)
      Buglewicz Dylan J.、Banks Austin B.、Hirakawa Hirokazu、Fujimori Akira、Kato Takamitsu A.
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 6157-6157

    • DOI

      10.1038/s41598-019-42600-4

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Acute Social Defeat Stress Increases Sleep in Mice2019

    • Author(s)
      Fujii Shinya、Kaushik Mahesh K.、Zhou Xuzhao、Korkutata Mustafa、Lazarus Michael
    • Journal Title

      Frontiers in Neuroscience

      Volume: 13 Pages: 322-322

    • DOI

      10.3389/fnins.2019.00322

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gating and the Need for Sleep: Dissociable Effects of Adenosine A1 and A2A Receptors2019

    • Author(s)
      Lazarus Michael、Oishi Yo、Bjorness Theresa E.、Greene Robert W.
    • Journal Title

      Frontiers in Neuroscience

      Volume: 13 Pages: 740-740

    • DOI

      10.3389/fnins.2019.00740

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Non-canonical cholinergic anti-inflammatory pathway-mediated activation of peritoneal macrophages induces Hes1 and blocks ischemia/ reperfusion injury in the kidney.2019

    • Author(s)
      Inoue T,Abe C, Kohro T, Tanaka S, Huang L, Yao J, Zheng S, Ye H, Inagi R, Stornetta RL, Rosin DL, Nangaku M, Wada Y, Okusa MD
    • Journal Title

      Kidney International

      Volume: 95(3) Issue: 3 Pages: 563-576

    • DOI

      10.1016/j.kint.2018.09.020

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Radiobiological Characterization of Canine Malignant Melanoma Cell Lines with Different Types of Ionizing Radiation and Efficacy Evaluation with Cytotoxic Agents2019

    • Author(s)
      Yoshikawa Hiroto、Sunada Shigeaki、Hirakawa Hirokazu、Fujimori Akira、Elmegerhi Suad、Leary Del、Kato Takamitsu
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 4 Pages: 841-841

    • DOI

      10.3390/ijms20040841

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Extracellular adenosine and slow-wave sleep are increased after ablation of nucleus accumbens core astrocytes and neurons in mice2019

    • Author(s)
      Zhou X, Oishi Y, Cherasse Y, Korkutata M, Fujii S, Lee CY, Lazarus M
    • Journal Title

      Neurochemistry International

      Volume: 124 Pages: 256-263

    • DOI

      10.1016/j.neuint.2019.01.020

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Progression of Peripheral Vestibular Dysfunctions in Patients With a Mitochondrial A3243G Mutation2019

    • Author(s)
      Inoue Aki、Iwasaki Shinichi、Fujimoto Chisato、Kinoshita Makoto、Yamasoba Tatsuya
    • Journal Title

      Otology & Neurotology

      Volume: 40 Issue: 3 Pages: 359-364

    • DOI

      10.1097/mao.0000000000002091

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sleep and wakefulness are controlled by ventral medial midbrain/pons GABAergic neurons in mice2018

    • Author(s)
      Takata Y, Oishi Y, Zhou XZ, Hasegawa E, Takahashi K, Cherasse Y, Sakurai T, Lazarus M
    • Journal Title

      Journal of Neuroscience

      Volume: 0598-18 Issue: 47 Pages: 10080-10092

    • DOI

      10.1523/jneurosci.0598-18.2018

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enhancing endogenous adenosine A2A receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function2018

    • Author(s)
      Korkutata M, Saitoh T, Cherasse Y, Ioka S, Duo F, Qin R, Murakoshi N, Fujii S, Zhou X, Sugiyama F, Chen JF, Kumagai H, Nagase H, Lazarus M
    • Journal Title

      Neuropharmacology

      Volume: 144 Pages: 122-132

    • DOI

      10.1016/j.neuropharm.2018.10.022

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Palmitoyl ascorbic acid 2-glucoside has the potential to protect mammalian cells from high-LET carbon-ion radiation2018

    • Author(s)
      Alexis H. Haskins, Dylan J. Buglewicz, Hirakawa Hirokazu, Akira Fujimori, Yasushi Aizawa, Takamitsu A. Kato
    • Journal Title

      Scientific Reports

      Volume: 8(1) Issue: 1 Pages: 1-7

    • DOI

      10.1038/s41598-018-31747-1

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Increased Chromosome Aberrations in Cells Exposed Simultaneously to Simulated Microgravity and Radiation.2018

    • Author(s)
      Hada M, Ikeda H, Rhone JR, Beitman AJ, Plante I, Souda H, Yoshida Y, Held KD, Fujiwara K, Saganti PB, Takahashi A.
    • Journal Title

      Int J Mol Sci.

      Volume: 20 Issue: 1 Pages: 43-43

    • DOI

      10.3390/ijms20010043

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of C1 neurons in anti-inflammatory reflex: Mediation between afferents and efferents.2018

    • Author(s)
      Chikara Abe, Tsuyoshi Inoue
    • Journal Title

      Neuroscience Research

      Volume: 136 Pages: 6-12

    • DOI

      10.1016/j.neures.2018.05.001

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Histone Deacetylase Inhibitor induced Radiation Sensitization Effects2018

    • Author(s)
      Ariungerel Gerelchuluun, Junko Maeda, Akira Fujimori et al.
    • Journal Title

      Journal of Molecular Sciences

      Volume: 19(2) Issue: 2 Pages: 496-496

    • DOI

      10.3390/ijms19020496

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cryptoendolithic Antarctic Black Fungus Cryomyces antarcticus Irradiated with2017

    • Author(s)
      Claudia Pacelli, Ralf Moeller, Akira Fujimori et al.
    • Journal Title

      Frontiers in Microbiology

      Volume: 8 Pages: 2002-2002

    • DOI

      10.3389/fmicb.2017.02002

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice2017

    • Author(s)
      Oishi Yo、Xu Qi、Wang Lu、Zhang Bin-Jia、Takahashi Koji、Takata Yohko、Luo Yan-Jia、Cherasse Yoan、Schiffmann Serge N.、de Kerchove d’Exaerde Alban、Urade Yoshihiro、Qu Wei-Min、Huang Zhi-Li、Lazarus Michael
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 1-12

    • DOI

      10.1038/s41467-017-00781-4

    • NAID

      120007134733

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Microgravity elicits reproducible alterations in cytoskeletal and metabolic gene and protein expression in space-flown Caenorhabditis elegans2016

    • Author(s)
      Higashibata A., Hashizume T., Nemoto K., Higashitani N., Etheridge T., Mori C., Harada S., Sugimoto T., Szewczyk NJ., Baba SA., Mogami Y., Fukui K., Higashitani A.
    • Journal Title

      npj Microgravity

      Volume: 2 Issue: 1 Pages: 15022-15022

    • DOI

      10.1038/npjmgrav.2015.22

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Fluid dynamics alter Caenorhabditis elegans body length via TGF-beta/DBL-1 neuromuscular signaling2016

    • Author(s)
      Harada S., Hashizume T., Nemoto K., Shao Z., Higashitani N., Etheridge T., Szewczyk NJ., Fukui K., Higashibata A., Higashitani A.
    • Journal Title

      npj Microgravity

      Volume: 2 Issue: 1 Pages: 16006-16006

    • DOI

      10.1038/npjmgrav.2016.6

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The relationship between widespread changes in gravity and cerebral blood flow2016

    • Author(s)
      Ogawa Y, Yanagida R, Ueda K, Aoki K, Iwasaki K
    • Journal Title

      Environmental Health and Preventive Medicine

      Volume: in press Issue: 4 Pages: 186-192

    • DOI

      10.1007/s12199-016-0513-7

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intrathecal morphine-3-glucuronide-induced nociceptive behavior via δ-2 opioid receptors in the spinal cord2016

    • Author(s)
      Takaaki Komatsu, Soh Katsuyama, Hiroshi Nagase, Hirokazu Mizoguchi, Chikai Sakurada, Minoru Tsuzuki, Shinobu Sakurada, Tsukasa Sakurada
    • Journal Title

      Pharmacology Biochemistry & Behavior

      Volume: 140 Pages: 68-74

    • DOI

      10.1016/j.pbb.2015.10.010

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Opioid systems in the lateral hypothalamus regulate feeding behavior through orexin and GABA neurons.2016

    • Author(s)
      Ardianto C, Yonemochi N, Yamamoto S, Yang L, Takenoya F, Shioda S, Nagase H, Ikeda H, Kamei J.
    • Journal Title

      Neuroscience.

      Volume: 320 Pages: 183-193

    • DOI

      10.1016/j.neuroscience.2016.02.002

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] High-fat diet feeding alters olfactory-, social-, and reward-related behaviors of mice independent of obesity.2016

    • Author(s)
      Takase K, Tsuneoka Y, Oda S, Kuroda M, Funato H
    • Journal Title

      Obesity

      Volume: 4 Issue: 4 Pages: 886-894

    • DOI

      10.1002/oby.21441

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Sleep as a biological problem: an overview of frontiers in sleep research2016

    • Author(s)
      Kanda T, Tsujino N, Kuramoto E, Koyama Y, Susaki EA, Chikahisa S, Funato H
    • Journal Title

      J Physiol Sci

      Volume: 66 Issue: 1 Pages: 1-13

    • DOI

      10.1007/s12576-015-0414-3

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nighttime administration of nicotine improves hepatic glucose metabolism via the hypothalamic orexin system in mice.2016

    • Author(s)
      Tsuneki H, Nagata T, Fujita M, Kon K, Wu N, Takatsuki M, Yamaguchi K, Wada T, Nishijo H, Yanagisawa M, Sakurai T, Sasaoka T.
    • Journal Title

      Endocrinology

      Volume: 157 Issue: 1 Pages: 195-206

    • DOI

      10.1210/en.2015-1488

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Plant nuclei move to escape ultraviolet-induced DNA damage and cell death.2016

    • Author(s)
      Iwabuchi K., Hidema J., Tamura K., Takagi S., Hara-Nishimura I.
    • Journal Title

      Plant Physiology

      Volume: 170 Issue: 2 Pages: 678-685

    • DOI

      10.1104/pp.15.01400

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive analysis of the skin fungal microbiota of astronauts during a half-year stay at the International Space Station2016

    • Author(s)
      Sugita T, Yamazaki T, Makimura K, Cho O, Yamada S, Ohshima H, Mukai C
    • Journal Title

      Med Mycol

      Volume: 54 Issue: 3 Pages: 232

    • DOI

      10.1093/mmy/myv121

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phylogenetic analysis of dermatophyte species using DNA sequence polymorphism in calmodulin gene2016

    • Author(s)
      Ahmadi B, Mirhendi H, Makimura K, de Hoog GS, Shidfar MR, Nouripour-Sisakht S, Jalalizand N
    • Journal Title

      Med Mycol

      Volume: 54 Issue: 5 Pages: 500

    • DOI

      10.1093/mmy/myw004

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Fatal Cyberlindnera fabianii fungemia in a patient with mixed phenotype acute leukemia after umbilical cord blood transplantation2016

    • Author(s)
      Katagiri S, Gotoh M, Tone K, Akahane D, Ito Y, Ohyashiki K, Makimura K
    • Journal Title

      Int J Hematol

      Volume: 103 Issue: 5 Pages: 592

    • DOI

      10.1007/s12185-016-1953-y

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Epidemiological Aspects of Dermatophytosis in Khuzestan, southwestern Iran, an Update2016

    • Author(s)
      Razaei-Matehkolaei A, Rafiei A, Makimura K, Graser Y, Gharghani M, Sadeghi-Nejad B
    • Journal Title

      Mycopathologia

      Volume: 181 Issue: 7-8 Pages: 547

    • DOI

      10.1007/s11046-016-9990-x

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Must but not Mir-335 affects skeletal muscle growth and regeneration2015

    • Author(s)
      Hiramuki Y, Sato T, Furuta Y, Surani A, Sehara-Fujisawa A
    • Journal Title

      PLoS ONE

      Volume: 10 Issue: 6 Pages: e0130436-e0130436

    • DOI

      10.1371/journal.pone.0130436

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] High-resolution live imaging reveals axon-glia interactions during peripheral nerve injury and repair in zebrafish2015

    • Author(s)
      Xiao Y, Faucherre A, Pola-Morell L, Heddleston J, Liu T, Chew T, Sato F, Sehara-Fujisawa A, Kawakami K, Lopez-Schier H
    • Journal Title

      Disease Models & Mechanisms

      Volume: 8 Issue: 6 Pages: 553-64

    • DOI

      10.1242/dmm.018184

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Early pathogenesis of Duchenne muscular dystrophy modelled in patient-derived human induced pluripotent stem cells2015

    • Author(s)
      Shoji E, Sakurai H, Nishino T, Nakahata T, Heike T, Awaya T, Fujii N, Manabe Y, Matsuo M, Sehara-Fujisawa A
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 12831-12831

    • DOI

      10.1038/srep12831

    • NAID

      120005649326

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular dynamics study on protein-water interplay in the mechanogating of the bacterial mechanosensitive channel MscL2015

    • Author(s)
      Sawada Y, Sokabe M
    • Journal Title

      Eur J Biophys

      Volume: 44 Issue: 7 Pages: 531-43

    • DOI

      10.1007/s00249-015-1065-2

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unidirectional incorporation of a bacterial mechanosensitive channel into liposomal membranes2015

    • Author(s)
      Nomura T, Cox CD, Bavi N, Sokabe M and Martinac B
    • Journal Title

      FASEB J.

      Volume: 29 Issue: 10 Pages: 4334-45

    • DOI

      10.1096/fj.15-275198

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Ion channels activated by mechanical forces in bacterial and eukaryotic cells2015

    • Author(s)
      Sokabe M, Sawada M, Kobayashi T
    • Journal Title

      Subcell Biochem

      Volume: 72 Pages: 613-626

    • DOI

      10.1007/978-94-017-9918-8_28

    • ISBN
      9789401799171, 9789401799188
    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hypergravity provokes a temporary reduction in CD4+CD8+ thymocyte number and a persistent decrease in medullary thymic epithelial cell frequency in mice.2015

    • Author(s)
      Tateishi R, Akiyama N, Miyauchi M, Yoshinaga R, Sasanuma H, Kudo T, Shimbo M, Shinohara M, Obata K, Inoue J, Shirakawa M, Shiba D, Asahara H, Yoshida N, Takahashi S, Morita H, Akiyama T
    • Journal Title

      PLOS ONE

      Volume: 10 Issue: 10 Pages: 1-17

    • DOI

      10.1371/journal.pone.0141650

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Feasibility of a short-arm centrifuge for mouse hypergravity experiments2015

    • Author(s)
      Morita H, et al.
    • Journal Title

      PLOS ONE

      Volume: 10(7): e133981 Issue: 7 Pages: 1-14

    • DOI

      10.1371/journal.pone.0133981

    • NAID

      120007136296

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Role of osteoclasis in the heterotopic ossification enhanced by fobrodysplasia ossificans progressiva-related activin-like kinase 2 mutation in mice2015

    • Author(s)
      Kawao N, Yano M, Tamura Y, Okumoto K, Okada K, Kaji H
    • Journal Title

      J Bone Miner Metab

      Volume: epub

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical charasteristics of patients with abnornal ocular/cervical vestibular evoked myogenic potentials in the presence of normal caloric responses2015

    • Author(s)
      Iwasaki S, Fujimoto C, Kinoshita M, Kamogashira T, Egami N, Yamasoba T
    • Journal Title

      Ann Otol Rhinol Laryngol

      Volume: 124 Pages: 458-65

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] The effect of center-of-pressure power spectrum in foam posturography.2015

    • Author(s)
      Fujimoto C, Egami N, Demura S, Yamasoba T, Iwasaki S.
    • Journal Title

      Neurosci Lett.

      Volume: 585 Pages: 92-7

    • DOI

      10.1016/j.neulet.2014.11.033

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transformation of naltrexone into mesembrane and investigation of the binding properties of its intermediate derivatives to opioid receptors2015

    • Author(s)
      Konoura K, Fujii H, Imaide S, Gouda H, Hirayama S, Hirono S, Nagase H
    • Journal Title

      Bioorg Med Chem

      Volume: 23 Issue: 3 Pages: 439-48

    • DOI

      10.1016/j.bmc.2014.12.032

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Peripheral opioid antagonist enhances the effect of anti-Tumor drug by blocking a cell growth-suppressive pathway in vivo2015

    • Author(s)
      Masami Suzuki, Fumiko Chiwaki, Yumi Sawada, Maho Ashikawa, Kazuhiko Aoyagi, Takeshi Fujita, Kazuyoshi Yanagihara, Masayuki Komatsu, Minoru Narita, Tsutomu Suzuki, Hiroshi Nagase, Ryoji Kushima, Hiromi Sakamoto, Takeo Fukagawa, Hitoshi Katai, Hitoshi Nakagama, Teruhiko Yoshida, Yasuhito Uezono, Hiroki Sasaki
    • Journal Title

      PLOS ONE

      Volume: 10 Issue: 4 Pages: 1-18

    • DOI

      10.1371/journal.pone.0123407

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Naltrindole derivatives with fluorinated ethyl substituents on 17-nitrogen as delta opioid receptor inverse agonist2015

    • Author(s)
      Nemoto T, Iihara Y, Hirayama S, Iwai T, Higashi E, Fujii H, Nagase H
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 25 Issue: 15 Pages: 2927-30

    • DOI

      10.1016/j.bmcl.2015.05.038

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Investigation of 7-benzylidenenaltrexone derivatives as a novel structural antitrichomonal lead compound2015

    • Author(s)
      Kutsumura, N.; Nakajima, R.; Koyama, Y.; Miyata, Y.; Saitoh, T.; Yamamoto, N.; Iwata, S.; Fujii, H.; Nagase, H.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 25 Issue: 21 Pages: 4890-4892

    • DOI

      10.1016/j.bmcl.2015.06.002

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Inhibition of opioid systems in the hypothalamus as well as the mesolimbic area suppresses feeding behavior of mice2015

    • Author(s)
      Ikeda H, Ardianto C, Yonemochi N, Yang L, Ohashi T, Ikegami M, Nagase H, Kamei J
    • Journal Title

      Neuroscience

      Volume: 311 Pages: 9-21

    • DOI

      10.1016/j.neuroscience.2015.10.002

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists2015

    • Author(s)
      Nagahara T, Saitoh T, Kutsumura N, Irukayama-Tomobe Y, Ogawa Y, Kuroda D, Gouda H, Kumagai H, Fujii H, Yanagisawa M, Nagase H
    • Journal Title

      J. Med. Chem

      Volume: 58 Issue: 20 Pages: 7931-7937

    • DOI

      10.1021/acs.jmedchem.5b00988

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain2015

    • Author(s)
      Nakajima R, Yamamoto N, Hirayama S, Iwai T, Saitoh A, Nagumo Y, Fujii H, Nagase H.
    • Journal Title

      Bioorg Med Chem.

      Volume: 23 Issue: 19 Pages: 6271-6279

    • DOI

      10.1016/j.bmc.2015.08.036

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Endothelin-1 as a master regulator of whole-body Na+ homeostasis2015

    • Author(s)
      Speed JS, Heimlich JB, Hyndman KA, Fox BM, Patel V, Yanagisawa M, Pollock JS, Titze JM, Pollock DM
    • Journal Title

      FASEB J

      Volume: 29 Issue: 12 Pages: 4937-44

    • DOI

      10.1096/fj.15-276584

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Functional ETA-ETB receptor cross-talk in basilar artery in situ from ETB receptor deficient rats2015

    • Author(s)
      Yoon S, Gariepy CE, Yanagisawa M, Zuccarello M, Rapoport RM
    • Journal Title

      J Cardiovasc Pharmacol

      Volume: epub

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 長期宇宙滞在時に解決すべき医学的課題~循環制御関連を中心に~2015

    • Author(s)
      古川聡
    • Journal Title

      循環制御

      Volume: 36 Pages: 66-8

    • Related Report
      2015 Research-status Report
    • Open Access
  • [Journal Article] UV-B-Induced CPD photolyase gene expression is regulated by UVR8-dependent and -independent pathways in Arabidopsis.2015

    • Author(s)
      Li N, Teranishi M, Yamaguchi H, Matsushita T, Watahiki MK, Tsuge T, Li SS, Hidema J
    • Journal Title

      Plant and Cell Physiology

      Volume: 56 Issue: 10 Pages: 2014-2023

    • DOI

      10.1093/pcp/pcv121

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] From Arabidopsis to cereal crops: Conservation of chloroplast protein degradation by autophagy indicates its fundamental role in plant productivity.2015

    • Author(s)
      Izumi M, Hidema J, Ishida H
    • Journal Title

      Plant Signaling & Behavior

      Volume: 10 Issue: 11 Pages: e1101199-e1101199

    • DOI

      10.1080/15592324.2015.1101199

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells.2015

    • Author(s)
      Ma H, Takahashi A, Yoshida Y, Adachi A, Kanai T, Ohno T, Nakano T.
    • Journal Title

      Radiat Oncol

      Volume: 10 Issue: 1 Pages: 225-225

    • DOI

      10.1186/s13014-015-0536-z

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Targeting of Carbon Ion-Induced G2 Checkpoint Activation in Lung Cancer Cells Using Wee-1 Inhibitor MK-1775.2015

    • Author(s)
      Ma H, Takahashi A, Sejimo Y, Adachi A, Kubo N, Isono M, Yoshida Y, Kanai T, Ohno T, Nakano T.
    • Journal Title

      Radiat Res

      Volume: 184 Issue: 6 Pages: 660-669

    • DOI

      10.1667/rr14171.1

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A critical role of Dectin-1 in hypersensitivity pneumonitis2015

    • Author(s)
      Higashino-Kameda M, Yabe-Wada T, Matsuba S, Takeda K, Anzawa K, Mochizuki T, Makimura K, Saijo S, Iwakura Y, Toga H, Nakamura A
    • Journal Title

      Inflamm Res

      Volume: 65 Issue: 3 Pages: 235

    • DOI

      10.1007/s00011-015-0910-1

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic and Phenotypic analyses of Calcineurin A subunit in Arthroderma vanbreuseghemii2015

    • Author(s)
      Alshahni MM, Shimizu K, Yoshimoto M, Yamada T, Nishiyama Y, Arai T, Makimura K
    • Journal Title

      Med Mycol

      Volume: 54 Issue: 2 Pages: 207

    • DOI

      10.1093/mmy/myv088

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dermatophytosis due to Microsporum incurvatum: Notification and Identification of a Neglected Pathogenic Species2015

    • Author(s)
      Rezaei-Matehkolaei A, Makimura K, Graser Y, Seyedmousavi S, Abastabar M, Rafiei A, Zhan P, Ronagh A, Jafarpour S
    • Journal Title

      Mycopathologia

      Volume: 181 Issue: 1-2 Pages: 107

    • DOI

      10.1007/s11046-015-9946-6

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Microbes and crewed space habitat2015

    • Author(s)
      Yamaguchi N, Nasu M
    • Journal Title

      J Dis Res

      Volume: 10 Pages: 1022-4

    • Related Report
      2015 Research-status Report
  • [Journal Article] Microbial observatory research in the International Space Station and Japanese Experiment Module "Kibo"2015

    • Author(s)
      Shirakawa M, Tanigaki F, Yamazaki T
    • Journal Title

      J Dis Res

      Volume: 10 Pages: 1025-30

    • Related Report
      2015 Research-status Report
  • [Journal Article] Significance of changes in the skin fungal microbiomes of astronauts staying on the International Space Station2015

    • Author(s)
      Sugita T, Cho O
    • Journal Title

      J Dis Res

      Volume: 10 Pages: 1031-4

    • Related Report
      2015 Research-status Report
  • [Journal Article] Bacterial Monitoring in the International Space Station2015

    • Author(s)
      Ichijo T, Yamaguchi N, nasu M
    • Journal Title

      J Dis Res

      Volume: 10 Pages: 1035-9

    • Related Report
      2015 Research-status Report
  • [Presentation] Does cancer progress faster in space? - My future plan of ISS-Kibo and Deep Space Gateway utilization experiments -2020

    • Author(s)
      Akihisa Takahashi
    • Organizer
      10th International Society of Radiation Neurobiology Conference ISRN-2020
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Combined effects of radiation and microgravity on the normal brain2020

    • Author(s)
      Yukari Yoshida, Espinosa-Jeffrey Araceli, Fernandez-Quezada David, Luquin de Anda Sonia, Akihisa Takahashi
    • Organizer
      10th International Society of Radiation Neurobiology Conference ISRN-2020
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Recommendations for space radiation research2020

    • Author(s)
      Akihisa Takahashi
    • Organizer
      第13回Quantum Medicine研究会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] RNA sequencing of cell cycle-related genes in human fibroblasts exposed simultaneously to radiation and simulated microgravity2020

    • Author(s)
      Akihisa Takahashi, Hiroko Ikeda, Masafumi Muratani, Jun Hidema, Keigi Fujiwara, Hikaru Souda, Yukari Yoshida, Megumi Hada
    • Organizer
      2020 NASA Human Research Program Investigators’ Workshop
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Increased chromosome aberrations in lymphoblastoid cells exposed simultaneously to simulated microgravity and radiation2020

    • Author(s)
      Sakuya Yamanouchi, Jordan Rhone, Akihisa Takahashi, Megumi Hada
    • Organizer
      2020 NASA Human Research Program Investigators’ Workshop
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Practicalities of sending C. elegans to space and the similarities of the worm’s adaptations to spaceflight and ageing2019

    • Author(s)
      Atsushi Higashitani
    • Organizer
      22nd International C. elegans Conference
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Ca2+ overload due to mitochondrial dysfunction causes muscle ECM degradation2019

    • Author(s)
      Surabhi Sudevan, Mai Takiura, Yukihiko Kubota, Nahoko Higashitani, Michael Cooke, Rebecca A Ellwood, Timothy Etheridge, Nathaniel J Szewczyk, Atsushi Higashitani
    • Organizer
      22nd International C. elegans Conference
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Bridging the Physiologic Gap: Using C. elegans to Improve Human Skeletal Muscle Health2019

    • Author(s)
      Atsushi Higashitani
    • Organizer
      22nd International C. elegans Conference
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Structured Review: Psychosocial Stress during Long-term Stays in Space2019

    • Author(s)
      Shin-ichiro Sasahara, Yuichi Oi, Shotaro Doki, Daisuke Hori, Yuh Ohtaki, Christina-Sylvia Andrea, Tsukasa Takahashi, Nagisa Shiraki, Yu Ikeda, Tomohiko Ikeda, Ryutaro Izumi, Tamaki Saito, Ichiyo Matsuzaki
    • Organizer
      32nd International Symposium on Space Technology and Science
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] C1 neurons mediate a stress-induced protection of acute kidney injury2019

    • Author(s)
      Chikara Abe
    • Organizer
      International Symposium on Bio-CHAINs from Single Molecules to Highly Organized Systems
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Radiation-protective abilities of DADS, a garlic oil component in X-ray irradiated mice2019

    • Author(s)
      Tetsuo Nakajima, Yasuharu Ninomiya and Mitsuru Nenoi
    • Organizer
      7th International Conference on Food Factors (ICoFF2019)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] How to research about simulated space environments on the Earth2019

    • Author(s)
      Akihisa Takahashi
    • Organizer
      International Conference on Mechanical, Electrical and Medical Intelligent System 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Assessment of Cancer Risk from Radiation Hazard in Space2019

    • Author(s)
      Akihisa Takahashi
    • Organizer
      3rd International Moon Village Workshop and Symposium
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Biological effects of high LET heavy ions in human blood lymphocytes and mouse cells2019

    • Author(s)
      P. Hande, D. Zeegers, S. Venkatesan, M. Seah, P. Velmurugan, S. Koh, S. Sethu, M. Jayapal, B. Banerjee, H. Hirakawa, C. Liu, R. Okayasu, A. Fujimori
    • Organizer
      第62回日本放射線影響学会大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Expression Profile of Cell Cycle-related Genes in Human Fibroblasts Exposed Simultaneously to Radiation and Simulated Microgravity2019

    • Author(s)
      Akihisa Takahashi, Hiroko Ikeda, Masafumi Muratani, Jun Hidema, Megumi Hada, Keigi Fujiwara, Hikaru Souda, Yukari Yoshida
    • Organizer
      35th Annual Meeting of the American Society for Gravitational and Space Research
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Increased Chromosome Aberrations in Cells Exposed Simultaneously to Simulated Microgravity and Radiation2019

    • Author(s)
      Megumi Hada, Jordan Rhone, Andrew J Beitman, Hiroko Ikeda, Ianik Plante, Hikaru Souda, Yukari Yoshida, Kathryn D Held, Keigi Fujiwara, Premkumar B Saganti, Akihisa Takahashi
    • Organizer
      35th Annual Meeting of the American Society for Gravitational and Space Research
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 宇宙環境を模擬した放射線と無重力による脳障害およびその回復機構の解析2019

    • Author(s)
      吉田由香里, Espinosa Araceli, David Fernández-Quezada, 髙橋昭久
    • Organizer
      日本宇宙生物科学会第33回大会
    • Related Report
      2019 Research-status Report
  • [Presentation] BIOINDICATORS OF HEAVY ION EXPOSURES IN HUMAN LYMPHOCYTES: USE OF MOLECULAR CYTOGENETIC TECHNIQUES2019

    • Author(s)
      Dimphy Zeegers, Shriram Venkatesan, Birendranath Banerjee, Swaminathan Sethu, Manikandan Jayapal, Akira Fujimori, Ryuichi Okayasu, Prakash Hande
    • Organizer
      日本宇宙生物科学会第33回大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Increased chromosome aberrations in cells exposed simultaneously to simulated microgravity and radiation.2019

    • Author(s)
      Rhone JR, Beitman A, Ikeda H, Souda H, Yoshida Y, Held KD, Fujiwara K, Takahashi A, Saganti PB, Hada M.
    • Organizer
      2019 NASA Human Research Program Investigators' Workshop
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Study on gravity-dependent skeletal muscle maintenance mechanisms using Zebrafish, aquatic organisms2018

    • Author(s)
      Fuminori Sato, Minyong Choi, Zi Wang, Kiyomi Imamura, Terumi Horiuchi, Wu Quan, Ikumi Fujita, Satoko Uchida, Mitsuyasu Kato, Fumiaki Tanigaki, Akira Higashibata, Masafumi Muratani, Junya Kobayashi, Akihisa Takahashi, Sumio Sugano, Fumio Matsuzaki, Yutaka Suzuki, Koichi Kawakami, Atsuko Sehara-Fujisawa
    • Organizer
      2018 ASCB EMBO Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects from chronic restraint-induced stress and total body Fe irradiation on the hematopoietic system in Trp53-heterozygous mice.2018

    • Author(s)
      Bing Wang, Kaoru Tanaka, Takanori Katsube, Yasuharu Ninomiya, Hirokazu Hirakawa, Cuihua Liu, Kouichi Maruyama, Guillaume Vares, Qing Liu, Tetsuo Nakajima, Akira Fujimori, Mitsuru Nenoi
    • Organizer
      The 64th Annual Radiation Research Society Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects from chronic restraint-induced stress and total body Fe-particle irradiation on the induction of chromosomal aberrations in splenocytes of Trp53-heterozygous mice2018

    • Author(s)
      Takanori Katsube, Bing Wang, Kaoru Tanaka, Yasuharu Ninomiya, Hirokazu Hirakawa, Cuihua Liu, Kouichi Maruyama, Guillaume Vares, Qing Liu, Tetsuo Nakajima, Akira Fujimori, Mitsuru Nenoi
    • Organizer
      The 64th Annual Radiation Research Society Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Residual Genotoxic Damage Induced by Accelerated Heavy Iron Particles in Bone Marrow Erythrocytes in Mice: Reduction of genotoxic effects by radioadaptive response and mild diet restriction?2018

    • Author(s)
      Bing Wang, Kaoru Tanaka, Takanori Katsube, Yasuharu Ninomiya, Hirokazu Hirakawa, Cuihua Liu, Kouichi Maruyama, Guillaume Vares, Tetsuo Nakajima, Akira Fujimori, Mitsuru Nenoi
    • Organizer
      The 3rd Global Chinese Congress of Radiation Research
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Effects of chronic restraint-induced psychological stress and ionizing radiation on mouse spleen cells2018

    • Author(s)
      Takanori Katsube, Bing Wang, Kaoru Tanaka, Yasuharu Ninomiya, Hirokazu Hirakawa, Cuihua Liu, Kouichi Maruyama, Guillaume Vares, Tetsuo Nakajima, Aiko Nagamatsu, Kenshi Suzuki, Taiki Kawagoshi, Naoko Shiomi, Yoshihisa Kubota, Qiang Liu, Akinori Morita, Akira Fujimori, Mitsuru Nenoi
    • Organizer
      The 3rd Global Chinese Congress of Radiation Research
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Reduction of high-dose-radiation-induced delayed genotoxic effects by induction of radioadaptive response and mild diet restriction in mice:The Superiority of The Mechanism of Heavy Ion Therapy in Institute of Modern Physic2018

    • Author(s)
      Bing Wang, Kaoru Tanaka, Takanori Katsube, Yasuharu Ninomiya, Mitsuru Nenoi
    • Organizer
      Institute of Modern Physic
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] FISH analysis of chromosomal aberrations in mouse splenocytes following total body irradiation with heavy ions (iron-56 ions) and X-rays. The Superiority of The Mechanism of Heavy Ion Therapy in Institute of Modern Physic2018

    • Author(s)
      Takanori Katsube, Bing Wang, Kaoru Tanaka, Yasuharu Ninomiya, Hirokazu Hirakawa, Cuihua Liu, Kouichi Maruyama, Guillaume Vares, Tetsuo Nakajima, Aiko Nagamatsu, Kenshi Suzuki, Taiki Kawagoshi, Naoko Shiomi, Yoshihisa Kubota, Qiang Liu, Akinori Morita, Akira Fujimori, Mitsuru Nenoi
    • Organizer
      Institute of Modern Physic
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] The link between REM sleep loss and the desire for junk food2018

    • Author(s)
      Michael Lazarus
    • Organizer
      European Sleep Research Society (ESRS)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] The link between REM sleep loss and the desire for junk food2018

    • Author(s)
      Michael Lazarus
    • Organizer
      Federation of European Neuroscience Societies (FENS)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Why do we fall asleep when bored? - The control of sleep and wakefulness by the nucleusaccumbens2018

    • Author(s)
      Michael Lazarus
    • Organizer
      Japan Neuroscience Society
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Design and synthesis of novel ligands of opioid receptors2015

    • Author(s)
      Nagase H
    • Organizer
      Pacifichem
    • Place of Presentation
      Honolulu, HI, USA
    • Year and Date
      2015-12-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Book] 宇宙を模擬した放射線と微小重力の複合曝露による染色体異常の増加2019

    • Author(s)
      髙橋昭久, 藤原敬己, 秦恵
    • Total Pages
      4
    • Publisher
      ニューサイエンス社
    • Related Report
      2018 Research-status Report
  • [Book] 4Arch Pharm Chem Life Sci「Synthesis of novel triplets with a 1,3,5-trioxazatriquinane skeleton and their pharmacologies for opioid receptors」2015

    • Author(s)
      Nagase H, Katsunuma N
    • Total Pages
      15
    • Publisher
      Wiley
    • Related Report
      2015 Research-status Report
  • [Book] Orexin and Sleep: Molecular, Functional and Clinical Aspects「Orexin and Metabolism」2015

    • Author(s)
      Funato H
    • Total Pages
      18
    • Publisher
      Springer
    • Related Report
      2015 Research-status Report
  • [Book] 平成27年度日本薬学会医薬化学部会賞を受賞し、Med Chem Newsに掲載「低分子オレキシン受容体アゴニストの創製」2015

    • Author(s)
      斉藤毅、長瀬博
    • Total Pages
      7
    • Publisher
      日本薬学会
    • Related Report
      2015 Research-status Report
  • [Book] メカノバイオロジー:細胞が力を感じ応答する仕組み2015

    • Author(s)
      曽我部正博(編集)
    • Total Pages
      332
    • Publisher
      化学同人
    • Related Report
      2015 Research-status Report
  • [Book] The Lipid, vol.27「Ⅲ.サルコぺニアの予防と治療、1.筋衛星細胞活性化による骨格筋再生」2015

    • Author(s)
      瀬原淳子
    • Total Pages
      6
    • Publisher
      メディカルレビュー社
    • Related Report
      2015 Research-status Report
  • [Book] 日本薬学会誌ファルマシア「オピニオン:メカノバイオロジーの可能性」2015

    • Author(s)
      曽我部正博
    • Total Pages
      3
    • Publisher
      日本薬学会
    • Related Report
      2015 Research-status Report
  • [Book] 日本生物物理学会誌生物物理「アクチン線維は張力を感じ、コフィリンとの相互作用を介して細胞骨格の動態を制御するメカノセンサーである」2015

    • Author(s)
      辰巳仁史、早川公英、曽我部正博
    • Total Pages
      5
    • Publisher
      日本生物物理学会
    • Related Report
      2015 Research-status Report
  • [Book] 血管医学「発展するメカノセンシング研究」2015

    • Author(s)
      曽我部正博
    • Total Pages
      13
    • Publisher
      メディカルレビュー社
    • Related Report
      2015 Research-status Report
  • [Book] JOHNS「起立性調節障害に自律神経はどう関与するか?」2015

    • Author(s)
      森田啓之
    • Total Pages
      4
    • Publisher
      東京医学社
    • Related Report
      2015 Research-status Report
  • [Book] PROGRESS IN MEDICINE「フレイルと骨粗鬆症の関連」2015

    • Author(s)
      梶博史
    • Total Pages
      4
    • Publisher
      ライフサイエンス
    • Related Report
      2015 Research-status Report
  • [Book] 循環制御「長期宇宙滞在時に解決すべき医学的課題~循環制御関連を中心に~」2015

    • Author(s)
      古川聡
    • Total Pages
      3
    • Publisher
      日本循環制御医学会
    • Related Report
      2015 Research-status Report
  • [Remarks] 宇宙に生きる 宇宙からひも解く新たな生命制御機構の統合的理解

    • URL

      https://living-in-space.jaxa.jp/

    • Related Report
      2020 Annual Research Report
  • [Remarks] 宇宙に生きる 宇宙からひも解く新たな生命制御機構の統合的理解

    • URL

      https://living-in-space.jp/

    • Related Report
      2019 Research-status Report
  • [Remarks] 宇宙に生きる 宇宙からひも解く新たな生命制御機構の統合的理解

    • URL

      http://living-in-space.jp/

    • Related Report
      2018 Research-status Report
  • [Remarks] 宇宙に生きる 宇宙からひも解く新たな生命制御機構の統合的理

    • URL

      http://living-in-space.jp/

    • Related Report
      2015 Research-status Report
  • [Funded Workshop] International Symposium on LIVING IN SPACE2019

    • Related Report
      2018 Research-status Report
  • [Funded Workshop] International Symposium on LIVING IN SPACE2017

    • Place of Presentation
      Tokyo
    • Related Report
      2016 Research-status Report

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Published: 2015-11-10   Modified: 2025-01-30  

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